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The map label for this gene is panF [H]

Identifier: 85058599

GI number: 85058599

Start: 1059027

End: 1059839

Strand: Reverse

Name: panF [H]

Synonym: SG0621

Alternate gene names: 85058599

Gene position: 1059839-1059027 (Counterclockwise)

Preceding gene: 85058600

Following gene: 85058598

Centisome position: 25.41

GC content: 52.64

Gene sequence:

>813_bases
ATGATAATTCTTGGCTGGTATGTCTCGCGTAACCAAAAAAACGGTGACGATTTTCTATTGGGTGGCCGATCAATGCAGAT
GATCCTAACGCTGGGATCGACGGTGGGCACTATGGTAGGTACAGTCTCAAGCGTCGGCGCGGTGGGCTTTGGTTACCTTA
ACGGCTGGGCCGGCATGCTGTACGGCATTGGCGGCGCGATTGGCATTTTGCTGGTGGCCCTCCTCTTTGAGCCGGCGCGC
AGAATGCGCTTTATGACCATGAGCGAAGAAATTTGTTATTACACCGGCGGTAGCCGTCTGGTTAAAAACCTGGTCGCTGT
TTTAATTTTTATTGCGTCTATCGGCTGGCTTGGCGCGCACATTCTAGGCGGTGGGTTATATCTCGCCTGGGCTAGCGGCA
TTGATATTAATACTGCAAAAATCATCATTGCGCTGGCATTTATTGTGTATATCGGAATTGGCGGTTATTCCGCGGTCGTG
TGGATTGACACGATCCAATCTATTGTATTATTCCTTGGCTTTATATTAATGGCGGTGCTGGCGGTCAATTATGTCGGTGG
CTGGAGCCATATTCAGCAGGCGGTGGATCCGGCGGCGCAAAACTTGTTTGCGGTGGATAAACTGGGATTGTTACCCGCGT
TCTCGCTGGCGCTGGTAATAGGCGTCGGCGTCATGGCCACCCCCTCCTACCGTCAGAGGATCTACTCGGCGAAAACCGTC
GGTGCGGTACGGCAATCGTTCACCATCACCGGCGTGCTGTATTTGTTTTTTCGTTCCTGCCGGCTATCATCGGCACGGCC
GCCTGGACCATGA

Upstream 100 bases:

>100_bases
AAGCGCAATGTCGTGCCATGCACATTGATGTAATACTGCCAGAATGTGAGTCATGAATAATATTTCTTTTCTGTTGTAGT
TCTCCGTTTATACCCTTGCC

Downstream 100 bases:

>100_bases
ATCCGCACCTTGAAAACAGCGGCTTCGCGTTCTTGTTTGCCACCCAAGTCCTGCCTCATGCGCTGGCGATGGTAGTGCTC
ATTGCAGAGATGTCAGCCAA

Product: putative proline-sodium transport protein

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MIILGWYVSRNQKNGDDFLLGGRSMQMILTLGSTVGTMVGTVSSVGAVGFGYLNGWAGMLYGIGGAIGILLVALLFEPAR
RMRFMTMSEEICYYTGGSRLVKNLVAVLIFIASIGWLGAHILGGGLYLAWASGIDINTAKIIIALAFIVYIGIGGYSAVV
WIDTIQSIVLFLGFILMAVLAVNYVGGWSHIQQAVDPAAQNLFAVDKLGLLPAFSLALVIGVGVMATPSYRQRIYSAKTV
GAVRQSFTITGVLYLFFRSCRLSSARPPGP

Sequences:

>Translated_270_residues
MIILGWYVSRNQKNGDDFLLGGRSMQMILTLGSTVGTMVGTVSSVGAVGFGYLNGWAGMLYGIGGAIGILLVALLFEPAR
RMRFMTMSEEICYYTGGSRLVKNLVAVLIFIASIGWLGAHILGGGLYLAWASGIDINTAKIIIALAFIVYIGIGGYSAVV
WIDTIQSIVLFLGFILMAVLAVNYVGGWSHIQQAVDPAAQNLFAVDKLGLLPAFSLALVIGVGVMATPSYRQRIYSAKTV
GAVRQSFTITGVLYLFFRSCRLSSARPPGP
>Mature_270_residues
MIILGWYVSRNQKNGDDFLLGGRSMQMILTLGSTVGTMVGTVSSVGAVGFGYLNGWAGMLYGIGGAIGILLVALLFEPAR
RMRFMTMSEEICYYTGGSRLVKNLVAVLIFIASIGWLGAHILGGGLYLAWASGIDINTAKIIIALAFIVYIGIGGYSAVV
WIDTIQSIVLFLGFILMAVLAVNYVGGWSHIQQAVDPAAQNLFAVDKLGLLPAFSLALVIGVGVMATPSYRQRIYSAKTV
GAVRQSFTITGVLYLFFRSCRLSSARPPGP

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI14140236, Length=193, Percent_Identity=29.5336787564767, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI87082237, Length=259, Percent_Identity=28.1853281853282, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 28821; Mature: 28821

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIILGWYVSRNQKNGDDFLLGGRSMQMILTLGSTVGTMVGTVSSVGAVGFGYLNGWAGML
CEEEEEEEECCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGIGGAIGILLVALLFEPARRMRFMTMSEEICYYTGGSRLVKNLVAVLIFIASIGWLGAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEEECHHHHHHHHHHHHHHHHHHHHHHHH
ILGGGLYLAWASGIDINTAKIIIALAFIVYIGIGGYSAVVWIDTIQSIVLFLGFILMAVL
HHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AVNYVGGWSHIQQAVDPAAQNLFAVDKLGLLPAFSLALVIGVGVMATPSYRQRIYSAKTV
HHHHCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
GAVRQSFTITGVLYLFFRSCRLSSARPPGP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MIILGWYVSRNQKNGDDFLLGGRSMQMILTLGSTVGTMVGTVSSVGAVGFGYLNGWAGML
CEEEEEEEECCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGIGGAIGILLVALLFEPARRMRFMTMSEEICYYTGGSRLVKNLVAVLIFIASIGWLGAH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEEECHHHHHHHHHHHHHHHHHHHHHHHH
ILGGGLYLAWASGIDINTAKIIIALAFIVYIGIGGYSAVVWIDTIQSIVLFLGFILMAVL
HHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AVNYVGGWSHIQQAVDPAAQNLFAVDKLGLLPAFSLALVIGVGVMATPSYRQRIYSAKTV
HHHHCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
GAVRQSFTITGVLYLFFRSCRLSSARPPGP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2193919; 9278503; 8226664 [H]