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The map label for this gene is lpxB

Identifier: 85059908

GI number: 85059908

Start: 3333930

End: 3335078

Strand: Reverse

Name: lpxB

Synonym: SG1930

Alternate gene names: 85059908

Gene position: 3335078-3333930 (Counterclockwise)

Preceding gene: 85059909

Following gene: 85059907

Centisome position: 79.96

GC content: 64.58

Gene sequence:

>1149_bases
ATGTCGGCACGCCCCATCACTATCGGTCTGGTGGCCGGCGAGACGTCGGGGGATATCCTCGGCGCCGGGTTGATACGCGC
GCTGCGCGGCCATTTGCCGGAGGCTCGCTTCGTCGGCGTTGCAGGCCCGCGTATGCAGGCGGAAGGGATGGAAGCCTGGT
ATGACATGGAAGAGCTGGCGGTGATGGGCATCGTGGAGGTGGTCGAGCGCCTGCCGCGGCTGCTGCGTATTCGCCGCGAC
CTGACCCGCCGCTTTACCGCGCTTCGTCCCGACGTCTTTGTCGGTATTGATGCGCCGGATTTTACGATTACGCTGGAAGG
CCGCCTTAAGCGGCGCGGTATCCGCACTATCCATTATGTCAGCCCCTCCGTCTGGGCCTGGCGGCAGAAGCGGGTGTTTA
AAATCGGCCGCGCCACCGATAACGTACTGGCCTTTCTGCCGTTCGAGAAGGCGTTTTACGACTGCTACAATGTCCCCTGT
CAGTTTATCGGCCATACGCTGGCGGACGCCATGTCTCTCGATCCGGATAAAGCCGCCGCGCGCCAGGCTCTGGGTATTGC
CGCTGAGGCGCGCTGCCTGGCGCTGCTGCCGGGCAGCCGCCAAAGCGAGGTGGCGATGCTGAGCGCGGACTTTCTGCGCG
CCGCCGAGCGGTTGTATGAGTGTTTTCCAGGGCTGGAGATTGTCGTACCGTTGGTGAATCCGGCCCGGCGGGCGCAGTTT
GAGCACATCTTGGTGGCGGTGGCGCCGGCGTTGCCGGTACGGCTTTTGGACAATCAGGCCCGCCAGGCCATGATCGCCGC
CGATGCCGCCCTGCTGGCTTCCGGCACCGCGTCCCTTGAGTGCATGCTGGCGAAGTGCCCGATGGTGGTGGGCTATCGCA
TGAAGCCCTTGACGTTCGCGCTGGCGCGGCGGTTGGTGAAGACGCCGTGGGTGTCGCTGCCCAATCTGCTGGCTGGCCGT
GAACTGGTCAAAGAGCTGTTGCAGGAGGCGTGCCAGCCGGAGGCGCTGGCGGCGGCCCTGGAGCCGCTGCTTGACGATGA
TGACCAGCGCGCGGCGTTGCTGGCTATGTTTCGCCAACTGCACCAACAAATTCGCTGTAACGCCGACGAACAGGCGGCGC
GCGCGGTGCTGGCGCTGATTAACCGTTAA

Upstream 100 bases:

>100_bases
AAGCCAAGCCCGAGCTGCAAGCGCTGGCGCAGGAACATCAGGTGGTTAATACCTTCCTGGACTTTCTGTTACGCTCCCAG
CGCGGTATTATCCGCTAATT

Downstream 100 bases:

>100_bases
TTCTTTTGCAGGTAGTGAAACCCATGACGGAATCTTTTATCTATCCTGCGGCGACGCTTATTGCCGGCGTCGATGAAGTG
GGGCGCGGACCTTTAGTGGG

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MSARPITIGLVAGETSGDILGAGLIRALRGHLPEARFVGVAGPRMQAEGMEAWYDMEELAVMGIVEVVERLPRLLRIRRD
LTRRFTALRPDVFVGIDAPDFTITLEGRLKRRGIRTIHYVSPSVWAWRQKRVFKIGRATDNVLAFLPFEKAFYDCYNVPC
QFIGHTLADAMSLDPDKAAARQALGIAAEARCLALLPGSRQSEVAMLSADFLRAAERLYECFPGLEIVVPLVNPARRAQF
EHILVAVAPALPVRLLDNQARQAMIAADAALLASGTASLECMLAKCPMVVGYRMKPLTFALARRLVKTPWVSLPNLLAGR
ELVKELLQEACQPEALAAALEPLLDDDDQRAALLAMFRQLHQQIRCNADEQAARAVLALINR

Sequences:

>Translated_382_residues
MSARPITIGLVAGETSGDILGAGLIRALRGHLPEARFVGVAGPRMQAEGMEAWYDMEELAVMGIVEVVERLPRLLRIRRD
LTRRFTALRPDVFVGIDAPDFTITLEGRLKRRGIRTIHYVSPSVWAWRQKRVFKIGRATDNVLAFLPFEKAFYDCYNVPC
QFIGHTLADAMSLDPDKAAARQALGIAAEARCLALLPGSRQSEVAMLSADFLRAAERLYECFPGLEIVVPLVNPARRAQF
EHILVAVAPALPVRLLDNQARQAMIAADAALLASGTASLECMLAKCPMVVGYRMKPLTFALARRLVKTPWVSLPNLLAGR
ELVKELLQEACQPEALAAALEPLLDDDDQRAALLAMFRQLHQQIRCNADEQAARAVLALINR
>Mature_381_residues
SARPITIGLVAGETSGDILGAGLIRALRGHLPEARFVGVAGPRMQAEGMEAWYDMEELAVMGIVEVVERLPRLLRIRRDL
TRRFTALRPDVFVGIDAPDFTITLEGRLKRRGIRTIHYVSPSVWAWRQKRVFKIGRATDNVLAFLPFEKAFYDCYNVPCQ
FIGHTLADAMSLDPDKAAARQALGIAAEARCLALLPGSRQSEVAMLSADFLRAAERLYECFPGLEIVVPLVNPARRAQFE
HILVAVAPALPVRLLDNQARQAMIAADAALLASGTASLECMLAKCPMVVGYRMKPLTFALARRLVKTPWVSLPNLLAGRE
LVKELLQEACQPEALAAALEPLLDDDDQRAALLAMFRQLHQQIRCNADEQAARAVLALINR

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family

Homologues:

Organism=Escherichia coli, GI1786379, Length=376, Percent_Identity=76.8617021276596, Blast_Score=567, Evalue=1e-163,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXB_SODGM (Q2NRM0)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_455610.1
- ProteinModelPortal:   Q2NRM0
- STRING:   Q2NRM0
- GeneID:   3867842
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG1930
- NMPDR:   fig|343509.6.peg.4184
- eggNOG:   COG0763
- HOGENOM:   HBG584837
- OMA:   DFTHRVA
- PhylomeDB:   Q2NRM0
- ProtClustDB:   PRK00025
- BioCyc:   SGLO343509:SG1930-MONOMER
- HAMAP:   MF_00392
- InterPro:   IPR003835
- TIGRFAMs:   TIGR00215

Pfam domain/function: PF02684 LpxB

EC number: =2.4.1.182

Molecular weight: Translated: 42151; Mature: 42020

Theoretical pI: Translated: 8.57; Mature: 8.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSARPITIGLVAGETSGDILGAGLIRALRGHLPEARFVGVAGPRMQAEGMEAWYDMEELA
CCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHH
VMGIVEVVERLPRLLRIRRDLTRRFTALRPDVFVGIDAPDFTITLEGRLKRRGIRTIHYV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEECCHHHHCCCCEEEEC
SPSVWAWRQKRVFKIGRATDNVLAFLPFEKAFYDCYNVPCQFIGHTLADAMSLDPDKAAA
CCCHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHH
RQALGIAAEARCLALLPGSRQSEVAMLSADFLRAAERLYECFPGLEIVVPLVNPARRAQF
HHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHH
EHILVAVAPALPVRLLDNQARQAMIAADAALLASGTASLECMLAKCPMVVGYRMKPLTFA
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHCCCCCHHHHH
LARRLVKTPWVSLPNLLAGRELVKELLQEACQPEALAAALEPLLDDDDQRAALLAMFRQL
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHH
HQQIRCNADEQAARAVLALINR
HHHHCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SARPITIGLVAGETSGDILGAGLIRALRGHLPEARFVGVAGPRMQAEGMEAWYDMEELA
CCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHH
VMGIVEVVERLPRLLRIRRDLTRRFTALRPDVFVGIDAPDFTITLEGRLKRRGIRTIHYV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEECCHHHHCCCCEEEEC
SPSVWAWRQKRVFKIGRATDNVLAFLPFEKAFYDCYNVPCQFIGHTLADAMSLDPDKAAA
CCCHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHH
RQALGIAAEARCLALLPGSRQSEVAMLSADFLRAAERLYECFPGLEIVVPLVNPARRAQF
HHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHH
EHILVAVAPALPVRLLDNQARQAMIAADAALLASGTASLECMLAKCPMVVGYRMKPLTFA
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHCCCCCHHHHH
LARRLVKTPWVSLPNLLAGRELVKELLQEACQPEALAAALEPLLDDDDQRAALLAMFRQL
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHH
HQQIRCNADEQAARAVLALINR
HHHHCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA