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The map label for this gene is zitB [H]

Identifier: 85058869

GI number: 85058869

Start: 1450578

End: 1451150

Strand: Reverse

Name: zitB [H]

Synonym: SG0891

Alternate gene names: 85058869

Gene position: 1451150-1450578 (Counterclockwise)

Preceding gene: 85058872

Following gene: 85058849

Centisome position: 34.79

GC content: 63.53

Gene sequence:

>573_bases
ATGCCGGCAGATCCTCTACATTCACACGCCCCCGCAACGCGGGCACACCACGGCAGCCACCACGGGCATGACCACGCCAC
GTCGCCGGAGGTGGACAGGGGCGCCCATCAACGCCTGCTGGCGGCGTTTGTCGTCACGGCGCTGTTCATGCTTATCGAAG
TGATCGGCGGCTGGTTATCCGGGTCGCTGGCGTTATTGGCGGATGCCGGGCATATGCTTACCGATACCACCGCACTGCTG
ATAGCATTGTTGGCGGTGCGGTTCGCGTCGCGGCGACCGAACAGCCGCCACACATTCGGCTATCTGCGCCTGACGACGCT
GGCGGCGTTTCTCAACGCTCTGGCGCTGCTGTTTATCACGGTGATGATTGTCTGGGAAGCCGCGCATCGCTTTCTTGTCC
CTCAACCCATCGCCGGATGGACCATGATGTCCATTGCCGTGGCCGCGCTGGTGGCGAATATTGTGTCATTCTGGCTGCTG
CACGGCGGCGGCGGCGGCGGCGGCGGCGGCGAAAAAAATATAACCTGCGCGCCGCGGCGCTGCATGTGCTGGGAGATTTG
CTCGGCTCGGTAG

Upstream 100 bases:

>100_bases
GCCACGACCGAACGATAAATGATAAAGGGCGATAGCGGTAGGTAAACTGATAGAGCAGCGCGGCCAGCGGCCGTTTCGCG
ACAGACAGACAGGAATCCCT

Downstream 100 bases:

>100_bases
GCGCCATTATCGCCGTGTTGTTGATCCTCTACACGGGCTGGCTACCGGTTGACCCGCTGTTGTCGATACTGGTTTCCTGT
CTGTTGCTGCGCAGCGGCTG

Product: putative cation transport protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 190; Mature: 189

Protein sequence:

>190_residues
MPADPLHSHAPATRAHHGSHHGHDHATSPEVDRGAHQRLLAAFVVTALFMLIEVIGGWLSGSLALLADAGHMLTDTTALL
IALLAVRFASRRPNSRHTFGYLRLTTLAAFLNALALLFITVMIVWEAAHRFLVPQPIAGWTMMSIAVAALVANIVSFWLL
HGGGGGGGGGEKNITCAPRRCMCWEICSAR

Sequences:

>Translated_190_residues
MPADPLHSHAPATRAHHGSHHGHDHATSPEVDRGAHQRLLAAFVVTALFMLIEVIGGWLSGSLALLADAGHMLTDTTALL
IALLAVRFASRRPNSRHTFGYLRLTTLAAFLNALALLFITVMIVWEAAHRFLVPQPIAGWTMMSIAVAALVANIVSFWLL
HGGGGGGGGGEKNITCAPRRCMCWEICSAR
>Mature_189_residues
PADPLHSHAPATRAHHGSHHGHDHATSPEVDRGAHQRLLAAFVVTALFMLIEVIGGWLSGSLALLADAGHMLTDTTALLI
ALLAVRFASRRPNSRHTFGYLRLTTLAAFLNALALLFITVMIVWEAAHRFLVPQPIAGWTMMSIAVAALVANIVSFWLLH
GGGGGGGGGEKNITCAPRRCMCWEICSAR

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI21359890, Length=130, Percent_Identity=35.3846153846154, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI52352805, Length=175, Percent_Identity=32, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI64762489, Length=156, Percent_Identity=33.974358974359, Blast_Score=78, Evalue=5e-15,
Organism=Homo sapiens, GI289803013, Length=156, Percent_Identity=33.974358974359, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI289803009, Length=156, Percent_Identity=33.974358974359, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI289803007, Length=156, Percent_Identity=33.974358974359, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI289803003, Length=156, Percent_Identity=33.974358974359, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI52352803, Length=129, Percent_Identity=37.2093023255814, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI21361112, Length=182, Percent_Identity=30.2197802197802, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI222080086, Length=112, Percent_Identity=30.3571428571429, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI40255009, Length=112, Percent_Identity=30.3571428571429, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1786966, Length=140, Percent_Identity=67.1428571428571, Blast_Score=164, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI193210990, Length=153, Percent_Identity=33.9869281045752, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI32564488, Length=125, Percent_Identity=34.4, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17550442, Length=125, Percent_Identity=31.2, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17550440, Length=125, Percent_Identity=31.2, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17555794, Length=99, Percent_Identity=35.3535353535354, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323899, Length=136, Percent_Identity=36.0294117647059, Blast_Score=92, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6324892, Length=134, Percent_Identity=36.5671641791045, Blast_Score=85, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24585900, Length=157, Percent_Identity=30.5732484076433, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24585898, Length=157, Percent_Identity=30.5732484076433, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24585896, Length=157, Percent_Identity=30.5732484076433, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI19921672, Length=157, Percent_Identity=30.5732484076433, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24583858, Length=161, Percent_Identity=32.9192546583851, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24656728, Length=129, Percent_Identity=36.4341085271318, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24656724, Length=129, Percent_Identity=36.4341085271318, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24656720, Length=129, Percent_Identity=36.4341085271318, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24656715, Length=129, Percent_Identity=36.4341085271318, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21357035, Length=129, Percent_Identity=36.4341085271318, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28574430, Length=136, Percent_Identity=35.2941176470588, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24584409, Length=116, Percent_Identity=35.3448275862069, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24645863, Length=110, Percent_Identity=32.7272727272727, Blast_Score=71, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 20340; Mature: 20209

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPADPLHSHAPATRAHHGSHHGHDHATSPEVDRGAHQRLLAAFVVTALFMLIEVIGGWLS
CCCCCCCCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GSLALLADAGHMLTDTTALLIALLAVRFASRRPNSRHTFGYLRLTTLAAFLNALALLFIT
CCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VMIVWEAAHRFLVPQPIAGWTMMSIAVAALVANIVSFWLLHGGGGGGGGGEKNITCAPRR
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCH
CMCWEICSAR
HHHHHHHCCC
>Mature Secondary Structure 
PADPLHSHAPATRAHHGSHHGHDHATSPEVDRGAHQRLLAAFVVTALFMLIEVIGGWLS
CCCCCCCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GSLALLADAGHMLTDTTALLIALLAVRFASRRPNSRHTFGYLRLTTLAAFLNALALLFIT
CCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VMIVWEAAHRFLVPQPIAGWTMMSIAVAALVANIVSFWLLHGGGGGGGGGEKNITCAPRR
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCH
CMCWEICSAR
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]