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The map label for this gene is pepP [H]

Identifier: 85059983

GI number: 85059983

Start: 3462031

End: 3463350

Strand: Reverse

Name: pepP [H]

Synonym: SG2005

Alternate gene names: 85059983

Gene position: 3463350-3462031 (Counterclockwise)

Preceding gene: 85059984

Following gene: 85059982

Centisome position: 83.03

GC content: 58.79

Gene sequence:

>1320_bases
ATGACTCCACAAGAATATACCCGCCGTCGTCAGGGGTTGCTGGCGAAAATGGCGCCGGGAAGCGCCGCGTTGATTTTTGC
CGCCCCCGAGGCGACGCGTAGCGCCGACAGTGACTATCCCTATCGCCAAAACAGTGATTTCTGGTATTTCACCGGTTTTA
ACGAGCCACAGGCGCTGCTGATTCTGGTCAAAAGCGATGAAAGCCACCACCACAGCGTCTTGTTTAACCGGGTGCGGGAT
AAAACCGCTGAAATTTGGACCGGCCGCCGTTTGGGTCAGGAGGCGGCGCCGGAGCGCCTGGGTGTTTCCCGGGCGTTGCC
GTGGGACGACATCGGCAGTCAATTGCATCTGCTGCTCAACGGTCTGGACGTGGTTTATCATGCGCAGGGAGAATATGAAT
TCGCCGATAAGCTGCTGTTTAGCGCGCTGGATAAACTGCGGCGCGGCGTGCGTCAGCAGTTGCAGGCGCCGGCCACGCTG
GTCGACTGGCGGCCTTGGGTGCACGAGATGCGGCTTATCAAATCTGAGGAAGAGCTGGCGGTGATGCGTCGCGCCTGTGA
AATCACCGCACTGGCGCATACCCGCGCCATGCAGCAATGCCGGCCCGGCCTGTACGAATATCAGCTGGAAGGCGAGATAC
AGCATGAATTCAACCGTCACGGCGCGCGCTTTCCGTCCTACAGCACTATTGCCGGCAGCGGTGAAAACGGTTGCATTTTG
CACTACACGGAAAACGCCTCCCGCATGCAAAGCGGCGATCTGGTGTTGATCGATGCCGGCTGTGAATACCAGGGCTACGC
AGGCGATATCACCCGCACCTTCCCGGTTAACGGCCGTTTCTCGCCGGAACAGCGCGCTGTCTATGATCTCGTCCTGGCGA
TGCTTAACCGCGCGCTTGAGCTCTACGGTCCGGGGCGCAGTATTCAAGAGGTGAGCGAAGAAGCGGTGCGCATCATGGTC
GCCGGTCTGGTGAAGATTGGCGTGATGAAAGGGGAGGTGGAGACGTTGATTGCCGCACAGGCGCATCAGCAGTTTTTTAT
GCATGGCCTAAGCCATTGGCTGGGGCTGGATGTCCACGACGTTGGTGATTATGGCTCTTCGGAGCGGAGCCGGATACTGG
AGCCGGGTATGGTGCTGACCGTCGAACCGGGCATCTATATCGCCAGCGACGCCGATGTGCCCGCCCCTTACCGCGGTATC
GGTATCCGCATTGAGGACAATATCGTTATCACTGCCACGGGTAATGAAAATCTCACCGCCTCTGTGGTCAAGGAGGCTGA
GGCGATTGAAACCCTTATGGCGGCGGCTCGCCAAGGATGA

Upstream 100 bases:

>100_bases
GCCGGCCGCTCCGGTATTACATTGACGACAACGCCGGATCTGAACCGGTGTTTTGGCCGCGGCTCACGAGCCGAGCATTT
CAATTAGACTGGAGGGAGCG

Downstream 100 bases:

>100_bases
CCGTCACCATTATTGGCGGCGGCATGGCCGGCGCGACTCTGGCGCTGGCGTTTTCGCATCTTAGCCGCGGTACCCTGCAA
ATCGATCTGGTGGAGGCGGA

Product: proline aminopeptidase P II

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MTPQEYTRRRQGLLAKMAPGSAALIFAAPEATRSADSDYPYRQNSDFWYFTGFNEPQALLILVKSDESHHHSVLFNRVRD
KTAEIWTGRRLGQEAAPERLGVSRALPWDDIGSQLHLLLNGLDVVYHAQGEYEFADKLLFSALDKLRRGVRQQLQAPATL
VDWRPWVHEMRLIKSEEELAVMRRACEITALAHTRAMQQCRPGLYEYQLEGEIQHEFNRHGARFPSYSTIAGSGENGCIL
HYTENASRMQSGDLVLIDAGCEYQGYAGDITRTFPVNGRFSPEQRAVYDLVLAMLNRALELYGPGRSIQEVSEEAVRIMV
AGLVKIGVMKGEVETLIAAQAHQQFFMHGLSHWLGLDVHDVGDYGSSERSRILEPGMVLTVEPGIYIASDADVPAPYRGI
GIRIEDNIVITATGNENLTASVVKEAEAIETLMAAARQG

Sequences:

>Translated_439_residues
MTPQEYTRRRQGLLAKMAPGSAALIFAAPEATRSADSDYPYRQNSDFWYFTGFNEPQALLILVKSDESHHHSVLFNRVRD
KTAEIWTGRRLGQEAAPERLGVSRALPWDDIGSQLHLLLNGLDVVYHAQGEYEFADKLLFSALDKLRRGVRQQLQAPATL
VDWRPWVHEMRLIKSEEELAVMRRACEITALAHTRAMQQCRPGLYEYQLEGEIQHEFNRHGARFPSYSTIAGSGENGCIL
HYTENASRMQSGDLVLIDAGCEYQGYAGDITRTFPVNGRFSPEQRAVYDLVLAMLNRALELYGPGRSIQEVSEEAVRIMV
AGLVKIGVMKGEVETLIAAQAHQQFFMHGLSHWLGLDVHDVGDYGSSERSRILEPGMVLTVEPGIYIASDADVPAPYRGI
GIRIEDNIVITATGNENLTASVVKEAEAIETLMAAARQG
>Mature_438_residues
TPQEYTRRRQGLLAKMAPGSAALIFAAPEATRSADSDYPYRQNSDFWYFTGFNEPQALLILVKSDESHHHSVLFNRVRDK
TAEIWTGRRLGQEAAPERLGVSRALPWDDIGSQLHLLLNGLDVVYHAQGEYEFADKLLFSALDKLRRGVRQQLQAPATLV
DWRPWVHEMRLIKSEEELAVMRRACEITALAHTRAMQQCRPGLYEYQLEGEIQHEFNRHGARFPSYSTIAGSGENGCILH
YTENASRMQSGDLVLIDAGCEYQGYAGDITRTFPVNGRFSPEQRAVYDLVLAMLNRALELYGPGRSIQEVSEEAVRIMVA
GLVKIGVMKGEVETLIAAQAHQQFFMHGLSHWLGLDVHDVGDYGSSERSRILEPGMVLTVEPGIYIASDADVPAPYRGIG
IRIEDNIVITATGNENLTASVVKEAEAIETLMAAARQG

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=453, Percent_Identity=32.4503311258278, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI149589008, Length=461, Percent_Identity=31.4533622559653, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI260593665, Length=308, Percent_Identity=37.012987012987, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI260593663, Length=255, Percent_Identity=37.6470588235294, Blast_Score=156, Evalue=3e-38,
Organism=Escherichia coli, GI1789275, Length=438, Percent_Identity=73.972602739726, Blast_Score=689, Evalue=0.0,
Organism=Escherichia coli, GI1788728, Length=274, Percent_Identity=32.1167883211679, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1790282, Length=330, Percent_Identity=29.0909090909091, Blast_Score=102, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17508215, Length=471, Percent_Identity=31.8471337579618, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI71989583, Length=378, Percent_Identity=26.984126984127, Blast_Score=137, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6320922, Length=438, Percent_Identity=29.2237442922374, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6321118, Length=468, Percent_Identity=28.8461538461538, Blast_Score=177, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6323273, Length=327, Percent_Identity=22.3241590214067, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19920384, Length=415, Percent_Identity=35.9036144578313, Blast_Score=232, Evalue=3e-61,
Organism=Drosophila melanogaster, GI21357079, Length=453, Percent_Identity=32.6710816777042, Blast_Score=195, Evalue=5e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 48974; Mature: 48843

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPQEYTRRRQGLLAKMAPGSAALIFAAPEATRSADSDYPYRQNSDFWYFTGFNEPQALL
CCCHHHHHHHHCCEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEECCCCCCCEEE
ILVKSDESHHHSVLFNRVRDKTAEIWTGRRLGQEAAPERLGVSRALPWDDIGSQLHLLLN
EEEECCCCCHHHHHHHHHHHHHHHHHCCHHCCHHCCHHHHCCCCCCCHHHHHHHHHHHHC
GLDVVYHAQGEYEFADKLLFSALDKLRRGVRQQLQAPATLVDWRPWVHEMRLIKSEEELA
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHCCHHHHH
VMRRACEITALAHTRAMQQCRPGLYEYQLEGEIQHEFNRHGARFPSYSTIAGSGENGCIL
HHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCCCCCCCEECCCCCCCEEE
HYTENASRMQSGDLVLIDAGCEYQGYAGDITRTFPVNGRFSPEQRAVYDLVLAMLNRALE
EEECCCCCCCCCCEEEEECCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
LYGPGRSIQEVSEEAVRIMVAGLVKIGVMKGEVETLIAAQAHQQFFMHGLSHWLGLDVHD
HCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEC
VGDYGSSERSRILEPGMVLTVEPGIYIASDADVPAPYRGIGIRIEDNIVITATGNENLTA
CCCCCCCCHHHHCCCCEEEEECCCEEEECCCCCCCCCCCEEEEEECCEEEEECCCCCCHH
SVVKEAEAIETLMAAARQG
HHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TPQEYTRRRQGLLAKMAPGSAALIFAAPEATRSADSDYPYRQNSDFWYFTGFNEPQALL
CCHHHHHHHHCCEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEECCCCCCCEEE
ILVKSDESHHHSVLFNRVRDKTAEIWTGRRLGQEAAPERLGVSRALPWDDIGSQLHLLLN
EEEECCCCCHHHHHHHHHHHHHHHHHCCHHCCHHCCHHHHCCCCCCCHHHHHHHHHHHHC
GLDVVYHAQGEYEFADKLLFSALDKLRRGVRQQLQAPATLVDWRPWVHEMRLIKSEEELA
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHCCHHHHH
VMRRACEITALAHTRAMQQCRPGLYEYQLEGEIQHEFNRHGARFPSYSTIAGSGENGCIL
HHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCCCCCCCEECCCCCCCEEE
HYTENASRMQSGDLVLIDAGCEYQGYAGDITRTFPVNGRFSPEQRAVYDLVLAMLNRALE
EEECCCCCCCCCCEEEEECCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
LYGPGRSIQEVSEEAVRIMVAGLVKIGVMKGEVETLIAAQAHQQFFMHGLSHWLGLDVHD
HCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEC
VGDYGSSERSRILEPGMVLTVEPGIYIASDADVPAPYRGIGIRIEDNIVITATGNENLTA
CCCCCCCCHHHHCCCCEEEEECCCEEEECCCCCCCCCCCEEEEEECCEEEEECCCCCCHH
SVVKEAEAIETLMAAARQG
HHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]