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The map label for this gene is fabB [H]

Identifier: 85059601

GI number: 85059601

Start: 2780070

End: 2781281

Strand: Reverse

Name: fabB [H]

Synonym: SG1623

Alternate gene names: 85059601

Gene position: 2781281-2780070 (Counterclockwise)

Preceding gene: 85059602

Following gene: 85059599

Centisome position: 66.68

GC content: 58.83

Gene sequence:

>1212_bases
ATGAAACGTGCTGTGATTACCGGCCTGGGGATCTTATCAAGTATCGGTAACGACCAAAAAGAAGTCCTGGCCTCGTTGCA
AGAAGGCCGCTCCGGGATTACCTTTTCCCAGGAATTGAAAGATTCCGGCATGCGCAGCCATGTCTGGGGCAATATTAAAC
TCGATACCACCGGGCTGATTGATCGCAAAATGGCGCGCTTTATGAGTGATGCCTCTGTCTACGCCTTTTTGTCCATGGAG
CAGGCGATTGCCGACGCCGGGCTGACGCCGGACATGGTGTCCAACGACCGTAGCGGCCTTATCGTCGGCTCCGGCGGCGG
CTCGCCGCGCAACCAGGTTGCCGGATCTGACGGCATGCGCGCCCGCGGCCTGCGCGGCGTGGGACCCTACATGGTTACCA
AGGCGATGGCCTCCGGCGTGTCGGCGTGTCTGGCGACCCCTTTCAAAATCCGCGGCGTTAACTACTCCATCAGTTCCGCC
TGTTCGACCTCCGCGCATTGTATCGGCAATGCGGTGGAAATGATCCAGCTCGGCAAACAGGATGTGGTGTTCGCCGGCGG
CGGTGAAGAGCTGTGTTGGGAAATGGCCTGTGAATTCGATGCCATGGGCGCGCTATCTACCCGCTACAACGAAACGCCGA
CCAAAGCATCGTGCACCTATGACGTCAATCGCGACGGGTTCGTTATCGCCGGCGGCGGCGGTATCGTGGTGGTGGAAGAG
CTGGAGCATGCTCTGGCCCGCGGCGCCCATATTTATGCTGAAATTATCGGTTATGGCGCGACTTCCGACGGCGCGGACAT
GGTCGCCCCGTCCGGCGAAGGCGCCATCCGTTGCATGCAGATGGCGTTGAAAGATGTCGATACCCCGGTAGATTACCTGA
ACGTCCACGGGACCTCTACGCCGGTTGGCGACGTCAAAGAGTTGTGGGCTATCCGGGAAACCTTCGGCAGCCAGCATCCG
GCGTTCTCCTCCACTAAGGCGATGACCGGTCATTCGCTGGGTGCCGCCGGGGTGCATGAAACCATCTTCACGCTGCTGAT
GCTGGAGCACGGGTTTATTGCTCCGAGCATCAATATCGAACAGCTTGATCCGCAGGCGGAAGGCATGAACGTCATTACCG
AGCCGACCCGACGTGCATTGACCACCGTCATGAGTAACAGCTTTGGTTTCGGCGGCACGAACGCAACGCTCGTGATGCGT
AAATACGGCTAA

Upstream 100 bases:

>100_bases
GTGCAAATTTTGCTAACATCCTCTGATCGGACTTGTTCAGCTTACATCTGTAAGCTAAAGTGAGTGACTGAAACTCAAAT
ATTATTACAAGAGGTATTAA

Downstream 100 bases:

>100_bases
GCCGTGTCGGGTGTGGCCGGGCCGTGGCGCCGGAGCCCCGTTGTCGTGCGCCGGCGTCAGCGTTCACGCTAACCAACGCG
TCCCTTTCTACCGTGACGGC

Product: 3-oxoacyl-(acyl-carrier-protein) synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MKRAVITGLGILSSIGNDQKEVLASLQEGRSGITFSQELKDSGMRSHVWGNIKLDTTGLIDRKMARFMSDASVYAFLSME
QAIADAGLTPDMVSNDRSGLIVGSGGGSPRNQVAGSDGMRARGLRGVGPYMVTKAMASGVSACLATPFKIRGVNYSISSA
CSTSAHCIGNAVEMIQLGKQDVVFAGGGEELCWEMACEFDAMGALSTRYNETPTKASCTYDVNRDGFVIAGGGGIVVVEE
LEHALARGAHIYAEIIGYGATSDGADMVAPSGEGAIRCMQMALKDVDTPVDYLNVHGTSTPVGDVKELWAIRETFGSQHP
AFSSTKAMTGHSLGAAGVHETIFTLLMLEHGFIAPSINIEQLDPQAEGMNVITEPTRRALTTVMSNSFGFGGTNATLVMR
KYG

Sequences:

>Translated_403_residues
MKRAVITGLGILSSIGNDQKEVLASLQEGRSGITFSQELKDSGMRSHVWGNIKLDTTGLIDRKMARFMSDASVYAFLSME
QAIADAGLTPDMVSNDRSGLIVGSGGGSPRNQVAGSDGMRARGLRGVGPYMVTKAMASGVSACLATPFKIRGVNYSISSA
CSTSAHCIGNAVEMIQLGKQDVVFAGGGEELCWEMACEFDAMGALSTRYNETPTKASCTYDVNRDGFVIAGGGGIVVVEE
LEHALARGAHIYAEIIGYGATSDGADMVAPSGEGAIRCMQMALKDVDTPVDYLNVHGTSTPVGDVKELWAIRETFGSQHP
AFSSTKAMTGHSLGAAGVHETIFTLLMLEHGFIAPSINIEQLDPQAEGMNVITEPTRRALTTVMSNSFGFGGTNATLVMR
KYG
>Mature_403_residues
MKRAVITGLGILSSIGNDQKEVLASLQEGRSGITFSQELKDSGMRSHVWGNIKLDTTGLIDRKMARFMSDASVYAFLSME
QAIADAGLTPDMVSNDRSGLIVGSGGGSPRNQVAGSDGMRARGLRGVGPYMVTKAMASGVSACLATPFKIRGVNYSISSA
CSTSAHCIGNAVEMIQLGKQDVVFAGGGEELCWEMACEFDAMGALSTRYNETPTKASCTYDVNRDGFVIAGGGGIVVVEE
LEHALARGAHIYAEIIGYGATSDGADMVAPSGEGAIRCMQMALKDVDTPVDYLNVHGTSTPVGDVKELWAIRETFGSQHP
AFSSTKAMTGHSLGAAGVHETIFTLLMLEHGFIAPSINIEQLDPQAEGMNVITEPTRRALTTVMSNSFGFGGTNATLVMR
KYG

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=418, Percent_Identity=33.0143540669856, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI41872631, Length=335, Percent_Identity=29.2537313432836, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI223972627, Length=167, Percent_Identity=39.5209580838323, Blast_Score=102, Evalue=8e-22,
Organism=Escherichia coli, GI1788663, Length=403, Percent_Identity=83.8709677419355, Blast_Score=699, Evalue=0.0,
Organism=Escherichia coli, GI1787337, Length=411, Percent_Identity=36.2530413625304, Blast_Score=219, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI71983541, Length=417, Percent_Identity=33.3333333333333, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71983535, Length=265, Percent_Identity=38.1132075471698, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI212642053, Length=355, Percent_Identity=28.169014084507, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17550940, Length=299, Percent_Identity=27.0903010033445, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320904, Length=448, Percent_Identity=30.3571428571429, Blast_Score=174, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24644341, Length=420, Percent_Identity=36.4285714285714, Blast_Score=228, Evalue=8e-60,
Organism=Drosophila melanogaster, GI221330659, Length=358, Percent_Identity=26.536312849162, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19920632, Length=336, Percent_Identity=26.7857142857143, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24581345, Length=363, Percent_Identity=23.4159779614325, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 42477; Mature: 42477

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRAVITGLGILSSIGNDQKEVLASLQEGRSGITFSQELKDSGMRSHVWGNIKLDTTGLI
CCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEHHHHHHCCCCHHEEEEEEECCCHHH
DRKMARFMSDASVYAFLSMEQAIADAGLTPDMVSNDRSGLIVGSGGGSPRNQVAGSDGMR
HHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHCCCCCEEEEECCCCCCCCCCCCCCCCC
ARGLRGVGPYMVTKAMASGVSACLATPFKIRGVNYSISSACSTSAHCIGNAVEMIQLGKQ
CCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCEEHHHHCCCCHHHHHHHHHHHHCCCC
DVVFAGGGEELCWEMACEFDAMGALSTRYNETPTKASCTYDVNRDGFVIAGGGGIVVVEE
CEEEECCCHHHHHHHHHCHHHCCCHHHCCCCCCCCCEEEEECCCCCEEEECCCCEEEHHH
LEHALARGAHIYAEIIGYGATSDGADMVAPSGEGAIRCMQMALKDVDTPVDYLNVHGTST
HHHHHHCCHHEEEHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCC
PVGDVKELWAIRETFGSQHPAFSSTKAMTGHSLGAAGVHETIFTLLMLEHGFIAPSINIE
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHH
QLDPQAEGMNVITEPTRRALTTVMSNSFGFGGTNATLVMRKYG
HCCCCCCCCCEECCHHHHHHHHHHHCCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MKRAVITGLGILSSIGNDQKEVLASLQEGRSGITFSQELKDSGMRSHVWGNIKLDTTGLI
CCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEHHHHHHCCCCHHEEEEEEECCCHHH
DRKMARFMSDASVYAFLSMEQAIADAGLTPDMVSNDRSGLIVGSGGGSPRNQVAGSDGMR
HHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHCCCCCEEEEECCCCCCCCCCCCCCCCC
ARGLRGVGPYMVTKAMASGVSACLATPFKIRGVNYSISSACSTSAHCIGNAVEMIQLGKQ
CCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCEEHHHHCCCCHHHHHHHHHHHHCCCC
DVVFAGGGEELCWEMACEFDAMGALSTRYNETPTKASCTYDVNRDGFVIAGGGGIVVVEE
CEEEECCCHHHHHHHHHCHHHCCCHHHCCCCCCCCCEEEEECCCCCEEEECCCCEEEHHH
LEHALARGAHIYAEIIGYGATSDGADMVAPSGEGAIRCMQMALKDVDTPVDYLNVHGTST
HHHHHHCCHHEEEHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCC
PVGDVKELWAIRETFGSQHPAFSSTKAMTGHSLGAAGVHETIFTLLMLEHGFIAPSINIE
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHH
QLDPQAEGMNVITEPTRRALTTVMSNSFGFGGTNATLVMRKYG
HCCCCCCCCCEECCHHHHHHHHHHHCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]