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The map label for this gene is metA

Identifier: 85060130

GI number: 85060130

Start: 3744276

End: 3745205

Strand: Reverse

Name: metA

Synonym: SG2152

Alternate gene names: 85060130

Gene position: 3745205-3744276 (Counterclockwise)

Preceding gene: 85060131

Following gene: 85060128

Centisome position: 89.79

GC content: 51.72

Gene sequence:

>930_bases
ATGCCGATTCGGGTATTCGACGAGTTACCTGCAGTGAATTTTCTGCGTAACGAAAATGTCTTTGTGATGACGTCCTCGCG
CGCCAGCACGCAGGAAATACGCTCGTTAAAAGTGCTGATCCTCAATCTGATGCCGAAGAAAATCGAAACCGAAAACCAAT
TTCTGCGTTTATTATCCAATTCGCCGCTGCAGGTGGATATTCAACTATTGCGCATCGACAGTCGAGAATCCAAGAACACG
CCCGCCGAGCATCTGAATAATTTTTACTGTAATTTTGAAGACATTCAGCATGATAATTTCGATGGCTTGGTGGTGACCGG
AGCGCCGCTGAGCCTGGTGGATTTTCATGATGTGGTCTTCTGGCCGCAGATTGACCGCGTGCTGCACTGGGCACGCGATC
ATGTGACGTCCACGCTGTTTGTCTGTTGGGCGGTTCAGGCGGCGTTGAATATCCTTTACGGCATTCCCAAAATGACCCGG
CAGCAGAAACTGGCGGGCGTCTATCAGCATCACCTGCTGAAACCGCATGCATTGTTGACGCGAGGCTTTGATGAGACCTT
TCTGGCCCCCCATTCCCGCAATGCGGATTTCCCTACGGCGATGATTCGCCAGCATACTGATCTGGAAATATTGGCGGAAT
CCGATGAGGCGGGAGCCTACTTGTTTGCCAGCCATGATAAGCGTCTGGCGTTTGTCACCGGGCATCCTGAATATGATGCG
CTGACCCTGGCCAGCGAGTATCACCGCGATCGGGAAAACGGTCTTAATCCATCGTTACCGGTTAACTATTTCCTGCAGGA
TAACCCCGACCTGACGCCAAAGGCCAGCTGGCGCAGCCACGGTCATTTGCTGGTTGCTAACTGGCTCAATTACTACGTCT
ATCAGATAACGCCGTACGATTTGCGGCGTATGAATCCGACGCTGGAATAG

Upstream 100 bases:

>100_bases
AAACATTTTCAACTAACGGCTGAGAACTCGACATCCGGCGGCAAAGGGGCTATCTTCAGGTATCTGGATGTCTAAATGTA
TGCTTTGAGGATCTAAGGTT

Downstream 100 bases:

>100_bases
GCGTTATCCGTCGATTAGGTCCTCTTCGACATTCTGCGCCGCTGTCCCCGGCGGCCGGGAGCGATTAAAAGTCGATGCAA
CTGGCGCCCTGTTCCACGCC

Product: homoserine O-succinyltransferase

Products: NA

Alternate protein names: Homoserine O-transsuccinylase; HTS

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MPIRVFDELPAVNFLRNENVFVMTSSRASTQEIRSLKVLILNLMPKKIETENQFLRLLSNSPLQVDIQLLRIDSRESKNT
PAEHLNNFYCNFEDIQHDNFDGLVVTGAPLSLVDFHDVVFWPQIDRVLHWARDHVTSTLFVCWAVQAALNILYGIPKMTR
QQKLAGVYQHHLLKPHALLTRGFDETFLAPHSRNADFPTAMIRQHTDLEILAESDEAGAYLFASHDKRLAFVTGHPEYDA
LTLASEYHRDRENGLNPSLPVNYFLQDNPDLTPKASWRSHGHLLVANWLNYYVYQITPYDLRRMNPTLE

Sequences:

>Translated_309_residues
MPIRVFDELPAVNFLRNENVFVMTSSRASTQEIRSLKVLILNLMPKKIETENQFLRLLSNSPLQVDIQLLRIDSRESKNT
PAEHLNNFYCNFEDIQHDNFDGLVVTGAPLSLVDFHDVVFWPQIDRVLHWARDHVTSTLFVCWAVQAALNILYGIPKMTR
QQKLAGVYQHHLLKPHALLTRGFDETFLAPHSRNADFPTAMIRQHTDLEILAESDEAGAYLFASHDKRLAFVTGHPEYDA
LTLASEYHRDRENGLNPSLPVNYFLQDNPDLTPKASWRSHGHLLVANWLNYYVYQITPYDLRRMNPTLE
>Mature_308_residues
PIRVFDELPAVNFLRNENVFVMTSSRASTQEIRSLKVLILNLMPKKIETENQFLRLLSNSPLQVDIQLLRIDSRESKNTP
AEHLNNFYCNFEDIQHDNFDGLVVTGAPLSLVDFHDVVFWPQIDRVLHWARDHVTSTLFVCWAVQAALNILYGIPKMTRQ
QKLAGVYQHHLLKPHALLTRGFDETFLAPHSRNADFPTAMIRQHTDLEILAESDEAGAYLFASHDKRLAFVTGHPEYDAL
TLASEYHRDRENGLNPSLPVNYFLQDNPDLTPKASWRSHGHLLVANWLNYYVYQITPYDLRRMNPTLE

Specific function: Methionine biosynthesis; HTS variant; first step. [C]

COG id: COG1897

COG function: function code E; Homoserine trans-succinylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HTS family

Homologues:

Organism=Escherichia coli, GI1790443, Length=309, Percent_Identity=80.2588996763754, Blast_Score=522, Evalue=1e-149,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): META_SODGM (Q2NQZ8)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_455832.1
- HSSP:   Q72X44
- ProteinModelPortal:   Q2NQZ8
- SMR:   Q2NQZ8
- STRING:   Q2NQZ8
- GeneID:   3868261
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG2152
- NMPDR:   fig|343509.6.peg.4749
- eggNOG:   COG1897
- HOGENOM:   HBG362506
- OMA:   QAGLYYH
- PhylomeDB:   Q2NQZ8
- ProtClustDB:   PRK05368
- BioCyc:   SGLO343509:SG2152-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00295
- InterPro:   IPR005697
- PANTHER:   PTHR20919
- PIRSF:   PIRSF000450
- ProDom:   PD037892
- TIGRFAMs:   TIGR01001

Pfam domain/function: PF04204 HTS

EC number: =2.3.1.46

Molecular weight: Translated: 35704; Mature: 35573

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: ACT_SITE 142-142

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIRVFDELPAVNFLRNENVFVMTSSRASTQEIRSLKVLILNLMPKKIETENQFLRLLSN
CCEEECCCCCCHHEECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCC
SPLQVDIQLLRIDSRESKNTPAEHLNNFYCNFEDIQHDNFDGLVVTGAPLSLVDFHDVVF
CCCEEEEEEEEECCCCCCCCCHHHHHCEEECHHHCCCCCCCEEEEECCCEEEEEHHHEEE
WPQIDRVLHWARDHVTSTLFVCWAVQAALNILYGIPKMTRQQKLAGVYQHHLLKPHALLT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHH
RGFDETFLAPHSRNADFPTAMIRQHTDLEILAESDEAGAYLFASHDKRLAFVTGHPEYDA
CCCCHHHCCCCCCCCCCCHHHHHCCCCEEEEECCCCCCEEEEEECCCEEEEEECCCCCCH
LTLASEYHRDRENGLNPSLPVNYFLQDNPDLTPKASWRSHGHLLVANWLNYYVYQITPYD
HHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEECCCEEEEEECCHH
LRRMNPTLE
HHCCCCCCC
>Mature Secondary Structure 
PIRVFDELPAVNFLRNENVFVMTSSRASTQEIRSLKVLILNLMPKKIETENQFLRLLSN
CEEECCCCCCHHEECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCC
SPLQVDIQLLRIDSRESKNTPAEHLNNFYCNFEDIQHDNFDGLVVTGAPLSLVDFHDVVF
CCCEEEEEEEEECCCCCCCCCHHHHHCEEECHHHCCCCCCCEEEEECCCEEEEEHHHEEE
WPQIDRVLHWARDHVTSTLFVCWAVQAALNILYGIPKMTRQQKLAGVYQHHLLKPHALLT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHH
RGFDETFLAPHSRNADFPTAMIRQHTDLEILAESDEAGAYLFASHDKRLAFVTGHPEYDA
CCCCHHHCCCCCCCCCCCHHHHHCCCCEEEEECCCCCCEEEEEECCCEEEEEECCCCCCH
LTLASEYHRDRENGLNPSLPVNYFLQDNPDLTPKASWRSHGHLLVANWLNYYVYQITPYD
HHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEECCCEEEEEECCHH
LRRMNPTLE
HHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA