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The map label for this gene is maeA

Identifier: 85058945

GI number: 85058945

Start: 1591518

End: 1593215

Strand: Reverse

Name: maeA

Synonym: SG0967

Alternate gene names: 85058945

Gene position: 1593215-1591518 (Counterclockwise)

Preceding gene: 85058946

Following gene: 85058944

Centisome position: 38.2

GC content: 57.42

Gene sequence:

>1698_bases
ATGGAACTGGAATACGAAAGCAAACGCCCCCTGTATATACCCCATGCCGGCCCTATTCTGCTGGAATTTCCCCTGCTGAA
TAAAGGCAGCGCTTTCTCCCTGGAAGAGCGTGACAATTTCAATTTGCAGGGTTTGCTGCCGGATACGGTGGAAACCATTG
AAGAGCAGGCCGAGCGAGCCTGGCGGCAGTACCAGGATTTTCGCACTAACATCGACCGCCATATTTATCTGCGAAATATC
CAGGATACCAACGAAACGCTGTTTTATCGCTTACTCGCGGCTCATTTGGCTGAAATGTTGCCAATTATCTATACTCCGAC
CGTCGGCGACGCCTGCGAGCGGTTTTCCGACATTTATCGCCGCGCGCGCGGCGTATTTATTTCTTATAATAACTGTGACA
AAATTGAGGATATGCTGCAAAACGCCACCAAGCAGAATGTCAAAGTGATTGTGGTTACCGACGGCGAGCGCATTTTGGGC
CTGGGCGATCAGGGGATTGGCGGCATGGGCATTCCCATCGGTAAACTGTCGCTGTATACCGCCTGCGGCGGCATCAGCCC
CGCCTACACTCTGCCTGTGGTGCTGGATGCTGGCACTAATAACCAGCAATTGCTTAACGACCCGCTGTATATGGGCTGGC
GCCATCCGCGCATCACCGGAGAGCAGTACGATAAGTTCGTCGATGCGTTTATTCAGGCGGTGAAACGCCGTTGGCCGAAC
GTCCTGCTGCAATTTGAAGATTTCGCCCAGAAAAACGCTACCCCGCTGCTCAATCGCTATCGCAGCGAATTGTGCTGCTT
TAATGATGATATTCAAGGCACCGCCGCCGTGACGCTGGGCTGTCTGCTGGCCGCCAGCCGCGCCGCGGGTAAACGCTTAC
GCGATCAAAAGGTGGTGTTCCTGGGCGCCGGCTCCGCCGGTTGCGGTATCGCCGAACAGATTACTGCGGAAATGCGCACC
GAAGGTCTCAGCGAGGACGAGGCTCGCCGCCGCGTCCTGATGGTCGATCGCTTTGGTCTGCTGACCGACAAACTGGCGAA
CCTGCTGGATTTCCAAAGTCGTCTGGTACAACCCAGCGATAGCCTCAGCGATTGGCAGTTGGACAGTGACACCATTTCGC
TGCAGGATGTGGTGCGCAACGCCAGACCGACGGTGTTGATCGGTGTCTCCGGCCAGCCGGGGCTTTTTACCGAAGAGATT
ATCCGGGATATGCATCAGCACTGCGAGCGGCCCATCGTGATGCCGCTGTCCAATCCTACCTCGCGCGTGGAGGCTACGCC
GGAAGATCTTTTACGCTGGACCGACGGCGCGGCCCTGGTGGCGACCGGCAGTCCGTTTGCGCCGGTGCAGTTTGAGGGCA
AAACTTACCCGATTGCACAGTGCAATAACGCCTATATTTTCCCCGGTATCGGTCTGGGCGTATTGGCTTCGGGCGCCGGC
CAAATAACCGACGCCATGCTGATCGCCGCCAGTCGGGCGCTGGCGGATTGCTCGCCGTTGGCCAACGGCGACGGCGGCGC
GCTGCTGCCGGACATTAACGATATTCAGTCGGTGTCGCGGGTGATCGCCATGGCGGTGGCCAAGGCGGCGCAGGTTCACG
GGGTGGCGCTGGTCACGTCTGAGGAAACCTTGTCTCTGGCCATCGAGCATAACTTCTGGCAGCCGCAGTACCGCGATTAT
CGCCGCACCTCTTTTTAA

