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The map label for this gene is lpxA

Identifier: 85059909

GI number: 85059909

Start: 3335081

End: 3335869

Strand: Reverse

Name: lpxA

Synonym: SG1931

Alternate gene names: 85059909

Gene position: 3335869-3335081 (Counterclockwise)

Preceding gene: 85059910

Following gene: 85059908

Centisome position: 79.97

GC content: 58.3

Gene sequence:

>789_bases
GTGATTGATCAATCCGCCTTTATACATCCCAGCGCTATTGTGGAAGACGGCGCTATCATCCACGCCGACGTGCATGTCGG
CCCGTTTTGCGTTATCGGGCCGCAGGTCGAAATCGGTGCGCGTACGGTGCTTGAGTCCCACGTGGTGGTGACCGGCATCA
CCCGCATAGGTGAAGATAACCAGATTTACCCGTTCGCCTCACTGGGCGACGTTAATCAGGATCTGAAATATGCCGGGGAG
CCGACGCGGGTCGAAATCGGGCACCGTAACCGGATCAGGGAAAGCGTGACCATTCATCGTGGCACGATACAGGGCGGAGA
AGTCACCCGGGTCGGTAGCGACAATTTGCTGATGGTGAATGCCCATGTCGCCCACGACTGCACGGTAGGCAGCCACTGCA
TTATGGCGAATAACGCCACGCTCGGCGGCCATGTGGCGGTCGACGATTACGCCATTATCGGCGGTATGACCGCGGTACAT
CAGTTCTGCGTCATCGGCGCCTACGTAATGGTCGGCGGCTGTTCCGGCGTTGCCCAGGATGTGCCGCCCTTTGTTATTGC
CCAGGGTAATCACGCCACGCCTTTCGGCCTGAATATCGAAGGGCTGAAGCGACGCGGTTTCGATCACGCCGCGCTGCACG
CGATACGCGCCGCTTACAAGATTATTTACCGCAGCGGCAAAACCCTCGACGAAGCCAAGCCCGAGCTGCAAGCGCTGGCG
CAGGAACATCAGGTGGTTAATACCTTCCTGGACTTTCTGTTACGCTCCCAGCGCGGTATTATCCGCTAA

Upstream 100 bases:

>100_bases
CGTCGCGGCGTCGCGCGCTTCAAAGGTGTTGCCAAAGTTGATGGCGAAGTGGCTTGCGAAGCGTCGATGATGTGCGCTCG
TCGCCGGGAGGCCTGAATAC

Downstream 100 bases:

>100_bases
TTATGTCGGCACGCCCCATCACTATCGGTCTGGTGGCCGGCGAGACGTCGGGGGATATCCTCGGCGCCGGGTTGATACGC
GCGCTGCGCGGCCATTTGCC

Product: acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MIDQSAFIHPSAIVEDGAIIHADVHVGPFCVIGPQVEIGARTVLESHVVVTGITRIGEDNQIYPFASLGDVNQDLKYAGE
PTRVEIGHRNRIRESVTIHRGTIQGGEVTRVGSDNLLMVNAHVAHDCTVGSHCIMANNATLGGHVAVDDYAIIGGMTAVH
QFCVIGAYVMVGGCSGVAQDVPPFVIAQGNHATPFGLNIEGLKRRGFDHAALHAIRAAYKIIYRSGKTLDEAKPELQALA
QEHQVVNTFLDFLLRSQRGIIR

Sequences:

>Translated_262_residues
MIDQSAFIHPSAIVEDGAIIHADVHVGPFCVIGPQVEIGARTVLESHVVVTGITRIGEDNQIYPFASLGDVNQDLKYAGE
PTRVEIGHRNRIRESVTIHRGTIQGGEVTRVGSDNLLMVNAHVAHDCTVGSHCIMANNATLGGHVAVDDYAIIGGMTAVH
QFCVIGAYVMVGGCSGVAQDVPPFVIAQGNHATPFGLNIEGLKRRGFDHAALHAIRAAYKIIYRSGKTLDEAKPELQALA
QEHQVVNTFLDFLLRSQRGIIR
>Mature_262_residues
MIDQSAFIHPSAIVEDGAIIHADVHVGPFCVIGPQVEIGARTVLESHVVVTGITRIGEDNQIYPFASLGDVNQDLKYAGE
PTRVEIGHRNRIRESVTIHRGTIQGGEVTRVGSDNLLMVNAHVAHDCTVGSHCIMANNATLGGHVAVDDYAIIGGMTAVH
QFCVIGAYVMVGGCSGVAQDVPPFVIAQGNHATPFGLNIEGLKRRGFDHAALHAIRAAYKIIYRSGKTLDEAKPELQALA
QEHQVVNTFLDFLLRSQRGIIR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily

Homologues:

Organism=Escherichia coli, GI1786378, Length=262, Percent_Identity=75.9541984732824, Blast_Score=423, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXA_SODGM (Q2NRL9)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_455611.1
- ProteinModelPortal:   Q2NRL9
- SMR:   Q2NRL9
- STRING:   Q2NRL9
- GeneID:   3867843
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG1931
- NMPDR:   fig|343509.6.peg.4185
- eggNOG:   COG1043
- HOGENOM:   HBG659295
- OMA:   GHTSIGE
- PhylomeDB:   Q2NRL9
- BioCyc:   SGLO343509:SG1931-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00387
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004
- PIRSF:   PIRSF000456
- TIGRFAMs:   TIGR01852

Pfam domain/function: PF00132 Hexapep; SSF51161 Trimer_LpxA_like

EC number: =2.3.1.129

Molecular weight: Translated: 28181; Mature: 28181

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDQSAFIHPSAIVEDGAIIHADVHVGPFCVIGPQVEIGARTVLESHVVVTGITRIGEDN
CCCCCCCCCCHHHCCCCCEEEEECCCCCEEEECCCEECCHHHHHHCCEEEEEEECCCCCC
QIYPFASLGDVNQDLKYAGEPTRVEIGHRNRIRESVTIHRGTIQGGEVTRVGSDNLLMVN
EEEEECCCCCCCHHHHHCCCCCEEEECCCHHHHHHEEEEECCCCCCCEEEECCCCEEEEE
AHVAHDCTVGSHCIMANNATLGGHVAVDDYAIIGGMTAVHQFCVIGAYVMVGGCSGVAQD
EEEECCCCCCCEEEEECCCCCCCEEEECCEEECCCHHHHHHHHHHHHHHHHCCCCCHHHC
VPPFVIAQGNHATPFGLNIEGLKRRGFDHAALHAIRAAYKIIYRSGKTLDEAKPELQALA
CCCEEEECCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHH
QEHQVVNTFLDFLLRSQRGIIR
HHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MIDQSAFIHPSAIVEDGAIIHADVHVGPFCVIGPQVEIGARTVLESHVVVTGITRIGEDN
CCCCCCCCCCHHHCCCCCEEEEECCCCCEEEECCCEECCHHHHHHCCEEEEEEECCCCCC
QIYPFASLGDVNQDLKYAGEPTRVEIGHRNRIRESVTIHRGTIQGGEVTRVGSDNLLMVN
EEEEECCCCCCCHHHHHCCCCCEEEECCCHHHHHHEEEEECCCCCCCEEEECCCCEEEEE
AHVAHDCTVGSHCIMANNATLGGHVAVDDYAIIGGMTAVHQFCVIGAYVMVGGCSGVAQD
EEEECCCCCCCEEEEECCCCCCCEEEECCEEECCCHHHHHHHHHHHHHHHHCCCCCHHHC
VPPFVIAQGNHATPFGLNIEGLKRRGFDHAALHAIRAAYKIIYRSGKTLDEAKPELQALA
CCCEEEECCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHH
QEHQVVNTFLDFLLRSQRGIIR
HHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA