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The map label for this gene is ubiH [H]

Identifier: 85059982

GI number: 85059982

Start: 3460856

End: 3462034

Strand: Reverse

Name: ubiH [H]

Synonym: SG2004

Alternate gene names: 85059982

Gene position: 3462034-3460856 (Counterclockwise)

Preceding gene: 85059983

Following gene: 85059981

Centisome position: 83.0

GC content: 65.9

Gene sequence:

>1179_bases
ATGACCGTCACCATTATTGGCGGCGGCATGGCCGGCGCGACTCTGGCGCTGGCGTTTTCGCATCTTAGCCGCGGTACCCT
GCAAATCGATCTGGTGGAGGCGGAGACACCGGAAAGCCGCGATCATCCGGGGTTTGACGCCCGAGCCATTGCCTTGGCGC
AGGGGACCTGCCGCGAGCTGACCGCCATTGGCGTCTGGCCGGCGCTGGCGTCCTGCGCCACCGCCATTACCCGGGTAGAG
GTGAGCGATAAAGGGCACCTGGGGAAAGTCCAGATCGCGGCCGAGGACTATCAGCTGCCGGCGCTGGGCTATGTCGTGGA
GCTGCATGCGGCCGGTAAACGGCTGTTCGAGCTGCTGCGCGAGGCGCCCGGCGTGCGGCTGCATTGTCCGGCGACGCTCA
CGCGCCTCAGGCGCGAGCGCGAAAAGACGATCATCACCCTGGATAATGGCGTGGAGCTCAACGCGCGGCTGGCGGTGGCG
GCGGACGGCTCGCGCTCGCCGCTGGCGTCGCAGTGCGGCATCCAATGGCGGCAGCGCGATTATCAGCAAATTGCGGTTAT
CGCCAACATCACCACCGCCGTGCCCCACGGCGGCGACGCCTTCGAGCGGTTCACCGCCCAGGGACCCTTGGCATTGTTGC
CCATGTCTGGCGCGCGCAGTTTTCTGGTCTGGTGCCTGCCGGCCTCGATTCGGCATGAGATTGCCGGCTGGGATGACGGG
CAGTTTTGTCAGGCGTTGCAGCGGGCGTTCGGCTGGCGGCTGGGACGAATTACCGCCGCCGGCGCACGCCAGTGTTATCC
TCTGCGCTTACGCACGGCGCAGCGGCATATTGCCCACCGCCTGGCGCTGGTGGGCAATGCCGCGCAGACCTTGCATCCCA
TCGCCGGCCAGGGATTCAACCTCGGCCTGCGCGATGTGATAACGCTGGCGGAAACGCTGGCGCAGGCGGCGGCCCAGGGG
GAAGATATCGGCGACTATGCCGTGCTGTCGTGCTATCAGCGGCGTCGTCAGCTGGATCAGGCGGGTACCGTCGGCATCAC
CGACGGGTTGATCCATCTATTCGCCAACCGTCATTTGCCGTTAGTGGTCGGCCGTAATCTGGGGCTGCTGGCCATGGCTC
ATATTCCGTCGCTGCGCGATGCACTGGTGCGTAAAACGCTGGGCTGGGTGGCCCGATGA

Upstream 100 bases:

>100_bases
ACAATATCGTTATCACTGCCACGGGTAATGAAAATCTCACCGCCTCTGTGGTCAAGGAGGCTGAGGCGATTGAAACCCTT
ATGGCGGCGGCTCGCCAAGG

Downstream 100 bases:

>100_bases
CCCTGTCCCGCACGCAAGGATCCAATACGCTATGCAAGCATTCGATATAGTCATTAACGGCGGCGGCATGGTCGGTCTGG
CGCTGGCCTGCGGCCTGCAG

Product: 2-octaprenyl-6-methoxyphenyl hydroxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MTVTIIGGGMAGATLALAFSHLSRGTLQIDLVEAETPESRDHPGFDARAIALAQGTCRELTAIGVWPALASCATAITRVE
VSDKGHLGKVQIAAEDYQLPALGYVVELHAAGKRLFELLREAPGVRLHCPATLTRLRREREKTIITLDNGVELNARLAVA
ADGSRSPLASQCGIQWRQRDYQQIAVIANITTAVPHGGDAFERFTAQGPLALLPMSGARSFLVWCLPASIRHEIAGWDDG
QFCQALQRAFGWRLGRITAAGARQCYPLRLRTAQRHIAHRLALVGNAAQTLHPIAGQGFNLGLRDVITLAETLAQAAAQG
EDIGDYAVLSCYQRRRQLDQAGTVGITDGLIHLFANRHLPLVVGRNLGLLAMAHIPSLRDALVRKTLGWVAR

Sequences:

>Translated_392_residues
MTVTIIGGGMAGATLALAFSHLSRGTLQIDLVEAETPESRDHPGFDARAIALAQGTCRELTAIGVWPALASCATAITRVE
VSDKGHLGKVQIAAEDYQLPALGYVVELHAAGKRLFELLREAPGVRLHCPATLTRLRREREKTIITLDNGVELNARLAVA
ADGSRSPLASQCGIQWRQRDYQQIAVIANITTAVPHGGDAFERFTAQGPLALLPMSGARSFLVWCLPASIRHEIAGWDDG
QFCQALQRAFGWRLGRITAAGARQCYPLRLRTAQRHIAHRLALVGNAAQTLHPIAGQGFNLGLRDVITLAETLAQAAAQG
EDIGDYAVLSCYQRRRQLDQAGTVGITDGLIHLFANRHLPLVVGRNLGLLAMAHIPSLRDALVRKTLGWVAR
>Mature_391_residues
TVTIIGGGMAGATLALAFSHLSRGTLQIDLVEAETPESRDHPGFDARAIALAQGTCRELTAIGVWPALASCATAITRVEV
SDKGHLGKVQIAAEDYQLPALGYVVELHAAGKRLFELLREAPGVRLHCPATLTRLRREREKTIITLDNGVELNARLAVAA
DGSRSPLASQCGIQWRQRDYQQIAVIANITTAVPHGGDAFERFTAQGPLALLPMSGARSFLVWCLPASIRHEIAGWDDGQ
FCQALQRAFGWRLGRITAAGARQCYPLRLRTAQRHIAHRLALVGNAAQTLHPIAGQGFNLGLRDVITLAETLAQAAAQGE
DIGDYAVLSCYQRRRQLDQAGTVGITDGLIHLFANRHLPLVVGRNLGLLAMAHIPSLRDALVRKTLGWVAR

Specific function: Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone [H]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiH/COQ6 family [H]

Homologues:

Organism=Homo sapiens, GI32967305, Length=385, Percent_Identity=28.051948051948, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI32967307, Length=373, Percent_Identity=28.9544235924933, Blast_Score=131, Evalue=1e-30,
Organism=Escherichia coli, GI1789274, Length=392, Percent_Identity=62.2448979591837, Blast_Score=496, Evalue=1e-141,
Organism=Escherichia coli, GI1789273, Length=392, Percent_Identity=32.6530612244898, Blast_Score=181, Evalue=6e-47,
Organism=Escherichia coli, GI1786883, Length=389, Percent_Identity=32.6478149100257, Blast_Score=169, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI25146631, Length=427, Percent_Identity=26.463700234192, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6321694, Length=294, Percent_Identity=27.891156462585, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19920760, Length=423, Percent_Identity=23.8770685579196, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042
- InterPro:   IPR018168
- InterPro:   IPR010971
- InterPro:   IPR011295 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: 1.14.13.-

Molecular weight: Translated: 42313; Mature: 42182

Theoretical pI: Translated: 9.14; Mature: 9.14

Prosite motif: PS01304 UBIH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTIIGGGMAGATLALAFSHLSRGTLQIDLVEAETPESRDHPGFDARAIALAQGTCREL
CEEEEEECCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHH
TAIGVWPALASCATAITRVEVSDKGHLGKVQIAAEDYQLPALGYVVELHAAGKRLFELLR
HHHHHHHHHHHHHHHHHEEEECCCCCCCEEEEEECCCCCCHHHHEEEHHHHHHHHHHHHH
EAPGVRLHCPATLTRLRREREKTIITLDNGVELNARLAVAADGSRSPLASQCGIQWRQRD
HCCCCEEECCHHHHHHHHHHCCEEEEECCCEEEEEEEEEEECCCCCCCHHHHCCHHHHCC
YQQIAVIANITTAVPHGGDAFERFTAQGPLALLPMSGARSFLVWCLPASIRHEIAGWDDG
HHHEEEEEEHHHCCCCCCHHHHHHHCCCCEEEEECCCCCEEEEEECCHHHHHHHCCCCCH
QFCQALQRAFGWRLGRITAAGARQCYPLRLRTAQRHIAHRLALVGNAAQTLHPIAGQGFN
HHHHHHHHHHCCCHHEEEECCCCCEEEHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCC
LGLRDVITLAETLAQAAAQGEDIGDYAVLSCYQRRRQLDQAGTVGITDGLIHLFANRHLP
CCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCE
LVVGRNLGLLAMAHIPSLRDALVRKTLGWVAR
EEECCCCCEEHHHHCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TVTIIGGGMAGATLALAFSHLSRGTLQIDLVEAETPESRDHPGFDARAIALAQGTCREL
EEEEEECCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHH
TAIGVWPALASCATAITRVEVSDKGHLGKVQIAAEDYQLPALGYVVELHAAGKRLFELLR
HHHHHHHHHHHHHHHHHEEEECCCCCCCEEEEEECCCCCCHHHHEEEHHHHHHHHHHHHH
EAPGVRLHCPATLTRLRREREKTIITLDNGVELNARLAVAADGSRSPLASQCGIQWRQRD
HCCCCEEECCHHHHHHHHHHCCEEEEECCCEEEEEEEEEEECCCCCCCHHHHCCHHHHCC
YQQIAVIANITTAVPHGGDAFERFTAQGPLALLPMSGARSFLVWCLPASIRHEIAGWDDG
HHHEEEEEEHHHCCCCCCHHHHHHHCCCCEEEEECCCCCEEEEEECCHHHHHHHCCCCCH
QFCQALQRAFGWRLGRITAAGARQCYPLRLRTAQRHIAHRLALVGNAAQTLHPIAGQGFN
HHHHHHHHHHCCCHHEEEECCCCCEEEHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCC
LGLRDVITLAETLAQAAAQGEDIGDYAVLSCYQRRRQLDQAGTVGITDGLIHLFANRHLP
CCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCE
LVVGRNLGLLAMAHIPSLRDALVRKTLGWVAR
EEECCCCCEEHHHHCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1339425; 9278503 [H]