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The map label for this gene is cysM

Identifier: 85059683

GI number: 85059683

Start: 2914277

End: 2915164

Strand: Reverse

Name: cysM

Synonym: SG1705

Alternate gene names: 85059683

Gene position: 2915164-2914277 (Counterclockwise)

Preceding gene: 85059684

Following gene: 85059682

Centisome position: 69.89

GC content: 61.04

Gene sequence:

>888_bases
GTGAAGACGCTTGAACATTGCATAGGCAACACCCCGCTCGTAAAGCTCCAGCGTATGGCTCCCGCCGGCGGCGGCGAAAT
CTGGCTGAAGATGGAAGGCAACAATCCGGCGGGATCGGTGAAAGATCGCGCAGCGTTATCCATGATCCAGCAGGCGGAAC
GGCGCGGCGAGATTGCGCCCGGTGATGTGTTAATTGAGGCGACCAGCGGCAATACCGGCATCGCCCTAGCGATGATTGCC
GCGCTGAAGGACTATCGCCTGAAACTACTGATGCCGGACAATATGAGTATCGAGCGGCAGGAGGCGATGCGCGCCTACGG
GGCTGAATTGATTTTGGTGGATCACGTCATGGGCATGGAGGGCGCGCGCGATCGGGCACGCGCCATTGCTCAGGCGACGG
GTGGGAAAGTCATGGATCAATTCAATAACCCCGATAATCCGCTGGCGCATTTTACCACCACCGGTCCGGAAATCTGGCGT
CAAACCGACGGGCGCATCAGTCATTTTGTCTCCAGCATGGGCACCACCGGCACCATCATGGGCGTCAGCCGATTTCTTAA
ATTCCGGCGGCCGGACGTGACCATCGTCGGGCTTCAGCCGGCGCCGGGCAGCAGCATTCCCGGCATCCGCCGCTGGCCGT
CCGCTTACCTGCCGGCTATTTTTGACCCTACGCTGGTGGACTTGACTCTGGATATCGACCAAGAGGCAGCGGAAAACACC
CAGCGCCGTCTGGCCCGGGAAGAAGGCATTTTCTGCGGCGTCAGCTCAGGCGGCGCGGTAGCCGGCGCATTGCGCGTGGC
CGCGAAGGCGCCGGGCAGTCTGGTGGTCGCCGTCTGCTGCGATCGTGGCGATCGTTATCTGTCCACGGGCATTTTTCACT
CAGACTGA

Upstream 100 bases:

>100_bases
AGGACGGAGGGGGACGCTGCGCAAGTCGCGTGTTACCTCACTGCACGACTAACAGGGCGGCCGTACGGTCGCCTGTTTTT
TTTATTGGGAACCCCAGGCC

Downstream 100 bases:

>100_bases
CGTTGCGACAGTCTTTTTGTCTAATTGGGGCCTTTGGCAGCACCTTTTTGCCTGTTGCAGGTCAAACAGTGGCAGGTCTC
TGGCCTGGTGAAATAAGGAA

Product: cysteine synthase B

Products: NA

Alternate protein names: CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MKTLEHCIGNTPLVKLQRMAPAGGGEIWLKMEGNNPAGSVKDRAALSMIQQAERRGEIAPGDVLIEATSGNTGIALAMIA
ALKDYRLKLLMPDNMSIERQEAMRAYGAELILVDHVMGMEGARDRARAIAQATGGKVMDQFNNPDNPLAHFTTTGPEIWR
QTDGRISHFVSSMGTTGTIMGVSRFLKFRRPDVTIVGLQPAPGSSIPGIRRWPSAYLPAIFDPTLVDLTLDIDQEAAENT
QRRLAREEGIFCGVSSGGAVAGALRVAAKAPGSLVVAVCCDRGDRYLSTGIFHSD

Sequences:

>Translated_295_residues
MKTLEHCIGNTPLVKLQRMAPAGGGEIWLKMEGNNPAGSVKDRAALSMIQQAERRGEIAPGDVLIEATSGNTGIALAMIA
ALKDYRLKLLMPDNMSIERQEAMRAYGAELILVDHVMGMEGARDRARAIAQATGGKVMDQFNNPDNPLAHFTTTGPEIWR
QTDGRISHFVSSMGTTGTIMGVSRFLKFRRPDVTIVGLQPAPGSSIPGIRRWPSAYLPAIFDPTLVDLTLDIDQEAAENT
QRRLAREEGIFCGVSSGGAVAGALRVAAKAPGSLVVAVCCDRGDRYLSTGIFHSD
>Mature_295_residues
MKTLEHCIGNTPLVKLQRMAPAGGGEIWLKMEGNNPAGSVKDRAALSMIQQAERRGEIAPGDVLIEATSGNTGIALAMIA
ALKDYRLKLLMPDNMSIERQEAMRAYGAELILVDHVMGMEGARDRARAIAQATGGKVMDQFNNPDNPLAHFTTTGPEIWR
QTDGRISHFVSSMGTTGTIMGVSRFLKFRRPDVTIVGLQPAPGSSIPGIRRWPSAYLPAIFDPTLVDLTLDIDQEAAENT
QRRLAREEGIFCGVSSGGAVAGALRVAAKAPGSLVVAVCCDRGDRYLSTGIFHSD

Specific function: Two cysteine synthase enzymes are found. Both catalyze the same reaction. Cysteine synthase B can also use thiosulfate in place of sulfide to give cysteine thiosulfonate as a product [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=308, Percent_Identity=35.7142857142857, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI295821200, Length=308, Percent_Identity=35.7142857142857, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI4557415, Length=308, Percent_Identity=35.7142857142857, Blast_Score=176, Evalue=3e-44,
Organism=Escherichia coli, GI2367138, Length=292, Percent_Identity=75.6849315068493, Blast_Score=451, Evalue=1e-128,
Organism=Escherichia coli, GI1788754, Length=305, Percent_Identity=42.9508196721311, Blast_Score=209, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17535051, Length=296, Percent_Identity=42.9054054054054, Blast_Score=224, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI17562970, Length=296, Percent_Identity=40.2027027027027, Blast_Score=215, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI32566674, Length=291, Percent_Identity=40.893470790378, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI115535073, Length=296, Percent_Identity=40.8783783783784, Blast_Score=206, Evalue=9e-54,
Organism=Caenorhabditis elegans, GI17561720, Length=298, Percent_Identity=38.255033557047, Blast_Score=189, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI32566672, Length=212, Percent_Identity=36.3207547169811, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17534315, Length=312, Percent_Identity=35.2564102564103, Blast_Score=140, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI25147552, Length=317, Percent_Identity=34.0694006309148, Blast_Score=136, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6321594, Length=311, Percent_Identity=33.4405144694534, Blast_Score=156, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6321449, Length=324, Percent_Identity=32.0987654320988, Blast_Score=137, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24643623, Length=312, Percent_Identity=39.1025641025641, Blast_Score=150, Evalue=9e-37,
Organism=Drosophila melanogaster, GI20129101, Length=312, Percent_Identity=39.1025641025641, Blast_Score=150, Evalue=9e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005858
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 31674; Mature: 31674

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLEHCIGNTPLVKLQRMAPAGGGEIWLKMEGNNPAGSVKDRAALSMIQQAERRGEIAP
CCCHHHHHCCCCCEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCC
GDVLIEATSGNTGIALAMIAALKDYRLKLLMPDNMSIERQEAMRAYGAELILVDHVMGME
CCEEEEECCCCCCHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHCCEEEEEEHHHCCC
GARDRARAIAQATGGKVMDQFNNPDNPLAHFTTTGPEIWRQTDGRISHFVSSMGTTGTIM
CCHHHHHHHHHHCCCHHHHHCCCCCCCCEEEECCCHHHHHCCCCHHHHHHHHCCCCHHHH
GVSRFLKFRRPDVTIVGLQPAPGSSIPGIRRWPSAYLPAIFDPTLVDLTLDIDQEAAENT
HHHHHHHHCCCCEEEEEECCCCCCCCCCCHHCCCHHCCHHCCCEEEEEEECCCHHHHHHH
QRRLAREEGIFCGVSSGGAVAGALRVAAKAPGSLVVAVCCDRGDRYLSTGIFHSD
HHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCCCCEEECCCCCCC
>Mature Secondary Structure
MKTLEHCIGNTPLVKLQRMAPAGGGEIWLKMEGNNPAGSVKDRAALSMIQQAERRGEIAP
CCCHHHHHCCCCCEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCC
GDVLIEATSGNTGIALAMIAALKDYRLKLLMPDNMSIERQEAMRAYGAELILVDHVMGME
CCEEEEECCCCCCHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHCCEEEEEEHHHCCC
GARDRARAIAQATGGKVMDQFNNPDNPLAHFTTTGPEIWRQTDGRISHFVSSMGTTGTIM
CCHHHHHHHHHHCCCHHHHHCCCCCCCCEEEECCCHHHHHCCCCHHHHHHHHCCCCHHHH
GVSRFLKFRRPDVTIVGLQPAPGSSIPGIRRWPSAYLPAIFDPTLVDLTLDIDQEAAENT
HHHHHHHHCCCCEEEEEECCCCCCCCCCCHHCCCHHCCHHCCCEEEEEEECCCHHHHHHH
QRRLAREEGIFCGVSSGGAVAGALRVAAKAPGSLVVAVCCDRGDRYLSTGIFHSD
HHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2188958; 9205837; 9278503 [H]