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The map label for this gene is ndk

Identifier: 85059742

GI number: 85059742

Start: 3019634

End: 3020065

Strand: Reverse

Name: ndk

Synonym: SG1764

Alternate gene names: 85059742

Gene position: 3020065-3019634 (Counterclockwise)

Preceding gene: 85059744

Following gene: 85059741

Centisome position: 72.4

GC content: 54.86

Gene sequence:

>432_bases
ATGACCATTGAACGTACCTTTTCCATTATCAAGCCGAACGCCGTGGCCAAAAACGTCATCGGTGCCATTATCCAGCGTTT
TGAAAGCACCGGGCTGACCGTGGTTGGCGCTAAAATGCTCCAGTTGACCCGTGAGCAGGCGGAAGGATTCTATGCCGAAC
ATAAAGGCAAACCGTTCTTCGACAGCCTGGTGGATTTTATGATCTCCGGCCCCATCCTGGTGCAGGTGCTGGAAGGCGAA
GACGCCGTGCGCCGCAATCGTGAAATCATGGGCGCCACCAACCTGGCCAATGCTTTAGCCGGCACCCTGCGCGCCGATTA
TGCTGACAGCTTTACTGAGAACGCGGTACACGGCTCGGATTCCGCTGAATCTGCCGCGCGCGAAATTGCTTATTTCTTTG
CCGATGGCGAAGTTTGCACCCGTATTCGCTAA

Upstream 100 bases:

>100_bases
TAGCGGAGCGCTTCGCGCGCCCCTATAATCTGCGCCACTTGCACCGGCCGGCGTAACAGCGAATTAGCGCGGCCATAACA
AAAATCACCTAGAGGTTCTT

Downstream 100 bases:

>100_bases
TCCTTGCCTCACAACAGGGAAAAAAGGCTTGCTTCACCTTTTAAGCCAGGCAGCTCTGCGCTAAAATCAGTGTCCAACGT
GCCCCGGATGAGGTGGTGAT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 143; Mature: 142

Protein sequence:

>143_residues
MTIERTFSIIKPNAVAKNVIGAIIQRFESTGLTVVGAKMLQLTREQAEGFYAEHKGKPFFDSLVDFMISGPILVQVLEGE
DAVRRNREIMGATNLANALAGTLRADYADSFTENAVHGSDSAESAAREIAYFFADGEVCTRIR

Sequences:

>Translated_143_residues
MTIERTFSIIKPNAVAKNVIGAIIQRFESTGLTVVGAKMLQLTREQAEGFYAEHKGKPFFDSLVDFMISGPILVQVLEGE
DAVRRNREIMGATNLANALAGTLRADYADSFTENAVHGSDSAESAAREIAYFFADGEVCTRIR
>Mature_142_residues
TIERTFSIIKPNAVAKNVIGAIIQRFESTGLTVVGAKMLQLTREQAEGFYAEHKGKPFFDSLVDFMISGPILVQVLEGED
AVRRNREIMGATNLANALAGTLRADYADSFTENAVHGSDSAESAAREIAYFFADGEVCTRIR

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=137, Percent_Identity=44.5255474452555, Blast_Score=127, Evalue=3e-30,
Organism=Homo sapiens, GI4826862, Length=140, Percent_Identity=40, Blast_Score=120, Evalue=3e-28,
Organism=Homo sapiens, GI38045913, Length=135, Percent_Identity=41.4814814814815, Blast_Score=119, Evalue=8e-28,
Organism=Homo sapiens, GI4557797, Length=135, Percent_Identity=41.4814814814815, Blast_Score=119, Evalue=9e-28,
Organism=Homo sapiens, GI66392227, Length=137, Percent_Identity=40.1459854014599, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI66392205, Length=137, Percent_Identity=40.1459854014599, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI4505409, Length=137, Percent_Identity=40.1459854014599, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI66392192, Length=137, Percent_Identity=40.1459854014599, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI66392203, Length=137, Percent_Identity=40.1459854014599, Blast_Score=118, Evalue=1e-27,
Organism=Homo sapiens, GI5031951, Length=137, Percent_Identity=38.6861313868613, Blast_Score=96, Evalue=1e-20,
Organism=Homo sapiens, GI37574614, Length=139, Percent_Identity=34.5323741007194, Blast_Score=94, Evalue=4e-20,
Organism=Homo sapiens, GI7019465, Length=139, Percent_Identity=34.5323741007194, Blast_Score=94, Evalue=5e-20,
Organism=Homo sapiens, GI4505413, Length=137, Percent_Identity=37.2262773722628, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI30023828, Length=136, Percent_Identity=36.0294117647059, Blast_Score=71, Evalue=3e-13,
Organism=Homo sapiens, GI148839372, Length=138, Percent_Identity=29.7101449275362, Blast_Score=64, Evalue=6e-11,
Organism=Escherichia coli, GI1788866, Length=143, Percent_Identity=76.2237762237762, Blast_Score=228, Evalue=9e-62,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=41.4814814814815, Blast_Score=120, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6322783, Length=135, Percent_Identity=45.1851851851852, Blast_Score=129, Evalue=2e-31,
Organism=Drosophila melanogaster, GI45549037, Length=137, Percent_Identity=42.3357664233577, Blast_Score=129, Evalue=6e-31,
Organism=Drosophila melanogaster, GI18860097, Length=136, Percent_Identity=37.5, Blast_Score=94, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_SODGM (Q2NS36)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_455444.1
- ProteinModelPortal:   Q2NS36
- SMR:   Q2NS36
- STRING:   Q2NS36
- GeneID:   3866923
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG1764
- NMPDR:   fig|343509.6.peg.3769
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- PhylomeDB:   Q2NS36
- BioCyc:   SGLO343509:SG1764-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15620; Mature: 15489

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIERTFSIIKPNAVAKNVIGAIIQRFESTGLTVVGAKMLQLTREQAEGFYAEHKGKPFF
CCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHCCCCCHH
DSLVDFMISGPILVQVLEGEDAVRRNREIMGATNLANALAGTLRADYADSFTENAVHGSD
HHHHHHHHCCHHEEEEECCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SAESAAREIAYFFADGEVCTRIR
HHHHHHHHHHHHHCCCHHHHCCC
>Mature Secondary Structure 
TIERTFSIIKPNAVAKNVIGAIIQRFESTGLTVVGAKMLQLTREQAEGFYAEHKGKPFF
CCHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHCCCCCHH
DSLVDFMISGPILVQVLEGEDAVRRNREIMGATNLANALAGTLRADYADSFTENAVHGSD
HHHHHHHHCCHHEEEEECCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
SAESAAREIAYFFADGEVCTRIR
HHHHHHHHHHHHHCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA