Click here to switch to the map view.

The map label for this gene is panE [H]

Identifier: 85058639

GI number: 85058639

Start: 1123399

End: 1124310

Strand: Reverse

Name: panE [H]

Synonym: SG0661

Alternate gene names: 85058639

Gene position: 1124310-1123399 (Counterclockwise)

Preceding gene: 85058640

Following gene: 85058638

Centisome position: 26.95

GC content: 56.14

Gene sequence:

>912_bases
ATGAAAATTACCGTTCTGGGTTGTGGCACATTAGGACAGCTGTGGCTAGCGGCGCTTAGCCGTCAGGGACACAACGTTCA
GGGATGGCTGAGGGTGCCGCAATCGGTATGCACCGTGGATGTTATCAGCCCAAAAGGGCAGGAAAACCGTTTACAATTGC
CCGCCAATAACGCTGAGCATCTGGCCGCAAGCGATCTGTTGCTGGTGACATTGAAAGCCTGGCAGGTATCCGGGGCGGTA
CGGGCGCTGTTGCCGCAACTGCGCGCCGATTGCGCCATCCTACTGCTGCATAACGGCCTCGGCACGCGTGAGGAGTTACC
TGTCCTGATCCAGCCGCTGATTATGGGTACCACCACCCATGCCGCCCACCGTGAAGAGAACAAAATCCACCATATCTATG
CCGGCACGACGCGCATCGGTCCCGGCAATAGTCAGGCGCAGCAAAGCAGCGCGATGGCGAAAGTGTTACATCATGCCCTG
CCGGAGGTTGCCTGGCATAACAATATCACCGCCTCAAGTTGGGTCAAGCTTGCCGCTAATTGCGTGATAAACCCCCTCAC
CGCCATTTACAATTGCCGCAACGGTGAGCTGGAACGCTATCCGGCCGAAATCGAAGCCATCTGCCGCGAAGTGGCGATGG
TGATGGACCGCGAGGGTTACCATACTCATTATGAAAGCCTGCTGTTCTATGTCGGCCAGGTAATCCGCAGCACCGCGGAT
AATGTTTCCTCTATGCTGCAGGATGTCCGAGCCCAGCGGCAATCGGAGATAGATTACATTACCGGCCATGTCCTGCGGCG
CGCACGTGCGCACGGGCTGAATATGCCGAAGAATCAGCGGCTATTTGATTGGGTGAAACGCAAGGAGGAAAGCTATGGAC
AAATCGATTCTTCTCTGTCTGGCCGATGGTAG

Upstream 100 bases:

>100_bases
GCGTGCATAACCTCCTGCCGTACAGCAGAAAAGTCTATACTTATGGCTCCAAGGTGATGCGCGGGCCGGAGCCCTTTTAT
TTGGCTACAGGGTAAGGAAA

Downstream 100 bases:

>100_bases
CGAGGAAACCGAAGCCGTCACGACGTTCGATTTGTTGGTACGCGCCGGAATGCAGGTACGCGCGGCCAGCGTCAACGGCG
ATGGCGGATTGACCATCGTC

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MKITVLGCGTLGQLWLAALSRQGHNVQGWLRVPQSVCTVDVISPKGQENRLQLPANNAEHLAASDLLLVTLKAWQVSGAV
RALLPQLRADCAILLLHNGLGTREELPVLIQPLIMGTTTHAAHREENKIHHIYAGTTRIGPGNSQAQQSSAMAKVLHHAL
PEVAWHNNITASSWVKLAANCVINPLTAIYNCRNGELERYPAEIEAICREVAMVMDREGYHTHYESLLFYVGQVIRSTAD
NVSSMLQDVRAQRQSEIDYITGHVLRRARAHGLNMPKNQRLFDWVKRKEESYGQIDSSLSGRW

Sequences:

>Translated_303_residues
MKITVLGCGTLGQLWLAALSRQGHNVQGWLRVPQSVCTVDVISPKGQENRLQLPANNAEHLAASDLLLVTLKAWQVSGAV
RALLPQLRADCAILLLHNGLGTREELPVLIQPLIMGTTTHAAHREENKIHHIYAGTTRIGPGNSQAQQSSAMAKVLHHAL
PEVAWHNNITASSWVKLAANCVINPLTAIYNCRNGELERYPAEIEAICREVAMVMDREGYHTHYESLLFYVGQVIRSTAD
NVSSMLQDVRAQRQSEIDYITGHVLRRARAHGLNMPKNQRLFDWVKRKEESYGQIDSSLSGRW
>Mature_303_residues
MKITVLGCGTLGQLWLAALSRQGHNVQGWLRVPQSVCTVDVISPKGQENRLQLPANNAEHLAASDLLLVTLKAWQVSGAV
RALLPQLRADCAILLLHNGLGTREELPVLIQPLIMGTTTHAAHREENKIHHIYAGTTRIGPGNSQAQQSSAMAKVLHHAL
PEVAWHNNITASSWVKLAANCVINPLTAIYNCRNGELERYPAEIEAICREVAMVMDREGYHTHYESLLFYVGQVIRSTAD
NVSSMLQDVRAQRQSEIDYITGHVLRRARAHGLNMPKNQRLFDWVKRKEESYGQIDSSLSGRW

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=303, Percent_Identity=59.7359735973597, Blast_Score=361, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 33753; Mature: 33753

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITVLGCGTLGQLWLAALSRQGHNVQGWLRVPQSVCTVDVISPKGQENRLQLPANNAEH
CEEEEEECCHHHHHHHHHHHHCCCCCHHHHHCCHHHHEEEEECCCCCCCEEECCCCCCHH
LAASDLLLVTLKAWQVSGAVRALLPQLRADCAILLLHNGLGTREELPVLIQPLIMGTTTH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCHHHHHHHHHCCCCH
AAHREENKIHHIYAGTTRIGPGNSQAQQSSAMAKVLHHALPEVAWHNNITASSWVKLAAN
HHHCCCCCEEEEEECCEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
CVINPLTAIYNCRNGELERYPAEIEAICREVAMVMDREGYHTHYESLLFYVGQVIRSTAD
HHHHHHHHHHCCCCCCCHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
NVSSMLQDVRAQRQSEIDYITGHVLRRARAHGLNMPKNQRLFDWVKRKEESYGQIDSSLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
GRW
CCC
>Mature Secondary Structure
MKITVLGCGTLGQLWLAALSRQGHNVQGWLRVPQSVCTVDVISPKGQENRLQLPANNAEH
CEEEEEECCHHHHHHHHHHHHCCCCCHHHHHCCHHHHEEEEECCCCCCCEEECCCCCCHH
LAASDLLLVTLKAWQVSGAVRALLPQLRADCAILLLHNGLGTREELPVLIQPLIMGTTTH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCHHHHHHHHHCCCCH
AAHREENKIHHIYAGTTRIGPGNSQAQQSSAMAKVLHHALPEVAWHNNITASSWVKLAAN
HHHCCCCCEEEEEECCEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
CVINPLTAIYNCRNGELERYPAEIEAICREVAMVMDREGYHTHYESLLFYVGQVIRSTAD
HHHHHHHHHHCCCCCCCHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
NVSSMLQDVRAQRQSEIDYITGHVLRRARAHGLNMPKNQRLFDWVKRKEESYGQIDSSLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
GRW
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]