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The map label for this gene is ilvC

Identifier: 85060369

GI number: 85060369

Start: 4098536

End: 4100014

Strand: Reverse

Name: ilvC

Synonym: SG2391

Alternate gene names: 85060369

Gene position: 4100014-4098536 (Counterclockwise)

Preceding gene: 85060371

Following gene: 85060368

Centisome position: 98.29

GC content: 56.8

Gene sequence:

>1479_bases
ATGGCTAACTATTTCAATACCTTAAACCTTCGTCAGCAGTTGGCGCAGTTAGGTAAATGTCGTTTCATGAGCCGGGATGA
ATTCGTCGATGAAGCGGATTACTTGAAAGGCAAAAAAGTGGTGATCATTGGCTGTGGTGCCCAAGGCTTGAACCAAGGGC
TGAATATGCGCGACTCCGGACTGGATATTGCCTATGCGCTGCGTAAAGAAGCCATTGCCGAGAAACGTCCCTCCTGGCGC
AAGGCGACCGAAAACGGTTTCCGCGTCGGCACCTATGAAGAGCTGGTGCCGGAAGCAGGCCTGGTGGTCAACCTGACCCC
GGACAAGCAACATTCCGCCGTGGTGCAGGCGGTACAGCCGCTGATGAAGCAAGGCGCCGCATTGGGCTATTCCCACGGCT
TCAACATCGTTGAAGTGGGCGAGCAAATCCGTCACGACATCACCGTTATCATGGTGGCGCCGAAATGTCCGGGTACCGAG
GTGCGTGAAGAGTACAAGCGCGGCTTCGGCGTGCCGACCCTTATCGCCGTGCATCCGGAAAACGATCCGAAGGGTGAGGG
CATGACGCTGGCCAAAGCCTGGGCGGCCGCGACCGGCGGCCATCGCGCGGGGGTTCTGGAATCCTCTTTCGTCGCCGAGG
TCAAGTCAGATCTGATGGGCGAGCAGACCATTCTGTGCGGCATGCTGCAGGCCGGCTCGCTGCTGTGCTTCGACAAAATG
GTGGCCGATGGCGTCGACCCGGCCTATGCCGGAAAACTGATTCAATTTGGCTGGGAAACCACTACCGAAGCGCTGAAACA
GGGCGGCATCACGCTGATGATGGACCGGCTGTCCAACAGCGCGAAATTGCGCGCTTATGCGTTGTCCGAGCAGCTCAAGC
AATTGATGCAGCCGCTGTTTGAAAAACATATGGACGATATCATCACCGGTGCCTTCTCCAGCGGCATGATGGCCGATTGG
GCCAACGGTGATGTTAAACTGCTCGGCTGGCGTGAAGAAACCGGCCGTTCGCCGTTCGAGAATGCACCGCAGTTCGACGG
CAAAATCAGCGAGCAGACCTACTTCGACCACGGCGTATTGATGATCGCCATGGCAAAAGCCGGCGTGGAACTGGCGTTTG
AAACCATGACCCGTTCCGGCATTATCGCCGAGTCGGCCTATTACGAATCGCTGCACGAATTGCCGCTCATCGCCAACACC
GTCGCGCGCAAGCGTTTGTATGAAATGAATGTGGTCATTTCTGACACCGCCGAGTACGGCAACTATCTGTTCGCCAATGC
CGCCGTGCCGTTGCTGAAAGAGGCGTTTATGGGCAACCTGCAGGTGGGCGATCTGGGTAAACCGGTGGCCGACGGTGAAA
TCGATAATGCGCGTCTGCGTGATGTCAATGAGGCTATCCGCCAGCATCCTATTGAAATCGTGGGCGCCGAACTGCGTGGC
TATATGAAGGATATGAAACGCATCGCGGTCGCGAACTGA

Upstream 100 bases:

>100_bases
AAGCAATGCTTTTCCTGCTTTATAGTGGTCGGCAGAGAAGAATCCTGTCCGCGGGCGAACGCCTGCGGCAAGCCCTAATA
CCTGATGATGGAGTTGCTAC

Downstream 100 bases:

>100_bases
CCGGCGGGAGGGGCATCCCGACGGGTGACGCTCCGTTCAAACTTCAGCCTCCACCGTCCGGCGGGGGGGGGGGCCGCCGT
GGGGATAAACCCCGGCGCCG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 492; Mature: 491

Protein sequence:

>492_residues
MANYFNTLNLRQQLAQLGKCRFMSRDEFVDEADYLKGKKVVIIGCGAQGLNQGLNMRDSGLDIAYALRKEAIAEKRPSWR
KATENGFRVGTYEELVPEAGLVVNLTPDKQHSAVVQAVQPLMKQGAALGYSHGFNIVEVGEQIRHDITVIMVAPKCPGTE
VREEYKRGFGVPTLIAVHPENDPKGEGMTLAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKM
VADGVDPAYAGKLIQFGWETTTEALKQGGITLMMDRLSNSAKLRAYALSEQLKQLMQPLFEKHMDDIITGAFSSGMMADW
ANGDVKLLGWREETGRSPFENAPQFDGKISEQTYFDHGVLMIAMAKAGVELAFETMTRSGIIAESAYYESLHELPLIANT
VARKRLYEMNVVISDTAEYGNYLFANAAVPLLKEAFMGNLQVGDLGKPVADGEIDNARLRDVNEAIRQHPIEIVGAELRG
YMKDMKRIAVAN

Sequences:

>Translated_492_residues
MANYFNTLNLRQQLAQLGKCRFMSRDEFVDEADYLKGKKVVIIGCGAQGLNQGLNMRDSGLDIAYALRKEAIAEKRPSWR
KATENGFRVGTYEELVPEAGLVVNLTPDKQHSAVVQAVQPLMKQGAALGYSHGFNIVEVGEQIRHDITVIMVAPKCPGTE
VREEYKRGFGVPTLIAVHPENDPKGEGMTLAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKM
VADGVDPAYAGKLIQFGWETTTEALKQGGITLMMDRLSNSAKLRAYALSEQLKQLMQPLFEKHMDDIITGAFSSGMMADW
ANGDVKLLGWREETGRSPFENAPQFDGKISEQTYFDHGVLMIAMAKAGVELAFETMTRSGIIAESAYYESLHELPLIANT
VARKRLYEMNVVISDTAEYGNYLFANAAVPLLKEAFMGNLQVGDLGKPVADGEIDNARLRDVNEAIRQHPIEIVGAELRG
YMKDMKRIAVAN
>Mature_491_residues
ANYFNTLNLRQQLAQLGKCRFMSRDEFVDEADYLKGKKVVIIGCGAQGLNQGLNMRDSGLDIAYALRKEAIAEKRPSWRK
ATENGFRVGTYEELVPEAGLVVNLTPDKQHSAVVQAVQPLMKQGAALGYSHGFNIVEVGEQIRHDITVIMVAPKCPGTEV
REEYKRGFGVPTLIAVHPENDPKGEGMTLAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKMV
ADGVDPAYAGKLIQFGWETTTEALKQGGITLMMDRLSNSAKLRAYALSEQLKQLMQPLFEKHMDDIITGAFSSGMMADWA
NGDVKLLGWREETGRSPFENAPQFDGKISEQTYFDHGVLMIAMAKAGVELAFETMTRSGIIAESAYYESLHELPLIANTV
ARKRLYEMNVVISDTAEYGNYLFANAAVPLLKEAFMGNLQVGDLGKPVADGEIDNARLRDVNEAIRQHPIEIVGAELRGY
MKDMKRIAVAN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=491, Percent_Identity=85.132382892057, Blast_Score=854, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323387, Length=279, Percent_Identity=32.258064516129, Blast_Score=113, Evalue=6e-26,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_SODGM (Q2NQA9)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_456071.1
- ProteinModelPortal:   Q2NQA9
- SMR:   Q2NQA9
- STRING:   Q2NQA9
- GeneID:   3868090
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG2391
- NMPDR:   fig|343509.6.peg.5163
- eggNOG:   COG0059
- HOGENOM:   HBG297205
- OMA:   EKHMDDI
- PhylomeDB:   Q2NQA9
- ProtClustDB:   PRK05225
- BioCyc:   SGLO343509:SG2391-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- InterPro:   IPR014359
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- PIRSF:   PIRSF000116
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 54013; Mature: 53881

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: ACT_SITE 132-132

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANYFNTLNLRQQLAQLGKCRFMSRDEFVDEADYLKGKKVVIIGCGAQGLNQGLNMRDSG
CCCCHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHCCCCEEEEEECCCHHHHCCCCCCCCC
LDIAYALRKEAIAEKRPSWRKATENGFRVGTYEELVPEAGLVVNLTPDKQHSAVVQAVQP
CHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHHCCCCCEEEEECCCHHHHHHHHHHHH
LMKQGAALGYSHGFNIVEVGEQIRHDITVIMVAPKCPGTEVREEYKRGFGVPTLIAVHPE
HHHCCCCCCHHCCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEECCC
NDPKGEGMTLAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKM
CCCCCCCEEHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHH
VADGVDPAYAGKLIQFGWETTTEALKQGGITLMMDRLSNSAKLRAYALSEQLKQLMQPLF
HHCCCCHHHHCHHHHCCCHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
EKHMDDIITGAFSSGMMADWANGDVKLLGWREETGRSPFENAPQFDGKISEQTYFDHGVL
HHHHHHHHHHHHCCCCEEECCCCCEEEEEEHHHHCCCCCCCCCCCCCCCCCCHHHCCCCE
MIAMAKAGVELAFETMTRSGIIAESAYYESLHELPLIANTVARKRLYEMNVVISDTAEYG
EEHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHEEEEEECCHHHC
NYLFANAAVPLLKEAFMGNLQVGDLGKPVADGEIDNARLRDVNEAIRQHPIEIVGAELRG
CEEEEHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHCCHHEEHHHHHH
YMKDMKRIAVAN
HHHHHHHHHCCC
>Mature Secondary Structure 
ANYFNTLNLRQQLAQLGKCRFMSRDEFVDEADYLKGKKVVIIGCGAQGLNQGLNMRDSG
CCCHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHCCCCEEEEEECCCHHHHCCCCCCCCC
LDIAYALRKEAIAEKRPSWRKATENGFRVGTYEELVPEAGLVVNLTPDKQHSAVVQAVQP
CHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHHCCCCCEEEEECCCHHHHHHHHHHHH
LMKQGAALGYSHGFNIVEVGEQIRHDITVIMVAPKCPGTEVREEYKRGFGVPTLIAVHPE
HHHCCCCCCHHCCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCCCEEEEECCC
NDPKGEGMTLAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKM
CCCCCCCEEHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHH
VADGVDPAYAGKLIQFGWETTTEALKQGGITLMMDRLSNSAKLRAYALSEQLKQLMQPLF
HHCCCCHHHHCHHHHCCCHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
EKHMDDIITGAFSSGMMADWANGDVKLLGWREETGRSPFENAPQFDGKISEQTYFDHGVL
HHHHHHHHHHHHCCCCEEECCCCCEEEEEEHHHHCCCCCCCCCCCCCCCCCCHHHCCCCE
MIAMAKAGVELAFETMTRSGIIAESAYYESLHELPLIANTVARKRLYEMNVVISDTAEYG
EEHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHEEEEEECCHHHC
NYLFANAAVPLLKEAFMGNLQVGDLGKPVADGEIDNARLRDVNEAIRQHPIEIVGAELRG
CEEEEHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHCCHHEEHHHHHH
YMKDMKRIAVAN
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA