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The map label for this gene is fumC [H]

Identifier: 84623594

GI number: 84623594

Start: 2140028

End: 2141431

Strand: Direct

Name: fumC [H]

Synonym: XOO_1937

Alternate gene names: 84623594

Gene position: 2140028-2141431 (Clockwise)

Preceding gene: 84623592

Following gene: 84623601

Centisome position: 43.32

GC content: 63.46

Gene sequence:

>1404_bases
ATGAGCGAACGTTTCAGGACCGAACACGACTGCATGGGCGAATTGCAGGTGCCCGCCGATGCGTTGTGGGGCGCGCAGAC
CCAGCGTGCAGTGCAGAATTTCCCGGTGTCCGGGCAGCCGATGCCACGCGGCTTCATTCGCGCGCTGGGCCTGATCAAGG
CGGCGGCGGCCGGCGTCAATGCCGAACTTGGATTGCTGCCGAAATCGATCTGCAAGACAGTGCAGGCCGCTGCGTTGCAA
GTGGCCGAGGGCAGCTTCGATGCGCAGTTTCCCATCGACGTCTACCAGACCGGTTCGGGCACCTCCTCCAACATGAATGC
TAATGAGGTCATCGCCACATTGGCCACGCGTGCCGGCAAGGACGCGGTGCATCCCAACGATCACGTCAATCTCGGTCAGA
GTTCCAACGACGTGGTGCCGACCGCCATTCGCGTGTCGGCACTGCTCGCTGTGCAGGAACATCTGCAACCGGCGCTCAAG
CATCTGCGCAAGACCATCGACAAGCGTGCGAAATCGCTGGACAAGATCGTCAAGACAGGCCGCACGCATTTGATGGATGC
GATGCCGCTGACGTTCGGCCAGGAGTTCGGCGCCTGGTCGGCGCAACTGCGTTCGGCGCAGGGGCGTATCGACGATGCGC
TGAAACGCCTGCGGCGGTTGCCGCTGGGCGGCACGGCGATCGGGACCGGCATCAATGCCGACCCACGTTTCGGTGGCAAG
GTGGCCAAGGCCCTGTCCAGCCTGAGCGGGGCCAGGTTCGAGAGCGCGGAAAACAAGTTCGAAGGACTCGCCGCGCAGGA
CGATGCGGTGGAGTTGTCTGGCCAGCTCAATGCGCTGGCGGTGGCGTTGATCAAGATCGCAAACGATTTGCGCTGGATGA
ATGCCGGTCCGTTGGCGGGTCTGGGCGAAATCGAATTGCCGGCGTTGCAGCCTGGCAGCTCGATCATGCCGGGTAAGGTC
AATCCAGTGATTCCCGAAGCCACGGTGATGGCCTGCGCGCAGGTCATCGGCCACCACACCGCGATCACCGTGGCCGGGCA
GACCGGTAATTTCCAGTTGAATGTGACGCTGCCGCTGATCGCTTACAACCTGCTGGATTCGATCACGCTGTTGGGCAATG
TCTCGCGCCTGTTGGCCGCTACCGCGATTGCCGGGCTGCAGGTGCGCCAGGCGCGCGTCCGCGAGGCGCTGGACCGCAAT
CCCATTCTGGTGACCGCGCTGAATCCGATCATCGGTTACGAAAAAGCCGCAGCGATTGCCAAGCGTGCCTACAAGGAGCA
GCGGCCGGTACTCGATGTGGCCAGGGAAGACAGCGGGCTCAGCGAAGCGGACCTGCGACGATTGCTCGACCCGGCCGCGT
TGACGCGTGGCGGTATCCATGCCGGCGGCGGTAGCGGTGGCTGA

Upstream 100 bases:

>100_bases
GGGTGTTGCACTTGGAAATTGAGTCTAAGCAGCCTCGCCAGCGTGGGTACGCCCGCTGCCAGCCATCCATCACCACAATC
AACGTGTGCGGAGAGTGCAG

Downstream 100 bases:

>100_bases
TCACTGCTGCGTGTGTAGGAGCGCGCTTGTGCGCGACTGGCTTGATCGATAAAGCCCCATCGCGCTCAAGCCCGCGCCGG
CCTGTTTTTTGCGACCCTGC

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MSERFRTEHDCMGELQVPADALWGAQTQRAVQNFPVSGQPMPRGFIRALGLIKAAAAGVNAELGLLPKSICKTVQAAALQ
VAEGSFDAQFPIDVYQTGSGTSSNMNANEVIATLATRAGKDAVHPNDHVNLGQSSNDVVPTAIRVSALLAVQEHLQPALK
HLRKTIDKRAKSLDKIVKTGRTHLMDAMPLTFGQEFGAWSAQLRSAQGRIDDALKRLRRLPLGGTAIGTGINADPRFGGK
VAKALSSLSGARFESAENKFEGLAAQDDAVELSGQLNALAVALIKIANDLRWMNAGPLAGLGEIELPALQPGSSIMPGKV
NPVIPEATVMACAQVIGHHTAITVAGQTGNFQLNVTLPLIAYNLLDSITLLGNVSRLLAATAIAGLQVRQARVREALDRN
PILVTALNPIIGYEKAAAIAKRAYKEQRPVLDVAREDSGLSEADLRRLLDPAALTRGGIHAGGGSGG

Sequences:

>Translated_467_residues
MSERFRTEHDCMGELQVPADALWGAQTQRAVQNFPVSGQPMPRGFIRALGLIKAAAAGVNAELGLLPKSICKTVQAAALQ
VAEGSFDAQFPIDVYQTGSGTSSNMNANEVIATLATRAGKDAVHPNDHVNLGQSSNDVVPTAIRVSALLAVQEHLQPALK
HLRKTIDKRAKSLDKIVKTGRTHLMDAMPLTFGQEFGAWSAQLRSAQGRIDDALKRLRRLPLGGTAIGTGINADPRFGGK
VAKALSSLSGARFESAENKFEGLAAQDDAVELSGQLNALAVALIKIANDLRWMNAGPLAGLGEIELPALQPGSSIMPGKV
NPVIPEATVMACAQVIGHHTAITVAGQTGNFQLNVTLPLIAYNLLDSITLLGNVSRLLAATAIAGLQVRQARVREALDRN
PILVTALNPIIGYEKAAAIAKRAYKEQRPVLDVAREDSGLSEADLRRLLDPAALTRGGIHAGGGSGG
>Mature_466_residues
SERFRTEHDCMGELQVPADALWGAQTQRAVQNFPVSGQPMPRGFIRALGLIKAAAAGVNAELGLLPKSICKTVQAAALQV
AEGSFDAQFPIDVYQTGSGTSSNMNANEVIATLATRAGKDAVHPNDHVNLGQSSNDVVPTAIRVSALLAVQEHLQPALKH
LRKTIDKRAKSLDKIVKTGRTHLMDAMPLTFGQEFGAWSAQLRSAQGRIDDALKRLRRLPLGGTAIGTGINADPRFGGKV
AKALSSLSGARFESAENKFEGLAAQDDAVELSGQLNALAVALIKIANDLRWMNAGPLAGLGEIELPALQPGSSIMPGKVN
PVIPEATVMACAQVIGHHTAITVAGQTGNFQLNVTLPLIAYNLLDSITLLGNVSRLLAATAIAGLQVRQARVREALDRNP
ILVTALNPIIGYEKAAAIAKRAYKEQRPVLDVAREDSGLSEADLRRLLDPAALTRGGIHAGGGSGG

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=455, Percent_Identity=46.8131868131868, Blast_Score=397, Evalue=1e-110,
Organism=Escherichia coli, GI1787896, Length=463, Percent_Identity=46.2203023758099, Blast_Score=406, Evalue=1e-114,
Organism=Escherichia coli, GI87082375, Length=468, Percent_Identity=38.8888888888889, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI1790398, Length=273, Percent_Identity=30.03663003663, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17553882, Length=456, Percent_Identity=45.1754385964912, Blast_Score=385, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI32565146, Length=321, Percent_Identity=44.2367601246106, Blast_Score=271, Evalue=7e-73,
Organism=Saccharomyces cerevisiae, GI6324993, Length=461, Percent_Identity=45.9869848156182, Blast_Score=414, Evalue=1e-116,
Organism=Drosophila melanogaster, GI78710009, Length=460, Percent_Identity=47.1739130434783, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24640179, Length=462, Percent_Identity=46.5367965367965, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24640177, Length=462, Percent_Identity=46.5367965367965, Blast_Score=407, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24662684, Length=459, Percent_Identity=45.5337690631808, Blast_Score=387, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24583245, Length=464, Percent_Identity=39.8706896551724, Blast_Score=372, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49187; Mature: 49056

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERFRTEHDCMGELQVPADALWGAQTQRAVQNFPVSGQPMPRGFIRALGLIKAAAAGVN
CCCCCCCCHHCCCCCCCCHHHHHCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCC
AELGLLPKSICKTVQAAALQVAEGSFDAQFPIDVYQTGSGTSSNMNANEVIATLATRAGK
CHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCC
DAVHPNDHVNLGQSSNDVVPTAIRVSALLAVQEHLQPALKHLRKTIDKRAKSLDKIVKTG
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RTHLMDAMPLTFGQEFGAWSAQLRSAQGRIDDALKRLRRLPLGGTAIGTGINADPRFGGK
HHHHHHHCCHHHCHHHCHHHHHHHHHCCHHHHHHHHHHHCCCCCCEECCCCCCCCCCCHH
VAKALSSLSGARFESAENKFEGLAAQDDAVELSGQLNALAVALIKIANDLRWMNAGPLAG
HHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCC
LGEIELPALQPGSSIMPGKVNPVIPEATVMACAQVIGHHTAITVAGQTGNFQLNVTLPLI
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEHHHH
AYNLLDSITLLGNVSRLLAATAIAGLQVRQARVREALDRNPILVTALNPIIGYEKAAAIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHH
KRAYKEQRPVLDVAREDSGLSEADLRRLLDPAALTRGGIHAGGGSGG
HHHHHHCCCHHHHHHCCCCCCHHHHHHHHCHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SERFRTEHDCMGELQVPADALWGAQTQRAVQNFPVSGQPMPRGFIRALGLIKAAAAGVN
CCCCCCCHHCCCCCCCCHHHHHCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCC
AELGLLPKSICKTVQAAALQVAEGSFDAQFPIDVYQTGSGTSSNMNANEVIATLATRAGK
CHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCC
DAVHPNDHVNLGQSSNDVVPTAIRVSALLAVQEHLQPALKHLRKTIDKRAKSLDKIVKTG
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RTHLMDAMPLTFGQEFGAWSAQLRSAQGRIDDALKRLRRLPLGGTAIGTGINADPRFGGK
HHHHHHHCCHHHCHHHCHHHHHHHHHCCHHHHHHHHHHHCCCCCCEECCCCCCCCCCCHH
VAKALSSLSGARFESAENKFEGLAAQDDAVELSGQLNALAVALIKIANDLRWMNAGPLAG
HHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCC
LGEIELPALQPGSSIMPGKVNPVIPEATVMACAQVIGHHTAITVAGQTGNFQLNVTLPLI
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEHHHH
AYNLLDSITLLGNVSRLLAATAIAGLQVRQARVREALDRNPILVTALNPIIGYEKAAAIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHH
KRAYKEQRPVLDVAREDSGLSEADLRRLLDPAALTRGGIHAGGGSGG
HHHHHHCCCHHHHHHCCCCCCHHHHHHHHCHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]