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The map label for this gene is nuoN

Identifier: 85059567

GI number: 85059567

Start: 2733543

End: 2735000

Strand: Reverse

Name: nuoN

Synonym: SG1589

Alternate gene names: 85059567

Gene position: 2735000-2733543 (Counterclockwise)

Preceding gene: 85059568

Following gene: 85059566

Centisome position: 65.57

GC content: 58.23

Gene sequence:

>1458_bases
ATGACAATAACTCCTCAACAACTGATCGCATTATTACCGCTGTTGATCGTCGGATTGACGGTGGTGGTTGTGATGCTGTG
CATTGCGTGGCGACGCAACCATTTTATTAACTCCACCCTGACGGTTATCGGGATTAACCTGGCGCTGCTGTCGCTGTGGT
TTGTGACGCAAAACGGCCCGATGGATGTGACGCCGCTGATGCGCGTCGACGGGTTTTCCATGTTCTATACCGGGTTGGTG
CTGGTGGCCAGTCTGGCGACCAGCACGCTGGCCTACGCTTGGCTGGCGGGTTATCCGGGCAACCGCGACGAGTTCTATCT
GCTGGTGCTGATTGCCACTATGGGCGGTATTCTGCTGGCCAGCGCCAACCATCTGGCGGCGCTGTTCCTGGGTATTGAGC
TGATTTCGCTGCCGCTGTTTGGCATGGTGGGCTATGCGTTTCGCCAAAAGCGCTCGCTGGAAGCTAGCATCAAATACACG
CTGCTGTCGGCGGCGGCGGCGTCTTTCTTGCTGTTTGGTATGGCGCTGGTGTATGCCCAAACCGGCCAGTTGTCTTTCAC
CGCCCTCGGTCAGACGCTTAATGACACCATGCTGACGCAGCCGGTGCTACTGGCGGGCCTGGGGATGATGGTGGTCGGTC
TTGGCTTCAAGTTGTCGCTGGTGCCGTTCCATTTGTGGACGCCGGATGTCTATCAGGGCGCGCCCGTGCCGGTGTCGACC
TTCCTGGCCACCGCCAGTAAAATCGCGATTTTCGCGGTCGTTATGCGCCTGTTTTTATATGCGCCGGTGACGCACAGCGA
TACGGTGCGGCTGGTGTTGGCGATTATCGCCTTCGCCTCTATGCTGTTCGGCAACCTGATGGCACTAAGCCAGAGCAACA
TCAAACGGGTGCTGGGCTATTCCTCCATCGCCCATCTGGGCTATTTGCTGGTGGGATTAATTGTGGTGCAGGCCCATACG
CTGGCGCTGGAAACCGTCGGCGTTTATTTAGCGGGATATCTGTTTGCCAGTCTGGGGGCGTTCGGCGTCGTCAGTCTGAT
GTCCAGCACCTACACCGGCGAGGATGCGGATTCGCTGTATTCTTACCGGGGTCTGTTTTGGCATAAGCCGCTGTTGTCAT
CTGTACTGACGGTGATGATGTTGTCGCTGGCGGGGATCCCCATGACCCTTGGCTTTATCGGCAAGTTCTACGTCATTGCT
CTGGGCGTGAACAGCCACCTGGGCTGGTTGACCGGCGCGGTCGTCGCCGGGAGCGCCATCGGGCTGTTCTACTACCTGCG
CATCATGGTCAGTCTGTACCTGTCGCCGCCGGAAAATCTGCGCCGCGATATGCCCTCCAACTGGGCGCTGACCGCCGGCG
GGGTGGTGGTGCTTATCTCCTCGCTGCTGGTGTTGTTGCTGGGTCTGTATCCGCAGCCGCTCATTACCCTGGTGCAATTG
GCGTACCCCATTCTCTAA

Upstream 100 bases:

>100_bases
GCCGATTATGGATACTTCAGCCGCCGCCATGAGCAACATTCAGCACTGGTTCGCCGCCGACGCCGGTTCCACTATTTCAA
CGACAAGGCCGTAATTCGCC

Downstream 100 bases:

>100_bases
CTGAGCGCTGCGGGTAGTGTCCCCGCGGCGTCGATGCGCCTTACGGCGATGATCATCAGCCAAAGCCCGTTTTTTCGGAT
TGCTCCGGCGAGAATAGTCC

Product: NADH dehydrogenase subunit N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MTITPQQLIALLPLLIVGLTVVVVMLCIAWRRNHFINSTLTVIGINLALLSLWFVTQNGPMDVTPLMRVDGFSMFYTGLV
LVASLATSTLAYAWLAGYPGNRDEFYLLVLIATMGGILLASANHLAALFLGIELISLPLFGMVGYAFRQKRSLEASIKYT
LLSAAAASFLLFGMALVYAQTGQLSFTALGQTLNDTMLTQPVLLAGLGMMVVGLGFKLSLVPFHLWTPDVYQGAPVPVST
FLATASKIAIFAVVMRLFLYAPVTHSDTVRLVLAIIAFASMLFGNLMALSQSNIKRVLGYSSIAHLGYLLVGLIVVQAHT
LALETVGVYLAGYLFASLGAFGVVSLMSSTYTGEDADSLYSYRGLFWHKPLLSSVLTVMMLSLAGIPMTLGFIGKFYVIA
LGVNSHLGWLTGAVVAGSAIGLFYYLRIMVSLYLSPPENLRRDMPSNWALTAGGVVVLISSLLVLLLGLYPQPLITLVQL
AYPIL

Sequences:

>Translated_485_residues
MTITPQQLIALLPLLIVGLTVVVVMLCIAWRRNHFINSTLTVIGINLALLSLWFVTQNGPMDVTPLMRVDGFSMFYTGLV
LVASLATSTLAYAWLAGYPGNRDEFYLLVLIATMGGILLASANHLAALFLGIELISLPLFGMVGYAFRQKRSLEASIKYT
LLSAAAASFLLFGMALVYAQTGQLSFTALGQTLNDTMLTQPVLLAGLGMMVVGLGFKLSLVPFHLWTPDVYQGAPVPVST
FLATASKIAIFAVVMRLFLYAPVTHSDTVRLVLAIIAFASMLFGNLMALSQSNIKRVLGYSSIAHLGYLLVGLIVVQAHT
LALETVGVYLAGYLFASLGAFGVVSLMSSTYTGEDADSLYSYRGLFWHKPLLSSVLTVMMLSLAGIPMTLGFIGKFYVIA
LGVNSHLGWLTGAVVAGSAIGLFYYLRIMVSLYLSPPENLRRDMPSNWALTAGGVVVLISSLLVLLLGLYPQPLITLVQL
AYPIL
>Mature_484_residues
TITPQQLIALLPLLIVGLTVVVVMLCIAWRRNHFINSTLTVIGINLALLSLWFVTQNGPMDVTPLMRVDGFSMFYTGLVL
VASLATSTLAYAWLAGYPGNRDEFYLLVLIATMGGILLASANHLAALFLGIELISLPLFGMVGYAFRQKRSLEASIKYTL
LSAAAASFLLFGMALVYAQTGQLSFTALGQTLNDTMLTQPVLLAGLGMMVVGLGFKLSLVPFHLWTPDVYQGAPVPVSTF
LATASKIAIFAVVMRLFLYAPVTHSDTVRLVLAIIAFASMLFGNLMALSQSNIKRVLGYSSIAHLGYLLVGLIVVQAHTL
ALETVGVYLAGYLFASLGAFGVVSLMSSTYTGEDADSLYSYRGLFWHKPLLSSVLTVMMLSLAGIPMTLGFIGKFYVIAL
GVNSHLGWLTGAVVAGSAIGLFYYLRIMVSLYLSPPENLRRDMPSNWALTAGGVVVLISSLLVLLLGLYPQPLITLVQLA
YPIL

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family

Homologues:

Organism=Homo sapiens, GI251831108, Length=317, Percent_Identity=23.6593059936909, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI251831117, Length=365, Percent_Identity=24.1095890410959, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI145693160, Length=485, Percent_Identity=78.5567010309278, Blast_Score=764, Evalue=0.0,
Organism=Escherichia coli, GI1788831, Length=204, Percent_Identity=30.8823529411765, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788829, Length=307, Percent_Identity=26.7100977198697, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1788614, Length=273, Percent_Identity=25.2747252747253, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUON_SODGM (Q2NSL1)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_455269.1
- STRING:   Q2NSL1
- GeneID:   3867884
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG1589
- NMPDR:   fig|343509.6.peg.3397
- eggNOG:   COG1007
- HOGENOM:   HBG747830
- OMA:   ALTQSNL
- PhylomeDB:   Q2NSL1
- ProtClustDB:   PRK05777
- BioCyc:   SGLO343509:SG1589-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_00445
- InterPro:   IPR010096
- InterPro:   IPR001750
- TIGRFAMs:   TIGR01770

Pfam domain/function: PF00361 Oxidored_q1

EC number: =1.6.99.5

Molecular weight: Translated: 52230; Mature: 52099

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xc090a08)-; HASH(0xf905b28)-; HASH(0xfc61c24)-; HASH(0xfc86afc)-; HASH(0xf911210)-; HASH(0xfc61e88)-; HASH(0xfc8c408)-; HASH(0xf82c98c)-; HASH(0xfc86bd4)-; HASH(0xfc6d5f8)-; HASH(0xfc8c294)-; HASH(0xf1b398c)-; HASH(0xf49fb0c)-; HASH(0xc4a8f14)-;

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTITPQQLIALLPLLIVGLTVVVVMLCIAWRRNHFINSTLTVIGINLALLSLWFVTQNGP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCC
MDVTPLMRVDGFSMFYTGLVLVASLATSTLAYAWLAGYPGNRDEFYLLVLIATMGGILLA
CCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
SANHLAALFLGIELISLPLFGMVGYAFRQKRSLEASIKYTLLSAAAASFLLFGMALVYAQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TGQLSFTALGQTLNDTMLTQPVLLAGLGMMVVGLGFKLSLVPFHLWTPDVYQGAPVPVST
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCHHH
FLATASKIAIFAVVMRLFLYAPVTHSDTVRLVLAIIAFASMLFGNLMALSQSNIKRVLGY
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSIAHLGYLLVGLIVVQAHTLALETVGVYLAGYLFASLGAFGVVSLMSSTYTGEDADSLY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
SYRGLFWHKPLLSSVLTVMMLSLAGIPMTLGFIGKFYVIALGVNSHLGWLTGAVVAGSAI
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHH
GLFYYLRIMVSLYLSPPENLRRDMPSNWALTAGGVVVLISSLLVLLLGLYPQPLITLVQL
HHHHHHHHHHHHHCCCCHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHH
AYPIL
HHCCH
>Mature Secondary Structure 
TITPQQLIALLPLLIVGLTVVVVMLCIAWRRNHFINSTLTVIGINLALLSLWFVTQNGP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCC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HHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA