Click here to switch to the map view.

The map label for this gene is edd [H]

Identifier: 85372935

GI number: 85372935

Start: 139212

End: 141017

Strand: Reverse

Name: edd [H]

Synonym: ELI_00540

Alternate gene names: 85372935

Gene position: 141017-139212 (Counterclockwise)

Preceding gene: 85372936

Following gene: 85372934

Centisome position: 4.62

GC content: 66.17

Gene sequence:

>1806_bases
ATGAGTAACCTTCACGACACCATCCACAAGGTCACCCAGCGCGTTATCGAGCGCTCGAAGCCTTCGCGCAAAGCCTATCT
CGAGCTGATGGACCGCGAAGCCGACCGCGCGCCCGATCGCAGCCAGGTCAGCTGTTCCAACCTCGCGCACGCCTATGCCG
GGGCGACCGACGACCAGGCGGTGATGAAGGCGGGCGGCGCGCCGAATATCGGCATCGTCACTGCCTATAACGACATGCTT
TCCGCGCATCAGCCCTATGGCCGATACCCTGAGCGGATGAAGATCTACGCCCGCGAGGCCGGGGCCACTGCGCAGGTCGC
GGGCGGCACTCCGGCGATGTGCGACGGGGTGACGCAGGGCGAGGACGGAATGGAACTCTCGCTTTTCAGCCGCGACACCA
TCGCCATGAGCACCGGCGTGGCGCTCAGCCATGCGATGTATGAAAGCGTCGCCTTGCTCGGCATTTGCGACAAGATCGTG
CCGGGCCTGCTGATGGGCGCGCTGCGGTTCGGCCACCTGCCCGCCATCTTTGTGCCGAGCGGGCCGATGCCGAGCGGTGT
CGCCAACAAGGAAAAGCAGCGCGTGCGCCAGCTCTATGCCGAGGGCAAGGTGGGCCGCGACGAATTGCTGGCGAGCGAGA
TGGGCAGCTACCACTCGCCCGGCACCTGCACCTTCTACGGCACCGCCAATTCCAACCAGATGATGATGGAGATGATGGGG
CTGCACATTCCCGGCAGCGCTTTCATTCAGCCCGGCACGAAACTTCGGCAGGCGCTCGACCGTGCGGCGGTGCATCGTCT
GGCCGCACTGACGGGATCGAAAGAGCGCAGCCTCGCGCGCTGTGTCGATGAAAAAGCGATCATCAACGCCGCCGTCGGGC
TTCTGGCGACGGGCGGCTCGACCAACCACGCCATCCATATCCCGGCCATGGCCCGTGCCGCAGGCGTAATCTTCGACTGG
ACCGATCTGAGCGAGCTTTCCAGCGCGGTGCCGCTGCTGGCGCGGGTCTATCCCAATGGCGCGGGGGACGTGAACCATTT
TCACGATGCGGGCGGCATGGGCTACGTGATCGGCGAATTGCTCGAAGCGGGCCTCGCCCACCGCGATATCGCCACGGTGT
GGGACAGTGACCTTTCCGCTTATGCACTCGAGCCCGGGCTGGATGACGACGCGCTGGCGTATCGCAACGTCGGCGAGAGC
GGCGATGACACCATGCTCCGCCCCGCCTCCGATCCCTTCAGCCCCGATGGCGGCATGCGGCTGGTGGAGGGCAATCTCGG
GCGTGCCTGCTTCAAGACCAGTGCCGTCGACAAGGAACGCTGGACTATCGAAGCGCCGTGCCGGGTGTTCGAGGACCAGC
CATCGGTCGCCGCGGCGTTCAAGGCGGGCGAGCTCGACCGGGATGTCGTCGTAGTGGTCCGCTTCCAGGGGCCCCGCGCC
AACGGAATGCCCGAACTGCACAGCCTCACGCCGCCGCTCGGCGTGCTGCAGGATCGCGGCTACCGCGTCGCGCTGGTCAC
CGATGGCCGCATGTCGGGGGCGAGCGGGAAAGTCCCAGCGGCGATCCACTGCACACCCGAGGCGCTTGGCAGCGGCCCGC
TGGCCAAGCTGCGCGATGGCGATGTGGTGAAGCTCTGCGCTAGCAACGGAACGCTTTCCACCTCTGCCGATCTCGACAAT
CGCGAGGCCGCTGCGGACCCGGCGCCCGATTGGGGCGTAGGCCGCGAGATGTTCAGCATGTTCCGAATGCACGCCGACGG
GGCCGAACAAGGTGCCAGTCCGATGTTGGCTGCGGCGGGTCTTTGA

Upstream 100 bases:

>100_bases
TGGAGCGAAAGCGACCTCAAGCCGAAGACCTACAGCGCCGGGACCTGGGGCCCGAGCGCCGCAATCGCGCTCGCCGAACG
CGACGGAGTGAGCTGGCACG

Downstream 100 bases:

>100_bases
TGGACCTCGTCGCCGTCGATATCGGGGGAACCCACGCCCGCTTCGCCATTGCCACTGTCGCGGAGGACGGCGCGATCACG
CTCGGCGAACCGGAGACGCT

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 601; Mature: 600

Protein sequence:

>601_residues
MSNLHDTIHKVTQRVIERSKPSRKAYLELMDREADRAPDRSQVSCSNLAHAYAGATDDQAVMKAGGAPNIGIVTAYNDML
SAHQPYGRYPERMKIYAREAGATAQVAGGTPAMCDGVTQGEDGMELSLFSRDTIAMSTGVALSHAMYESVALLGICDKIV
PGLLMGALRFGHLPAIFVPSGPMPSGVANKEKQRVRQLYAEGKVGRDELLASEMGSYHSPGTCTFYGTANSNQMMMEMMG
LHIPGSAFIQPGTKLRQALDRAAVHRLAALTGSKERSLARCVDEKAIINAAVGLLATGGSTNHAIHIPAMARAAGVIFDW
TDLSELSSAVPLLARVYPNGAGDVNHFHDAGGMGYVIGELLEAGLAHRDIATVWDSDLSAYALEPGLDDDALAYRNVGES
GDDTMLRPASDPFSPDGGMRLVEGNLGRACFKTSAVDKERWTIEAPCRVFEDQPSVAAAFKAGELDRDVVVVVRFQGPRA
NGMPELHSLTPPLGVLQDRGYRVALVTDGRMSGASGKVPAAIHCTPEALGSGPLAKLRDGDVVKLCASNGTLSTSADLDN
REAAADPAPDWGVGREMFSMFRMHADGAEQGASPMLAAAGL

Sequences:

>Translated_601_residues
MSNLHDTIHKVTQRVIERSKPSRKAYLELMDREADRAPDRSQVSCSNLAHAYAGATDDQAVMKAGGAPNIGIVTAYNDML
SAHQPYGRYPERMKIYAREAGATAQVAGGTPAMCDGVTQGEDGMELSLFSRDTIAMSTGVALSHAMYESVALLGICDKIV
PGLLMGALRFGHLPAIFVPSGPMPSGVANKEKQRVRQLYAEGKVGRDELLASEMGSYHSPGTCTFYGTANSNQMMMEMMG
LHIPGSAFIQPGTKLRQALDRAAVHRLAALTGSKERSLARCVDEKAIINAAVGLLATGGSTNHAIHIPAMARAAGVIFDW
TDLSELSSAVPLLARVYPNGAGDVNHFHDAGGMGYVIGELLEAGLAHRDIATVWDSDLSAYALEPGLDDDALAYRNVGES
GDDTMLRPASDPFSPDGGMRLVEGNLGRACFKTSAVDKERWTIEAPCRVFEDQPSVAAAFKAGELDRDVVVVVRFQGPRA
NGMPELHSLTPPLGVLQDRGYRVALVTDGRMSGASGKVPAAIHCTPEALGSGPLAKLRDGDVVKLCASNGTLSTSADLDN
REAAADPAPDWGVGREMFSMFRMHADGAEQGASPMLAAAGL
>Mature_600_residues
SNLHDTIHKVTQRVIERSKPSRKAYLELMDREADRAPDRSQVSCSNLAHAYAGATDDQAVMKAGGAPNIGIVTAYNDMLS
AHQPYGRYPERMKIYAREAGATAQVAGGTPAMCDGVTQGEDGMELSLFSRDTIAMSTGVALSHAMYESVALLGICDKIVP
GLLMGALRFGHLPAIFVPSGPMPSGVANKEKQRVRQLYAEGKVGRDELLASEMGSYHSPGTCTFYGTANSNQMMMEMMGL
HIPGSAFIQPGTKLRQALDRAAVHRLAALTGSKERSLARCVDEKAIINAAVGLLATGGSTNHAIHIPAMARAAGVIFDWT
DLSELSSAVPLLARVYPNGAGDVNHFHDAGGMGYVIGELLEAGLAHRDIATVWDSDLSAYALEPGLDDDALAYRNVGESG
DDTMLRPASDPFSPDGGMRLVEGNLGRACFKTSAVDKERWTIEAPCRVFEDQPSVAAAFKAGELDRDVVVVVRFQGPRAN
GMPELHSLTPPLGVLQDRGYRVALVTDGRMSGASGKVPAAIHCTPEALGSGPLAKLRDGDVVKLCASNGTLSTSADLDNR
EAAADPAPDWGVGREMFSMFRMHADGAEQGASPMLAAAGL

