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The map label for this gene is typA [H]

Identifier: 85060207

GI number: 85060207

Start: 3880626

End: 3882437

Strand: Reverse

Name: typA [H]

Synonym: SG2229

Alternate gene names: 85060207

Gene position: 3882437-3880626 (Counterclockwise)

Preceding gene: 85060211

Following gene: 85060205

Centisome position: 93.08

GC content: 55.63

Gene sequence:

>1812_bases
GTGATCGAAAATCTGCGTAACATCGCCATCATCGCGCACGTAGACCATGGTAAAACTACCTTGGTTGACAAATTGTTGCA
ACAATCCGGCACGCTTGGTGACCGTAACGATGCAACCGAACGCGTGATGGACTCCAACGATTTGGAGAAAGAGCGTGGGA
TTACCATCCTCGCTAAAAATACCGCCATCAACTGGCACGATTACCGCATCAACATCGTCGACACCCCCGGACACGCCGAC
TTCGGCGGCGAAGTTGAGCGCGTAATGTCAATGGTTGACTCGGTATTGCTGCTGGTCGATGCCATGGATGGTCCGATGCC
CCAGACCCGTTTCGTGACGCAGAAAGCGTTCGCTTATGGTCTGAAACCTATCGTGGTTATCAACAAAGTTGACCGCCCCG
GCGCGCGCCCTGACTGGGTAGTGGATCAGGTCTTCGATCTGTTCGTCAATCTGGGCGCCACCGACGAGCAGCTTGATTTT
CCGATCGTCTACGCATCAGCGCTGCTGGGTATTGCCGGTCTGGAACATGAAAACATGGCCGACGATATGACGCCGCTGTT
TGAATCCATCGTGAAAAATGTCGAAGCGCCGAACGTTGACGTCGACGGCCTGTTCCAGATGCAGATTTCCCAGCTGGACT
ATAACAGCTATGTCGGTGTTATCGGCGTCGGGCGCATCAAGCGCGGCTCGGTAAAACCGCACCAGAACGTGACCGTGGTG
GACAGCGAAGGTAAACGCCGCAACGGTAAAGTGGGCCAGGTTCTGGGCCATATGGGCCTGCAGCGCATTGAATCCAAACT
GGCCGAAGCCGGCGATATCATCGCGATTACCGGGTTGGGCGAGCTGAATATTTCCGATACCCTTTGCGATCAGGCTCAGG
TAGAAGCGCTGCCGCCGTTGACGGTCGATGAACCGACCGTCTCCATGTCGTTCGGCGTCAACACCTCGCCGTTCTGCGGT
AAAGAAGGGAAATACGTTACCTCGCGCCAGATCCTGGAGCGTCTGAACAAAGAGCTGGTACATAACGTGGCGTTGCGGGT
GGAAGAAACCGAAGATCCGGATACCTTCCGCGTTTCCGGCCGCGGCGAGCTGCACCTCTCGGTGCTTATCGAAAACATGC
GTCGTGAAGGGTTCGAGATCGCCGTTTCCCGCCCGAAAGTCATTTTCCGTACCGTCGATGGCGCTAAACAGGAACCTTTT
GAATCGGTTACGCTAGATATTGAAGAGCAGCATCAGGGACCGGTCATGGAAGCGATGGGCATCCGTAAAGGTGAGATGCG
CGACATGCTGCCGGACGGCAAAGGCCGCATCCGTCTGGATTATGTGATCCCGAGCCGGGGCTTGATCGGTTTCCGTACTG
ATTTTCTGACCATGACCTCGGGAACCGGTCTTTTGTACTCCACCTTTAGTCACTACGACGATGTGCGTCCCGGTGAAATC
GGCCAGCGCCAGAACGGCGTGTTGATCTCCAACGGTCAGGGTAAAGCGGTAGCCTACGCCCTGTACAGCCTGCAGGATCG
TGGTCGCCTGTTCCTGGGGCACGGTGCGGAAGTTTACGAAGGCCAGATCATCGGTATTCACACCCGCTCCAACGATCTGA
CGGTGAACTGTCTGACCGGCAAGAAGCTGACCAACATGCGCGCGTCCGGTACCGACGAAGCGACGACGCTGGTGCCGGCG
ATCAAGATGTCTCTGGAGCAGGCGTTGGAATTCATCGATGATGATGAATTGGTAGAAGTGACGCCGCAATCCATCCGTTT
GCGTAAGCGTTATCTGACCGAAAACGAACGTAAGCGCGCCAATCGCTTGTAA

Upstream 100 bases:

>100_bases
AAAAGACACAATCGCCAAGAACGACGGATCTTGTTTAGTCCCTCGCCTAATCCGTGTACAATAGCGCGCCATTTCTAACT
CTAATGCCTGAGGCAAAGTT

Downstream 100 bases:

>100_bases
CGGTTGACGCCCCCCGGGCGGCACCGAAATCGCGATGCCGGTTGACCCAGTTCAACCGGCATTTTTTTTGCCGCGCGCCG
CCGCGCGCCTTACTACGAAG

Product: putative GTP-binding elongation factor

Products: NA

Alternate protein names: Tyrosine phosphorylated protein A [H]

Number of amino acids: Translated: 603; Mature: 603

Protein sequence:

>603_residues
MIENLRNIAIIAHVDHGKTTLVDKLLQQSGTLGDRNDATERVMDSNDLEKERGITILAKNTAINWHDYRINIVDTPGHAD
FGGEVERVMSMVDSVLLLVDAMDGPMPQTRFVTQKAFAYGLKPIVVINKVDRPGARPDWVVDQVFDLFVNLGATDEQLDF
PIVYASALLGIAGLEHENMADDMTPLFESIVKNVEAPNVDVDGLFQMQISQLDYNSYVGVIGVGRIKRGSVKPHQNVTVV
DSEGKRRNGKVGQVLGHMGLQRIESKLAEAGDIIAITGLGELNISDTLCDQAQVEALPPLTVDEPTVSMSFGVNTSPFCG
KEGKYVTSRQILERLNKELVHNVALRVEETEDPDTFRVSGRGELHLSVLIENMRREGFEIAVSRPKVIFRTVDGAKQEPF
ESVTLDIEEQHQGPVMEAMGIRKGEMRDMLPDGKGRIRLDYVIPSRGLIGFRTDFLTMTSGTGLLYSTFSHYDDVRPGEI
GQRQNGVLISNGQGKAVAYALYSLQDRGRLFLGHGAEVYEGQIIGIHTRSNDLTVNCLTGKKLTNMRASGTDEATTLVPA
IKMSLEQALEFIDDDELVEVTPQSIRLRKRYLTENERKRANRL

Sequences:

>Translated_603_residues
MIENLRNIAIIAHVDHGKTTLVDKLLQQSGTLGDRNDATERVMDSNDLEKERGITILAKNTAINWHDYRINIVDTPGHAD
FGGEVERVMSMVDSVLLLVDAMDGPMPQTRFVTQKAFAYGLKPIVVINKVDRPGARPDWVVDQVFDLFVNLGATDEQLDF
PIVYASALLGIAGLEHENMADDMTPLFESIVKNVEAPNVDVDGLFQMQISQLDYNSYVGVIGVGRIKRGSVKPHQNVTVV
DSEGKRRNGKVGQVLGHMGLQRIESKLAEAGDIIAITGLGELNISDTLCDQAQVEALPPLTVDEPTVSMSFGVNTSPFCG
KEGKYVTSRQILERLNKELVHNVALRVEETEDPDTFRVSGRGELHLSVLIENMRREGFEIAVSRPKVIFRTVDGAKQEPF
ESVTLDIEEQHQGPVMEAMGIRKGEMRDMLPDGKGRIRLDYVIPSRGLIGFRTDFLTMTSGTGLLYSTFSHYDDVRPGEI
GQRQNGVLISNGQGKAVAYALYSLQDRGRLFLGHGAEVYEGQIIGIHTRSNDLTVNCLTGKKLTNMRASGTDEATTLVPA
IKMSLEQALEFIDDDELVEVTPQSIRLRKRYLTENERKRANRL
>Mature_603_residues
MIENLRNIAIIAHVDHGKTTLVDKLLQQSGTLGDRNDATERVMDSNDLEKERGITILAKNTAINWHDYRINIVDTPGHAD
FGGEVERVMSMVDSVLLLVDAMDGPMPQTRFVTQKAFAYGLKPIVVINKVDRPGARPDWVVDQVFDLFVNLGATDEQLDF
PIVYASALLGIAGLEHENMADDMTPLFESIVKNVEAPNVDVDGLFQMQISQLDYNSYVGVIGVGRIKRGSVKPHQNVTVV
DSEGKRRNGKVGQVLGHMGLQRIESKLAEAGDIIAITGLGELNISDTLCDQAQVEALPPLTVDEPTVSMSFGVNTSPFCG
KEGKYVTSRQILERLNKELVHNVALRVEETEDPDTFRVSGRGELHLSVLIENMRREGFEIAVSRPKVIFRTVDGAKQEPF
ESVTLDIEEQHQGPVMEAMGIRKGEMRDMLPDGKGRIRLDYVIPSRGLIGFRTDFLTMTSGTGLLYSTFSHYDDVRPGEI
GQRQNGVLISNGQGKAVAYALYSLQDRGRLFLGHGAEVYEGQIIGIHTRSNDLTVNCLTGKKLTNMRASGTDEATTLVPA
IKMSLEQALEFIDDDELVEVTPQSIRLRKRYLTENERKRANRL

Specific function: Probably interacts with the ribosomes in a GTP dependent manner. GTPase that mediates interactions between enteropathogenic E.coli (EPEC) and epithelial cells [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=515, Percent_Identity=25.8252427184466, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI94966754, Length=135, Percent_Identity=43.7037037037037, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI18390331, Length=147, Percent_Identity=40.8163265306122, Blast_Score=113, Evalue=5e-25,
Organism=Homo sapiens, GI25306287, Length=172, Percent_Identity=34.8837209302326, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI19923640, Length=172, Percent_Identity=34.8837209302326, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI25306283, Length=172, Percent_Identity=34.8837209302326, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI4503483, Length=147, Percent_Identity=36.734693877551, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI310132016, Length=113, Percent_Identity=41.5929203539823, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI310110807, Length=113, Percent_Identity=41.5929203539823, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI310123363, Length=113, Percent_Identity=41.5929203539823, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI34147630, Length=272, Percent_Identity=28.6764705882353, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI217272894, Length=136, Percent_Identity=35.2941176470588, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI217272892, Length=136, Percent_Identity=35.2941176470588, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI94966752, Length=129, Percent_Identity=29.4573643410853, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI48994988, Length=602, Percent_Identity=85.2159468438538, Blast_Score=1074, Evalue=0.0,
Organism=Escherichia coli, GI1788922, Length=502, Percent_Identity=27.2908366533865, Blast_Score=152, Evalue=6e-38,
Organism=Escherichia coli, GI1789738, Length=183, Percent_Identity=37.1584699453552, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1790835, Length=211, Percent_Identity=29.3838862559242, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790412, Length=242, Percent_Identity=30.1652892561983, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1789737, Length=242, Percent_Identity=30.1652892561983, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1789559, Length=137, Percent_Identity=34.3065693430657, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17557151, Length=403, Percent_Identity=28.287841191067, Blast_Score=129, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17533571, Length=146, Percent_Identity=39.7260273972603, Blast_Score=112, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17556745, Length=524, Percent_Identity=25.1908396946565, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71988819, Length=130, Percent_Identity=38.4615384615385, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI71988811, Length=130, Percent_Identity=38.4615384615385, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17506493, Length=159, Percent_Identity=33.9622641509434, Blast_Score=98, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17552882, Length=172, Percent_Identity=32.5581395348837, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17556456, Length=291, Percent_Identity=26.8041237113402, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI115532067, Length=271, Percent_Identity=25.4612546125461, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115532065, Length=271, Percent_Identity=25.4612546125461, Blast_Score=68, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323320, Length=498, Percent_Identity=27.3092369477912, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6324707, Length=149, Percent_Identity=39.5973154362416, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6320593, Length=149, Percent_Identity=39.5973154362416, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6323098, Length=179, Percent_Identity=36.3128491620112, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6322359, Length=153, Percent_Identity=37.2549019607843, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324761, Length=237, Percent_Identity=29.535864978903, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6324166, Length=144, Percent_Identity=36.8055555555556, Blast_Score=88, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6325337, Length=277, Percent_Identity=24.187725631769, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6319594, Length=277, Percent_Identity=24.187725631769, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322937, Length=276, Percent_Identity=22.8260869565217, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI78706572, Length=522, Percent_Identity=26.8199233716475, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24582462, Length=181, Percent_Identity=39.7790055248619, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI28574573, Length=139, Percent_Identity=38.8489208633094, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24585711, Length=151, Percent_Identity=36.4238410596026, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24585713, Length=151, Percent_Identity=36.4238410596026, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24585709, Length=151, Percent_Identity=36.4238410596026, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI221458488, Length=171, Percent_Identity=36.8421052631579, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI281363316, Length=326, Percent_Identity=28.2208588957055, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17864358, Length=326, Percent_Identity=28.2208588957055, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI19921738, Length=233, Percent_Identity=30.9012875536481, Blast_Score=86, Evalue=9e-17,
Organism=Drosophila melanogaster, GI21357743, Length=190, Percent_Identity=32.6315789473684, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28572034, Length=128, Percent_Identity=34.375, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 66829; Mature: 66829

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIENLRNIAIIAHVDHGKTTLVDKLLQQSGTLGDRNDATERVMDSNDLEKERGITILAKN
CCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCHHHCCEEEEEEC
TAINWHDYRINIVDTPGHADFGGEVERVMSMVDSVLLLVDAMDGPMPQTRFVTQKAFAYG
CEEEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHC
LKPIVVINKVDRPGARPDWVVDQVFDLFVNLGATDEQLDFPIVYASALLGIAGLEHENMA
CCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCH
DDMTPLFESIVKNVEAPNVDVDGLFQMQISQLDYNSYVGVIGVGRIKRGSVKPHQNVTVV
HHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHCCCCCEEEEEEECCEECCCCCCCCCEEEE
DSEGKRRNGKVGQVLGHMGLQRIESKLAEAGDIIAITGLGELNISDTLCDQAQVEALPPL
ECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHCCCHHHHCCCCC
TVDEPTVSMSFGVNTSPFCGKEGKYVTSRQILERLNKELVHNVALRVEETEDPDTFRVSG
CCCCCCEEEEECCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHEEEECCCCCCEEEECC
RGELHLSVLIENMRREGFEIAVSRPKVIFRTVDGAKQEPFESVTLDIEEQHQGPVMEAMG
CCCEEHHHHHHHHHCCCEEEEECCCEEEEEECCCCCCCCCCCEEEEEHHCCCCCHHHHHC
IRKGEMRDMLPDGKGRIRLDYVIPSRGLIGFRTDFLTMTSGTGLLYSTFSHYDDVRPGEI
CCCCCHHHCCCCCCCCEEEEEEECCCCCEEEEECEEEEECCCCCEEHHHHHCCCCCCCCC
GQRQNGVLISNGQGKAVAYALYSLQDRGRLFLGHGAEVYEGQIIGIHTRSNDLTVNCLTG
CCCCCCEEEECCCCCEEEEEEEECCCCCEEEEECCCEEECCEEEEEEECCCCEEEEEECC
KKLTNMRASGTDEATTLVPAIKMSLEQALEFIDDDELVEVTPQSIRLRKRYLTENERKRA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHCCHHHHHH
NRL
CCC
>Mature Secondary Structure
MIENLRNIAIIAHVDHGKTTLVDKLLQQSGTLGDRNDATERVMDSNDLEKERGITILAKN
CCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCHHHCCEEEEEEC
TAINWHDYRINIVDTPGHADFGGEVERVMSMVDSVLLLVDAMDGPMPQTRFVTQKAFAYG
CEEEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHC
LKPIVVINKVDRPGARPDWVVDQVFDLFVNLGATDEQLDFPIVYASALLGIAGLEHENMA
CCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCH
DDMTPLFESIVKNVEAPNVDVDGLFQMQISQLDYNSYVGVIGVGRIKRGSVKPHQNVTVV
HHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHCCCCCEEEEEEECCEECCCCCCCCCEEEE
DSEGKRRNGKVGQVLGHMGLQRIESKLAEAGDIIAITGLGELNISDTLCDQAQVEALPPL
ECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHCCCHHHHCCCCC
TVDEPTVSMSFGVNTSPFCGKEGKYVTSRQILERLNKELVHNVALRVEETEDPDTFRVSG
CCCCCCEEEEECCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHEEEECCCCCCEEEECC
RGELHLSVLIENMRREGFEIAVSRPKVIFRTVDGAKQEPFESVTLDIEEQHQGPVMEAMG
CCCEEHHHHHHHHHCCCEEEEECCCEEEEEECCCCCCCCCCCEEEEEHHCCCCCHHHHHC
IRKGEMRDMLPDGKGRIRLDYVIPSRGLIGFRTDFLTMTSGTGLLYSTFSHYDDVRPGEI
CCCCCHHHCCCCCCCCEEEEEEECCCCCEEEEECEEEEECCCCCEEHHHHHCCCCCCCCC
GQRQNGVLISNGQGKAVAYALYSLQDRGRLFLGHGAEVYEGQIIGIHTRSNDLTVNCLTG
CCCCCCEEEECCCCCEEEEEEEECCCCCEEEEECCCEEECCEEEEEEECCCCEEEEEECC
KKLTNMRASGTDEATTLVPAIKMSLEQALEFIDDDELVEVTPQSIRLRKRYLTENERKRA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHCCHHHHHH
NRL
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9622352 [H]