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The map label for this gene is hexR [H]

Identifier: 85059247

GI number: 85059247

Start: 2134161

End: 2135018

Strand: Reverse

Name: hexR [H]

Synonym: SG1269

Alternate gene names: 85059247

Gene position: 2135018-2134161 (Counterclockwise)

Preceding gene: 85059249

Following gene: 85059246

Centisome position: 51.19

GC content: 50.58

Gene sequence:

>858_bases
ATGAACATGCTGGAAAAGATCAATACTCATCTGGAGTTACTGAGTAAATCCGAACGTAAGGTCGCGGAAGTCATCTTGCT
CTCCCCTCAAACCGCTATCCATTCCAGCATCGCCATCCTGGCCCGTACGGCCGACGTTAGCGAACCAACTGTCAACCGTT
TTTGCCGCCGTTTAGGAAGCAAAGGCTATCCTGATTTTAAATTGCATCTCGCCCAAAGTCTGGCGAATTGGACGCTGTAT
GTAAACCGCAATGTGGATGAAGACGATAGCGTAGATTCCTATACTCATAAAATCTTCGAGTCCGCGATGGCGAGTCTGGA
GCAGGTTAAAAACAGTCTCGATATTGCCGCGGTCAATCGGGCAGTTGACCTTCTGACCCAGGCCAAAAAAATTTCCTTTT
TTGGCCTTGGCGCTTCGGCGGCGGTGGCGCATGATGCGATGAATAAATTTTTCCGTTTCAATATCCCGGTGGTTTACTCA
GAGGATATTGTACTACAACGCATGAGCTGCATGAATTCCAGCGAAGGTGATGTCGTGGTGCTGATTTCTCATACCGGGCG
CACCAAAATTCTGGTAGAACTCTCGGCGCTGGTGCGGGAGAATGATGCGACGGTTATCGCCATCACCTCGCCACGCTCGC
CGCTGGCGCTTGAGGCCTCTTTGACTCTGGAGCTGGATGTGCCTAAGGACACGAATATGTTCATGCCGATGACATCACGT
CTGGCACAATTGACCGTGATCGATGTCCTGGCAACCGGTTTTACGCTGCGGCGCGGCGCAAAATTCCGGGATAACTTGAA
GCGGGTCAAGGACGCCCTGAAAGAATCGCGCTTTGATAAAACGGAATTAGGACTTTAA

Upstream 100 bases:

>100_bases
GGTTTCGCTGCCTTTGACTACCAGCTCGTAGTATATTTCATTAAATCGGTAATGATTTCTCCTTTGTGTGAAATCGGCAA
AATCCATGAGCTATTCACTT

Downstream 100 bases:

>100_bases
CGAAGGCATCCAGGAAACCTTCGTGCCCTCTGCGACGGCCGGGCTGCCGCAGAGGGCTTTTACCAGCAGGGATTACCCGG
CGCGGGGACCGGTCAAACGT

Product: DNA-binding transcriptional regulator HexR

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MNMLEKINTHLELLSKSERKVAEVILLSPQTAIHSSIAILARTADVSEPTVNRFCRRLGSKGYPDFKLHLAQSLANWTLY
VNRNVDEDDSVDSYTHKIFESAMASLEQVKNSLDIAAVNRAVDLLTQAKKISFFGLGASAAVAHDAMNKFFRFNIPVVYS
EDIVLQRMSCMNSSEGDVVVLISHTGRTKILVELSALVRENDATVIAITSPRSPLALEASLTLELDVPKDTNMFMPMTSR
LAQLTVIDVLATGFTLRRGAKFRDNLKRVKDALKESRFDKTELGL

Sequences:

>Translated_285_residues
MNMLEKINTHLELLSKSERKVAEVILLSPQTAIHSSIAILARTADVSEPTVNRFCRRLGSKGYPDFKLHLAQSLANWTLY
VNRNVDEDDSVDSYTHKIFESAMASLEQVKNSLDIAAVNRAVDLLTQAKKISFFGLGASAAVAHDAMNKFFRFNIPVVYS
EDIVLQRMSCMNSSEGDVVVLISHTGRTKILVELSALVRENDATVIAITSPRSPLALEASLTLELDVPKDTNMFMPMTSR
LAQLTVIDVLATGFTLRRGAKFRDNLKRVKDALKESRFDKTELGL
>Mature_285_residues
MNMLEKINTHLELLSKSERKVAEVILLSPQTAIHSSIAILARTADVSEPTVNRFCRRLGSKGYPDFKLHLAQSLANWTLY
VNRNVDEDDSVDSYTHKIFESAMASLEQVKNSLDIAAVNRAVDLLTQAKKISFFGLGASAAVAHDAMNKFFRFNIPVVYS
EDIVLQRMSCMNSSEGDVVVLISHTGRTKILVELSALVRENDATVIAITSPRSPLALEASLTLELDVPKDTNMFMPMTSR
LAQLTVIDVLATGFTLRRGAKFRDNLKRVKDALKESRFDKTELGL

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=285, Percent_Identity=78.9473684210526, Blast_Score=462, Evalue=1e-131,
Organism=Escherichia coli, GI1788767, Length=262, Percent_Identity=27.4809160305344, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87082130, Length=190, Percent_Identity=29.4736842105263, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI87082369, Length=240, Percent_Identity=23.75, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 31658; Mature: 31658

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMLEKINTHLELLSKSERKVAEVILLSPQTAIHSSIAILARTADVSEPTVNRFCRRLGS
CCHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHEEECCCCCCHHHHHHHHHHCC
KGYPDFKLHLAQSLANWTLYVNRNVDEDDSVDSYTHKIFESAMASLEQVKNSLDIAAVNR
CCCCCHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVDLLTQAKKISFFGLGASAAVAHDAMNKFFRFNIPVVYSEDIVLQRMSCMNSSEGDVVV
HHHHHHHHHHHEEEECCCHHHHHHHHHHHHEEECCCEEECCHHHHHHHHHCCCCCCCEEE
LISHTGRTKILVELSALVRENDATVIAITSPRSPLALEASLTLELDVPKDTNMFMPMTSR
EEECCCCEEEEEEHHHHHCCCCCEEEEEECCCCCEEEEEEEEEEEECCCCCCEECHHHHH
LAQLTVIDVLATGFTLRRGAKFRDNLKRVKDALKESRFDKTELGL
HHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHCCCCHHHCCC
>Mature Secondary Structure
MNMLEKINTHLELLSKSERKVAEVILLSPQTAIHSSIAILARTADVSEPTVNRFCRRLGS
CCHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHEEECCCCCCHHHHHHHHHHCC
KGYPDFKLHLAQSLANWTLYVNRNVDEDDSVDSYTHKIFESAMASLEQVKNSLDIAAVNR
CCCCCHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVDLLTQAKKISFFGLGASAAVAHDAMNKFFRFNIPVVYSEDIVLQRMSCMNSSEGDVVV
HHHHHHHHHHHEEEECCCHHHHHHHHHHHHEEECCCEEECCHHHHHHHHHCCCCCCCEEE
LISHTGRTKILVELSALVRENDATVIAITSPRSPLALEASLTLELDVPKDTNMFMPMTSR
EEECCCCEEEEEEHHHHHCCCCCEEEEEECCCCCEEEEEEEEEEEECCCCCCEECHHHHH
LAQLTVIDVLATGFTLRRGAKFRDNLKRVKDALKESRFDKTELGL
HHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 1704005; 7567469 [H]