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The map label for this gene is aroE

Identifier: 85060220

GI number: 85060220

Start: 3903450

End: 3904268

Strand: Reverse

Name: aroE

Synonym: SG2242

Alternate gene names: 85060220

Gene position: 3904268-3903450 (Counterclockwise)

Preceding gene: 85060221

Following gene: 85060219

Centisome position: 93.6

GC content: 58.61

Gene sequence:

>819_bases
ATGGATACCTTTGCCGTTTTTGGTAATCCGATTAACCATAGTCGTTCACCGCGCATCCATGCGCTATTTGTCGCCGAGAC
AGGTATAACCCATCCTTACGGTCGGGTACTGGCGCCGCTGGATGGCTTTGAGCAAACGCTGCGGCAGTTTTTCGACGCGG
GCGGCTTGGGGGCGAATATTACCCTGCCGTTTAAAGAACGTGCGTTTTCGCTATGCGATCAACTCACCGAGCGAGGCGCT
TTGGCGGGGGCGGTGAATACCATCAAGAAACAGCCGGACGGTTCCTTGCTGGGGGACAATACCGACGGCATTGGTCTGGT
CAGCGATTTGCAGCGTCTCGATCTACTGCGCCAGGACAGCCGAGTTCTGTTAGTAGGTGTCGGCGGCGCGGCGCGGGGCG
TGGTCCTGCCGCTGCTGGCCTACGGCTGCAAAGTGGTGCTGACTAACCGCACTTTTCCGCGCGCGCAGAAGCTGGTCGGG
TTTTATCACCATGTGGGCGATATTAGCGCGCTGCCGCTGGAGCGCCTGGGCACGCCGGATTATGATCTGATTATTAACGC
GACTTCCACCGGTGTGCAGGGCAGTATCCCGCCGCTGCCGGCATCGCTCATTACATCATCGGTCTGTTGCTATGACATGT
ATTACCAACAAGGCGATACGCCGTTCATCACCTGGTGCCGTCGGCAGGGCTCGCTGCGCTGCGCCGATGGCCTCGGTATG
CTGGTGGGCCAGGCGGCCTCGTCTTTTTTGCTGTGGCATGGTGTTTTACCCTCAGTTTTGCCGGTGTTGGAAACGTTGCG
CGCGGAGCTGAGTGCATGA

Upstream 100 bases:

>100_bases
CTGGACGAAGCGGTGGAAGGACGACTCAATCCCACTGAGATACGCGATGCTCTGAGCGGCGAATTGATTCGACAGGGCTG
ATTATAACCGGAGTGTCACC

Downstream 100 bases:

>100_bases
ACCAGGCGATCCATTTTCCCGATCTTGAACAATGGGATGACGAGCGTCAAAGCATGTGTTTTCCGGCGTTGGTGAGCGGC
ATGCGCGTGGAGTGCCAGGT

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MDTFAVFGNPINHSRSPRIHALFVAETGITHPYGRVLAPLDGFEQTLRQFFDAGGLGANITLPFKERAFSLCDQLTERGA
LAGAVNTIKKQPDGSLLGDNTDGIGLVSDLQRLDLLRQDSRVLLVGVGGAARGVVLPLLAYGCKVVLTNRTFPRAQKLVG
FYHHVGDISALPLERLGTPDYDLIINATSTGVQGSIPPLPASLITSSVCCYDMYYQQGDTPFITWCRRQGSLRCADGLGM
LVGQAASSFLLWHGVLPSVLPVLETLRAELSA

Sequences:

>Translated_272_residues
MDTFAVFGNPINHSRSPRIHALFVAETGITHPYGRVLAPLDGFEQTLRQFFDAGGLGANITLPFKERAFSLCDQLTERGA
LAGAVNTIKKQPDGSLLGDNTDGIGLVSDLQRLDLLRQDSRVLLVGVGGAARGVVLPLLAYGCKVVLTNRTFPRAQKLVG
FYHHVGDISALPLERLGTPDYDLIINATSTGVQGSIPPLPASLITSSVCCYDMYYQQGDTPFITWCRRQGSLRCADGLGM
LVGQAASSFLLWHGVLPSVLPVLETLRAELSA
>Mature_272_residues
MDTFAVFGNPINHSRSPRIHALFVAETGITHPYGRVLAPLDGFEQTLRQFFDAGGLGANITLPFKERAFSLCDQLTERGA
LAGAVNTIKKQPDGSLLGDNTDGIGLVSDLQRLDLLRQDSRVLLVGVGGAARGVVLPLLAYGCKVVLTNRTFPRAQKLVG
FYHHVGDISALPLERLGTPDYDLIINATSTGVQGSIPPLPASLITSSVCCYDMYYQQGDTPFITWCRRQGSLRCADGLGM
LVGQAASSFLLWHGVLPSVLPVLETLRAELSA

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1789675, Length=272, Percent_Identity=59.9264705882353, Blast_Score=350, Evalue=6e-98,
Organism=Escherichia coli, GI1787983, Length=265, Percent_Identity=26.0377358490566, Blast_Score=70, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320332, Length=279, Percent_Identity=26.1648745519713, Blast_Score=73, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_SODGM (Q2NQQ8)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_455922.1
- HSSP:   Q9SQT8
- ProteinModelPortal:   Q2NQQ8
- SMR:   Q2NQQ8
- STRING:   Q2NQQ8
- GeneID:   3866719
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG2242
- NMPDR:   fig|343509.6.peg.4922
- eggNOG:   COG0169
- HOGENOM:   HBG553408
- OMA:   DQYVVFG
- PhylomeDB:   Q2NQQ8
- ProtClustDB:   PRK00258
- BioCyc:   SGLO343509:SG2242-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 29237; Mature: 29237

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: ACT_SITE 65-65

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTFAVFGNPINHSRSPRIHALFVAETGITHPYGRVLAPLDGFEQTLRQFFDAGGLGANI
CCCEEEECCCCCCCCCCCEEEEEEECCCCCCCCHHHHCCCHHHHHHHHHHHCCCCCCCEE
TLPFKERAFSLCDQLTERGALAGAVNTIKKQPDGSLLGDNTDGIGLVSDLQRLDLLRQDS
EECHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
RVLLVGVGGAARGVVLPLLAYGCKVVLTNRTFPRAQKLVGFYHHVGDISALPLERLGTPD
CEEEEECCCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHCCCCC
YDLIINATSTGVQGSIPPLPASLITSSVCCYDMYYQQGDTPFITWCRRQGSLRCADGLGM
CEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEHEECCCCCEEEHHHHHH
LVGQAASSFLLWHGVLPSVLPVLETLRAELSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDTFAVFGNPINHSRSPRIHALFVAETGITHPYGRVLAPLDGFEQTLRQFFDAGGLGANI
CCCEEEECCCCCCCCCCCEEEEEEECCCCCCCCHHHHCCCHHHHHHHHHHHCCCCCCCEE
TLPFKERAFSLCDQLTERGALAGAVNTIKKQPDGSLLGDNTDGIGLVSDLQRLDLLRQDS
EECHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
RVLLVGVGGAARGVVLPLLAYGCKVVLTNRTFPRAQKLVGFYHHVGDISALPLERLGTPD
CEEEEECCCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHCCCCC
YDLIINATSTGVQGSIPPLPASLITSSVCCYDMYYQQGDTPFITWCRRQGSLRCADGLGM
CEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEHEECCCCCEEEHHHHHH
LVGQAASSFLLWHGVLPSVLPVLETLRAELSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA