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The map label for this gene is rmlA2 [H]

Identifier: 85060358

GI number: 85060358

Start: 4084431

End: 4085312

Strand: Reverse

Name: rmlA2 [H]

Synonym: SG2380

Alternate gene names: 85060358

Gene position: 4085312-4084431 (Counterclockwise)

Preceding gene: 85060359

Following gene: 85060357

Centisome position: 97.94

GC content: 58.5

Gene sequence:

>882_bases
ATGAAAGGTATTGTCTTGGCGGGCGGCAGCGGCAGTCGCCTCTATCCGATTACCCGCGGTATTTCCAAACAGCTGTTGCC
CGTGTACGACAAGCCGATGATTTATTATCCGCTATCTGTACTGATGCTGGCGGGGATCCGCGACATTCTGATTATCACCA
CACCAGAAGAGATGCCATTATTCAAGCGGTTGCTCGGCGCGGGCGAGGCGTTTGGCGTTCGTCTGACTTATGCCGCCCAG
CCGAGTCCCGACGGCATAGCGCAGGCGTTCCTGATTGGCGAAAGCTTTATCGGCGGTGACCGTTGCTGCCTGGTGCTCGG
CGATAATATCTATTTCGGTCAGGGGTTCAGTCCCAAGCTGCGGCAGGTGGCGTCACGCGAGCAGGGCGCGACGCTATTCG
CCTATCAGGTGATGGATCCTGAGCGTTTCGGCGTGGTGGCGTTCGACGACGATTTTCGCGCCGTCGCGCTTGAGGAAAAA
CCGGCCCATCCACGCTCACGCTGGGCGGTGACCGGGCTTTATTTCTATGATCGTCAGGTGGTGGATTTCGCCAGGCGGGT
CACGCCTTCGGCGCGCGGAGAACTGGAGATTACGTCGATAAACCAGATGTATCTGGAGCAGCGCGGGCTGCACGTCGAGC
TGCTGGGGCGGGGTTTTGCCTGGCTGGATACCGGCACTCATGACAGCCTGATTGAAGCCAGTACCTTTGTGCAGACCGTT
GAGAAGCGCCAGGGGTTTAAAATCGCCTGTCTGGAGGAAATCGGTTGGCGCAACGGTTGGCTCGATGATGACGGCGCGCG
GCGCGCGGCGCAGGCACTGGCGAAAACCGGTTATGGACAATATCTGTTGGATCTGCTCAATGTCCGTCCACGCCAATACT
GA

Upstream 100 bases:

>100_bases
GGTATTTGACCCATCGTGAGTGGTGGCAGCGCGTTCTGGACGGCAGCTATCGCGGCGAACGTCTCGGTCTCGGGCCAGGC
TTGTAAGGCGAGGAGTGCAG

Downstream 100 bases:

>100_bases
TCTCCTGACCTGGGAGAGCGACTTTTTTGGCCGCCGTCTGGGCCGTGTCGCATTTGATGATGCCGCGCCCTGTCTGACGT
CCGGGGGACTTACGGCGTTT

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 2; dTDP-glucose pyrophosphorylase 2; dTDP-glucose synthase 2 [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MKGIVLAGGSGSRLYPITRGISKQLLPVYDKPMIYYPLSVLMLAGIRDILIITTPEEMPLFKRLLGAGEAFGVRLTYAAQ
PSPDGIAQAFLIGESFIGGDRCCLVLGDNIYFGQGFSPKLRQVASREQGATLFAYQVMDPERFGVVAFDDDFRAVALEEK
PAHPRSRWAVTGLYFYDRQVVDFARRVTPSARGELEITSINQMYLEQRGLHVELLGRGFAWLDTGTHDSLIEASTFVQTV
EKRQGFKIACLEEIGWRNGWLDDDGARRAAQALAKTGYGQYLLDLLNVRPRQY

Sequences:

>Translated_293_residues
MKGIVLAGGSGSRLYPITRGISKQLLPVYDKPMIYYPLSVLMLAGIRDILIITTPEEMPLFKRLLGAGEAFGVRLTYAAQ
PSPDGIAQAFLIGESFIGGDRCCLVLGDNIYFGQGFSPKLRQVASREQGATLFAYQVMDPERFGVVAFDDDFRAVALEEK
PAHPRSRWAVTGLYFYDRQVVDFARRVTPSARGELEITSINQMYLEQRGLHVELLGRGFAWLDTGTHDSLIEASTFVQTV
EKRQGFKIACLEEIGWRNGWLDDDGARRAAQALAKTGYGQYLLDLLNVRPRQY
>Mature_293_residues
MKGIVLAGGSGSRLYPITRGISKQLLPVYDKPMIYYPLSVLMLAGIRDILIITTPEEMPLFKRLLGAGEAFGVRLTYAAQ
PSPDGIAQAFLIGESFIGGDRCCLVLGDNIYFGQGFSPKLRQVASREQGATLFAYQVMDPERFGVVAFDDDFRAVALEEK
PAHPRSRWAVTGLYFYDRQVVDFARRVTPSARGELEITSINQMYLEQRGLHVELLGRGFAWLDTGTHDSLIEASTFVQTV
EKRQGFKIACLEEIGWRNGWLDDDGARRAAQALAKTGYGQYLLDLLNVRPRQY

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1790224, Length=293, Percent_Identity=78.839590443686, Blast_Score=494, Evalue=1e-141,
Organism=Escherichia coli, GI1788351, Length=285, Percent_Identity=63.1578947368421, Blast_Score=383, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI133931050, Length=229, Percent_Identity=24.4541484716157, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320148, Length=258, Percent_Identity=25.1937984496124, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21355443, Length=251, Percent_Identity=22.7091633466135, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24644084, Length=251, Percent_Identity=22.7091633466135, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32711; Mature: 32711

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIVLAGGSGSRLYPITRGISKQLLPVYDKPMIYYPLSVLMLAGIRDILIITTPEEMPL
CCCEEEECCCCCEEEHHHHCCCCCCCCCCCCCEEEHHHHHHHHCCCCEEEEEECCCCCHH
FKRLLGAGEAFGVRLTYAAQPSPDGIAQAFLIGESFIGGDRCCLVLGDNIYFGQGFSPKL
HHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHCCCCCCCCEEEEEECCEEEECCCCCHHH
RQVASREQGATLFAYQVMDPERFGVVAFDDDFRAVALEEKPAHPRSRWAVTGLYFYDRQV
HHHHHHCCCCEEEEEEECCCCCEEEEEECCCCEEEEECCCCCCCCCCEEEEEEEEHHHHH
VDFARRVTPSARGELEITSINQMYLEQRGLHVELLGRGFAWLDTGTHDSLIEASTFVQTV
HHHHHHCCCCCCCEEEEEEHHHHHHHHCCCEEEEECCCEEEEECCCCCHHHHHHHHHHHH
EKRQGFKIACLEEIGWRNGWLDDDGARRAAQALAKTGYGQYLLDLLNVRPRQY
HHHCCCEEEEHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKGIVLAGGSGSRLYPITRGISKQLLPVYDKPMIYYPLSVLMLAGIRDILIITTPEEMPL
CCCEEEECCCCCEEEHHHHCCCCCCCCCCCCCEEEHHHHHHHHCCCCEEEEEECCCCCHH
FKRLLGAGEAFGVRLTYAAQPSPDGIAQAFLIGESFIGGDRCCLVLGDNIYFGQGFSPKL
HHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHCCCCCCCCEEEEEECCEEEECCCCCHHH
RQVASREQGATLFAYQVMDPERFGVVAFDDDFRAVALEEKPAHPRSRWAVTGLYFYDRQV
HHHHHHCCCCEEEEEEECCCCCEEEEEECCCCEEEEECCCCCCCCCCEEEEEEEEHHHHH
VDFARRVTPSARGELEITSINQMYLEQRGLHVELLGRGFAWLDTGTHDSLIEASTFVQTV
HHHHHHCCCCCCCEEEEEEHHHHHHHHCCCEEEEECCCEEEEECCCCCHHHHHHHHHHHH
EKRQGFKIACLEEIGWRNGWLDDDGARRAAQALAKTGYGQYLLDLLNVRPRQY
HHHCCCEEEEHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503; 7559340 [H]