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=593, Percent_Identity=55.8178752107926, Blast_Score=655, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=555, Percent_Identity=29.5495495495495, Blast_Score=182, Evalue=7e-47,
Organism=Escherichia coli, GI1786464, Length=480, Percent_Identity=30.4166666666667, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI2367371, Length=461, Percent_Identity=30.8026030368764, Blast_Score=138, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6322476, Length=464, Percent_Identity=28.6637931034483, Blast_Score=145, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 63651; Mature: 63520

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNLHDTIHKVTQRVIERSKPSRKAYLELMDREADRAPDRSQVSCSNLAHAYAGATDDQA
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCHH
VMKAGGAPNIGIVTAYNDMLSAHQPYGRYPERMKIYAREAGATAQVAGGTPAMCDGVTQG
HHHCCCCCCCEEEEECHHHHHCCCCCCCCCHHHEEEEHHCCCEEEECCCCCHHHCCCCCC
EDGMELSLFSRDTIAMSTGVALSHAMYESVALLGICDKIVPGLLMGALRFGHLPAIFVPS
CCCCEEEEECCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
GPMPSGVANKEKQRVRQLYAEGKVGRDELLASEMGSYHSPGTCTFYGTANSNQMMMEMMG
CCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHC
LHIPGSAFIQPGTKLRQALDRAAVHRLAALTGSKERSLARCVDEKAIINAAVGLLATGGS
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEECCCC
TNHAIHIPAMARAAGVIFDWTDLSELSSAVPLLARVYPNGAGDVNHFHDAGGMGYVIGEL
CCCEEECCHHHHHCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHH
LEAGLAHRDIATVWDSDLSAYALEPGLDDDALAYRNVGESGDDTMLRPASDPFSPDGGMR
HHHCHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHCCCCCCCCCEECCCCCCCCCCCCCE
LVEGNLGRACFKTSAVDKERWTIEAPCRVFEDQPSVAAAFKAGELDRDVVVVVRFQGPRA
EEECCCCHHHHHHCCCCCCCEEEECCHHHHCCCCCHHHHHHCCCCCCCEEEEEEECCCCC
NGMPELHSLTPPLGVLQDRGYRVALVTDGRMSGASGKVPAAIHCTPEALGSGPLAKLRDG
CCCCHHHHCCCCHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEECHHHHCCCCCCCCCCC
DVVKLCASNGTLSTSADLDNREAAADPAPDWGVGREMFSMFRMHADGAEQGASPMLAAAG
CEEEEEECCCCEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHCCCCCCHHHCC
L
C
>Mature Secondary Structure 
SNLHDTIHKVTQRVIERSKPSRKAYLELMDREADRAPDRSQVSCSNLAHAYAGATDDQA
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCHH
VMKAGGAPNIGIVTAYNDMLSAHQPYGRYPERMKIYAREAGATAQVAGGTPAMCDGVTQG
HHHCCCCCCCEEEEECHHHHHCCCCCCCCCHHHEEEEHHCCCEEEECCCCCHHHCCCCCC
EDGMELSLFSRDTIAMSTGVALSHAMYESVALLGICDKIVPGLLMGALRFGHLPAIFVPS
CCCCEEEEECCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
GPMPSGVANKEKQRVRQLYAEGKVGRDELLASEMGSYHSPGTCTFYGTANSNQMMMEMMG
CCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHC
LHIPGSAFIQPGTKLRQALDRAAVHRLAALTGSKERSLARCVDEKAIINAAVGLLATGGS
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEECCCC
TNHAIHIPAMARAAGVIFDWTDLSELSSAVPLLARVYPNGAGDVNHFHDAGGMGYVIGEL
CCCEEECCHHHHHCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHH
LEAGLAHRDIATVWDSDLSAYALEPGLDDDALAYRNVGESGDDTMLRPASDPFSPDGGMR
HHHCHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHCCCCCCCCCEECCCCCCCCCCCCCE
LVEGNLGRACFKTSAVDKERWTIEAPCRVFEDQPSVAAAFKAGELDRDVVVVVRFQGPRA
EEECCCCHHHHHHCCCCCCCEEEECCHHHHCCCCCHHHHHHCCCCCCCEEEEEEECCCCC
NGMPELHSLTPPLGVLQDRGYRVALVTDGRMSGASGKVPAAIHCTPEALGSGPLAKLRDG
CCCCHHHHCCCCHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEECHHHHCCCCCCCCCCC
DVVKLCASNGTLSTSADLDNREAAADPAPDWGVGREMFSMFRMHADGAEQGASPMLAAAG
CEEEEEECCCCEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHCCCCCCHHHCC
L
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2254282 [H]