Upstream 100 bases:

>100_bases
GCAGTAAAAAAATATATTACAACTCCGGCCGGACAATCACTGCCGTGATCTTTTATGCTGTTTCTACAGCCAACATTATC
AGTAACGATGAGTGAAGAAA

Downstream 100 bases:

>100_bases
ATCCTCCATCAACCGGCCGGGAAAACCCGGCCGGTTCAGGGGCAAATTTGCGGCATTGGCCTGACTTGCCCCTCGCACAC
CTTGCTTCAGCCCGACAGGT

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME

Number of amino acids: Translated: 565; Mature: 565

Protein sequence:

>565_residues
MELEYESKRPLYIPHAGPILLEFPLLNKGSAFSLEERDNFNLQGLLPDTVETIEEQAERAWRQYQDFRTNIDRHIYLRNI
QDTNETLFYRLLAAHLAEMLPIIYTPTVGDACERFSDIYRRARGVFISYNNCDKIEDMLQNATKQNVKVIVVTDGERILG
LGDQGIGGMGIPIGKLSLYTACGGISPAYTLPVVLDAGTNNQQLLNDPLYMGWRHPRITGEQYDKFVDAFIQAVKRRWPN
VLLQFEDFAQKNATPLLNRYRSELCCFNDDIQGTAAVTLGCLLAASRAAGKRLRDQKVVFLGAGSAGCGIAEQITAEMRT
EGLSEDEARRRVLMVDRFGLLTDKLANLLDFQSRLVQPSDSLSDWQLDSDTISLQDVVRNARPTVLIGVSGQPGLFTEEI
IRDMHQHCERPIVMPLSNPTSRVEATPEDLLRWTDGAALVATGSPFAPVQFEGKTYPIAQCNNAYIFPGIGLGVLASGAG
QITDAMLIAASRALADCSPLANGDGGALLPDINDIQSVSRVIAMAVAKAAQVHGVALVTSEETLSLAIEHNFWQPQYRDY
RRTSF

Sequences:

>Translated_565_residues
MELEYESKRPLYIPHAGPILLEFPLLNKGSAFSLEERDNFNLQGLLPDTVETIEEQAERAWRQYQDFRTNIDRHIYLRNI
QDTNETLFYRLLAAHLAEMLPIIYTPTVGDACERFSDIYRRARGVFISYNNCDKIEDMLQNATKQNVKVIVVTDGERILG
LGDQGIGGMGIPIGKLSLYTACGGISPAYTLPVVLDAGTNNQQLLNDPLYMGWRHPRITGEQYDKFVDAFIQAVKRRWPN
VLLQFEDFAQKNATPLLNRYRSELCCFNDDIQGTAAVTLGCLLAASRAAGKRLRDQKVVFLGAGSAGCGIAEQITAEMRT
EGLSEDEARRRVLMVDRFGLLTDKLANLLDFQSRLVQPSDSLSDWQLDSDTISLQDVVRNARPTVLIGVSGQPGLFTEEI
IRDMHQHCERPIVMPLSNPTSRVEATPEDLLRWTDGAALVATGSPFAPVQFEGKTYPIAQCNNAYIFPGIGLGVLASGAG
QITDAMLIAASRALADCSPLANGDGGALLPDINDIQSVSRVIAMAVAKAAQVHGVALVTSEETLSLAIEHNFWQPQYRDY
RRTSF
>Mature_565_residues
MELEYESKRPLYIPHAGPILLEFPLLNKGSAFSLEERDNFNLQGLLPDTVETIEEQAERAWRQYQDFRTNIDRHIYLRNI
QDTNETLFYRLLAAHLAEMLPIIYTPTVGDACERFSDIYRRARGVFISYNNCDKIEDMLQNATKQNVKVIVVTDGERILG
LGDQGIGGMGIPIGKLSLYTACGGISPAYTLPVVLDAGTNNQQLLNDPLYMGWRHPRITGEQYDKFVDAFIQAVKRRWPN
VLLQFEDFAQKNATPLLNRYRSELCCFNDDIQGTAAVTLGCLLAASRAAGKRLRDQKVVFLGAGSAGCGIAEQITAEMRT
EGLSEDEARRRVLMVDRFGLLTDKLANLLDFQSRLVQPSDSLSDWQLDSDTISLQDVVRNARPTVLIGVSGQPGLFTEEI
IRDMHQHCERPIVMPLSNPTSRVEATPEDLLRWTDGAALVATGSPFAPVQFEGKTYPIAQCNNAYIFPGIGLGVLASGAG
QITDAMLIAASRALADCSPLANGDGGALLPDINDIQSVSRVIAMAVAKAAQVHGVALVTSEETLSLAIEHNFWQPQYRDY
RRTSF

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family

Homologues:

Organism=Homo sapiens, GI4505143, Length=541, Percent_Identity=42.8835489833641, Blast_Score=451, Evalue=1e-127,
Organism=Homo sapiens, GI62420882, Length=560, Percent_Identity=42.5, Blast_Score=444, Evalue=1e-124,
Organism=Homo sapiens, GI62420880, Length=560, Percent_Identity=42.5, Blast_Score=444, Evalue=1e-124,
Organism=Homo sapiens, GI239049447, Length=560, Percent_Identity=42.5, Blast_Score=444, Evalue=1e-124,
Organism=Homo sapiens, GI4505145, Length=554, Percent_Identity=41.6967509025271, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI270265879, Length=465, Percent_Identity=44.9462365591398, Blast_Score=390, Evalue=1e-108,
Organism=Escherichia coli, GI87081919, Length=565, Percent_Identity=73.8053097345133, Blast_Score=855, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17537199, Length=543, Percent_Identity=44.5672191528545, Blast_Score=430, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6322823, Length=558, Percent_Identity=44.9820788530466, Blast_Score=466, Evalue=1e-132,
Organism=Drosophila melanogaster, GI21356279, Length=521, Percent_Identity=45.2975047984645, Blast_Score=455, Evalue=1e-128,
Organism=Drosophila melanogaster, GI281362672, Length=521, Percent_Identity=45.2975047984645, Blast_Score=455, Evalue=1e-128,
Organism=Drosophila melanogaster, GI281362674, Length=521, Percent_Identity=45.2975047984645, Blast_Score=455, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24646388, Length=528, Percent_Identity=43.3712121212121, Blast_Score=433, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24646386, Length=528, Percent_Identity=43.3712121212121, Blast_Score=432, Evalue=1e-121,
Organism=Drosophila melanogaster, GI78707232, Length=503, Percent_Identity=38.5685884691849, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI281363505, Length=503, Percent_Identity=38.5685884691849, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI78707236, Length=503, Percent_Identity=38.5685884691849, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI78707242, Length=534, Percent_Identity=39.1385767790262, Blast_Score=380, Evalue=1e-106,
Organism=Drosophila melanogaster, GI78707238, Length=534, Percent_Identity=39.1385767790262, Blast_Score=380, Evalue=1e-106,
Organism=Drosophila melanogaster, GI78707240, Length=524, Percent_Identity=39.3129770992366, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI281363503, Length=501, Percent_Identity=38.3233532934132, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI19922384, Length=538, Percent_Identity=30.1115241635688, Blast_Score=262, Evalue=4e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MAO1_SODGM (Q2NUD3)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_454647.1
- HSSP:   O59029
- ProteinModelPortal:   Q2NUD3
- SMR:   Q2NUD3
- STRING:   Q2NUD3
- GeneID:   3867094
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG0967
- NMPDR:   fig|343509.6.peg.2010
- eggNOG:   COG0281
- HOGENOM:   HBG289821
- OMA:   IQDNNET
- PhylomeDB:   Q2NUD3
- ProtClustDB:   PRK13529
- BioCyc:   SGLO343509:SG0967-MONOMER
- HAMAP:   MF_01619
- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000106
- PRINTS:   PR00072
- SMART:   SM00919

Pfam domain/function: PF00390 malic; PF03949 Malic_M

EC number: =1.1.1.38

Molecular weight: Translated: 62561; Mature: 62561

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: ACT_SITE 104-104 ACT_SITE 175-175 BINDING 157-157 BINDING 270-270 BINDING 418-418

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELEYESKRPLYIPHAGPILLEFPLLNKGSAFSLEERDNFNLQGLLPDTVETIEEQAERA
CCCCCCCCCCEECCCCCCEEEEECCCCCCCCEEECCCCCCCEEECCCHHHHHHHHHHHHH
WRQYQDFRTNIDRHIYLRNIQDTNETLFYRLLAAHLAEMLPIIYTPTVGDACERFSDIYR
HHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHH
RARGVFISYNNCDKIEDMLQNATKQNVKVIVVTDGERILGLGDQGIGGMGIPIGKLSLYT
HHCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCCCCCCCCCHHHHHHHH
ACGGISPAYTLPVVLDAGTNNQQLLNDPLYMGWRHPRITGEQYDKFVDAFIQAVKRRWPN
HCCCCCCCEEEEEEEECCCCCHHHHCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCH
VLLQFEDFAQKNATPLLNRYRSELCCFNDDIQGTAAVTLGCLLAASRAAGKRLRDQKVVF
HEEEHHHHHCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEE
LGAGSAGCGIAEQITAEMRTEGLSEDEARRRVLMVDRFGLLTDKLANLLDFQSRLVQPSD
EECCCCCCCHHHHHHHHHHHCCCCHHHHHCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCC
SLSDWQLDSDTISLQDVVRNARPTVLIGVSGQPGLFTEEIIRDMHQHCERPIVMPLSNPT
CCCCCCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEECCCCC
SRVEATPEDLLRWTDGAALVATGSPFAPVQFEGKTYPIAQCNNAYIFPGIGLGVLASGAG
HHCCCCHHHHHHHCCCCEEEECCCCCCCEEECCCCCCCEECCCEEEECCCCHHHHCCCCC
QITDAMLIAASRALADCSPLANGDGGALLPDINDIQSVSRVIAMAVAKAAQVHGVALVTS
HHHHHHHHHHHHHHHCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEC
EETLSLAIEHNFWQPQYRDYRRTSF
CCEEEEEEECCCCCCHHHHHHCCCC
>Mature Secondary Structure
MELEYESKRPLYIPHAGPILLEFPLLNKGSAFSLEERDNFNLQGLLPDTVETIEEQAERA
CCCCCCCCCCEECCCCCCEEEEECCCCCCCCEEECCCCCCCEEECCCHHHHHHHHHHHHH
WRQYQDFRTNIDRHIYLRNIQDTNETLFYRLLAAHLAEMLPIIYTPTVGDACERFSDIYR
HHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHH
RARGVFISYNNCDKIEDMLQNATKQNVKVIVVTDGERILGLGDQGIGGMGIPIGKLSLYT
HHCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCCCCCCCCCHHHHHHHH
ACGGISPAYTLPVVLDAGTNNQQLLNDPLYMGWRHPRITGEQYDKFVDAFIQAVKRRWPN
HCCCCCCCEEEEEEEECCCCCHHHHCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCH
VLLQFEDFAQKNATPLLNRYRSELCCFNDDIQGTAAVTLGCLLAASRAAGKRLRDQKVVF
HEEEHHHHHCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEE
LGAGSAGCGIAEQITAEMRTEGLSEDEARRRVLMVDRFGLLTDKLANLLDFQSRLVQPSD
EECCCCCCCHHHHHHHHHHHCCCCHHHHHCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCC
SLSDWQLDSDTISLQDVVRNARPTVLIGVSGQPGLFTEEIIRDMHQHCERPIVMPLSNPT
CCCCCCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEECCCCC
SRVEATPEDLLRWTDGAALVATGSPFAPVQFEGKTYPIAQCNNAYIFPGIGLGVLASGAG
HHCCCCHHHHHHHCCCCEEEECCCCCCCEEECCCCCCCEECCCEEEECCCCHHHHCCCCC
QITDAMLIAASRALADCSPLANGDGGALLPDINDIQSVSRVIAMAVAKAAQVHGVALVTS
HHHHHHHHHHHHHHHCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEC
EETLSLAIEHNFWQPQYRDYRRTSF
CCEEEEEEECCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA