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The map label for this gene is mtnN

Identifier: 85058481

GI number: 85058481

Start: 871917

End: 872618

Strand: Reverse

Name: mtnN

Synonym: SG0503

Alternate gene names: 85058481

Gene position: 872618-871917 (Counterclockwise)

Preceding gene: 85058486

Following gene: 85058480

Centisome position: 20.92

GC content: 59.4

Gene sequence:

>702_bases
ATGAAAATTGGTATTATCGGCGCAATGGAACAGGAAGTAGCGCTGCTGCGCGATCGCATAGACCACTCTACCCTGTGTCA
GCAGGCGGGGTGTGAAATTTATATGGGTCAGCTACACGGTGTTGAGGTGGCGTTGGTGAAATCTGGCATCGGCAAAGTTT
CCGCCGCGCTGGGCACGACGCTATTGCTGGATCATTTTAAACCGGAGCTGGTCATCAATACCGGCTCTGCCGGCGGTTTG
GCGCCGTCGTTGAAGGTCGGCGATATCGTGGTGTCCCATGAAGTGCGCTATCACGATGTCGATGTGACCGCTTTCGGCTA
TGAACCTGGCCAGATGGCGCAGTGTCCGGCGTCGTTTAATGCCGCCCCGTCGCTGGTAGCGCTGGCAGAGGAGAGCGTCG
ATCGTCTGGGTATGCATGCGGTACGCGGTCTGGTGGTCAGCGGCGATGCCTTTATCAACGACGCCGACGGCCTGGCCCAT
ATCCGCCAGACCTTCCCGCAGGCTATCGCCGTGGAAATGGAGGCGACGGCCATCGCCCATGTGTGCCATCAGTTCGCCGT
CCCCTTCGTCGTGGTGCGCGCGATTTCCGATGTCGCGGATCAAGCATCCCATCTGAGCTTTGATGAATTCCTCACCGTGG
CGGCGCAAAGCTCCTCCCGCCTGGTGGAGGAAATGGTGCAAGCGCTGGCCGGCCAGCGGTAA

Upstream 100 bases:

>100_bases
AGCCCACCGGCCGTTATTTCTCCGCACCAGGCATGCTAGAATGCAGCCTATGAACGCCCCCTAACATTTCAATACGCATT
TTTTAACGGGAACGCTTTTT

Downstream 100 bases:

>100_bases
ATGCGCTACCGACGCGCGGCGCAACGGGTGGTCAGCCTCGCGCCCCACACCACGGAACTGGCTTACGCCGCCGGCATGGG
GGCGGTGCTGGTGGCGGCCA

Product: 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase

Products: NA

Alternate protein names: MTA/SAH nucleosidase; MTAN; 5'-methylthioadenosine nucleosidase; MTA nucleosidase; S-adenosylhomocysteine nucleosidase; AdoHcy nucleosidase; SAH nucleosidase; SRH nucleosidase

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MKIGIIGAMEQEVALLRDRIDHSTLCQQAGCEIYMGQLHGVEVALVKSGIGKVSAALGTTLLLDHFKPELVINTGSAGGL
APSLKVGDIVVSHEVRYHDVDVTAFGYEPGQMAQCPASFNAAPSLVALAEESVDRLGMHAVRGLVVSGDAFINDADGLAH
IRQTFPQAIAVEMEATAIAHVCHQFAVPFVVVRAISDVADQASHLSFDEFLTVAAQSSSRLVEEMVQALAGQR

Sequences:

>Translated_233_residues
MKIGIIGAMEQEVALLRDRIDHSTLCQQAGCEIYMGQLHGVEVALVKSGIGKVSAALGTTLLLDHFKPELVINTGSAGGL
APSLKVGDIVVSHEVRYHDVDVTAFGYEPGQMAQCPASFNAAPSLVALAEESVDRLGMHAVRGLVVSGDAFINDADGLAH
IRQTFPQAIAVEMEATAIAHVCHQFAVPFVVVRAISDVADQASHLSFDEFLTVAAQSSSRLVEEMVQALAGQR
>Mature_233_residues
MKIGIIGAMEQEVALLRDRIDHSTLCQQAGCEIYMGQLHGVEVALVKSGIGKVSAALGTTLLLDHFKPELVINTGSAGGL
APSLKVGDIVVSHEVRYHDVDVTAFGYEPGQMAQCPASFNAAPSLVALAEESVDRLGMHAVRGLVVSGDAFINDADGLAH
IRQTFPQAIAVEMEATAIAHVCHQFAVPFVVVRAISDVADQASHLSFDEFLTVAAQSSSRLVEEMVQALAGQR

Specific function: Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively

COG id: COG0775

COG function: function code F; Nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/UDP phosphorylase family. MtnN subfamily

Homologues:

Organism=Escherichia coli, GI1786354, Length=230, Percent_Identity=72.1739130434783, Blast_Score=305, Evalue=2e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNN_SODGM (Q2NVP7)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_454183.1
- HSSP:   P0AF12
- ProteinModelPortal:   Q2NVP7
- SMR:   Q2NVP7
- STRING:   Q2NVP7
- GeneID:   3868282
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG0503
- NMPDR:   fig|343509.6.peg.1137
- eggNOG:   COG0775
- HOGENOM:   HBG367723
- OMA:   AMEQEVT
- PhylomeDB:   Q2NVP7
- ProtClustDB:   PRK05584
- BioCyc:   SGLO343509:SG0503-MONOMER
- HAMAP:   MF_01684
- InterPro:   IPR010049
- InterPro:   IPR018017
- InterPro:   IPR000845
- PANTHER:   PTHR21234
- TIGRFAMs:   TIGR01704

Pfam domain/function: PF01048 PNP_UDP_1

EC number: =3.2.2.9

Molecular weight: Translated: 24658; Mature: 24658

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: ACT_SITE 12-12 BINDING 78-78 BINDING 152-152 BINDING 197-197

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGIIGAMEQEVALLRDRIDHSTLCQQAGCEIYMGQLHGVEVALVKSGIGKVSAALGTT
CEEEEECCHHHHHHHHHHHCCHHHHHHHCCCEEEEECCCCEEEEEEHHCCHHHHHHHHHH
LLLDHFKPELVINTGSAGGLAPSLKVGDIVVSHEVRYHDVDVTAFGYEPGQMAQCPASFN
HHHHCCCCEEEEECCCCCCCCCCCEECCEEEECCEEEEEEEEEEECCCCCCCCCCCCCCC
AAPSLVALAEESVDRLGMHAVRGLVVSGDAFINDADGLAHIRQTFPQAIAVEMEATAIAH
CCCHHHHHHHHHHHHHHHHHHHCEEEECCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
VCHQFAVPFVVVRAISDVADQASHLSFDEFLTVAAQSSSRLVEEMVQALAGQR
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKIGIIGAMEQEVALLRDRIDHSTLCQQAGCEIYMGQLHGVEVALVKSGIGKVSAALGTT
CEEEEECCHHHHHHHHHHHCCHHHHHHHCCCEEEEECCCCEEEEEEHHCCHHHHHHHHHH
LLLDHFKPELVINTGSAGGLAPSLKVGDIVVSHEVRYHDVDVTAFGYEPGQMAQCPASFN
HHHHCCCCEEEEECCCCCCCCCCCEECCEEEECCEEEEEEEEEEECCCCCCCCCCCCCCC
AAPSLVALAEESVDRLGMHAVRGLVVSGDAFINDADGLAHIRQTFPQAIAVEMEATAIAH
CCCHHHHHHHHHHHHHHHHHHHCEEEECCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
VCHQFAVPFVVVRAISDVADQASHLSFDEFLTVAAQSSSRLVEEMVQALAGQR
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA