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The map label for this gene is edd [H]

Identifier: 84623851

GI number: 84623851

Start: 2432954

End: 2434870

Strand: Direct

Name: edd [H]

Synonym: XOO_2194

Alternate gene names: 84623851

Gene position: 2432954-2434870 (Clockwise)

Preceding gene: 84623850

Following gene: 84623852

Centisome position: 49.25

GC content: 67.19

Gene sequence:

>1917_bases
ATGAGCCTGCATCCGAATATCCAAGCCGTCACCGACCGTATCCGCAAGCGCAGCGCTCCCTCGCGCGCGGCGTATCTGGC
CGGTCTCGATGCCGCCCTGCGTGAGGGCCCGTTCCGTAGCCGGTTGAGTTGCGGCAATCTTGCGCACGGTTTCGCTGCGT
CCACGCCGACCGACAAATCGCGTCTGCGCGGCGCGGCCACGCCGAACCTGGGCATCATCACCGCCTATAACGACATGCTG
TCGGCGCATCAGCCGTTCGAGCATTACCCGCAGCTGATCCGCGAAACCGCGCGCTCACTCGGCGCCACTGCGCAGGTGGC
CGGCGGCGTGCCGGCGATGTGCGACGGCGTGACCCAGGGCCGCGCCGGCATGGAATTGTCGCTGTTCTCGCGCGACAACA
TCGCTCAGGCCGCGGCTATCGGTCTGAGCCACGACATGTTCGACAGCGTGGTGTACCTGGGCGTATGCGACAAGATCGTG
CCGGGTCTGCTGATCGGTGCGCTGGCATTCGGCCATCTGCCGGCGATCTTCATGCCGGCCGGCCCGATGACCCCGGGCAT
TCCGAACAAGCAGAAGGCCGAAGTGCGCGAACGCTACGCCGCTGGCGAAGCCACCCGCGCCGAGCTGCTGGAAGCCGAAT
CCTCGTCCTACCACTCGCCCGGCACCTGCACGTTCTATGGCACGGCGAATTCCAACCAGGTGTTGCTCGAAGCGATGGGC
GTGCAGTTGCCCGGCGCCTCGTTCGTCAATCCGGAGCTGCCGTTGCGCGATGCACTGACCCGCGAAGGCACTGCACGTGC
CTTGGCGATCTCTGCGCTGGGCGATGACTTCCGCCCGTTCGGTCGTTTGATCGACGAGCGTGCCATCGTCAATGCGGTGG
TCGCGCTGATGGCGACCGGCGGGTCGACCAACCACACCATCCACTGGATCGCAGTGGCGCGTGCGGCTGGCATTGTGTTG
ACCTGGGACGACATGGATCTGATCTCGCAGACCGTGCCGCTGCTGACCCGCATCTACCCGAACGGCGAAGCCGACGTGAA
TCGCTTCCAGGCCGCAGGCGGCACCGCGTTCGTGTTCCGCGAATTGATGGACGCCGGCTACATGCATGACGACCTGACGA
CCGTCGTCGAAGGCGGCATGCGCGCCTACGTCAACGAGCCGCGTCTGCAGGAGGGCAAGGTGACCTACGTGCCGGGCACC
GCGACCACTGCCGACGACAGCGTTGCGCGTCCGGTCAGCGATGCGTTCGAATCGCAGGGCGGGCTGCGTCTGCTGCGCGG
CAACCTCGGCCGCTCGTTGATCAAGCTCTCCGCAGTCAAGCCGCAGCATCGCAGCATCGAAGCGCCTGCAGTGGTGATCG
ACACCCCGCAAGTGCTCAACAAGCTGCATGCCGCCGGCGTGCTGCCGCACGATTTCGTGGTGGTGCTGCGCTACCAGGGC
CCTCGTGCGAACGGCATGCCCGAGCTGCATTCGATGGCGCCGCTGCTGGGCCTGCTGCAGAACCAGGGCCGGCGTGTGGC
ACTGGTCACCGACGGCCGCCTGTCCGGTGCCTCGGGCAAGTTCCCGGCAGCGATCCACCTGACCCCGGAAGCCGCACGCG
GCGGCCCGATCGGGCGCGTACGCGAGGGCGACATCGTGCGCCTGGACGGCGAAGCCGGCACGCTGGAAGTACTGGTGTCG
GCCGAAGAATGGGCATCGCGCGAGGTCGCCCCGAACACGGCGGTGGCCGGCAATGATCTAGGCCGCAACCTGTTCGCCAT
CAACCGTCAGGTGGTCGGCCCGGCCGACCAGGGCGCGATTTCGATTTCCTGCGGCCCGACCCACCCGGACGGCGCGCTGT
GGAGCTACGACGCCGAATACGAACTCGGTGCCGACGCAGCCGCTGCAGCCGCACCGCACGAGTCCAAGGACGCCTGA

Upstream 100 bases:

>100_bases
GCGAGTCGTTTGATGCGAGTCCCTCGCAACAACCCGCACATCCATGTGCGGGGAATTAAAAGAGCTTCTCCTTCCCACCG
TTTCTCATAGCCGGTAGCCA

Downstream 100 bases:

>100_bases
TCCTTCTTCCCTCTCTCTGCGGCCGCTGCGGCGGTCGCCGTCTAACGGAGTTGCAATGACGATTGCCCAGACCCAGAACA
CCGCCGAACAGTTGCTGCGC

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 638; Mature: 637

Protein sequence:

>638_residues
MSLHPNIQAVTDRIRKRSAPSRAAYLAGLDAALREGPFRSRLSCGNLAHGFAASTPTDKSRLRGAATPNLGIITAYNDML
SAHQPFEHYPQLIRETARSLGATAQVAGGVPAMCDGVTQGRAGMELSLFSRDNIAQAAAIGLSHDMFDSVVYLGVCDKIV
PGLLIGALAFGHLPAIFMPAGPMTPGIPNKQKAEVRERYAAGEATRAELLEAESSSYHSPGTCTFYGTANSNQVLLEAMG
VQLPGASFVNPELPLRDALTREGTARALAISALGDDFRPFGRLIDERAIVNAVVALMATGGSTNHTIHWIAVARAAGIVL
TWDDMDLISQTVPLLTRIYPNGEADVNRFQAAGGTAFVFRELMDAGYMHDDLTTVVEGGMRAYVNEPRLQEGKVTYVPGT
ATTADDSVARPVSDAFESQGGLRLLRGNLGRSLIKLSAVKPQHRSIEAPAVVIDTPQVLNKLHAAGVLPHDFVVVLRYQG
PRANGMPELHSMAPLLGLLQNQGRRVALVTDGRLSGASGKFPAAIHLTPEAARGGPIGRVREGDIVRLDGEAGTLEVLVS
AEEWASREVAPNTAVAGNDLGRNLFAINRQVVGPADQGAISISCGPTHPDGALWSYDAEYELGADAAAAAAPHESKDA

Sequences:

>Translated_638_residues
MSLHPNIQAVTDRIRKRSAPSRAAYLAGLDAALREGPFRSRLSCGNLAHGFAASTPTDKSRLRGAATPNLGIITAYNDML
SAHQPFEHYPQLIRETARSLGATAQVAGGVPAMCDGVTQGRAGMELSLFSRDNIAQAAAIGLSHDMFDSVVYLGVCDKIV
PGLLIGALAFGHLPAIFMPAGPMTPGIPNKQKAEVRERYAAGEATRAELLEAESSSYHSPGTCTFYGTANSNQVLLEAMG
VQLPGASFVNPELPLRDALTREGTARALAISALGDDFRPFGRLIDERAIVNAVVALMATGGSTNHTIHWIAVARAAGIVL
TWDDMDLISQTVPLLTRIYPNGEADVNRFQAAGGTAFVFRELMDAGYMHDDLTTVVEGGMRAYVNEPRLQEGKVTYVPGT
ATTADDSVARPVSDAFESQGGLRLLRGNLGRSLIKLSAVKPQHRSIEAPAVVIDTPQVLNKLHAAGVLPHDFVVVLRYQG
PRANGMPELHSMAPLLGLLQNQGRRVALVTDGRLSGASGKFPAAIHLTPEAARGGPIGRVREGDIVRLDGEAGTLEVLVS
AEEWASREVAPNTAVAGNDLGRNLFAINRQVVGPADQGAISISCGPTHPDGALWSYDAEYELGADAAAAAAPHESKDA
>Mature_637_residues
SLHPNIQAVTDRIRKRSAPSRAAYLAGLDAALREGPFRSRLSCGNLAHGFAASTPTDKSRLRGAATPNLGIITAYNDMLS
AHQPFEHYPQLIRETARSLGATAQVAGGVPAMCDGVTQGRAGMELSLFSRDNIAQAAAIGLSHDMFDSVVYLGVCDKIVP
GLLIGALAFGHLPAIFMPAGPMTPGIPNKQKAEVRERYAAGEATRAELLEAESSSYHSPGTCTFYGTANSNQVLLEAMGV
QLPGASFVNPELPLRDALTREGTARALAISALGDDFRPFGRLIDERAIVNAVVALMATGGSTNHTIHWIAVARAAGIVLT
WDDMDLISQTVPLLTRIYPNGEADVNRFQAAGGTAFVFRELMDAGYMHDDLTTVVEGGMRAYVNEPRLQEGKVTYVPGTA
TTADDSVARPVSDAFESQGGLRLLRGNLGRSLIKLSAVKPQHRSIEAPAVVIDTPQVLNKLHAAGVLPHDFVVVLRYQGP
RANGMPELHSMAPLLGLLQNQGRRVALVTDGRLSGASGKFPAAIHLTPEAARGGPIGRVREGDIVRLDGEAGTLEVLVSA
EEWASREVAPNTAVAGNDLGRNLFAINRQVVGPADQGAISISCGPTHPDGALWSYDAEYELGADAAAAAAPHESKDA

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=602, Percent_Identity=52.8239202657807, Blast_Score=662, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=547, Percent_Identity=27.6051188299817, Blast_Score=163, Evalue=3e-41,
Organism=Escherichia coli, GI2367371, Length=462, Percent_Identity=29.6536796536797, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1786464, Length=458, Percent_Identity=29.0393013100437, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6322476, Length=483, Percent_Identity=30.2277432712215, Blast_Score=176, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 67407; Mature: 67276

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLHPNIQAVTDRIRKRSAPSRAAYLAGLDAALREGPFRSRLSCGNLAHGFAASTPTDKS
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCHH
RLRGAATPNLGIITAYNDMLSAHQPFEHYPQLIRETARSLGATAQVAGGVPAMCDGVTQG
HCCCCCCCCCEEEEECHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHCCCCCHHHCCCCCC
RAGMELSLFSRDNIAQAAAIGLSHDMFDSVVYLGVCDKIVPGLLIGALAFGHLPAIFMPA
CCCCEEEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECC
GPMTPGIPNKQKAEVRERYAAGEATRAELLEAESSSYHSPGTCTFYGTANSNQVLLEAMG
CCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEEEEECC
VQLPGASFVNPELPLRDALTREGTARALAISALGDDFRPFGRLIDERAIVNAVVALMATG
CCCCCCCCCCCCCCHHHHHCCCCCHHEEEEEHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
GSTNHTIHWIAVARAAGIVLTWDDMDLISQTVPLLTRIYPNGEADVNRFQAAGGTAFVFR
CCCCCEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHH
ELMDAGYMHDDLTTVVEGGMRAYVNEPRLQEGKVTYVPGTATTADDSVARPVSDAFESQG
HHHHCCCCCHHHHHHHHCCHHHHCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHCCC
GLRLLRGNLGRSLIKLSAVKPQHRSIEAPAVVIDTPQVLNKLHAAGVLPHDFVVVLRYQG
CEEEEHHHHCHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHCCCCCCCEEEEEEECC
PRANGMPELHSMAPLLGLLQNQGRRVALVTDGRLSGASGKFPAAIHLTPEAARGGPIGRV
CCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCC
REGDIVRLDGEAGTLEVLVSAEEWASREVAPNTAVAGNDLGRNLFAINRQVVGPADQGAI
CCCCEEEECCCCCEEEEEEECHHHHCCCCCCCCCCCCCCCCCCEEEECCEEECCCCCCEE
SISCGPTHPDGALWSYDAEYELGADAAAAAAPHESKDA
EEEECCCCCCCCEEECCCCCCCCCCHHHHCCCCCCCCC
>Mature Secondary Structure 
SLHPNIQAVTDRIRKRSAPSRAAYLAGLDAALREGPFRSRLSCGNLAHGFAASTPTDKS
CCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCHH
RLRGAATPNLGIITAYNDMLSAHQPFEHYPQLIRETARSLGATAQVAGGVPAMCDGVTQG
HCCCCCCCCCEEEEECHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHCCCCCHHHCCCCCC
RAGMELSLFSRDNIAQAAAIGLSHDMFDSVVYLGVCDKIVPGLLIGALAFGHLPAIFMPA
CCCCEEEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECC
GPMTPGIPNKQKAEVRERYAAGEATRAELLEAESSSYHSPGTCTFYGTANSNQVLLEAMG
CCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEEEEECC
VQLPGASFVNPELPLRDALTREGTARALAISALGDDFRPFGRLIDERAIVNAVVALMATG
CCCCCCCCCCCCCCHHHHHCCCCCHHEEEEEHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
GSTNHTIHWIAVARAAGIVLTWDDMDLISQTVPLLTRIYPNGEADVNRFQAAGGTAFVFR
CCCCCEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHH
ELMDAGYMHDDLTTVVEGGMRAYVNEPRLQEGKVTYVPGTATTADDSVARPVSDAFESQG
HHHHCCCCCHHHHHHHHCCHHHHCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHCCC
GLRLLRGNLGRSLIKLSAVKPQHRSIEAPAVVIDTPQVLNKLHAAGVLPHDFVVVLRYQG
CEEEEHHHHCHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHCCCCCCCEEEEEEECC
PRANGMPELHSMAPLLGLLQNQGRRVALVTDGRLSGASGKFPAAIHLTPEAARGGPIGRV
CCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCC
REGDIVRLDGEAGTLEVLVSAEEWASREVAPNTAVAGNDLGRNLFAINRQVVGPADQGAI
CCCCEEEECCCCCEEEEEEECHHHHCCCCCCCCCCCCCCCCCCEEEECCEEECCCCCCEE
SISCGPTHPDGALWSYDAEYELGADAAAAAAPHESKDA
EEEECCCCCCCCEEECCCCCCCCCCHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]