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The map label for this gene is hemA

Identifier: 85059855

GI number: 85059855

Start: 3212826

End: 3214088

Strand: Reverse

Name: hemA

Synonym: SG1877

Alternate gene names: 85059855

Gene position: 3214088-3212826 (Counterclockwise)

Preceding gene: 85059863

Following gene: 85059854

Centisome position: 77.06

GC content: 59.94

Gene sequence:

>1263_bases
ATGACATTGCTCGCACTCGGTATCAATCACAAAACAGCGCCGGTCGCTTTGCGCGAAAGGGTGGCGTTCTCACCCGAGAC
CCTCGACCAGGCGCTGGGCAGCTTGCTTGCGCACCCGCTGGTGCAGGGCGGCGTCGTGCTGTCTACCTGTAACCGCACTG
AGCTGTATTTGAGTGTTGAGCAACAGGCTGATTTGCAAGAGGCGCTGGTACGCTGGCTGTGCGATTATCACCAGCTGGAG
CCGGACGAGGTGCGCCAGAGTCTTTACTGGCATCTGGGCGACGAAGCCGTCAGCCATTTGATGCGCGTTGCCAGCGGCCT
GGACTCTTTGGTGCTCGGCGAGCCGCAAATTTTGGGACAGGTAAAGAAAGCCTTCGCTGAATCCCGCCGGGGGCACGGCC
TGTCGGTGGACCTGGAGCGATGGTTTCAGAAATCCTTTTCGGTTGCCAAACGGGTCCGCACCGAAACCGAGATCGGCTCC
CACGCGGTGTCGGTGGCGTTCGCCGCCTGCACGCTGGCGCGGCAGATATTTGAATCCCTGGCCGACGTGACGGTGCTGCT
GGTGGGCGCCGGCGAAACGATTGAGCTGGTGGCGCGCCACCTGCGCGAGCATAAAGTCAAGCGCCTGCTTATCGCTAACC
GCACCCCCGAGCGGGCGCAGCGGCTGGCGGAAGACGTTGGCGCTGATGTCATCAATCTGGCGGAAATTGATAGCCAATTG
GGTGAGGCAGACATTATTATCACCTCTACCGCCAGCACGCTGCCGATTATCGGTAAAGGAATGGTGGAGCGAGCGTTGAA
ACAGCGCCGTTATCAGCCCATGTTATTGGTGGATATCGCCGTACCGCGCGATATCGAACCGGAGGTGGCAAAGTTGGCAG
ATGCCTATCTGTATACGGTGGACGATCTCCAGGCCATCATAGAAAAAAATCTGGCGCAGCGTAAACATGCCGCGGTATTG
GCGGAAACCATCGTTGCGCAGGAAAGTATGGATTTTATGGGTTGGCTGCGCAGCCAGTCGGCGGTGGAGGCGATTCGCGA
TTACCGCACGCAGGCCGATAGCCTGCGGGAGGAGTTTGAAGCCCGCGCGCTGGCCGCACTGCGCCTTGGCGCCGACCCGG
AACAGGTGGTGAAAGACATGGCGTACAAGCTGACCAACCGTCTTATCCATACGCCGACCAAATCGCTGCAGCAGGCCGCC
CGCGAAGGCGACGCCGAGCGTCTACAAATTTTGCGCGACGGTCTCGGACTGGACACGCACTGA

Upstream 100 bases:

>100_bases
GAGGAAAGTGCGGTGCGGCTTTTCTTGCACCTGTGCATCAAGTAGAATGCGCGCAGACGATAACCATATTAACGCTTGTA
CTACTCTGTAACCTTAATCC

Downstream 100 bases:

>100_bases
TATACATAAGGTAAACCACCACGTATGAAGTCCTCGATAGTCGCCAAATTGGAGGCGTTGCAAGAGCGCCGCGAAGAAGT
GGAAGTTCTGCTCGGCGATC

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MTLLALGINHKTAPVALRERVAFSPETLDQALGSLLAHPLVQGGVVLSTCNRTELYLSVEQQADLQEALVRWLCDYHQLE
PDEVRQSLYWHLGDEAVSHLMRVASGLDSLVLGEPQILGQVKKAFAESRRGHGLSVDLERWFQKSFSVAKRVRTETEIGS
HAVSVAFAACTLARQIFESLADVTVLLVGAGETIELVARHLREHKVKRLLIANRTPERAQRLAEDVGADVINLAEIDSQL
GEADIIITSTASTLPIIGKGMVERALKQRRYQPMLLVDIAVPRDIEPEVAKLADAYLYTVDDLQAIIEKNLAQRKHAAVL
AETIVAQESMDFMGWLRSQSAVEAIRDYRTQADSLREEFEARALAALRLGADPEQVVKDMAYKLTNRLIHTPTKSLQQAA
REGDAERLQILRDGLGLDTH

Sequences:

>Translated_420_residues
MTLLALGINHKTAPVALRERVAFSPETLDQALGSLLAHPLVQGGVVLSTCNRTELYLSVEQQADLQEALVRWLCDYHQLE
PDEVRQSLYWHLGDEAVSHLMRVASGLDSLVLGEPQILGQVKKAFAESRRGHGLSVDLERWFQKSFSVAKRVRTETEIGS
HAVSVAFAACTLARQIFESLADVTVLLVGAGETIELVARHLREHKVKRLLIANRTPERAQRLAEDVGADVINLAEIDSQL
GEADIIITSTASTLPIIGKGMVERALKQRRYQPMLLVDIAVPRDIEPEVAKLADAYLYTVDDLQAIIEKNLAQRKHAAVL
AETIVAQESMDFMGWLRSQSAVEAIRDYRTQADSLREEFEARALAALRLGADPEQVVKDMAYKLTNRLIHTPTKSLQQAA
REGDAERLQILRDGLGLDTH
>Mature_419_residues
TLLALGINHKTAPVALRERVAFSPETLDQALGSLLAHPLVQGGVVLSTCNRTELYLSVEQQADLQEALVRWLCDYHQLEP
DEVRQSLYWHLGDEAVSHLMRVASGLDSLVLGEPQILGQVKKAFAESRRGHGLSVDLERWFQKSFSVAKRVRTETEIGSH
AVSVAFAACTLARQIFESLADVTVLLVGAGETIELVARHLREHKVKRLLIANRTPERAQRLAEDVGADVINLAEIDSQLG
EADIIITSTASTLPIIGKGMVERALKQRRYQPMLLVDIAVPRDIEPEVAKLADAYLYTVDDLQAIIEKNLAQRKHAAVLA
ETIVAQESMDFMGWLRSQSAVEAIRDYRTQADSLREEFEARALAALRLGADPEQVVKDMAYKLTNRLIHTPTKSLQQAAR
EGDAERLQILRDGLGLDTH

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=418, Percent_Identity=76.7942583732057, Blast_Score=641, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_SODGM (Q2NRS3)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_455557.1
- ProteinModelPortal:   Q2NRS3
- SMR:   Q2NRS3
- STRING:   Q2NRS3
- GeneID:   3866351
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG1877
- NMPDR:   fig|343509.6.peg.4015
- eggNOG:   COG0373
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- PhylomeDB:   Q2NRS3
- ProtClustDB:   PRK00045
- BioCyc:   SGLO343509:SG1877-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR003462
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR13812
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 46592; Mature: 46461

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 109-109 BINDING 120-120

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLLALGINHKTAPVALRERVAFSPETLDQALGSLLAHPLVQGGVVLSTCNRTELYLSVE
CEEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCEEEEEEEH
QQADLQEALVRWLCDYHQLEPDEVRQSLYWHLGDEAVSHLMRVASGLDSLVLGEPQILGQ
HHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHCCCHHHHHH
VKKAFAESRRGHGLSVDLERWFQKSFSVAKRVRTETEIGSHAVSVAFAACTLARQIFESL
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADVTVLLVGAGETIELVARHLREHKVKRLLIANRTPERAQRLAEDVGADVINLAEIDSQL
HHHHEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHC
GEADIIITSTASTLPIIGKGMVERALKQRRYQPMLLVDIAVPRDIEPEVAKLADAYLYTV
CCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
DDLQAIIEKNLAQRKHAAVLAETIVAQESMDFMGWLRSQSAVEAIRDYRTQADSLREEFE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARALAALRLGADPEQVVKDMAYKLTNRLIHTPTKSLQQAAREGDAERLQILRDGLGLDTH
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TLLALGINHKTAPVALRERVAFSPETLDQALGSLLAHPLVQGGVVLSTCNRTELYLSVE
EEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCEEEEEEEH
QQADLQEALVRWLCDYHQLEPDEVRQSLYWHLGDEAVSHLMRVASGLDSLVLGEPQILGQ
HHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHCCCHHHHHH
VKKAFAESRRGHGLSVDLERWFQKSFSVAKRVRTETEIGSHAVSVAFAACTLARQIFESL
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADVTVLLVGAGETIELVARHLREHKVKRLLIANRTPERAQRLAEDVGADVINLAEIDSQL
HHHHEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHC
GEADIIITSTASTLPIIGKGMVERALKQRRYQPMLLVDIAVPRDIEPEVAKLADAYLYTV
CCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
DDLQAIIEKNLAQRKHAAVLAETIVAQESMDFMGWLRSQSAVEAIRDYRTQADSLREEFE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARALAALRLGADPEQVVKDMAYKLTNRLIHTPTKSLQQAAREGDAERLQILRDGLGLDTH
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA