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The map label for this gene is hisA

Identifier: 85059103

GI number: 85059103

Start: 1867879

End: 1868619

Strand: Reverse

Name: hisA

Synonym: SG1125

Alternate gene names: 85059103

Gene position: 1868619-1867879 (Counterclockwise)

Preceding gene: 85059104

Following gene: 85059102

Centisome position: 44.8

GC content: 64.51

Gene sequence:

>741_bases
GTGATTATACCCGCTTTGGATTTGATTGATGGAGCCGTCGTGCGGCTCCATCAGGGCGATTATCAGACACAATGCCACTA
CGGCGCCGATCCGCTGCCGCGGCTGCAAGATTACCTGCGCCAGGGCGCCGAGGTGCTACATCTGGTGGATTTGACCGGCG
CCCGCGATCCGCAAACGCGCCAAATCCCGCTGTTGCGCCGGCTGCTGGCCGGGGTGGCGCCAGCGCTAGTGCAGGTCGGC
GGCGGTATCCGCAGCGCGGCGGATGTCGAGGTGCTGCTGGAGGCTGGCGCCACCCGTGTGGTGGTCGGCTCTACCGCGGT
ACTCCAGCCGCAGGAGGTACAGCGCTGGTTTGAACGTTTCGGCCCTGACGCGCTGGTGCTGGCGCTGGACGTGCGCATCG
ACGACGACGGCCAGCGCCGGGTGGCGATAAGCGGCTGGCAGGAAGACTCCGGCGCGACACTTGAACAGGTGATAACGCAG
TATCGCCCGCTCGGGCTTAAACATGTGCTGTGTACCGATATCTCCCGCGACGGCACGCTGACGGGCAGCAATGTGTCTCT
GTATCGCTCGCTGTGCGACGCCTGGTCCGATATCGCTTTCCAATCTTCCGGCGGCATCGGCAGCCTGGCGGACATCGCCC
AGCTTCGCCACAGCGGCGTGCAGGGCGTCATCGTCGGCCGCTCGCTGTTGGAAAACAAATTCACCGTGGCGGAGGCGCTG
GCATGCTGGCAAAACGCATAA

Upstream 100 bases:

>100_bases
CGCGGTGGAGCAGGATAATTTCTTCGGCGTGCAGTTTCACCCGGAGCGCTCCGGCGCCGCCGGCCGCCAGCTGCTGAAAA
ATTTTTTGGAGATGTAACCG

Downstream 100 bases:

>100_bases
TTCCCTGTCTGGATGTCCGGCAGGGCCAGGTGGTAAAAGGGGTGCAATTCCGAAATCACGAAATCATCGGCGGTATTGTG
CCGCTGGTGTGCCGCTATGC

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MIIPALDLIDGAVVRLHQGDYQTQCHYGADPLPRLQDYLRQGAEVLHLVDLTGARDPQTRQIPLLRRLLAGVAPALVQVG
GGIRSAADVEVLLEAGATRVVVGSTAVLQPQEVQRWFERFGPDALVLALDVRIDDDGQRRVAISGWQEDSGATLEQVITQ
YRPLGLKHVLCTDISRDGTLTGSNVSLYRSLCDAWSDIAFQSSGGIGSLADIAQLRHSGVQGVIVGRSLLENKFTVAEAL
ACWQNA

Sequences:

>Translated_246_residues
MIIPALDLIDGAVVRLHQGDYQTQCHYGADPLPRLQDYLRQGAEVLHLVDLTGARDPQTRQIPLLRRLLAGVAPALVQVG
GGIRSAADVEVLLEAGATRVVVGSTAVLQPQEVQRWFERFGPDALVLALDVRIDDDGQRRVAISGWQEDSGATLEQVITQ
YRPLGLKHVLCTDISRDGTLTGSNVSLYRSLCDAWSDIAFQSSGGIGSLADIAQLRHSGVQGVIVGRSLLENKFTVAEAL
ACWQNA
>Mature_246_residues
MIIPALDLIDGAVVRLHQGDYQTQCHYGADPLPRLQDYLRQGAEVLHLVDLTGARDPQTRQIPLLRRLLAGVAPALVQVG
GGIRSAADVEVLLEAGATRVVVGSTAVLQPQEVQRWFERFGPDALVLALDVRIDDDGQRRVAISGWQEDSGATLEQVITQ
YRPLGLKHVLCTDISRDGTLTGSNVSLYRSLCDAWSDIAFQSSGGIGSLADIAQLRHSGVQGVIVGRSLLENKFTVAEAL
ACWQNA

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=246, Percent_Identity=71.1382113821138, Blast_Score=350, Evalue=5e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_SODGM (Q2NTX5)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_454805.1
- HSSP:   P16250
- ProteinModelPortal:   Q2NTX5
- SMR:   Q2NTX5
- STRING:   Q2NTX5
- GeneID:   3867553
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG1125
- NMPDR:   fig|343509.6.peg.2308
- eggNOG:   COG0106
- HOGENOM:   HBG541613
- OMA:   SIIYTDI
- PhylomeDB:   Q2NTX5
- ProtClustDB:   PRK00748
- BioCyc:   SGLO343509:SG1125-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 26570; Mature: 26570

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: ACT_SITE 7-7 ACT_SITE 130-130

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIPALDLIDGAVVRLHQGDYQTQCHYGADPLPRLQDYLRQGAEVLHLVDLTGARDPQTR
CCCCCHHHHCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHEEEHHCCCCCCCCCCC
QIPLLRRLLAGVAPALVQVGGGIRSAADVEVLLEAGATRVVVGSTAVLQPQEVQRWFERF
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEECCCCEECHHHHHHHHHHH
GPDALVLALDVRIDDDGQRRVAISGWQEDSGATLEQVITQYRPLGLKHVLCTDISRDGTL
CCCEEEEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCHHHHHHCCCCCCCC
TGSNVSLYRSLCDAWSDIAFQSSGGIGSLADIAQLRHSGVQGVIVGRSLLENKFTVAEAL
CCCCHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHH
ACWQNA
HHHCCC
>Mature Secondary Structure
MIIPALDLIDGAVVRLHQGDYQTQCHYGADPLPRLQDYLRQGAEVLHLVDLTGARDPQTR
CCCCCHHHHCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHEEEHHCCCCCCCCCCC
QIPLLRRLLAGVAPALVQVGGGIRSAADVEVLLEAGATRVVVGSTAVLQPQEVQRWFERF
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEECCCCEECHHHHHHHHHHH
GPDALVLALDVRIDDDGQRRVAISGWQEDSGATLEQVITQYRPLGLKHVLCTDISRDGTL
CCCEEEEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCHHHHHHCCCCCCCC
TGSNVSLYRSLCDAWSDIAFQSSGGIGSLADIAQLRHSGVQGVIVGRSLLENKFTVAEAL
CCCCHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHH
ACWQNA
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA