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The map label for this gene is pgi

Identifier: 85060124

GI number: 85060124

Start: 3726605

End: 3728254

Strand: Reverse

Name: pgi

Synonym: SG2146

Alternate gene names: 85060124

Gene position: 3728254-3726605 (Counterclockwise)

Preceding gene: 85060126

Following gene: 85060123

Centisome position: 89.38

GC content: 52.73

Gene sequence:

>1650_bases
ATGAAAGATATCAATCCTAGTCATACCGCGGCCTGGAAAGCGCTGCAACAACATTTCGCTACGATGAAAGACGTGCAGAT
AAGCGACCTGTTCGCGCAGGAGCCTGAGCGTTTTTCCTCTTTCTCGGCCACCTTCAACGATCAGATGCTGGTGGACTACT
CGAAAAACCGCATCACCGCCGAAACATTGACCCGGCTGCTGGCGCTGGCGGAAGAGTGTGGCGTCAAGGAGGCTATCGCC
GCCATGTTCAGCGGCGAGAAAATCAACCGTACCGAAGATCGAGCGGTGTTGCATGTTGCGCTGCGCAACCGCAGCAATAC
GCCGATTAACGTGGACGACAAAGATGTCATGCCGGACGTTAATGCGGTGCTGGTAAAAATGAAACAATTTTGCGATCGGG
TAATCGGCGGCGAATGGAAAGGGTATACCGGCCGCATCATTACCGATATCGTTAATATCGGCATCGGTGGCTCCGATCTT
GGCCCGTATATGGTGACCGAGGCGCTGCGGCCTTATAAAAATCATCTCAATATGCACTATGTGTCCAACGTGGATGGAAC
GCATATTGCCGAAACGATAAAAGACCTGGATCCGGCTACCACGTTATTCCTGGTTGCGTCCAAGACCTTTACTACCCAGG
AAACCATGACCAACGCCCACAGCGCCCGGGATTGGTTCTTGAAAACCGCCGGGGATGAGCAACATGTCGCCCGCCATTTC
GCCGCGCTGTCTACCAACGCAAAAGCGGTAGCGGAATTTGGCATCGATACCGAGAATATGTTTGAGTTCTGGGATTGGGT
GGGAGGCCGCTATTCGCTCTGGTCCGCCATCGGTCTGTCCATTGCGCTGTCGCTCGGTTTCGATAATTTTGAAAAACTGC
TCAGCGGCGCGCACGCTATGGACCACCACTTCGTCTCGACGCCGCTGGATAAGAATTTACCGGTGCTGCTGGCGCTCATC
GGTATTTGGTATAACAATTTCTTCGGCATGGAGACGGAGGCGATTTTACCTTACGATCAATACATGCACCGTTTCGCCGC
TTATTTCCAGCAGGGAAATATGGAGTCGAACGGGAAATATGTCGATCGTGAGGGGCATCCTGTCAGCTATCAAACCGGAC
CTATTATTTGGGGTGAACCGGGCACCAACGGTCAGCATTCGTTTTATCAGCTGATCCACCAAGGCACTAAAATTGTCCCC
TGCGACTTTATCGCGCCTGCCATCAGCCACAATCCCCTTACCGATCATCACGCCAAGCTGCTCTCCAATTTCTTTGCTCA
GACCGAAGCGCTGGCTTTCGGCAAGTCACGCGAAGCGGTGGAGCAGGAATTCAGCGCGGCCGGGAAATCACCGGATCAAG
TGCAGCATGTTGCGCCGTTTAAAGTGTTTGAGGGCAATCGCCCCACCAACTCCATCTTGCTGCGCGAGATTACCCCTTAT
AGTCTGGGCGCGCTGATTGCGCTGTACGAACACAAGATTTTCACGCAAGGGGCGATATTGAATATTTATACCTTTGACCA
GTGGGGCGTTGAGTTAGGCAAACAACTCGCCAACCGCATTCTGCCGGAATTGGCGCAGGATAATCCGATTGATGCCCATG
ATAGTTCCACCAACGGCCTGATCAATCGCTATAAATCCTGGCGTCACTGA

Upstream 100 bases:

>100_bases
AGGCGATATCATTAGCGCAAGAAAAGGCATCCCCTGCGCGGCGTTAAGCGATACAATCGAAAAAATATGCGACGATTTAA
TCACCTATAAGAGTATTGTT

Downstream 100 bases:

>100_bases
TAAACTTTTCTTGAGAGCACGCGGCCAGTTTCTGGTCGCCATTCTGTTAGCGCCTGGCGATCAACAGAGTAAAGCGTGAC
GGCGGTAGCGATTTAGAAAC

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 549; Mature: 549

Protein sequence:

>549_residues
MKDINPSHTAAWKALQQHFATMKDVQISDLFAQEPERFSSFSATFNDQMLVDYSKNRITAETLTRLLALAEECGVKEAIA
AMFSGEKINRTEDRAVLHVALRNRSNTPINVDDKDVMPDVNAVLVKMKQFCDRVIGGEWKGYTGRIITDIVNIGIGGSDL
GPYMVTEALRPYKNHLNMHYVSNVDGTHIAETIKDLDPATTLFLVASKTFTTQETMTNAHSARDWFLKTAGDEQHVARHF
AALSTNAKAVAEFGIDTENMFEFWDWVGGRYSLWSAIGLSIALSLGFDNFEKLLSGAHAMDHHFVSTPLDKNLPVLLALI
GIWYNNFFGMETEAILPYDQYMHRFAAYFQQGNMESNGKYVDREGHPVSYQTGPIIWGEPGTNGQHSFYQLIHQGTKIVP
CDFIAPAISHNPLTDHHAKLLSNFFAQTEALAFGKSREAVEQEFSAAGKSPDQVQHVAPFKVFEGNRPTNSILLREITPY
SLGALIALYEHKIFTQGAILNIYTFDQWGVELGKQLANRILPELAQDNPIDAHDSSTNGLINRYKSWRH

Sequences:

>Translated_549_residues
MKDINPSHTAAWKALQQHFATMKDVQISDLFAQEPERFSSFSATFNDQMLVDYSKNRITAETLTRLLALAEECGVKEAIA
AMFSGEKINRTEDRAVLHVALRNRSNTPINVDDKDVMPDVNAVLVKMKQFCDRVIGGEWKGYTGRIITDIVNIGIGGSDL
GPYMVTEALRPYKNHLNMHYVSNVDGTHIAETIKDLDPATTLFLVASKTFTTQETMTNAHSARDWFLKTAGDEQHVARHF
AALSTNAKAVAEFGIDTENMFEFWDWVGGRYSLWSAIGLSIALSLGFDNFEKLLSGAHAMDHHFVSTPLDKNLPVLLALI
GIWYNNFFGMETEAILPYDQYMHRFAAYFQQGNMESNGKYVDREGHPVSYQTGPIIWGEPGTNGQHSFYQLIHQGTKIVP
CDFIAPAISHNPLTDHHAKLLSNFFAQTEALAFGKSREAVEQEFSAAGKSPDQVQHVAPFKVFEGNRPTNSILLREITPY
SLGALIALYEHKIFTQGAILNIYTFDQWGVELGKQLANRILPELAQDNPIDAHDSSTNGLINRYKSWRH
>Mature_549_residues
MKDINPSHTAAWKALQQHFATMKDVQISDLFAQEPERFSSFSATFNDQMLVDYSKNRITAETLTRLLALAEECGVKEAIA
AMFSGEKINRTEDRAVLHVALRNRSNTPINVDDKDVMPDVNAVLVKMKQFCDRVIGGEWKGYTGRIITDIVNIGIGGSDL
GPYMVTEALRPYKNHLNMHYVSNVDGTHIAETIKDLDPATTLFLVASKTFTTQETMTNAHSARDWFLKTAGDEQHVARHF
AALSTNAKAVAEFGIDTENMFEFWDWVGGRYSLWSAIGLSIALSLGFDNFEKLLSGAHAMDHHFVSTPLDKNLPVLLALI
GIWYNNFFGMETEAILPYDQYMHRFAAYFQQGNMESNGKYVDREGHPVSYQTGPIIWGEPGTNGQHSFYQLIHQGTKIVP
CDFIAPAISHNPLTDHHAKLLSNFFAQTEALAFGKSREAVEQEFSAAGKSPDQVQHVAPFKVFEGNRPTNSILLREITPY
SLGALIALYEHKIFTQGAILNIYTFDQWGVELGKQLANRILPELAQDNPIDAHDSSTNGLINRYKSWRH

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=544, Percent_Identity=63.4191176470588, Blast_Score=717, Evalue=0.0,
Organism=Homo sapiens, GI296080693, Length=544, Percent_Identity=59.5588235294118, Blast_Score=655, Evalue=0.0,
Organism=Escherichia coli, GI1790457, Length=548, Percent_Identity=82.8467153284672, Blast_Score=967, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996708, Length=546, Percent_Identity=62.4542124542125, Blast_Score=716, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996703, Length=541, Percent_Identity=62.8465804066543, Blast_Score=715, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319673, Length=545, Percent_Identity=57.2477064220184, Blast_Score=634, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651916, Length=547, Percent_Identity=62.1572212065813, Blast_Score=707, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651914, Length=547, Percent_Identity=62.1572212065813, Blast_Score=707, Evalue=0.0,
Organism=Drosophila melanogaster, GI17737445, Length=547, Percent_Identity=62.1572212065813, Blast_Score=707, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_SODGM (Q2NR04)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_455826.1
- HSSP:   Q3TEE7
- ProteinModelPortal:   Q2NR04
- SMR:   Q2NR04
- STRING:   Q2NR04
- GeneID:   3868255
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG2146
- NMPDR:   fig|343509.6.peg.4725
- eggNOG:   COG0166
- HOGENOM:   HBG352954
- OMA:   GPKIVSQ
- PhylomeDB:   Q2NR04
- ProtClustDB:   PRK00179
- BioCyc:   SGLO343509:SG2146-MONOMER
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 61552; Mature: 61552

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 355-355 ACT_SITE 386-386 ACT_SITE 514-514

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDINPSHTAAWKALQQHFATMKDVQISDLFAQEPERFSSFSATFNDQMLVDYSKNRITA
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHCCCCCCCEEEECCCCEECH
ETLTRLLALAEECGVKEAIAAMFSGEKINRTEDRAVLHVALRNRSNTPINVDDKDVMPDV
HHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCHHHHEEEEEECCCCCCCCCCCCHHCCCCH
NAVLVKMKQFCDRVIGGEWKGYTGRIITDIVNIGIGGSDLGPYMVTEALRPYKNHLNMHY
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEE
VSNVDGTHIAETIKDLDPATTLFLVASKTFTTQETMTNAHSARDWFLKTAGDEQHVARHF
ECCCCCHHHHHHHHHCCCHHEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AALSTNAKAVAEFGIDTENMFEFWDWVGGRYSLWSAIGLSIALSLGFDNFEKLLSGAHAM
HHHCCCHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHEECCHHHHHHHHHCHHHH
DHHFVSTPLDKNLPVLLALIGIWYNNFFGMETEAILPYDQYMHRFAAYFQQGNMESNGKY
HCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHCCCCCCCCCE
VDREGHPVSYQTGPIIWGEPGTNGQHSFYQLIHQGTKIVPCDFIAPAISHNPLTDHHAKL
ECCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCEECHHHHHHHHCCCCCCHHHHHH
LSNFFAQTEALAFGKSREAVEQEFSAAGKSPDQVQHVAPFKVFEGNRPTNSILLREITPY
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHCCCEEEECCCCCCCCEEEEECCCH
SLGALIALYEHKIFTQGAILNIYTFDQWGVELGKQLANRILPELAQDNPIDAHDSSTNGL
HHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
INRYKSWRH
HHHHHHCCC
>Mature Secondary Structure
MKDINPSHTAAWKALQQHFATMKDVQISDLFAQEPERFSSFSATFNDQMLVDYSKNRITA
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHCCCCCCCEEEECCCCEECH
ETLTRLLALAEECGVKEAIAAMFSGEKINRTEDRAVLHVALRNRSNTPINVDDKDVMPDV
HHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCHHHHEEEEEECCCCCCCCCCCCHHCCCCH
NAVLVKMKQFCDRVIGGEWKGYTGRIITDIVNIGIGGSDLGPYMVTEALRPYKNHLNMHY
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEE
VSNVDGTHIAETIKDLDPATTLFLVASKTFTTQETMTNAHSARDWFLKTAGDEQHVARHF
ECCCCCHHHHHHHHHCCCHHEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AALSTNAKAVAEFGIDTENMFEFWDWVGGRYSLWSAIGLSIALSLGFDNFEKLLSGAHAM
HHHCCCHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHEECCHHHHHHHHHCHHHH
DHHFVSTPLDKNLPVLLALIGIWYNNFFGMETEAILPYDQYMHRFAAYFQQGNMESNGKY
HCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHCCCCCCCCCE
VDREGHPVSYQTGPIIWGEPGTNGQHSFYQLIHQGTKIVPCDFIAPAISHNPLTDHHAKL
ECCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCEECHHHHHHHHCCCCCCHHHHHH
LSNFFAQTEALAFGKSREAVEQEFSAAGKSPDQVQHVAPFKVFEGNRPTNSILLREITPY
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHCCCEEEECCCCCCCCEEEEECCCH
SLGALIALYEHKIFTQGAILNIYTFDQWGVELGKQLANRILPELAQDNPIDAHDSSTNGL
HHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
INRYKSWRH
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA