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The map label for this gene is hisA [H]

Identifier: 84623780

GI number: 84623780

Start: 2349486

End: 2350220

Strand: Direct

Name: hisA [H]

Synonym: XOO_2123

Alternate gene names: 84623780

Gene position: 2349486-2350220 (Clockwise)

Preceding gene: 84623779

Following gene: 84623781

Centisome position: 47.56

GC content: 66.26

Gene sequence:

>735_bases
ATGAGTTTCACCGTTTACCCGGCGCTGGATATTCGCAATGGCCGCGTGGTGCGCTTGCTGCAGGGCGATTACGCACGCGA
AACGCACTACGGCAACGACGTGCTGCCGCGTGCACAGGCATTCGCCGACGCCGGCGCGCAATGGATGCATCTGGTCGATC
TGGATGCGGCGAAGGCGGGCGGCTACACACTGGCCACCACACTTGGCGAAATCGCGCGTGCCACCGGCTTGCAGGTGCAG
ACCGGCGGCGGCGTGCGTTCGCGCGACGATGTGGCGAGCATCCTGGATGCCGGTGCCGCGCGCGTGGTGATCGGCTCGTT
GGCGGTACGCGACAGCGAGATGGTGATCGCTTGGCTGCAGGAATTCGGTGCCGATCGCCTGACCATTGCATTGGATACAC
GCCAGGATACCGACGGCATCTGGCAGTTGCCGGTGCACGGCTGGACCGAAACGGCAGACGCCACGCTGGACCAGTTGGCC
GTGCGTTACGCGCAGGCCGGTCTGAAACATCTGCTCTGCACCGACATCGCCCGCGACGGCATGCTGTCCGGCCCCAACGC
GGCGCTGTACGCGCACTTGCGTTCGCTCACGCCGCAGCTGCAGGTGCAGGTCTCCGGCGGCGCGCGCAATCTGGCCGACG
TCGCCGCTGCCAAGGCCGCAGGTTGCGCCGGCATCGTGCTTGGCAAGGCCTTGCTGGAAGGGCATCTGGATCTCGACGAG
GCACTGGCATGCTGA

Upstream 100 bases:

>100_bases
TCGTGCAGAACGGCTTGCGCTGCGGCGCGCAGTTTCACCCTGAGCGGTCGGCCGACACCGGTGCACGCATCCTGCACAAT
TTTCTTGAGATGAGCTTCCC

Downstream 100 bases:

>100_bases
GCCGTCGCATTATTCCGTGCCTGGACGTGCGCAATGGCCGCGTGGTCAAGGGCGTCAAGTTCCACGACCACATCGACATG
GGCGACATCGTCGAACTGGC

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MSFTVYPALDIRNGRVVRLLQGDYARETHYGNDVLPRAQAFADAGAQWMHLVDLDAAKAGGYTLATTLGEIARATGLQVQ
TGGGVRSRDDVASILDAGAARVVIGSLAVRDSEMVIAWLQEFGADRLTIALDTRQDTDGIWQLPVHGWTETADATLDQLA
VRYAQAGLKHLLCTDIARDGMLSGPNAALYAHLRSLTPQLQVQVSGGARNLADVAAAKAAGCAGIVLGKALLEGHLDLDE
ALAC

Sequences:

>Translated_244_residues
MSFTVYPALDIRNGRVVRLLQGDYARETHYGNDVLPRAQAFADAGAQWMHLVDLDAAKAGGYTLATTLGEIARATGLQVQ
TGGGVRSRDDVASILDAGAARVVIGSLAVRDSEMVIAWLQEFGADRLTIALDTRQDTDGIWQLPVHGWTETADATLDQLA
VRYAQAGLKHLLCTDIARDGMLSGPNAALYAHLRSLTPQLQVQVSGGARNLADVAAAKAAGCAGIVLGKALLEGHLDLDE
ALAC
>Mature_243_residues
SFTVYPALDIRNGRVVRLLQGDYARETHYGNDVLPRAQAFADAGAQWMHLVDLDAAKAGGYTLATTLGEIARATGLQVQT
GGGVRSRDDVASILDAGAARVVIGSLAVRDSEMVIAWLQEFGADRLTIALDTRQDTDGIWQLPVHGWTETADATLDQLAV
RYAQAGLKHLLCTDIARDGMLSGPNAALYAHLRSLTPQLQVQVSGGARNLADVAAAKAAGCAGIVLGKALLEGHLDLDEA
LAC

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=240, Percent_Identity=47.9166666666667, Blast_Score=228, Evalue=4e-61,
Organism=Escherichia coli, GI1788336, Length=134, Percent_Identity=27.6119402985075, Blast_Score=64, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 25758; Mature: 25627

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFTVYPALDIRNGRVVRLLQGDYARETHYGNDVLPRAQAFADAGAQWMHLVDLDAAKAG
CCEEEEEEEEECCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCC
GYTLATTLGEIARATGLQVQTGGGVRSRDDVASILDAGAARVVIGSLAVRDSEMVIAWLQ
CCHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHCCCHHEEHHHHHCCCHHHHHHHHH
EFGADRLTIALDTRQDTDGIWQLPVHGWTETADATLDQLAVRYAQAGLKHLLCTDIARDG
HHCCCEEEEEEECCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
MLSGPNAALYAHLRSLTPQLQVQVSGGARNLADVAAAKAAGCAGIVLGKALLEGHLDLDE
CCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHH
ALAC
HHCC
>Mature Secondary Structure 
SFTVYPALDIRNGRVVRLLQGDYARETHYGNDVLPRAQAFADAGAQWMHLVDLDAAKAG
CEEEEEEEEECCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCC
GYTLATTLGEIARATGLQVQTGGGVRSRDDVASILDAGAARVVIGSLAVRDSEMVIAWLQ
CCHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHCCCHHEEHHHHHCCCHHHHHHHHH
EFGADRLTIALDTRQDTDGIWQLPVHGWTETADATLDQLAVRYAQAGLKHLLCTDIARDG
HHCCCEEEEEEECCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
MLSGPNAALYAHLRSLTPQLQVQVSGGARNLADVAAAKAAGCAGIVLGKALLEGHLDLDE
CCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHH
ALAC
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]