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The map label for this gene is degS [H]

Identifier: 85058190

GI number: 85058190

Start: 389816

End: 390880

Strand: Reverse

Name: degS [H]

Synonym: SG0212

Alternate gene names: 85058190

Gene position: 390880-389816 (Counterclockwise)

Preceding gene: 85058191

Following gene: 85058182

Centisome position: 9.37

GC content: 57.09

Gene sequence:

>1065_bases
ATGCTCCTAAAGTTGCTTCGTGCCGTGATAATCGGTTTCATTGTCGCAGCCCTGTTGCTGGTACTGGTGCCTACGCTTCG
CTCCACGACCGGCCAGTTATTGCACCCCGCCGATAATAGCGATAGCGAACAGCCCGTCAGTTACAACCAGGGGGTGCGCC
GCGCCGCGCCGGCGGTGGTCTATGTCTATAACCGCAGCATGAACAGCAGCGCCCACAATCAGCTGGAAATCCGCACGCTG
GGCTCTGGCGTGATTATGAATCAAAAAGGCTACCTGCTAACCAACAAACATGTCATCAACGATGCCGAGCAGATCATCGT
CGCACTACAGGATGGCCGGGTCTATGAAGCGCTGCTGGTCGGTTCGGACAGCCTGACCGATCTGGCGGTGCTGAAAATCG
ACGCCAGCAACCTGCCGGTGATTCCCATCAATCCCAACCGGCAGCCTCACATCGGCGACGTCGTCATGGCCATCGGTAAT
CCCTACAATTTGGGACAGACCATAACCCAAGGCATCATCAGCGCCACCGGCCGCATCGGCCTTAGCCCCTCCGGGCGGCA
AAATTTCCTGCAGACTGACGCGTCCATCAATCACGGCAACTCCGGCGGCGCGCTGATTAACACGCTGGGCGAACTGGTAG
GGATCAATACCCTATCGTTCGATAAGAGCAACAACGGCGAAACTCCAGAAGGCATCGGTTTTGCCATTCCTACCGAGCTG
GCCACCAAGGTGATGAACAAATTGATTTGCGATGGCCGGGTGATCCGCGGTTATATCGGTATCGGCGGCCGTGAAGTAGC
GCCCATGCATAATGGCGGCGGCCTCGATCGCATTCAGGGCATCATCGTCAACGAAGTGACCCCCGGCGGACCGGCGGCAC
AAGCCGGCATTCAGGTGGAGAATGTCATCCTGAGCGTCAACCACAAACCGGCCATCTCCGCCATTGAAACGATGGATCAG
GTGGCGGAAATTCGTCCCGGCTCTCGCATACCGGTCGAGATCCTGCGTAACGGCAAGAAATTGACGGTGGAAGTCACCAT
TCAGGAGTACCCGGCTTCAAATTAA

Upstream 100 bases:

>100_bases
CTGTTATTGCGCTAAGCATTTAAAAAACGGACGCCGGCGCTGCGGTGTCCGTTTAACTCGTGCTATCCTGCCGCTATTTT
CCACTATCCCTGCGAGTCCC

Downstream 100 bases:

>100_bases
TCTGCCGCGTCCGCAACCGTGCTGTTACGGCCGCGACAGGACCGCGTGGCAGGCAGCGCGCGCCCCCGTGAGCAAAACGG
CGAGCGCGGCTTTATTCCCC

Product: serine endoprotease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MLLKLLRAVIIGFIVAALLLVLVPTLRSTTGQLLHPADNSDSEQPVSYNQGVRRAAPAVVYVYNRSMNSSAHNQLEIRTL
GSGVIMNQKGYLLTNKHVINDAEQIIVALQDGRVYEALLVGSDSLTDLAVLKIDASNLPVIPINPNRQPHIGDVVMAIGN
PYNLGQTITQGIISATGRIGLSPSGRQNFLQTDASINHGNSGGALINTLGELVGINTLSFDKSNNGETPEGIGFAIPTEL
ATKVMNKLICDGRVIRGYIGIGGREVAPMHNGGGLDRIQGIIVNEVTPGGPAAQAGIQVENVILSVNHKPAISAIETMDQ
VAEIRPGSRIPVEILRNGKKLTVEVTIQEYPASN

Sequences:

>Translated_354_residues
MLLKLLRAVIIGFIVAALLLVLVPTLRSTTGQLLHPADNSDSEQPVSYNQGVRRAAPAVVYVYNRSMNSSAHNQLEIRTL
GSGVIMNQKGYLLTNKHVINDAEQIIVALQDGRVYEALLVGSDSLTDLAVLKIDASNLPVIPINPNRQPHIGDVVMAIGN
PYNLGQTITQGIISATGRIGLSPSGRQNFLQTDASINHGNSGGALINTLGELVGINTLSFDKSNNGETPEGIGFAIPTEL
ATKVMNKLICDGRVIRGYIGIGGREVAPMHNGGGLDRIQGIIVNEVTPGGPAAQAGIQVENVILSVNHKPAISAIETMDQ
VAEIRPGSRIPVEILRNGKKLTVEVTIQEYPASN
>Mature_354_residues
MLLKLLRAVIIGFIVAALLLVLVPTLRSTTGQLLHPADNSDSEQPVSYNQGVRRAAPAVVYVYNRSMNSSAHNQLEIRTL
GSGVIMNQKGYLLTNKHVINDAEQIIVALQDGRVYEALLVGSDSLTDLAVLKIDASNLPVIPINPNRQPHIGDVVMAIGN
PYNLGQTITQGIISATGRIGLSPSGRQNFLQTDASINHGNSGGALINTLGELVGINTLSFDKSNNGETPEGIGFAIPTEL
ATKVMNKLICDGRVIRGYIGIGGREVAPMHNGGGLDRIQGIIVNEVTPGGPAAQAGIQVENVILSVNHKPAISAIETMDQ
VAEIRPGSRIPVEILRNGKKLTVEVTIQEYPASN

Specific function: Senses the OMP signal triggered by the accumulation of unassembled porins in the envelope and then initiates rseA degradation by cleaving it in its periplasmic domain, making it an attractive substrate for subsequent cleavage by rseP [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=286, Percent_Identity=34.2657342657343, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI22129776, Length=300, Percent_Identity=34.3333333333333, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI24308541, Length=313, Percent_Identity=30.9904153354633, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI7019477, Length=314, Percent_Identity=30.8917197452229, Blast_Score=122, Evalue=4e-28,
Organism=Escherichia coli, GI1789630, Length=356, Percent_Identity=76.123595505618, Blast_Score=541, Evalue=1e-155,
Organism=Escherichia coli, GI1789629, Length=271, Percent_Identity=47.9704797047971, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1786356, Length=279, Percent_Identity=41.9354838709677, Blast_Score=200, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24646839, Length=291, Percent_Identity=31.2714776632302, Blast_Score=119, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011783
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 37585; Mature: 37585

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLKLLRAVIIGFIVAALLLVLVPTLRSTTGQLLHPADNSDSEQPVSYNQGVRRAAPAVV
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCHHCCHHHHCCEEE
YVYNRSMNSSAHNQLEIRTLGSGVIMNQKGYLLTNKHVINDAEQIIVALQDGRVYEALLV
EEEECCCCCCCCCEEEEEEECCCEEECCCCCEEECCHHHCCCEEEEEEEECCCEEEEEEE
GSDSLTDLAVLKIDASNLPVIPINPNRQPHIGDVVMAIGNPYNLGQTITQGIISATGRIG
CCCCCCEEEEEEECCCCCCEEECCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCC
LSPSGRQNFLQTDASINHGNSGGALINTLGELVGINTLSFDKSNNGETPEGIGFAIPTEL
CCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCEEECCCCCCCCCCCCCCEECCHHH
ATKVMNKLICDGRVIRGYIGIGGREVAPMHNGGGLDRIQGIIVNEVTPGGPAAQAGIQVE
HHHHHHHHHCCCEEEEEEECCCCEEECCCCCCCCHHHHCEEEEECCCCCCCHHHCCCEEE
NVILSVNHKPAISAIETMDQVAEIRPGSRIPVEILRNGKKLTVEVTIQEYPASN
EEEEEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCCCEEEEEEEEECCCCCC
>Mature Secondary Structure
MLLKLLRAVIIGFIVAALLLVLVPTLRSTTGQLLHPADNSDSEQPVSYNQGVRRAAPAVV
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCHHCCHHHHCCEEE
YVYNRSMNSSAHNQLEIRTLGSGVIMNQKGYLLTNKHVINDAEQIIVALQDGRVYEALLV
EEEECCCCCCCCCEEEEEEECCCEEECCCCCEEECCHHHCCCEEEEEEEECCCEEEEEEE
GSDSLTDLAVLKIDASNLPVIPINPNRQPHIGDVVMAIGNPYNLGQTITQGIISATGRIG
CCCCCCEEEEEEECCCCCCEEECCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCC
LSPSGRQNFLQTDASINHGNSGGALINTLGELVGINTLSFDKSNNGETPEGIGFAIPTEL
CCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCEEECCCCCCCCCCCCCCEECCHHH
ATKVMNKLICDGRVIRGYIGIGGREVAPMHNGGGLDRIQGIIVNEVTPGGPAAQAGIQVE
HHHHHHHHHCCCEEEEEEECCCCEEECCCCCCCCHHHHCEEEEECCCCCCCHHHCCCEEE
NVILSVNHKPAISAIETMDQVAEIRPGSRIPVEILRNGKKLTVEVTIQEYPASN
EEEEEECCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCCCEEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]