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The map label for this gene is hisD

Identifier: 85373346

GI number: 85373346

Start: 560784

End: 562076

Strand: Reverse

Name: hisD

Synonym: ELI_02595

Alternate gene names: 85373346

Gene position: 562076-560784 (Counterclockwise)

Preceding gene: 85373347

Following gene: 85373345

Centisome position: 18.41

GC content: 64.97

Gene sequence:

>1293_bases
GTGCAGCGCCTCAAGAACACCGATCCCGATTTCGAAGCGAAATTCGCCAAGATCGTCGAAGCCCGCCGCGAGAGTTCGCA
GGACGTAGGGCGCGACGTCTTCGACATCCTAGCCCGCGTCAAGGCGATGGGTGACAAAGCACTCGTCGAATATACGACCC
GCTTCGACCAGCATAATCTGACCAATGACAACGATTGGATGATCGCGCCGGATCAGTGCAAGGCTGCCTACGATGCGCTC
GATGCCGACCTGCGCGACGCGTTGCAGCTCGCCGCAGATCGCATCCAGGCCTACCACGAGGACCAGTTGCCGCACGATCG
CGACTATACCGACGATGCGGGCGTGCGGCTGGGTGCGAAATGGCGGCCGGTCGATGCGGCGGGGCTATACGTGCCCGGTG
GCCGGGCAGCCTATCCCTCTTCGCTGCTGATGAACGCGATCCCGGCCAAGGTCGCCGGCGTCGAGCGGCTTGCCATCGTC
ACCCCGACCCCCAAGGGTGAAACCAATCCGCTCGTGCTCGCAGCGGCGCATATCGTTGGCGTGGACGAAATCTGGCGGGT
CGGCGGGGCGCAGGCCATTGGCGCGCTTGCCTACGGGACCGATCGCATCGAGCGGGTCGATGTCATCACCGGCCCCGGCA
ATGCCTGGGTGGCCGAGGCCAAGCGCCAGCTCTACGGCGTGGTCGGCATCGACATGGTGGCAGGGCCGAGCGAAATCCTC
GTCATCGCGGACGGCAAGAACGACCCCGACTGGATCGCCGCCGACCTGCTCAGCCAGGCCGAGCACGACCCGACCAGCCA
GTCGATCCTCATCACCGACGATGCCGATTTCGCCGAGCAGGTCGAGGACCGTGTGGACGTGCAATCCGCGATGCTGGCGA
CCCGCAAGGTCGCGCGCGAGAGCTGGGACGCGCATGGCGTGCTGATCGTCGTCGAGGACCTCGAACAGGCGATCCCGCTC
GCCAACCGGCTCGCTGCCGAGCATGTCGAACTGGCAGTGGATGATCCGGAGGCCCTGATGGGTAAGTTGCACCATGCCGG
CAGCATCTTTCTTGGGCGCATGGTCCCTGAAGCGGTCGGTGACTATGTCGCCGGGCCCAACCACGTGCTTCCCACCGGTC
GCCGTGCGCGCTTTGCAAGCGGCCTGTCGGTGCTCGATTTCATGAAGCGGACCAGCTTCATCTCCATGGACAAGGCCGGC
CTCGAAGCGATCGGGCCTGCCGCCATCAAACTGGCGCATGCCGAGGGCCTGCCCGCCCATGCCGCCTCGATAGAATTGCG
ACTGAAGACATGA

Upstream 100 bases:

>100_bases
CGCGGCTGATCGTCAATCGCGCGGCGCTCAAGACCGATAGTCGCGTAGCCGAGCTGGTCGAGGCATTCCGTGCCGATGCA
GACAATCGGAAAGCAGCATA

Downstream 100 bases:

>100_bases
ACCAGCGTTCTCAATCACGCTCCGCCGCGCGGCTCGCCGCCGTCCAGGCGCTGTACCAGCGTCACATGGAAAAAACGCCG
CTCGCCAGGCTGCTCGACGA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MQRLKNTDPDFEAKFAKIVEARRESSQDVGRDVFDILARVKAMGDKALVEYTTRFDQHNLTNDNDWMIAPDQCKAAYDAL
DADLRDALQLAADRIQAYHEDQLPHDRDYTDDAGVRLGAKWRPVDAAGLYVPGGRAAYPSSLLMNAIPAKVAGVERLAIV
TPTPKGETNPLVLAAAHIVGVDEIWRVGGAQAIGALAYGTDRIERVDVITGPGNAWVAEAKRQLYGVVGIDMVAGPSEIL
VIADGKNDPDWIAADLLSQAEHDPTSQSILITDDADFAEQVEDRVDVQSAMLATRKVARESWDAHGVLIVVEDLEQAIPL
ANRLAAEHVELAVDDPEALMGKLHHAGSIFLGRMVPEAVGDYVAGPNHVLPTGRRARFASGLSVLDFMKRTSFISMDKAG
LEAIGPAAIKLAHAEGLPAHAASIELRLKT

Sequences:

>Translated_430_residues
MQRLKNTDPDFEAKFAKIVEARRESSQDVGRDVFDILARVKAMGDKALVEYTTRFDQHNLTNDNDWMIAPDQCKAAYDAL
DADLRDALQLAADRIQAYHEDQLPHDRDYTDDAGVRLGAKWRPVDAAGLYVPGGRAAYPSSLLMNAIPAKVAGVERLAIV
TPTPKGETNPLVLAAAHIVGVDEIWRVGGAQAIGALAYGTDRIERVDVITGPGNAWVAEAKRQLYGVVGIDMVAGPSEIL
VIADGKNDPDWIAADLLSQAEHDPTSQSILITDDADFAEQVEDRVDVQSAMLATRKVARESWDAHGVLIVVEDLEQAIPL
ANRLAAEHVELAVDDPEALMGKLHHAGSIFLGRMVPEAVGDYVAGPNHVLPTGRRARFASGLSVLDFMKRTSFISMDKAG
LEAIGPAAIKLAHAEGLPAHAASIELRLKT
>Mature_430_residues
MQRLKNTDPDFEAKFAKIVEARRESSQDVGRDVFDILARVKAMGDKALVEYTTRFDQHNLTNDNDWMIAPDQCKAAYDAL
DADLRDALQLAADRIQAYHEDQLPHDRDYTDDAGVRLGAKWRPVDAAGLYVPGGRAAYPSSLLMNAIPAKVAGVERLAIV
TPTPKGETNPLVLAAAHIVGVDEIWRVGGAQAIGALAYGTDRIERVDVITGPGNAWVAEAKRQLYGVVGIDMVAGPSEIL
VIADGKNDPDWIAADLLSQAEHDPTSQSILITDDADFAEQVEDRVDVQSAMLATRKVARESWDAHGVLIVVEDLEQAIPL
ANRLAAEHVELAVDDPEALMGKLHHAGSIFLGRMVPEAVGDYVAGPNHVLPTGRRARFASGLSVLDFMKRTSFISMDKAG
LEAIGPAAIKLAHAEGLPAHAASIELRLKT

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=408, Percent_Identity=41.421568627451, Blast_Score=298, Evalue=3e-82,
Organism=Saccharomyces cerevisiae, GI6319819, Length=402, Percent_Identity=36.318407960199, Blast_Score=249, Evalue=6e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46461; Mature: 46461

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRLKNTDPDFEAKFAKIVEARRESSQDVGRDVFDILARVKAMGDKALVEYTTRFDQHNL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCC
TNDNDWMIAPDQCKAAYDALDADLRDALQLAADRIQAYHEDQLPHDRDYTDDAGVRLGAK
CCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCC
WRPVDAAGLYVPGGRAAYPSSLLMNAIPAKVAGVERLAIVTPTPKGETNPLVLAAAHIVG
CCCCCCCCEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEHHHHHC
VDEIWRVGGAQAIGALAYGTDRIERVDVITGPGNAWVAEAKRQLYGVVGIDMVAGPSEIL
HHHHHHCCCHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHEEEEECCCCEEE
VIADGKNDPDWIAADLLSQAEHDPTSQSILITDDADFAEQVEDRVDVQSAMLATRKVARE
EEECCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
SWDAHGVLIVVEDLEQAIPLANRLAAEHVELAVDDPEALMGKLHHAGSIFLGRMVPEAVG
CCCCCEEEEEEHHHHHHCCHHHHHHHHHHEEEECCHHHHHHHHHHCCHHHHHHHHHHHHH
DYVAGPNHVLPTGRRARFASGLSVLDFMKRTSFISMDKAGLEAIGPAAIKLAHAEGLPAH
HHCCCCCCCCCCCCHHHHHHCHHHHHHHHHHHHHCCCCCCHHHCCHHHEEEECCCCCCCC
AASIELRLKT
CEEEEEEECC
>Mature Secondary Structure
MQRLKNTDPDFEAKFAKIVEARRESSQDVGRDVFDILARVKAMGDKALVEYTTRFDQHNL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCC
TNDNDWMIAPDQCKAAYDALDADLRDALQLAADRIQAYHEDQLPHDRDYTDDAGVRLGAK
CCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCC
WRPVDAAGLYVPGGRAAYPSSLLMNAIPAKVAGVERLAIVTPTPKGETNPLVLAAAHIVG
CCCCCCCCEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEHHHHHC
VDEIWRVGGAQAIGALAYGTDRIERVDVITGPGNAWVAEAKRQLYGVVGIDMVAGPSEIL
HHHHHHCCCHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHEEEEECCCCEEE
VIADGKNDPDWIAADLLSQAEHDPTSQSILITDDADFAEQVEDRVDVQSAMLATRKVARE
EEECCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
SWDAHGVLIVVEDLEQAIPLANRLAAEHVELAVDDPEALMGKLHHAGSIFLGRMVPEAVG
CCCCCEEEEEEHHHHHHCCHHHHHHHHHHEEEECCHHHHHHHHHHCCHHHHHHHHHHHHH
DYVAGPNHVLPTGRRARFASGLSVLDFMKRTSFISMDKAGLEAIGPAAIKLAHAEGLPAH
HHCCCCCCCCCCCCHHHHHHCHHHHHHHHHHHHHCCCCCCHHHCCHHHEEEECCCCCCCC
AASIELRLKT
CEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA