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The map label for this gene is gltP

Identifier: 85060099

GI number: 85060099

Start: 3678039

End: 3679337

Strand: Reverse

Name: gltP

Synonym: SG2121

Alternate gene names: 85060099

Gene position: 3679337-3678039 (Counterclockwise)

Preceding gene: 85060103

Following gene: 85060096

Centisome position: 88.21

GC content: 52.66

Gene sequence:

>1299_bases
ATGAAAAAGTTAAAAGTAACGCTCGCCTGGCAAATTCTTTTTGCCTTGATACTCGGCATTCTCCTTGGCGCGGTACTCCA
TAACCAGGGCGAATTACGTGATTGGATGATGGCCAATATACTTTCGCCGGCCGGGGATATTTTTATCCGCATGATTAAAA
TGATCGTGGTGCCCATTGTGGTGGCTACGCTGGTTGTCGGCATTGCAGGAATTGGCGATGCTAAAAAGCTCGGCAGTATC
GGATTCAAAACTATCTTGTATTTCGAGATAATCACGACCCTGGCGATTATTCTGGGGATTACCCTTGCCAACGTGTTCCA
TCCCGGCTACGGGATCGATATGTCAACGCTGGCGGTAGTTGATATCTCAAAATATGAACAGACCACTGTCGCAGTGCAAT
CGGGTGGCCATAGTCTGGTCGACACGATCTTATCGCTTATTCCGGCGAATATTTTTGCCTCGATGGCAAAGGGCGATATG
CTACCGATCATCTTCTTCTCCGTGTTATTCGGCCTGGGCCTGGCCTCATTGCCGGAAAATACCCGCGCGCCATTACTCAA
TGTGTTTAATGCGGTGGCGGAAACGATGTTCAAAGTCACACATATGGTGATGCGCTATGCGCCGGTAGGGGTATTTGCGC
TAATTTCGGTCACCGTGGCGACCTTTGGTTTCGCCTCGCTGCTGCCTTTGGCCAAGCTGGTGCTGCTGGTGTATGGCGCC
ATTATCTTTTTTGCTCTGGTGGTGCTGGGCGCCGTGGCGCGGCTTTGCCGATTGCGTATCTGGACATTGATTTGCATCTT
GAAGGAAGAGTTGATTCTGGCCTTTTCCACCGCCAGTTCGGAAAGCGTATTGCCGCGTATTATCGAAAAAATGGAGGCCT
ACGGCGTTCCGGCGGCCATTACCGGCTTCGTGGTACCGACCGGCTATTCGTTCAATCTGGACGGCTCGACGCTGTATCAG
AGCATTGCCGCCATCTTCATTGCCCAGCTCTACGGCATTGAACTGTCTTTGGGGCAGGAAGTGGTGCTGGTGCTGACGCT
GATGGTGACCTCCAAAGGGATCGCGGGGGTACCAGGCGTGTCCTTTGTGGTGCTGCTGGCGACCCTGGGTAGCGTGGGTA
TTCCGCTGGAGGGGCTGGCGTTTATCGCTGGTGTCGACCGTATTCTGGATATGGCGCGCACAGCGCTTAACGTGGTAGGG
AATGCGCTGGCGGTATTGGTGATAGCCAAATGGGAAAATCAATACGATAGTGTGCAGGCGCTGGCGTATGAAAAAGAGAT
GCTGGAATCCCGGGACTGA

Upstream 100 bases:

>100_bases
CCCCGCTTCGCATGATCATAAGAGGTGAATAAGTGAAGCCGGTGACGGAGATGGACAGGTGTTCGTCACGGTGGGGCCAA
CTATGGAAAGCACTATTGTT

Downstream 100 bases:

>100_bases
CCCTTAAGCTCCGGCAAACGACCCTTGCGCTTCGGCAAACGGGGGCGATGATCCCCCCCTGTCAGCCGGACGCGGAGCCG
GGGCCTGCGTGAGAGACCCC

Product: glutamate/aspartate:proton symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MKKLKVTLAWQILFALILGILLGAVLHNQGELRDWMMANILSPAGDIFIRMIKMIVVPIVVATLVVGIAGIGDAKKLGSI
GFKTILYFEIITTLAIILGITLANVFHPGYGIDMSTLAVVDISKYEQTTVAVQSGGHSLVDTILSLIPANIFASMAKGDM
LPIIFFSVLFGLGLASLPENTRAPLLNVFNAVAETMFKVTHMVMRYAPVGVFALISVTVATFGFASLLPLAKLVLLVYGA
IIFFALVVLGAVARLCRLRIWTLICILKEELILAFSTASSESVLPRIIEKMEAYGVPAAITGFVVPTGYSFNLDGSTLYQ
SIAAIFIAQLYGIELSLGQEVVLVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVG
NALAVLVIAKWENQYDSVQALAYEKEMLESRD

Sequences:

>Translated_432_residues
MKKLKVTLAWQILFALILGILLGAVLHNQGELRDWMMANILSPAGDIFIRMIKMIVVPIVVATLVVGIAGIGDAKKLGSI
GFKTILYFEIITTLAIILGITLANVFHPGYGIDMSTLAVVDISKYEQTTVAVQSGGHSLVDTILSLIPANIFASMAKGDM
LPIIFFSVLFGLGLASLPENTRAPLLNVFNAVAETMFKVTHMVMRYAPVGVFALISVTVATFGFASLLPLAKLVLLVYGA
IIFFALVVLGAVARLCRLRIWTLICILKEELILAFSTASSESVLPRIIEKMEAYGVPAAITGFVVPTGYSFNLDGSTLYQ
SIAAIFIAQLYGIELSLGQEVVLVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVG
NALAVLVIAKWENQYDSVQALAYEKEMLESRD
>Mature_432_residues
MKKLKVTLAWQILFALILGILLGAVLHNQGELRDWMMANILSPAGDIFIRMIKMIVVPIVVATLVVGIAGIGDAKKLGSI
GFKTILYFEIITTLAIILGITLANVFHPGYGIDMSTLAVVDISKYEQTTVAVQSGGHSLVDTILSLIPANIFASMAKGDM
LPIIFFSVLFGLGLASLPENTRAPLLNVFNAVAETMFKVTHMVMRYAPVGVFALISVTVATFGFASLLPLAKLVLLVYGA
IIFFALVVLGAVARLCRLRIWTLICILKEELILAFSTASSESVLPRIIEKMEAYGVPAAITGFVVPTGYSFNLDGSTLYQ
SIAAIFIAQLYGIELSLGQEVVLVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVG
NALAVLVIAKWENQYDSVQALAYEKEMLESRD

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI40254478, Length=506, Percent_Identity=27.2727272727273, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI169790839, Length=444, Percent_Identity=28.3783783783784, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI194239697, Length=463, Percent_Identity=27.4298056155508, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI66773030, Length=484, Percent_Identity=26.2396694214876, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI21314632, Length=433, Percent_Identity=27.4826789838337, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI4827012, Length=267, Percent_Identity=33.7078651685393, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI262359914, Length=394, Percent_Identity=26.9035532994924, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI5032093, Length=406, Percent_Identity=27.3399014778325, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI223468564, Length=279, Percent_Identity=29.3906810035842, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI223468566, Length=279, Percent_Identity=29.3906810035842, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI301601644, Length=151, Percent_Identity=33.7748344370861, Blast_Score=86, Evalue=9e-17,
Organism=Escherichia coli, GI1790514, Length=432, Percent_Identity=78.7037037037037, Blast_Score=683, Evalue=0.0,
Organism=Escherichia coli, GI1789947, Length=414, Percent_Identity=38.6473429951691, Blast_Score=300, Evalue=1e-82,
Organism=Escherichia coli, GI1788024, Length=407, Percent_Identity=26.5356265356265, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1789473, Length=393, Percent_Identity=24.6819338422392, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17537407, Length=430, Percent_Identity=26.9767441860465, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71996953, Length=449, Percent_Identity=26.7260579064588, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI193206505, Length=477, Percent_Identity=28.3018867924528, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71983099, Length=417, Percent_Identity=27.5779376498801, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71983106, Length=421, Percent_Identity=27.5534441805226, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI193206654, Length=459, Percent_Identity=25.2723311546841, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17541374, Length=404, Percent_Identity=26.2376237623762, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24583025, Length=454, Percent_Identity=28.8546255506608, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI17137668, Length=454, Percent_Identity=28.8546255506608, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24583023, Length=454, Percent_Identity=28.8546255506608, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI281360481, Length=454, Percent_Identity=25.9911894273128, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI281360483, Length=454, Percent_Identity=25.9911894273128, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI17137666, Length=454, Percent_Identity=25.9911894273128, Blast_Score=99, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46227; Mature: 46227

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1 ; PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHCCC
>Mature Secondary Structure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HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]