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The map label for this gene is 84623959

Identifier: 84623959

GI number: 84623959

Start: 2562550

End: 2563113

Strand: Direct

Name: 84623959

Synonym: XOO_2302

Alternate gene names: NA

Gene position: 2562550-2563113 (Clockwise)

Preceding gene: 84623958

Following gene: 84623960

Centisome position: 51.87

GC content: 59.22

Gene sequence:

>564_bases
ATGCTGGACACCTTCTCCGCCGAGGAACCCTTGATGCTGATCCCGCCGATCAACCTGCATGCTTGGATCGAGGAACACCG
CCACCTGCTCAAACCGCCGGTGGGCAACAAGTGCATCCAGCAGGATGGCTTCATCATCATGATTGTTGGTGGCCCGAATG
CACGCACCGACTATCACTACGACGAAGGCCCGGAGTGGTTCTTCCAACTCGAAGGCGAGATGGTGCTGAAGGTGCAGGAC
GATGGCGTGGCGCGCGACATCCCGATCCGTGCCGGTGAAATCTTTCTGCTGCCGCCCAGGGTGCCGCATTCACCGCAACG
CGCTGCCGGCTCAATCGGCATCGTGATCGAGCGCGTGCGTTTGCCACATGAGCAAGATGGCCTGCAGTGGTATTGCCCGC
AGTGCAATCACAAGTTGTATGAAGCGATGTTCCCGCTGAAAAACATCGAAACCGACTTCCCTCCGGTGTTCGATCATTTC
TATCGTTCGCTCGCGCTGCGTACGTGCTCGCAGTGCGGGCATCTGCACCCTGCGCCTGAGCGCTATGCCGCGGTCGAGGA
TTGA

Upstream 100 bases:

>100_bases
GATGCGGCGCTGGCGAAGATCCAGGCTGATCGCGCCGAACGCTGAGCCGCACGCAACTGCATGGCCAACCGCCGCATCCA
TGTGAGGCGAGCGGTTGGCT

Downstream 100 bases:

>100_bases
CAGCGCCATGGCATGCGATCGCGCGCAGCAGGTTTGCCGCACGCATGCGTCGAAACCAGCGCCATGCTGCGCGCACTGAT
CGACCTCAAACCGCGCGATG

Product: 3-hydroxyanthranilate 3,4-dioxygenase

Products: NA

Alternate protein names: 3-hydroxyanthranilate oxygenase; 3-HAO; 3-hydroxyanthranilic acid dioxygenase; HAD [H]

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MLDTFSAEEPLMLIPPINLHAWIEEHRHLLKPPVGNKCIQQDGFIIMIVGGPNARTDYHYDEGPEWFFQLEGEMVLKVQD
DGVARDIPIRAGEIFLLPPRVPHSPQRAAGSIGIVIERVRLPHEQDGLQWYCPQCNHKLYEAMFPLKNIETDFPPVFDHF
YRSLALRTCSQCGHLHPAPERYAAVED

Sequences:

>Translated_187_residues
MLDTFSAEEPLMLIPPINLHAWIEEHRHLLKPPVGNKCIQQDGFIIMIVGGPNARTDYHYDEGPEWFFQLEGEMVLKVQD
DGVARDIPIRAGEIFLLPPRVPHSPQRAAGSIGIVIERVRLPHEQDGLQWYCPQCNHKLYEAMFPLKNIETDFPPVFDHF
YRSLALRTCSQCGHLHPAPERYAAVED
>Mature_187_residues
MLDTFSAEEPLMLIPPINLHAWIEEHRHLLKPPVGNKCIQQDGFIIMIVGGPNARTDYHYDEGPEWFFQLEGEMVLKVQD
DGVARDIPIRAGEIFLLPPRVPHSPQRAAGSIGIVIERVRLPHEQDGLQWYCPQCNHKLYEAMFPLKNIETDFPPVFDHF
YRSLALRTCSQCGHLHPAPERYAAVED

Specific function: Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-HAO family [H]

Homologues:

Organism=Homo sapiens, GI188497625, Length=152, Percent_Identity=48.0263157894737, Blast_Score=156, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI17562218, Length=155, Percent_Identity=43.2258064516129, Blast_Score=140, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6322485, Length=167, Percent_Identity=43.1137724550898, Blast_Score=147, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010329
- InterPro:   IPR011051
- InterPro:   IPR014710 [H]

Pfam domain/function: PF06052 3-HAO [H]

EC number: =1.13.11.6 [H]

Molecular weight: Translated: 21431; Mature: 21431

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDTFSAEEPLMLIPPINLHAWIEEHRHLLKPPVGNKCIQQDGFIIMIVGGPNARTDYHY
CCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCHHCCCCCEEEEEECCCCCCCCCCC
DEGPEWFFQLEGEMVLKVQDDGVARDIPIRAGEIFLLPPRVPHSPQRAAGSIGIVIERVR
CCCCCEEEEECCEEEEEECCCCCEECCCCCCCEEEEECCCCCCCHHHHCCCCEEEEEECC
LPHEQDGLQWYCPQCNHKLYEAMFPLKNIETDFPPVFDHFYRSLALRTCSQCGHLHPAPE
CCCCCCCCEEECCCCCHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHH
RYAAVED
HHCCCCC
>Mature Secondary Structure
MLDTFSAEEPLMLIPPINLHAWIEEHRHLLKPPVGNKCIQQDGFIIMIVGGPNARTDYHY
CCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCHHCCCCCEEEEEECCCCCCCCCCC
DEGPEWFFQLEGEMVLKVQDDGVARDIPIRAGEIFLLPPRVPHSPQRAAGSIGIVIERVR
CCCCCEEEEECCEEEEEECCCCCEECCCCCCCEEEEECCCCCCCHHHHCCCCEEEEEECC
LPHEQDGLQWYCPQCNHKLYEAMFPLKNIETDFPPVFDHFYRSLALRTCSQCGHLHPAPE
CCCCCCCCEEECCCCCHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHH
RYAAVED
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]