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The map label for this gene is nuoL [H]

Identifier: 85059569

GI number: 85059569

Start: 2736642

End: 2738486

Strand: Reverse

Name: nuoL [H]

Synonym: SG1591

Alternate gene names: 85059569

Gene position: 2738486-2736642 (Counterclockwise)

Preceding gene: 85059570

Following gene: 85059568

Centisome position: 65.65

GC content: 60.92

Gene sequence:

>1845_bases
ATGAACCTACTCTATTTAACCCTAGTTTTCCCCTTGGCGGGGTTCCTGCTGCTGGCGTTTTCCCGCGGCCGCTGGTCGGA
AAACCTTGCCGCGACGGTCGGCGTCGGCAGCGTCGGGCTGGCGGCATTGACCACCCTCTGGGTGGCGCTGGATTTTCTCG
ACGCCCGCGGCGACGGTGCGGCGGTGTATGCCCAGACGCTGTGGCACTGGATGGCGGTGGGTGATTTCCAGATACCCATT
ACGCTCAGCCTCGACGGCCTGTCGCTGACGATGCTGTCGGTGGTCACCGGCGTCGGCTTCTTCATCCATCTTTATGCCTC
CTGGTATATGTGCGGGGAAGAGGGCTATTCGCGTTTCTTCGCCTATACCAATCTGTTTATCGCCAGCATGTTGGTGCTGG
TGCTGGCGGATAACCTGTTGCTTATGTATCTCGGCTGGGAAGGGGTAGGGCTTTGCAGCTATCTGCTTATCGGCTTCTAT
TATACCGAGTCGAAAAATGGCGCAGCGGCCATGAAGGCATTTGTCGTCACCCGCGTCGGGGATGTGTTGCTGGCGTTCGC
GCTGTTTATCCTCTACGACCAGCTCGGAACGTTGAACTTCCACAATCTGATGGTGCTGGCGCCGCAAAAACTGGCGGAAG
GCTCTCCGGCCATCATCTGGGCGACGCTGATGCTGCTGGGCGGCGCGGTCGGGAAGTCGGCGCAGCTGCCGCTGCAAACC
TGGCTGGCGGATGCCATGGCCGGCCCGACCCCGGTCTCGGCGCTGATCCATGCCGCGACCATGGTGACCGCCGGCGTGTA
TCTTATCGCCCGTACCCACGGTCTGTTCCTGATGGCGCCGGACGTGTTGCATCTGGTGGGGATTGTCGGCGTGGTAACGC
TGGTATTGGCCGGCTTCGCCGCGTTGGTGCAGACCGATATCAAGCGGGTGCTCGCCTATTCCACCATGAGCCAGATAGGC
TACATGTTTCTGGCGCTGGGCGTTCAGGCGTGGGACGCGGCTATTTTTCACCTGATGACCCACGCGTTTTTTAAGGCGCT
GCTGTTCTTGTCCTCTGGTTCGGTGATCCTGGCCTGCCATCACGAGCAGAACATCTTCAAAATGGGCGGCCTGCGCAAAT
CGATTCCGCTGGTCTATATCTGCTTTCTGGTGGGCGGCGCGGCGTTGTCGGCGTTGCCGCTGGTCACCGCCGGCTTCTAT
TCCAAGGATGAAATTCTCTGGGGGGCGCTGGCCAACGGCCATAGCGCCCTGATGATGGCCGGCCTGGTGGGGGCGTTCCT
CACGTCGGTCTATACCTTCCGCATGATCTTTATCGTGTTCCATGGCGAGGCGAAGATTAAAGCCCACGTCTGCCGCGGGA
TCAGCCATCATCTGCCGCTGGTAGTGCTTTTGGTGCTCTCTACCTTTATCGGCGCCTGGATCACGCCGCCGCTGGCGGGG
GTTCTGCCGGCCAGCGTGTTCGGTCATGACGGTAAGCTGGCGTTGGAAATCACCTCGGGCGCGGTCGCCATCATTGGTAT
TTGTCTGGCGGCGGTCCTGTGGCTGGGCCAGCGTCGTCTGGTGAACGCCGTGGCCGCCAGCGCGCCGGGGCGTTTCCTGA
CGGTTTGGTGGTTCCACGCCTGGGGATTCGACTGGCTTTACGACAAGATCTTCGTCAAACCTTACCTGGTCATTGCGCGG
CTGCTAGCACGCGATCCGCTCAATGCAGTGATGAATCTTCCCGCGCTGCTGGCGCGCTGGGCCGGACGTGGCCTGACGGT
GAGCGAAAACGGGCAGTTGCGTTGGTATGCGGCGTCGATGGGTCTGGGTGCGGTTATCGTGGTGGCGCTGCTGGTATTCG
TCTGA

Upstream 100 bases:

>100_bases
CGCTGGCCGCCGCCGAGGCCAGTATCGGCCTGGCACTGCTGCTGCAGCTGCATCGCCGCCGCCGGACCCTGGATATCGAT
TCAGTCAGCGAGATGCACGG

Downstream 100 bases:

>100_bases
ATACCCCGAGCTTCGTTTCCGGCTTAGGGCGGAGCGGCGGGTAACGTACTGCTCCGCTGACACGCCAGTTTATTGATTTT
ACAATTAGGGACGCAAAACG

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L; NUO12 [H]

Number of amino acids: Translated: 614; Mature: 614

Protein sequence:

>614_residues
MNLLYLTLVFPLAGFLLLAFSRGRWSENLAATVGVGSVGLAALTTLWVALDFLDARGDGAAVYAQTLWHWMAVGDFQIPI
TLSLDGLSLTMLSVVTGVGFFIHLYASWYMCGEEGYSRFFAYTNLFIASMLVLVLADNLLLMYLGWEGVGLCSYLLIGFY
YTESKNGAAAMKAFVVTRVGDVLLAFALFILYDQLGTLNFHNLMVLAPQKLAEGSPAIIWATLMLLGGAVGKSAQLPLQT
WLADAMAGPTPVSALIHAATMVTAGVYLIARTHGLFLMAPDVLHLVGIVGVVTLVLAGFAALVQTDIKRVLAYSTMSQIG
YMFLALGVQAWDAAIFHLMTHAFFKALLFLSSGSVILACHHEQNIFKMGGLRKSIPLVYICFLVGGAALSALPLVTAGFY
SKDEILWGALANGHSALMMAGLVGAFLTSVYTFRMIFIVFHGEAKIKAHVCRGISHHLPLVVLLVLSTFIGAWITPPLAG
VLPASVFGHDGKLALEITSGAVAIIGICLAAVLWLGQRRLVNAVAASAPGRFLTVWWFHAWGFDWLYDKIFVKPYLVIAR
LLARDPLNAVMNLPALLARWAGRGLTVSENGQLRWYAASMGLGAVIVVALLVFV

Sequences:

>Translated_614_residues
MNLLYLTLVFPLAGFLLLAFSRGRWSENLAATVGVGSVGLAALTTLWVALDFLDARGDGAAVYAQTLWHWMAVGDFQIPI
TLSLDGLSLTMLSVVTGVGFFIHLYASWYMCGEEGYSRFFAYTNLFIASMLVLVLADNLLLMYLGWEGVGLCSYLLIGFY
YTESKNGAAAMKAFVVTRVGDVLLAFALFILYDQLGTLNFHNLMVLAPQKLAEGSPAIIWATLMLLGGAVGKSAQLPLQT
WLADAMAGPTPVSALIHAATMVTAGVYLIARTHGLFLMAPDVLHLVGIVGVVTLVLAGFAALVQTDIKRVLAYSTMSQIG
YMFLALGVQAWDAAIFHLMTHAFFKALLFLSSGSVILACHHEQNIFKMGGLRKSIPLVYICFLVGGAALSALPLVTAGFY
SKDEILWGALANGHSALMMAGLVGAFLTSVYTFRMIFIVFHGEAKIKAHVCRGISHHLPLVVLLVLSTFIGAWITPPLAG
VLPASVFGHDGKLALEITSGAVAIIGICLAAVLWLGQRRLVNAVAASAPGRFLTVWWFHAWGFDWLYDKIFVKPYLVIAR
LLARDPLNAVMNLPALLARWAGRGLTVSENGQLRWYAASMGLGAVIVVALLVFV
>Mature_614_residues
MNLLYLTLVFPLAGFLLLAFSRGRWSENLAATVGVGSVGLAALTTLWVALDFLDARGDGAAVYAQTLWHWMAVGDFQIPI
TLSLDGLSLTMLSVVTGVGFFIHLYASWYMCGEEGYSRFFAYTNLFIASMLVLVLADNLLLMYLGWEGVGLCSYLLIGFY
YTESKNGAAAMKAFVVTRVGDVLLAFALFILYDQLGTLNFHNLMVLAPQKLAEGSPAIIWATLMLLGGAVGKSAQLPLQT
WLADAMAGPTPVSALIHAATMVTAGVYLIARTHGLFLMAPDVLHLVGIVGVVTLVLAGFAALVQTDIKRVLAYSTMSQIG
YMFLALGVQAWDAAIFHLMTHAFFKALLFLSSGSVILACHHEQNIFKMGGLRKSIPLVYICFLVGGAALSALPLVTAGFY
SKDEILWGALANGHSALMMAGLVGAFLTSVYTFRMIFIVFHGEAKIKAHVCRGISHHLPLVVLLVLSTFIGAWITPPLAG
VLPASVFGHDGKLALEITSGAVAIIGICLAAVLWLGQRRLVNAVAASAPGRFLTVWWFHAWGFDWLYDKIFVKPYLVIAR
LLARDPLNAVMNLPALLARWAGRGLTVSENGQLRWYAASMGLGAVIVVALLVFV

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=472, Percent_Identity=37.0762711864407, Blast_Score=271, Evalue=2e-72,
Organism=Escherichia coli, GI1788614, Length=604, Percent_Identity=78.3112582781457, Blast_Score=949, Evalue=0.0,
Organism=Escherichia coli, GI1788829, Length=419, Percent_Identity=34.1288782816229, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1788827, Length=351, Percent_Identity=30.7692307692308, Blast_Score=117, Evalue=3e-27,
Organism=Escherichia coli, GI1788831, Length=502, Percent_Identity=29.0836653386454, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI2367154, Length=316, Percent_Identity=30.379746835443, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1788613, Length=407, Percent_Identity=26.7813267813268, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI145693160, Length=319, Percent_Identity=25.3918495297806, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 66173; Mature: 66173

Theoretical pI: Translated: 8.53; Mature: 8.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLYLTLVFPLAGFLLLAFSRGRWSENLAATVGVGSVGLAALTTLWVALDFLDARGDGA
CCEEHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCH
AVYAQTLWHWMAVGDFQIPITLSLDGLSLTMLSVVTGVGFFIHLYASWYMCGEEGYSRFF
HHHHHHHHHHHHCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
AYTNLFIASMLVLVLADNLLLMYLGWEGVGLCSYLLIGFYYTESKNGAAAMKAFVVTRVG
HHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHH
DVLLAFALFILYDQLGTLNFHNLMVLAPQKLAEGSPAIIWATLMLLGGAVGKSAQLPLQT
HHHHHHHHHHHHHHHCCCCCCCEEEECCHHHCCCCCHHHHHHHHHHCCCCCCCCCCCHHH
WLADAMAGPTPVSALIHAATMVTAGVYLIARTHGLFLMAPDVLHLVGIVGVVTLVLAGFA
HHHHHHCCCCHHHHHHHHHHHHHHHHHHEEECCCEEEECHHHHHHHHHHHHHHHHHHHHH
ALVQTDIKRVLAYSTMSQIGYMFLALGVQAWDAAIFHLMTHAFFKALLFLSSGSVILACH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
HEQNIFKMGGLRKSIPLVYICFLVGGAALSALPLVTAGFYSKDEILWGALANGHSALMMA
CCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCHHHHHHH
GLVGAFLTSVYTFRMIFIVFHGEAKIKAHVCRGISHHLPLVVLLVLSTFIGAWITPPLAG
HHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCHHH
VLPASVFGHDGKLALEITSGAVAIIGICLAAVLWLGQRRLVNAVAASAPGRFLTVWWFHA
HCCHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHH
WGFDWLYDKIFVKPYLVIARLLARDPLNAVMNLPALLARWAGRGLTVSENGQLRWYAASM
CCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEECCCCCEEEEEECC
GLGAVIVVALLVFV
CHHHHHHHHHHHHC
>Mature Secondary Structure
MNLLYLTLVFPLAGFLLLAFSRGRWSENLAATVGVGSVGLAALTTLWVALDFLDARGDGA
CCEEHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCH
AVYAQTLWHWMAVGDFQIPITLSLDGLSLTMLSVVTGVGFFIHLYASWYMCGEEGYSRFF
HHHHHHHHHHHHCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
AYTNLFIASMLVLVLADNLLLMYLGWEGVGLCSYLLIGFYYTESKNGAAAMKAFVVTRVG
HHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHH
DVLLAFALFILYDQLGTLNFHNLMVLAPQKLAEGSPAIIWATLMLLGGAVGKSAQLPLQT
HHHHHHHHHHHHHHHCCCCCCCEEEECCHHHCCCCCHHHHHHHHHHCCCCCCCCCCCHHH
WLADAMAGPTPVSALIHAATMVTAGVYLIARTHGLFLMAPDVLHLVGIVGVVTLVLAGFA
HHHHHHCCCCHHHHHHHHHHHHHHHHHHEEECCCEEEECHHHHHHHHHHHHHHHHHHHHH
ALVQTDIKRVLAYSTMSQIGYMFLALGVQAWDAAIFHLMTHAFFKALLFLSSGSVILACH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
HEQNIFKMGGLRKSIPLVYICFLVGGAALSALPLVTAGFYSKDEILWGALANGHSALMMA
CCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCHHHHHHH
GLVGAFLTSVYTFRMIFIVFHGEAKIKAHVCRGISHHLPLVVLLVLSTFIGAWITPPLAG
HHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCHHH
VLPASVFGHDGKLALEITSGAVAIIGICLAAVLWLGQRRLVNAVAASAPGRFLTVWWFHA
HCCHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHH
WGFDWLYDKIFVKPYLVIARLLARDPLNAVMNLPALLARWAGRGLTVSENGQLRWYAASM
CCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEECCCCCEEEEEECC
GLGAVIVVALLVFV
CHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7690854; 9205837; 9278503 [H]