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The map label for this gene is trxA [H]

Identifier: 85060365

GI number: 85060365

Start: 4092998

End: 4093324

Strand: Reverse

Name: trxA [H]

Synonym: SG2387

Alternate gene names: 85060365

Gene position: 4093324-4092998 (Counterclockwise)

Preceding gene: 85060368

Following gene: 85060364

Centisome position: 98.13

GC content: 47.4

Gene sequence:

>327_bases
ATGAGCGATAAAATTATTCATCTGAGTGACGATAGCTTCGAAAAGGACGTATTACAGGCCAAAGGGCTATTTCTGGTCGA
TTTCTGGGCAGAATGGTGTGGTCCTTGTAAAATGATTGCGCCTATTCTGGCAGAAGTCGCTGATGAATTCGACGGCAAAC
TGACCGTCGCTAAATTGAACATCGACGAGAATCCGGCCACTGCACCGAAGTATGGTATCCGCGGCATTCCAACCCTGTTG
TTGTTCCGCGATGGTGAAGTGGTAGCCACCAAGGTTGGAGCCCTGTCTAAAGGACAGTTGAAAGAGTTCCTTAACGCAAA
TCTGTAA

Upstream 100 bases:

>100_bases
GTTAACTATTGCATTACGAAAGTGTATACAGTGAAATAAAGTCAACCTGTTGTTGGGCATTGCTGCAACGGCAGGTAACG
ATAATCCTGTGGAGTAAAAC

Downstream 100 bases:

>100_bases
GCGGTATTGCGAATCTTCCTCTGGGCGCTGGCGTTCATAAGCATTTCTCATATTGACCGCTAGACGCCCATCAAGAACCA
TGCTAAGTTTATGCGCACTG

Product: thioredoxin 1

Products: NA

Alternate protein names: Trx-1 [H]

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MSDKIIHLSDDSFEKDVLQAKGLFLVDFWAEWCGPCKMIAPILAEVADEFDGKLTVAKLNIDENPATAPKYGIRGIPTLL
LFRDGEVVATKVGALSKGQLKEFLNANL

Sequences:

>Translated_108_residues
MSDKIIHLSDDSFEKDVLQAKGLFLVDFWAEWCGPCKMIAPILAEVADEFDGKLTVAKLNIDENPATAPKYGIRGIPTLL
LFRDGEVVATKVGALSKGQLKEFLNANL
>Mature_107_residues
SDKIIHLSDDSFEKDVLQAKGLFLVDFWAEWCGPCKMIAPILAEVADEFDGKLTVAKLNIDENPATAPKYGIRGIPTLLL
FRDGEVVATKVGALSKGQLKEFLNANL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI5031973, Length=86, Percent_Identity=41.8604651162791, Blast_Score=77, Evalue=2e-15,
Organism=Homo sapiens, GI21361657, Length=84, Percent_Identity=42.8571428571429, Blast_Score=75, Evalue=8e-15,
Organism=Homo sapiens, GI21361403, Length=92, Percent_Identity=36.9565217391304, Blast_Score=74, Evalue=3e-14,
Organism=Homo sapiens, GI224493972, Length=103, Percent_Identity=33.0097087378641, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI42794771, Length=103, Percent_Identity=33.0097087378641, Blast_Score=64, Evalue=2e-11,
Organism=Homo sapiens, GI20070125, Length=92, Percent_Identity=34.7826086956522, Blast_Score=64, Evalue=4e-11,
Organism=Escherichia coli, GI87082331, Length=108, Percent_Identity=84.2592592592593, Blast_Score=192, Evalue=4e-51,
Organism=Escherichia coli, GI1788936, Length=109, Percent_Identity=37.6146788990826, Blast_Score=84, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI212646193, Length=96, Percent_Identity=37.5, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71998175, Length=95, Percent_Identity=36.8421052631579, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI115532252, Length=113, Percent_Identity=32.7433628318584, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI115532254, Length=113, Percent_Identity=32.7433628318584, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17549970, Length=87, Percent_Identity=36.7816091954023, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17556044, Length=86, Percent_Identity=34.8837209302326, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=88, Percent_Identity=36.3636363636364, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=95, Percent_Identity=41.0526315789474, Blast_Score=71, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6321648, Length=97, Percent_Identity=37.1134020618557, Blast_Score=67, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6324862, Length=89, Percent_Identity=35.9550561797753, Blast_Score=64, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24639826, Length=87, Percent_Identity=37.9310344827586, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28573567, Length=93, Percent_Identity=35.4838709677419, Blast_Score=73, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19921434, Length=97, Percent_Identity=36.0824742268041, Blast_Score=73, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17648013, Length=86, Percent_Identity=38.3720930232558, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24583090, Length=86, Percent_Identity=38.3720930232558, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24664269, Length=97, Percent_Identity=32.9896907216495, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11836; Mature: 11705

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKIIHLSDDSFEKDVLQAKGLFLVDFWAEWCGPCKMIAPILAEVADEFDGKLTVAKLN
CCCCEEEECCCCHHHHHHHHCCCEEEEEHHHHCCHHHHHHHHHHHHHHHCCCEEEEEEEE
IDENPATAPKYGIRGIPTLLLFRDGEVVATKVGALSKGQLKEFLNANL
CCCCCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCHHHHHHHHCCCC
>Mature Secondary Structure 
SDKIIHLSDDSFEKDVLQAKGLFLVDFWAEWCGPCKMIAPILAEVADEFDGKLTVAKLN
CCCEEEECCCCHHHHHHHHCCCEEEEEHHHHCCHHHHHHHHHHHHHHHCCCEEEEEEEE
IDENPATAPKYGIRGIPTLLLFRDGEVVATKVGALSKGQLKEFLNANL
CCCCCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]