Click here to switch to the map view.

The map label for this gene is fabR [H]

Identifier: 85060134

GI number: 85060134

Start: 3757133

End: 3757786

Strand: Reverse

Name: fabR [H]

Synonym: SG2156

Alternate gene names: 85060134

Gene position: 3757786-3757133 (Counterclockwise)

Preceding gene: 85060136

Following gene: 85060133

Centisome position: 90.09

GC content: 58.87

Gene sequence:

>654_bases
ATGGTTTATATGGGCGTCAGAGCGCAACAGAAAGAGCGGACCCGGCGTTCGCTCATTGAGGCGGCATTCAGCCAGTTGAG
CGCTGAACGCAGTTTCGCCAGCCTGAGCCTGCGTGAAGTCGCCCGCCAAGCTGGTATTGCGCCCACCTCGTTTTATCGCC
ATTTCCGCGATGTGGATGAGTTGGGCCTCACTATGGTGGACGAAAGCGGACTGATGTTGCGCCAGCTGATGCGCCAGGCG
CGTCAGCGTATCGCCAAGGGCGGCAGCGTGATCCGCACGTCGGTGGCCACGTTTATGGAATTTATCGGTAACAACCCCAA
CGCTTTCCGCCTGCTGCTGCGTGAACGTTCCGGCACCTCCAGCGCCTTCCGCGCCGCGGTGGCGCGGGAAATCCAGCATT
TCATCGCCGAGCTCGCCGATTATTTGGAAATCGAGAACCATATGTCGCGCAGCTTTACCGAAGCGCAGGCGGAGGCGATG
GTTATCATCGTGTTCAATGCCGGCGCCGAGGCGCTGGATGTCGATCTTGAGCAGCGCCGCCAGCTGGAAGAGCGGCTGGT
GCTGCAGCTGCGCATGATATCCAAAGGGGCTTTTTATTGGTACCGTCGCGAGCAGGAAAAAGCGCTGACCCTTACTCAGA
ATAATGGCAGGTAA

Upstream 100 bases:

>100_bases
TCGTGGCAGGAGGCTCGGGACGTTAAAATACACAGTTTGTATCAACGCTGTTGCAACAAATTTTGATATAGTTGTTTTTT
TACATTAATGGCGAGGCTGG

Downstream 100 bases:

>100_bases
CAGATGACCCAACACACCCTCGCAGAGAAAGGCACACTGCTGTTGGCACTGATCGCGGGCTTGTCCCTTAACGGCAGTTT
CACCGCGCTTTTCAGCGCCA

Product: DNA-binding transcriptional repressor FabR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MVYMGVRAQQKERTRRSLIEAAFSQLSAERSFASLSLREVARQAGIAPTSFYRHFRDVDELGLTMVDESGLMLRQLMRQA
RQRIAKGGSVIRTSVATFMEFIGNNPNAFRLLLRERSGTSSAFRAAVAREIQHFIAELADYLEIENHMSRSFTEAQAEAM
VIIVFNAGAEALDVDLEQRRQLEERLVLQLRMISKGAFYWYRREQEKALTLTQNNGR

Sequences:

>Translated_217_residues
MVYMGVRAQQKERTRRSLIEAAFSQLSAERSFASLSLREVARQAGIAPTSFYRHFRDVDELGLTMVDESGLMLRQLMRQA
RQRIAKGGSVIRTSVATFMEFIGNNPNAFRLLLRERSGTSSAFRAAVAREIQHFIAELADYLEIENHMSRSFTEAQAEAM
VIIVFNAGAEALDVDLEQRRQLEERLVLQLRMISKGAFYWYRREQEKALTLTQNNGR
>Mature_217_residues
MVYMGVRAQQKERTRRSLIEAAFSQLSAERSFASLSLREVARQAGIAPTSFYRHFRDVDELGLTMVDESGLMLRQLMRQA
RQRIAKGGSVIRTSVATFMEFIGNNPNAFRLLLRERSGTSSAFRAAVAREIQHFIAELADYLEIENHMSRSFTEAQAEAM
VIIVFNAGAEALDVDLEQRRQLEERLVLQLRMISKGAFYWYRREQEKALTLTQNNGR

Specific function: Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, fabR directly influences the physical properties of the membrane bilayer [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI145693209, Length=211, Percent_Identity=90.9952606635071, Blast_Score=390, Evalue=1e-110,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 24871; Mature: 24871

Theoretical pI: Translated: 10.26; Mature: 10.26

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVYMGVRAQQKERTRRSLIEAAFSQLSAERSFASLSLREVARQAGIAPTSFYRHFRDVDE
CEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LGLTMVDESGLMLRQLMRQARQRIAKGGSVIRTSVATFMEFIGNNPNAFRLLLRERSGTS
HCCEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCH
SAFRAAVAREIQHFIAELADYLEIENHMSRSFTEAQAEAMVIIVFNAGAEALDVDLEQRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCHHHHCCHHHHH
QLEERLVLQLRMISKGAFYWYRREQEKALTLTQNNGR
HHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEECCCCC
>Mature Secondary Structure
MVYMGVRAQQKERTRRSLIEAAFSQLSAERSFASLSLREVARQAGIAPTSFYRHFRDVDE
CEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LGLTMVDESGLMLRQLMRQARQRIAKGGSVIRTSVATFMEFIGNNPNAFRLLLRERSGTS
HCCEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCH
SAFRAAVAREIQHFIAELADYLEIENHMSRSFTEAQAEAMVIIVFNAGAEALDVDLEQRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCHHHHCCHHHHH
QLEERLVLQLRMISKGAFYWYRREQEKALTLTQNNGR
HHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA