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The map label for this gene is trpC [H]

Identifier: 85059377

GI number: 85059377

Start: 2323062

End: 2324420

Strand: Reverse

Name: trpC [H]

Synonym: SG1399

Alternate gene names: 85059377

Gene position: 2324420-2323062 (Counterclockwise)

Preceding gene: 85059378

Following gene: 85059376

Centisome position: 55.73

GC content: 60.19

Gene sequence:

>1359_bases
ATGCAGGACACGGTACTTGCGAAAATCGTCGCAGATAAATATGAATGGGTTGCCGAGCACCAACGGCTGAGGCCGTTGGA
CAGTTTCCGCCATCAGGTTCAGCCCAGCACCCGGAGTTTTTATCACGCGCTGTCCGGTACCCGCACGGCATTTATACTGG
AATGCAAAAAGGCATCGCCGTCCAAAGGACTTATTCGCGATGATTTCAACCCGGTCGCCATCGCAGGCGTTTACAGGCAT
TACGCTTCCGCGATTTCAGTACTGACCGACGAGAAATATTTTCAAGGCAGCTTCGATTATCTGCGCGAAGTGAGCCGCTC
GGTGAGCCAGCCGGTATTATGCAAAGATTTTATTGTCGACCCCTGGCAGATTTACTTCGCGCGCCTGCATCAGGCGGACG
CTGTTCTGCTGATGTTGTCCGTCCTCGACGACGATACCTACCGCGCGTTGGCGGCGGTGGCCCACAGCCTGAATATGGGC
GTGTTGACAGAAGTCACCAGCGATGAAGAGCGCGAGCGCGCCATTGCGCTGGGCGCAAAAATCGTGGGCATCAACAACCG
CGACCTGCGCGATCTGTCGATTGATTTGAACCGCACCCGCACGCTCGGTCCGCGGCTGCCGGCGGGCGTGACGGTTATCA
GCGAATCCGGTATTAACCGCTATCGCCAAGTGAGCGAGCTCAGCCACTACGCCAACTGCTTCCTGATTGGCAGCGCGCTA
ATGTCTGAACCCGATCTGACGATGGCGGTGCATCGGGTCTTGCTGGGCGAAAACAAAGTGTGCGGACTTACCCGCGCCGT
CGATGCGCGCGCTGCTCTGGAAGCGGGCGCGATTTACGGCGGGCTGATTTTTGTCCCCGGCTCCCCGCGGTGTGTGGATA
TCGACACCGCCCGCACCGTGATGGCCGGCGCTGCGCTGCGCTATGTCGGCGTGTTTCGCGATGCGCAGGTGGAAGACGTC
GCTGCGACCGCCAGCGTGCTGTCGCTGGCGGCAGTCCAACTGCACGGCGACGAAGATCAGAGCTATATCGATGCGCTGCG
CCGCGCCCTGCCGCCCGAGTGCCGTATCTGGAAGGCGCTGGATATGCGCCAGGCCCTGCCGGCGCGCGATCTGAGCCAGG
TCGATCGCTACGTACTGGACAACGGCGGCGGCAGCGGCAAACCTTTCGACTGGTCGCTGTTAAACGGAGCCACGTTGGAT
AACGTCATGCTGGCGGGCGGCCTGGCGGCGGACAACTGCGTGGCGGCAGCCCGTCTCGGTTGCGCCGGACTGGACTTCAA
CTCCGGCGTGGAAAGCGCGCCGGGTATTAAAGATCATCATAAACTGGCTACGGTATTTCAGACGCTGAGCGCCTATTAA

Upstream 100 bases:

>100_bases
GAAAATCTCCGTGACAACACCCATCGGGCGCTGGAGGAAATTCACAGCGGTGCCCCCTATGCGCGCGTGATGGCACTGGC
AGCAAGAGGATAAAAAAGTC

Downstream 100 bases:

>100_bases
CCTTCAGCCTGACACCGTGAGAGATAATCAAGCATGACACGACTTAATCCCTATTTTGGCGAGTTTGGCGGCATGTATGT
GCCGCAAATCCTGATGCCTG

Product: bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: Indole-3-glycerol phosphate synthase; IGPS; N-(5'-phospho-ribosyl)anthranilate isomerase; PRAI [H]

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MQDTVLAKIVADKYEWVAEHQRLRPLDSFRHQVQPSTRSFYHALSGTRTAFILECKKASPSKGLIRDDFNPVAIAGVYRH
YASAISVLTDEKYFQGSFDYLREVSRSVSQPVLCKDFIVDPWQIYFARLHQADAVLLMLSVLDDDTYRALAAVAHSLNMG
VLTEVTSDEERERAIALGAKIVGINNRDLRDLSIDLNRTRTLGPRLPAGVTVISESGINRYRQVSELSHYANCFLIGSAL
MSEPDLTMAVHRVLLGENKVCGLTRAVDARAALEAGAIYGGLIFVPGSPRCVDIDTARTVMAGAALRYVGVFRDAQVEDV
AATASVLSLAAVQLHGDEDQSYIDALRRALPPECRIWKALDMRQALPARDLSQVDRYVLDNGGGSGKPFDWSLLNGATLD
NVMLAGGLAADNCVAAARLGCAGLDFNSGVESAPGIKDHHKLATVFQTLSAY

Sequences:

>Translated_452_residues
MQDTVLAKIVADKYEWVAEHQRLRPLDSFRHQVQPSTRSFYHALSGTRTAFILECKKASPSKGLIRDDFNPVAIAGVYRH
YASAISVLTDEKYFQGSFDYLREVSRSVSQPVLCKDFIVDPWQIYFARLHQADAVLLMLSVLDDDTYRALAAVAHSLNMG
VLTEVTSDEERERAIALGAKIVGINNRDLRDLSIDLNRTRTLGPRLPAGVTVISESGINRYRQVSELSHYANCFLIGSAL
MSEPDLTMAVHRVLLGENKVCGLTRAVDARAALEAGAIYGGLIFVPGSPRCVDIDTARTVMAGAALRYVGVFRDAQVEDV
AATASVLSLAAVQLHGDEDQSYIDALRRALPPECRIWKALDMRQALPARDLSQVDRYVLDNGGGSGKPFDWSLLNGATLD
NVMLAGGLAADNCVAAARLGCAGLDFNSGVESAPGIKDHHKLATVFQTLSAY
>Mature_452_residues
MQDTVLAKIVADKYEWVAEHQRLRPLDSFRHQVQPSTRSFYHALSGTRTAFILECKKASPSKGLIRDDFNPVAIAGVYRH
YASAISVLTDEKYFQGSFDYLREVSRSVSQPVLCKDFIVDPWQIYFARLHQADAVLLMLSVLDDDTYRALAAVAHSLNMG
VLTEVTSDEERERAIALGAKIVGINNRDLRDLSIDLNRTRTLGPRLPAGVTVISESGINRYRQVSELSHYANCFLIGSAL
MSEPDLTMAVHRVLLGENKVCGLTRAVDARAALEAGAIYGGLIFVPGSPRCVDIDTARTVMAGAALRYVGVFRDAQVEDV
AATASVLSLAAVQLHGDEDQSYIDALRRALPPECRIWKALDMRQALPARDLSQVDRYVLDNGGGSGKPFDWSLLNGATLD
NVMLAGGLAADNCVAAARLGCAGLDFNSGVESAPGIKDHHKLATVFQTLSAY

Specific function: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the trpF domain; the second reaction is catalyzed by the synthase, coded by the trpC domain [H]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the trpF family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=450, Percent_Identity=72, Blast_Score=656, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322638, Length=233, Percent_Identity=37.7682403433476, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6320210, Length=214, Percent_Identity=32.7102803738318, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS; PF00697 PRAI [H]

EC number: =4.1.1.48; =5.3.1.24 [H]

Molecular weight: Translated: 49300; Mature: 49300

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDTVLAKIVADKYEWVAEHQRLRPLDSFRHQVQPSTRSFYHALSGTRTAFILECKKASP
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHCCCCEEEEEEECCCCC
SKGLIRDDFNPVAIAGVYRHYASAISVLTDEKYFQGSFDYLREVSRSVSQPVLCKDFIVD
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHCCCCCHHHHCCC
PWQIYFARLHQADAVLLMLSVLDDDTYRALAAVAHSLNMGVLTEVTSDEERERAIALGAK
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCEE
IVGINNRDLRDLSIDLNRTRTLGPRLPAGVTVISESGINRYRQVSELSHYANCFLIGSAL
EEECCCCCCCEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHEEHHHH
MSEPDLTMAVHRVLLGENKVCGLTRAVDARAALEAGAIYGGLIFVPGSPRCVDIDTARTV
HCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCEECCEEEECCCCCEEECHHHHHH
MAGAALRYVGVFRDAQVEDVAATASVLSLAAVQLHGDEDQSYIDALRRALPPECRIWKAL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHCCCCHHHHHHH
DMRQALPARDLSQVDRYVLDNGGGSGKPFDWSLLNGATLDNVMLAGGLAADNCVAAARLG
HHHHCCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHEECCCCHHHHHHHHHHC
CAGLDFNSGVESAPGIKDHHKLATVFQTLSAY
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQDTVLAKIVADKYEWVAEHQRLRPLDSFRHQVQPSTRSFYHALSGTRTAFILECKKASP
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHCCCCEEEEEEECCCCC
SKGLIRDDFNPVAIAGVYRHYASAISVLTDEKYFQGSFDYLREVSRSVSQPVLCKDFIVD
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHCCCCCHHHHCCC
PWQIYFARLHQADAVLLMLSVLDDDTYRALAAVAHSLNMGVLTEVTSDEERERAIALGAK
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCEE
IVGINNRDLRDLSIDLNRTRTLGPRLPAGVTVISESGINRYRQVSELSHYANCFLIGSAL
EEECCCCCCCEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHEEHHHH
MSEPDLTMAVHRVLLGENKVCGLTRAVDARAALEAGAIYGGLIFVPGSPRCVDIDTARTV
HCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCEECCEEEECCCCCEEECHHHHHH
MAGAALRYVGVFRDAQVEDVAATASVLSLAAVQLHGDEDQSYIDALRRALPPECRIWKAL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHCCCCHHHHHHH
DMRQALPARDLSQVDRYVLDNGGGSGKPFDWSLLNGATLDNVMLAGGLAADNCVAAARLG
HHHHCCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHEECCCCHHHHHHHHHHC
CAGLDFNSGVESAPGIKDHHKLATVFQTLSAY
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]