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The map label for this gene is zwf [H]

Identifier: 85372936

GI number: 85372936

Start: 141010

End: 142464

Strand: Reverse

Name: zwf [H]

Synonym: ELI_00545

Alternate gene names: 85372936

Gene position: 142464-141010 (Counterclockwise)

Preceding gene: 85372937

Following gene: 85372935

Centisome position: 4.67

GC content: 64.12

Gene sequence:

>1455_bases
ATGAGCTTTACTGCCGACCGCCTGTTGCTGTTCGGCGCGACAGGAGACCTGTCGCAGCGCATGCTGCTGCCCTCGTTGGC
CGCGCTGCATGCCGACCACCTGATCGGTGACGATCTGCAGATCATCGGCACTGCGCGCTCGGACCTCGACGATGCCGGCT
TCCGCAACTTCGCCCGCGAGGCGCTGGAGAAATTCATGCCCGCCGAGCGGCGCAGCGACATGGCGGGCTTCCTCAATCGC
CTGTCCTATCAGCCGCTCGATGCGACCACGCTGGAGGGGTACAAGGAGCTGGCCGACAAGGCCTGTTGTTCCGAGCACGG
CACAGCGATCTTTCTCTCCACCGCGCCGAGCCTGTTCGAGCCGACGATTGCAGGGCTCCGGCATGCCGGGCTGGCGGGCG
AGAATGTGCGGATCGGTCTGGAAAAGCCGCTCGGCACCTCGCTGGAGACATCCTGCGAGATCAACGATGCCGTCGCTGCG
GCTTTCAGCGAGGACCGGACTTATCGGATCGATCACTACCTCGGCAAGGAGACGGTGCAGAACCTGATGGCGCTGCGCTT
CGCCAATATCCTGTTCGAGCCGATCTGGAATTCGAATTATATCGAGCATGTCCAGATCACTGTCGCCGAAACGGTCGGGC
TGGAAGGGCGCGTCGCTTTCTACGACGATGCCGGCGCGTTGCGCGACATGGTGCAGAACCACATGCTGCAATTGCTGGCG
CTGGTCTGCATGGAACCGCCGACCGATTTCGACGCCACCGCCATCCGCGACGAGAAGGTCAAGGTGCTGCGCGCACTGCG
CAAGGTCGACGCGGGCGAGACCGTGACCGGCCAGTATCGTGCGGGCGCGATCGACGGAAAATCCGTGCCCGGCTACGACG
AGGAATTGGGCCCAAAGGACGGTGGGGACAGCGACACCGAGACTTTCGTCGCGATCAAGGCGCATGTCGAGAACTGGCGC
TGGAAGGGCGTGCCGTTCTACCTGCGCACCGGCAAGCGCCTGCCGGAACGGGTGACCGAAATCGTCGTTCAGTTCCGCTG
CATCCCGCATTCGATCTTCAGTTCGAAAGGCGCGACCACCCAGCCCAACCGGCTGGTGATCGGCATCCAGCCGGACGAGA
ACGTGACGCTCAACGTGATGGCCAAGGTTCCGGGACTGGGGCGTGACGGCATCCGGCTGCGGCAAGTCCCGCTCAATATC
GCCATGCCCGATGCCTTCAGCGGCAAGACCCGCCGGATCGCCTATGAACGCCTGCTGCTCGACCTGATCGAAGGCGACCA
GACGCTGTTCGTGCGCCGCGACGAGGTGGAGGCGCAATGGGAATGGATCGACGCCATCCGCGCGACGTGGAGCGAAAGCG
ACCTCAAGCCGAAGACCTACAGCGCCGGGACCTGGGGCCCGAGCGCCGCAATCGCGCTCGCCGAACGCGACGGAGTGAGC
TGGCACGATGAGTAA

Upstream 100 bases:

>100_bases
CTGATCCTGCGCCATTGAATAGCTATGCGCGACACTGGTAGTGGAGGCCGCGCGCTGGTAGCAACCGTCCTCGCATGATG
CATGAGGAGTGTCCCGCCGC

Downstream 100 bases:

>100_bases
CCTTCACGACACCATCCACAAGGTCACCCAGCGCGTTATCGAGCGCTCGAAGCCTTCGCGCAAAGCCTATCTCGAGCTGA
TGGACCGCGAAGCCGACCGC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MSFTADRLLLFGATGDLSQRMLLPSLAALHADHLIGDDLQIIGTARSDLDDAGFRNFAREALEKFMPAERRSDMAGFLNR
LSYQPLDATTLEGYKELADKACCSEHGTAIFLSTAPSLFEPTIAGLRHAGLAGENVRIGLEKPLGTSLETSCEINDAVAA
AFSEDRTYRIDHYLGKETVQNLMALRFANILFEPIWNSNYIEHVQITVAETVGLEGRVAFYDDAGALRDMVQNHMLQLLA
LVCMEPPTDFDATAIRDEKVKVLRALRKVDAGETVTGQYRAGAIDGKSVPGYDEELGPKDGGDSDTETFVAIKAHVENWR
WKGVPFYLRTGKRLPERVTEIVVQFRCIPHSIFSSKGATTQPNRLVIGIQPDENVTLNVMAKVPGLGRDGIRLRQVPLNI
AMPDAFSGKTRRIAYERLLLDLIEGDQTLFVRRDEVEAQWEWIDAIRATWSESDLKPKTYSAGTWGPSAAIALAERDGVS
WHDE

Sequences:

>Translated_484_residues
MSFTADRLLLFGATGDLSQRMLLPSLAALHADHLIGDDLQIIGTARSDLDDAGFRNFAREALEKFMPAERRSDMAGFLNR
LSYQPLDATTLEGYKELADKACCSEHGTAIFLSTAPSLFEPTIAGLRHAGLAGENVRIGLEKPLGTSLETSCEINDAVAA
AFSEDRTYRIDHYLGKETVQNLMALRFANILFEPIWNSNYIEHVQITVAETVGLEGRVAFYDDAGALRDMVQNHMLQLLA
LVCMEPPTDFDATAIRDEKVKVLRALRKVDAGETVTGQYRAGAIDGKSVPGYDEELGPKDGGDSDTETFVAIKAHVENWR
WKGVPFYLRTGKRLPERVTEIVVQFRCIPHSIFSSKGATTQPNRLVIGIQPDENVTLNVMAKVPGLGRDGIRLRQVPLNI
AMPDAFSGKTRRIAYERLLLDLIEGDQTLFVRRDEVEAQWEWIDAIRATWSESDLKPKTYSAGTWGPSAAIALAERDGVS
WHDE
>Mature_483_residues
SFTADRLLLFGATGDLSQRMLLPSLAALHADHLIGDDLQIIGTARSDLDDAGFRNFAREALEKFMPAERRSDMAGFLNRL
SYQPLDATTLEGYKELADKACCSEHGTAIFLSTAPSLFEPTIAGLRHAGLAGENVRIGLEKPLGTSLETSCEINDAVAAA
FSEDRTYRIDHYLGKETVQNLMALRFANILFEPIWNSNYIEHVQITVAETVGLEGRVAFYDDAGALRDMVQNHMLQLLAL
VCMEPPTDFDATAIRDEKVKVLRALRKVDAGETVTGQYRAGAIDGKSVPGYDEELGPKDGGDSDTETFVAIKAHVENWRW
KGVPFYLRTGKRLPERVTEIVVQFRCIPHSIFSSKGATTQPNRLVIGIQPDENVTLNVMAKVPGLGRDGIRLRQVPLNIA
MPDAFSGKTRRIAYERLLLDLIEGDQTLFVRRDEVEAQWEWIDAIRATWSESDLKPKTYSAGTWGPSAAIALAERDGVSW
HDE

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=493, Percent_Identity=36.7139959432049, Blast_Score=282, Evalue=6e-76,
Organism=Homo sapiens, GI109389365, Length=493, Percent_Identity=36.7139959432049, Blast_Score=282, Evalue=6e-76,
Organism=Homo sapiens, GI52145310, Length=493, Percent_Identity=29.4117647058824, Blast_Score=176, Evalue=4e-44,
Organism=Escherichia coli, GI1788158, Length=481, Percent_Identity=47.4012474012474, Blast_Score=435, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17538218, Length=493, Percent_Identity=35.6997971602434, Blast_Score=295, Evalue=5e-80,
Organism=Saccharomyces cerevisiae, GI6324088, Length=472, Percent_Identity=34.5338983050847, Blast_Score=251, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24643352, Length=482, Percent_Identity=33.6099585062241, Blast_Score=264, Evalue=9e-71,
Organism=Drosophila melanogaster, GI24643350, Length=482, Percent_Identity=33.6099585062241, Blast_Score=264, Evalue=1e-70,
Organism=Drosophila melanogaster, GI221513548, Length=496, Percent_Identity=28.0241935483871, Blast_Score=177, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 53626; Mature: 53495

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFTADRLLLFGATGDLSQRMLLPSLAALHADHLIGDDLQIIGTARSDLDDAGFRNFARE
CCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHH
ALEKFMPAERRSDMAGFLNRLSYQPLDATTLEGYKELADKACCSEHGTAIFLSTAPSLFE
HHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHH
PTIAGLRHAGLAGENVRIGLEKPLGTSLETSCEINDAVAAAFSEDRTYRIDHYLGKETVQ
HHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCEEHHHHHCHHHHH
NLMALRFANILFEPIWNSNYIEHVQITVAETVGLEGRVAFYDDAGALRDMVQNHMLQLLA
HHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCEEEEECCHHHHHHHHHHHHHHHHH
LVCMEPPTDFDATAIRDEKVKVLRALRKVDAGETVTGQYRAGAIDGKSVPGYDEELGPKD
HHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCCCCCHHCCCCC
GGDSDTETFVAIKAHVENWRWKGVPFYLRTGKRLPERVTEIVVQFRCIPHSIFSSKGATT
CCCCCCCEEEEEEEECCCCEECCCCEEECCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCC
QPNRLVIGIQPDENVTLNVMAKVPGLGRDGIRLRQVPLNIAMPDAFSGKTRRIAYERLLL
CCCEEEEEECCCCCEEEEEEEECCCCCCCCCEEEEECCEEECCCCCCCCHHHHHHHHHHH
DLIEGDQTLFVRRDEVEAQWEWIDAIRATWSESDLKPKTYSAGTWGPSAAIALAERDGVS
HHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCC
WHDE
CCCC
>Mature Secondary Structure 
SFTADRLLLFGATGDLSQRMLLPSLAALHADHLIGDDLQIIGTARSDLDDAGFRNFARE
CCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHH
ALEKFMPAERRSDMAGFLNRLSYQPLDATTLEGYKELADKACCSEHGTAIFLSTAPSLFE
HHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHH
PTIAGLRHAGLAGENVRIGLEKPLGTSLETSCEINDAVAAAFSEDRTYRIDHYLGKETVQ
HHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCEEHHHHHCHHHHH
NLMALRFANILFEPIWNSNYIEHVQITVAETVGLEGRVAFYDDAGALRDMVQNHMLQLLA
HHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCEEEEECCHHHHHHHHHHHHHHHHH
LVCMEPPTDFDATAIRDEKVKVLRALRKVDAGETVTGQYRAGAIDGKSVPGYDEELGPKD
HHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCCCCCHHCCCCC
GGDSDTETFVAIKAHVENWRWKGVPFYLRTGKRLPERVTEIVVQFRCIPHSIFSSKGATT
CCCCCCCEEEEEEEECCCCEECCCCEEECCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCC
QPNRLVIGIQPDENVTLNVMAKVPGLGRDGIRLRQVPLNIAMPDAFSGKTRRIAYERLLL
CCCEEEEEECCCCCEEEEEEEECCCCCCCCCEEEEECCEEECCCCCCCCHHHHHHHHHHH
DLIEGDQTLFVRRDEVEAQWEWIDAIRATWSESDLKPKTYSAGTWGPSAAIALAERDGVS
HHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCC
WHDE
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2254282 [H]