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The map label for this gene is pntAA [H]

Identifier: 84625092

GI number: 84625092

Start: 3892268

End: 3893365

Strand: Reverse

Name: pntAA [H]

Synonym: XOO_3435

Alternate gene names: 84625092

Gene position: 3893365-3892268 (Counterclockwise)

Preceding gene: 84625093

Following gene: 84625088

Centisome position: 78.81

GC content: 68.12

Gene sequence:

>1098_bases
ATGGCTGTGCAGGTGCTGGTGCTGAAAGAACGGGCCGATGGCGAACGCCGTGTGGCCGCGACGCCGGAAACGGTCAAGAA
ACTGGTCGCACGTGGTGCCAGCGTATGGATCGAGCCGGACGCCGGCCGTGCCAGCAGCATGGACAATGCGGTGTATCTGC
AGGCCGGTGCGCAGCCCGCCGGCGCCGACGCCGTGGCACGGGCCGATGTGCTGCTCTGCGTGCAGGCGCCACTCACCCCA
ACGCTGCTGCAGTGCAAACCGCACACGGTGGTGATCGGCATGCTGTCGCCGGACGCGGATCCGGCGCGCGCGCAGGCGTT
TGCCGCGCGCGCTCTGATCGTGTTTCCACTGGAGCGCCTGCCGCGCACCACGCGTGCGCAATCGATGGATGTGTTGAGTT
CGCAAGCCGGCATGGCCGGCTACAAGGCGGTGCTACTTGCCGCGCAACTGGCGCCGCGCTTTTTCCCGATGCTGACCACG
GCGGCCGGCACCATGCGCCCGTGCAAGGTATTGGTGATCGGCGCGGGCGTGGCCGGTCTGCAGGCGATCGCCACCGCCAA
ACGGCTCGGTGCGCAGGTGGAAGGCTTCGATGTGCGGCCGGAAACGCGTGAGCAGATCGCCTCGCTGGGCGCACGGTTCC
TGGATCTGGGCGTGAGCGCGGCCGGCGAAGGAGGCTACGCGCGCCAGCTCACCGACGACGAACGTGCCGAACAGCAGCGC
CGTCTGGCAGAGCATCTCAAGGGCGTGGATGTGGTGGTGTGCACCGCGGCGGTTCCAGTCCGGCCGGCGCCGAAGATCGT
GACTGCCGAGATGGCGCGGGGCATGCGCGCCGGCAGCGTGATTGTGGATCTGGCGGCGGAAACCGGCGGCAATTGCGCGG
CTACCCGCCCAGGCGAGACCTATGACCTCGACGGCGTAATGATCGCCGGCCCGCTCAATCTGGCCAGCCAGGGTGCCGTG
CATGCCAGCGAGATGTTCGCGCGCAACGTGTACGCATTCGCTGCCTTGTTGATCAAGGACGGCGCGCTGCCCTTCGATTG
GGACGATGAGTTGCTGGCGAAGACGCGGTGGTCGGCGCCGGCAGTGGCCACCAGCTAA

Upstream 100 bases:

>100_bases
GGCAAGCACGTTTTGCGCCGGAAGGCGTGGTCGGCACCAACGGCGTGCGTGCCGCGCTCTGCTGGCATCGCCGCGACTGG
GCGCAAGACCGGAGCAACGC

Downstream 100 bases:

>100_bases
GCGACGTAGCAAGCGCATCGTGGGCAATCGGCCAAGCGCGATGCGCCGCGTACCGTGCGCAGCCGTCGAGCGGGTGCGGA
TGATCTGCAAGTCGTCTGAT

Product: pyridine nucleotide transhydrogenase

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Pyridine nucleotide transhydrogenase subunit alpha 1 [H]

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MAVQVLVLKERADGERRVAATPETVKKLVARGASVWIEPDAGRASSMDNAVYLQAGAQPAGADAVARADVLLCVQAPLTP
TLLQCKPHTVVIGMLSPDADPARAQAFAARALIVFPLERLPRTTRAQSMDVLSSQAGMAGYKAVLLAAQLAPRFFPMLTT
AAGTMRPCKVLVIGAGVAGLQAIATAKRLGAQVEGFDVRPETREQIASLGARFLDLGVSAAGEGGYARQLTDDERAEQQR
RLAEHLKGVDVVVCTAAVPVRPAPKIVTAEMARGMRAGSVIVDLAAETGGNCAATRPGETYDLDGVMIAGPLNLASQGAV
HASEMFARNVYAFAALLIKDGALPFDWDDELLAKTRWSAPAVATS

Sequences:

>Translated_365_residues
MAVQVLVLKERADGERRVAATPETVKKLVARGASVWIEPDAGRASSMDNAVYLQAGAQPAGADAVARADVLLCVQAPLTP
TLLQCKPHTVVIGMLSPDADPARAQAFAARALIVFPLERLPRTTRAQSMDVLSSQAGMAGYKAVLLAAQLAPRFFPMLTT
AAGTMRPCKVLVIGAGVAGLQAIATAKRLGAQVEGFDVRPETREQIASLGARFLDLGVSAAGEGGYARQLTDDERAEQQR
RLAEHLKGVDVVVCTAAVPVRPAPKIVTAEMARGMRAGSVIVDLAAETGGNCAATRPGETYDLDGVMIAGPLNLASQGAV
HASEMFARNVYAFAALLIKDGALPFDWDDELLAKTRWSAPAVATS
>Mature_364_residues
AVQVLVLKERADGERRVAATPETVKKLVARGASVWIEPDAGRASSMDNAVYLQAGAQPAGADAVARADVLLCVQAPLTPT
LLQCKPHTVVIGMLSPDADPARAQAFAARALIVFPLERLPRTTRAQSMDVLSSQAGMAGYKAVLLAAQLAPRFFPMLTTA
AGTMRPCKVLVIGAGVAGLQAIATAKRLGAQVEGFDVRPETREQIASLGARFLDLGVSAAGEGGYARQLTDDERAEQQRR
LAEHLKGVDVVVCTAAVPVRPAPKIVTAEMARGMRAGSVIVDLAAETGGNCAATRPGETYDLDGVMIAGPLNLASQGAVH
ASEMFARNVYAFAALLIKDGALPFDWDDELLAKTRWSAPAVATS

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=352, Percent_Identity=39.2045454545455, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI122939153, Length=352, Percent_Identity=39.2045454545455, Blast_Score=228, Evalue=1e-59,
Organism=Escherichia coli, GI1787887, Length=370, Percent_Identity=41.0810810810811, Blast_Score=271, Evalue=6e-74,
Organism=Caenorhabditis elegans, GI17550456, Length=351, Percent_Identity=39.6011396011396, Blast_Score=248, Evalue=4e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 38233; Mature: 38101

Theoretical pI: Translated: 7.86; Mature: 7.86

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVQVLVLKERADGERRVAATPETVKKLVARGASVWIEPDAGRASSMDNAVYLQAGAQPA
CEEEEEEEECCCCCCCEEECCHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEEECCCCC
GADAVARADVLLCVQAPLTPTLLQCKPHTVVIGMLSPDADPARAQAFAARALIVFPLERL
CCHHHHHCEEEEEEECCCCCCEEECCCCEEEEEEECCCCCHHHHHHHHHHHHEEEEHHHC
PRTTRAQSMDVLSSQAGMAGYKAVLLAAQLAPRFFPMLTTAAGTMRPCKVLVIGAGVAGL
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHH
QAIATAKRLGAQVEGFDVRPETREQIASLGARFLDLGVSAAGEGGYARQLTDDERAEQQR
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHH
RLAEHLKGVDVVVCTAAVPVRPAPKIVTAEMARGMRAGSVIVDLAAETGGNCAATRPGET
HHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHCCCCCCCEEEEEECCCCCCEEECCCCCC
YDLDGVMIAGPLNLASQGAVHASEMFARNVYAFAALLIKDGALPFDWDDELLAKTRWSAP
EECCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCC
AVATS
CCCCC
>Mature Secondary Structure 
AVQVLVLKERADGERRVAATPETVKKLVARGASVWIEPDAGRASSMDNAVYLQAGAQPA
EEEEEEEECCCCCCCEEECCHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEEECCCCC
GADAVARADVLLCVQAPLTPTLLQCKPHTVVIGMLSPDADPARAQAFAARALIVFPLERL
CCHHHHHCEEEEEEECCCCCCEEECCCCEEEEEEECCCCCHHHHHHHHHHHHEEEEHHHC
PRTTRAQSMDVLSSQAGMAGYKAVLLAAQLAPRFFPMLTTAAGTMRPCKVLVIGAGVAGL
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHH
QAIATAKRLGAQVEGFDVRPETREQIASLGARFLDLGVSAAGEGGYARQLTDDERAEQQR
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHH
RLAEHLKGVDVVVCTAAVPVRPAPKIVTAEMARGMRAGSVIVDLAAETGGNCAATRPGET
HHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHCCCCCCCEEEEEECCCCCCEEECCCCCC
YDLDGVMIAGPLNLASQGAVHASEMFARNVYAFAALLIKDGALPFDWDDELLAKTRWSAP
EECCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCC
AVATS
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9823893; 9335295; 8662004 [H]