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The map label for this gene is pepA [H]

Identifier: 85373163

GI number: 85373163

Start: 381326

End: 382711

Strand: Reverse

Name: pepA [H]

Synonym: ELI_01680

Alternate gene names: 85373163

Gene position: 382711-381326 (Counterclockwise)

Preceding gene: 85373166

Following gene: 85373162

Centisome position: 12.54

GC content: 65.15

Gene sequence:

>1386_bases
ATGTCCAAATCCGATCTGATACAGCCCGACCACGGGCAAGACGCCATTGCCATCCATCTCGTCAACAAGGATAGCTTCGA
AGACTGGAGCAAATCGCTTTCCGCCGGGCAGCGCGCGGCGCTCGCCGCCCAGAAATTCGATGGCTCGGGCTACCAGGTCG
GCATAGTGCCTGATGGCGATGGATGGTTCGCGGTCGGCGGCGTTGCCGATCCGGAGGAACTCTCGAGCTGGTGCATGGCC
AAGCTGGCGGAGGTCCTTCCCGAAGGCACCTATCGCCGTGCTGAAGGCAATCCAGGCCCGGCCGTTCACGGCTGGCTGAC
GGCGCAATACAGTTTCGAGAAATACACCAAGCCTGAAAACCCGGTCGGCCCGCGCATCCTGCTGAGCAAGGAGGTCAAGG
CTATCGGGCCAGCTCTCTCGGAGGCCCACGCCGTCTGCGAAGTGCGCCGCATGGTCGATACGCCCGCCGAAGACATGGGG
CCCGCCGCGCTCGAATCCGAGTGCGAGAAGCTGGCCAAGACATACGATGCCAAACTCCAGGTCACCAAGGGCGACACGCT
GGAGCAGGAGTACCCGATGGTCCACGCTGTCGGCCGCGCCGCTGATCGCAAGCATGCGCCGCGCATCATGCACCTGACCT
GGGGCAAGGAGGGCGACCCCAAGATTGCTATCGTCGGCAAGGGCGTGGCCTTCGACAGCGGTGGACTCGATGTGAAATCG
GCCGTCGGCATGAAGCTGATGAAGAAGGATATGGGCGGCGCGGCCCATGCCATCGCGCTCGCGGGGCTGATCATGGAGGC
CGGGCTGCCGGTACGGTTGCACCTGCTCGTCCCCGCGGTCGAAAACGCGATCTCCAGCAATTCCTTCCGCCCCGGCGACG
TGCTCAAGACGCGCAAGGGGCTGACGGTGGAGATCGGCAATACCGATGCCGAAGGGCGGCTTATCCTCGGCGATGCGCTG
ACGCGCGCGAGCGAGGAAGAGCCCGAGCTTATCATCGATTTCGCCACGCTGACAGGTGCCGCGCGCGTCGCGCTCGGCCC
CGACCTGCCGGCGCTGATGACCCGGCGCGACGAGACTGCCGAAGCGCTGATCGAAGCGGGCAAGGCCTGCGACGACGAGC
CGTGGCGACTGCCGCTGCCCGAAGCCTACCGCGAATGGCTCAAATCCGACATTGCCGACATGAACAACGCGCATGGCAAT
GCCTATGCCGGGGCCAGCGTCGCCGGCCTGTTCCTCGACCGCTTCGTCGGCGAAGACATCGAATGGGCCCATTTCGACAC
CTTCGCTTGGCGTCCCTTCGCCAAGCCCGGCCGTCCCAAGGGCGGGGACGCCTATGGCCTGCGGGCGAGCTGGCACATGC
TGCAGCGACGCTACAGCGCAGGGTAA

Upstream 100 bases:

>100_bases
GCGACCGCCAGGGCGACGAGACAAGTTTGCTTCATGCGGTTTGACTCCCTTCGATGCGCTTCCCATTAACATTGCTTCAC
GCCGCTTGCATGGGAAATCG

Downstream 100 bases:

>100_bases
AGGGCGCGCCGCGCGCTTGATAGCCCGCAAGGGGCGGTCTAAGCGCGCAGAACAGGACAGAATACGGGGCTTCCAGCAAG
CGTGAGCGAAAACGCGACCT

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MSKSDLIQPDHGQDAIAIHLVNKDSFEDWSKSLSAGQRAALAAQKFDGSGYQVGIVPDGDGWFAVGGVADPEELSSWCMA
KLAEVLPEGTYRRAEGNPGPAVHGWLTAQYSFEKYTKPENPVGPRILLSKEVKAIGPALSEAHAVCEVRRMVDTPAEDMG
PAALESECEKLAKTYDAKLQVTKGDTLEQEYPMVHAVGRAADRKHAPRIMHLTWGKEGDPKIAIVGKGVAFDSGGLDVKS
AVGMKLMKKDMGGAAHAIALAGLIMEAGLPVRLHLLVPAVENAISSNSFRPGDVLKTRKGLTVEIGNTDAEGRLILGDAL
TRASEEEPELIIDFATLTGAARVALGPDLPALMTRRDETAEALIEAGKACDDEPWRLPLPEAYREWLKSDIADMNNAHGN
AYAGASVAGLFLDRFVGEDIEWAHFDTFAWRPFAKPGRPKGGDAYGLRASWHMLQRRYSAG

Sequences:

>Translated_461_residues
MSKSDLIQPDHGQDAIAIHLVNKDSFEDWSKSLSAGQRAALAAQKFDGSGYQVGIVPDGDGWFAVGGVADPEELSSWCMA
KLAEVLPEGTYRRAEGNPGPAVHGWLTAQYSFEKYTKPENPVGPRILLSKEVKAIGPALSEAHAVCEVRRMVDTPAEDMG
PAALESECEKLAKTYDAKLQVTKGDTLEQEYPMVHAVGRAADRKHAPRIMHLTWGKEGDPKIAIVGKGVAFDSGGLDVKS
AVGMKLMKKDMGGAAHAIALAGLIMEAGLPVRLHLLVPAVENAISSNSFRPGDVLKTRKGLTVEIGNTDAEGRLILGDAL
TRASEEEPELIIDFATLTGAARVALGPDLPALMTRRDETAEALIEAGKACDDEPWRLPLPEAYREWLKSDIADMNNAHGN
AYAGASVAGLFLDRFVGEDIEWAHFDTFAWRPFAKPGRPKGGDAYGLRASWHMLQRRYSAG
>Mature_460_residues
SKSDLIQPDHGQDAIAIHLVNKDSFEDWSKSLSAGQRAALAAQKFDGSGYQVGIVPDGDGWFAVGGVADPEELSSWCMAK
LAEVLPEGTYRRAEGNPGPAVHGWLTAQYSFEKYTKPENPVGPRILLSKEVKAIGPALSEAHAVCEVRRMVDTPAEDMGP
AALESECEKLAKTYDAKLQVTKGDTLEQEYPMVHAVGRAADRKHAPRIMHLTWGKEGDPKIAIVGKGVAFDSGGLDVKSA
VGMKLMKKDMGGAAHAIALAGLIMEAGLPVRLHLLVPAVENAISSNSFRPGDVLKTRKGLTVEIGNTDAEGRLILGDALT
RASEEEPELIIDFATLTGAARVALGPDLPALMTRRDETAEALIEAGKACDDEPWRLPLPEAYREWLKSDIADMNNAHGNA
YAGASVAGLFLDRFVGEDIEWAHFDTFAWRPFAKPGRPKGGDAYGLRASWHMLQRRYSAG

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=283, Percent_Identity=36.0424028268551, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI47155554, Length=287, Percent_Identity=34.4947735191638, Blast_Score=142, Evalue=9e-34,
Organism=Escherichia coli, GI87082123, Length=294, Percent_Identity=42.5170068027211, Blast_Score=199, Evalue=4e-52,
Organism=Escherichia coli, GI1790710, Length=350, Percent_Identity=36, Blast_Score=181, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17556903, Length=300, Percent_Identity=38.3333333333333, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17565172, Length=187, Percent_Identity=32.620320855615, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI221379063, Length=285, Percent_Identity=35.0877192982456, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI221379062, Length=285, Percent_Identity=35.0877192982456, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI21357381, Length=285, Percent_Identity=35.0877192982456, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24661038, Length=296, Percent_Identity=31.0810810810811, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI21355725, Length=296, Percent_Identity=30.7432432432432, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24662227, Length=284, Percent_Identity=27.112676056338, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI20129969, Length=326, Percent_Identity=26.6871165644172, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24646701, Length=305, Percent_Identity=30.1639344262295, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24646703, Length=305, Percent_Identity=30.1639344262295, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21358201, Length=305, Percent_Identity=30.1639344262295, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21355645, Length=327, Percent_Identity=24.7706422018349, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24662223, Length=327, Percent_Identity=24.7706422018349, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI19922386, Length=352, Percent_Identity=25.2840909090909, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI20129963, Length=302, Percent_Identity=26.158940397351, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI161077148, Length=307, Percent_Identity=26.0586319218241, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI20130057, Length=307, Percent_Identity=26.0586319218241, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 49686; Mature: 49555

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKSDLIQPDHGQDAIAIHLVNKDSFEDWSKSLSAGQRAALAAQKFDGSGYQVGIVPDGD
CCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEEECCC
GWFAVGGVADPEELSSWCMAKLAEVLPEGTYRRAEGNPGPAVHGWLTAQYSFEKYTKPEN
CCEEECCCCCHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCEEEEEEEEECHHHCCCCCC
PVGPRILLSKEVKAIGPALSEAHAVCEVRRMVDTPAEDMGPAALESECEKLAKTYDAKLQ
CCCCEEEEEHHHHHHCHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHCCEEE
VTKGDTLEQEYPMVHAVGRAADRKHAPRIMHLTWGKEGDPKIAIVGKGVAFDSGGLDVKS
EECCCCCCHHCCHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEECCEEECCCCCCHHH
AVGMKLMKKDMGGAAHAIALAGLIMEAGLPVRLHLLVPAVENAISSNSFRPGDVLKTRKG
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHCCCCCCCCHHHHCCCC
LTVEIGNTDAEGRLILGDALTRASEEEPELIIDFATLTGAARVALGPDLPALMTRRDETA
CEEEECCCCCCCEEEEEHHHHCCCCCCCCEEEEEEHHCCCEEEEECCCCHHHHHCCCHHH
EALIEAGKACDDEPWRLPLPEAYREWLKSDIADMNNAHGNAYAGASVAGLFLDRFVGEDI
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCC
EWAHFDTFAWRPFAKPGRPKGGDAYGLRASWHMLQRRYSAG
CEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKSDLIQPDHGQDAIAIHLVNKDSFEDWSKSLSAGQRAALAAQKFDGSGYQVGIVPDGD
CCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEEECCC
GWFAVGGVADPEELSSWCMAKLAEVLPEGTYRRAEGNPGPAVHGWLTAQYSFEKYTKPEN
CCEEECCCCCHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCEEEEEEEEECHHHCCCCCC
PVGPRILLSKEVKAIGPALSEAHAVCEVRRMVDTPAEDMGPAALESECEKLAKTYDAKLQ
CCCCEEEEEHHHHHHCHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHCCEEE
VTKGDTLEQEYPMVHAVGRAADRKHAPRIMHLTWGKEGDPKIAIVGKGVAFDSGGLDVKS
EECCCCCCHHCCHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEECCEEECCCCCCHHH
AVGMKLMKKDMGGAAHAIALAGLIMEAGLPVRLHLLVPAVENAISSNSFRPGDVLKTRKG
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHCCCCCCCCHHHHCCCC
LTVEIGNTDAEGRLILGDALTRASEEEPELIIDFATLTGAARVALGPDLPALMTRRDETA
CEEEECCCCCCCEEEEEHHHHCCCCCCCCEEEEEEHHCCCEEEEECCCCHHHHHCCCHHH
EALIEAGKACDDEPWRLPLPEAYREWLKSDIADMNNAHGNAYAGASVAGLFLDRFVGEDI
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCC
EWAHFDTFAWRPFAKPGRPKGGDAYGLRASWHMLQRRYSAG
CEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA