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The map label for this gene is wecG [H]

Identifier: 85060352

GI number: 85060352

Start: 4078163

End: 4078903

Strand: Reverse

Name: wecG [H]

Synonym: SG2374

Alternate gene names: 85060352

Gene position: 4078903-4078163 (Counterclockwise)

Preceding gene: 85060353

Following gene: 85060351

Centisome position: 97.79

GC content: 58.84

Gene sequence:

>741_bases
ATGCATAATAACGACGGGGTACCCCACTATCAAATCCGCGGCCTGTCCCTGTGGGGATTTCGCGATCGGGCTGACTTCAT
CGATTATCTGTTTGCAGGCGGACGGCTTAAAACCGGCACGCTGGTGGCGATTAACGCCGAGAAAGTGCTCAACGCCGAGC
GGGATGCGGCGCTGAAAAAGTTGCTCGACGAGGCGGAATACAAATATGCCGATGGTATCAGCATCGTGCGTTCGATCCGC
CGTAAATATCGCCATGCCGAAGTAAGCCGTATTGCAGGGGCGGATTTATGGGAAGATTTAATGGCCCGCGCCGGCAGGGA
GGGTGTGCCGGTGTTTTTGGTCGGCGGCCGCCCGGTGGTGCTGATGCGGACCGAAGCGCAACTGCGCGCACGCTGGAATG
TCAACATTGTCGGCCGGCAGGATGGTTATTTTAGCGTCGACGCACAGCCGGCCCTGGTTGAACGCATCCGCGCCAGCGGG
GCCGCCATTGTCACCGTTGCCATGGGGTCGCCGCGTCAGGAGCAACTGATAGCGTTAATCCGGCGGGAGCATCCTGCGGC
GCTGTACATGGGCGTGGGCGGTACCTATGACGTGTTTACCAGACACGTCAAGCGCGCGCCCAAGGGATGGCAGGATCTTG
GTCTGGAGTGGCTTTACCGTCTATTAAGCCAGCCGTCACGCCTGCAGCGCCAGCTTAAACTTTTACGTTATCTGGGCTAT
CATATCAGCGGACGCCTGTAG

Upstream 100 bases:

>100_bases
CCTGCTGTTCCGACATGCGGGATTCATTCGGCCGCGCACCGCCGGATTAAACGACTACAACGCTATGCCGTAACCGATTA
CACCCCATGGGAAAAAGAGA

Downstream 100 bases:

>100_bases
CGAGTGGAAGGAAAAGGCGCGCCGTCGACGTAAGTGAGCAAAGGGTAATCGAACGCATCATTTCTTTGAAAAATCACTAG
ACAGCCGGCGCGTAAATCCG

Product: putative UDP-N-acetyl-D-mannosaminuronic acid transferase

Products: C55-PP-GlcNAc-ManNAcA; UDP [C]

Alternate protein names: UDP-ManNAcA transferase [H]

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MHNNDGVPHYQIRGLSLWGFRDRADFIDYLFAGGRLKTGTLVAINAEKVLNAERDAALKKLLDEAEYKYADGISIVRSIR
RKYRHAEVSRIAGADLWEDLMARAGREGVPVFLVGGRPVVLMRTEAQLRARWNVNIVGRQDGYFSVDAQPALVERIRASG
AAIVTVAMGSPRQEQLIALIRREHPAALYMGVGGTYDVFTRHVKRAPKGWQDLGLEWLYRLLSQPSRLQRQLKLLRYLGY
HISGRL

Sequences:

>Translated_246_residues
MHNNDGVPHYQIRGLSLWGFRDRADFIDYLFAGGRLKTGTLVAINAEKVLNAERDAALKKLLDEAEYKYADGISIVRSIR
RKYRHAEVSRIAGADLWEDLMARAGREGVPVFLVGGRPVVLMRTEAQLRARWNVNIVGRQDGYFSVDAQPALVERIRASG
AAIVTVAMGSPRQEQLIALIRREHPAALYMGVGGTYDVFTRHVKRAPKGWQDLGLEWLYRLLSQPSRLQRQLKLLRYLGY
HISGRL
>Mature_246_residues
MHNNDGVPHYQIRGLSLWGFRDRADFIDYLFAGGRLKTGTLVAINAEKVLNAERDAALKKLLDEAEYKYADGISIVRSIR
RKYRHAEVSRIAGADLWEDLMARAGREGVPVFLVGGRPVVLMRTEAQLRARWNVNIVGRQDGYFSVDAQPALVERIRASG
AAIVTVAMGSPRQEQLIALIRREHPAALYMGVGGTYDVFTRHVKRAPKGWQDLGLEWLYRLLSQPSRLQRQLKLLRYLGY
HISGRL

Specific function: Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in ECA synthesis [H]

COG id: COG1922

COG function: function code M; Teichoic acid biosynthesis proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 26 family [H]

Homologues:

Organism=Escherichia coli, GI2367289, Length=246, Percent_Identity=67.8861788617886, Blast_Score=325, Evalue=2e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023085
- InterPro:   IPR004629 [H]

Pfam domain/function: PF03808 Glyco_tran_WecB [H]

EC number: 2.4.1.- [C]

Molecular weight: Translated: 27852; Mature: 27852

Theoretical pI: Translated: 10.58; Mature: 10.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNNDGVPHYQIRGLSLWGFRDRADFIDYLFAGGRLKTGTLVAINAEKVLNAERDAALKK
CCCCCCCCCEEEEEEEEECCCCHHHHHHHHHCCCEECCCEEEEEEHHHHHCCHHHHHHHH
LLDEAEYKYADGISIVRSIRRKYRHAEVSRIAGADLWEDLMARAGREGVPVFLVGGRPVV
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEECCCEEE
LMRTEAQLRARWNVNIVGRQDGYFSVDAQPALVERIRASGAAIVTVAMGSPRQEQLIALI
EEECCHHEEEEECEEEEECCCCEEEECCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHH
RREHPAALYMGVGGTYDVFTRHVKRAPKGWQDLGLEWLYRLLSQPSRLQRQLKLLRYLGY
HCCCCCEEEEECCCCHHHHHHHHHHCCCCHHHHCHHHHHHHHCCHHHHHHHHHHHHHHHH
HISGRL
HHCCCC
>Mature Secondary Structure
MHNNDGVPHYQIRGLSLWGFRDRADFIDYLFAGGRLKTGTLVAINAEKVLNAERDAALKK
CCCCCCCCCEEEEEEEEECCCCHHHHHHHHHCCCEECCCEEEEEEHHHHHCCHHHHHHHH
LLDEAEYKYADGISIVRSIRRKYRHAEVSRIAGADLWEDLMARAGREGVPVFLVGGRPVV
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEECCCEEE
LMRTEAQLRARWNVNIVGRQDGYFSVDAQPALVERIRASGAAIVTVAMGSPRQEQLIALI
EEECCHHEEEEECEEEEECCCCEEEECCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHH
RREHPAALYMGVGGTYDVFTRHVKRAPKGWQDLGLEWLYRLLSQPSRLQRQLKLLRYLGY
HCCCCCEEEEECCCCHHHHHHHHHHCCCCHHHHCHHHHHHHHCCHHHHHHHHHHHHHHHH
HISGRL
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosaminuronic-acid; undecaprenyl-N-acetyl-alpha-D-glucosaminyl-pyrophosphate [C]

Specific reaction: UDP-N-acetyl-D-mannosaminuronic-acid + undecaprenyl-N-acetyl-alpha-D-glucosaminyl-pyrophosphate = C55-PP-GlcNAc-ManNAcA + UDP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA