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The map label for this gene is hpt [H]

Identifier: 84623420

GI number: 84623420

Start: 1948756

End: 1949310

Strand: Direct

Name: hpt [H]

Synonym: XOO_1763

Alternate gene names: 84623420

Gene position: 1948756-1949310 (Clockwise)

Preceding gene: 84623419

Following gene: 84623421

Centisome position: 39.45

GC content: 66.67

Gene sequence:

>555_bases
ATGTCCACGCTCACCATTTCCCAGGCCCTGGCCCAAGCCGATCTGCTGGTCGACCGTCCGGCCATCGATGCCGCCGTCGC
CACCATCGCCGATGCGATCGCGCGCGACTATGCCGGCGAAGTGCCGGTGTATCTGACCATCATGCACGGCGCGCTGCCAT
TCTCCGGCCAGCTGGCGCTGGAGCTGGGCGCACGCGGCCAGGACCTGCAATTCGATTACCTGCATGCCACGCGCTACCGC
GGCGAGACCACCGGCGGAGAGCTGGTGTGGAAGCACCGCCCGGCCACTGCGCTGTTCGGCCGCCGCGTGATCCTGGTCGA
CGACATCCTCGACGAGGGTTACACGCTGCAGGGCGTGTGCCAGTGGTGCCTGGAGCAGGGCGCGACCGATGTGCGCGTGG
CAGTGCTGACCGTCAAGCGTCACGACCGCTGCGTGCCGGGCGTGACGGCCGATTACGTGGGCGTGGAAGTGGCCGACCGT
TACGTGTTCGGCTTCGGCATGGACGTCAACGAGCAACTGCGCGGCATTCCTGCCATCTATGCGATGAAGCAGTAA

Upstream 100 bases:

>100_bases
GCCTGATCGGCCGCGGCGCATTGGGCTGGGATGGCCTGCTCGCCGGCACCGACGTCTCATTCACCACTCCTCATTCTGCC
CATTTCGGAACAACTGCCTG

Downstream 100 bases:

>100_bases
CCCGCCGTTTTCCGCTCGCAGACGTGCGAGCTGCCGAGCGCGCCTTGCTGCGCGCACCGTCGTTGATTTGTTGCAGAGGT
CGGTTGTGTCCGCAAATTCC

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 184; Mature: 183

Protein sequence:

>184_residues
MSTLTISQALAQADLLVDRPAIDAAVATIADAIARDYAGEVPVYLTIMHGALPFSGQLALELGARGQDLQFDYLHATRYR
GETTGGELVWKHRPATALFGRRVILVDDILDEGYTLQGVCQWCLEQGATDVRVAVLTVKRHDRCVPGVTADYVGVEVADR
YVFGFGMDVNEQLRGIPAIYAMKQ

Sequences:

>Translated_184_residues
MSTLTISQALAQADLLVDRPAIDAAVATIADAIARDYAGEVPVYLTIMHGALPFSGQLALELGARGQDLQFDYLHATRYR
GETTGGELVWKHRPATALFGRRVILVDDILDEGYTLQGVCQWCLEQGATDVRVAVLTVKRHDRCVPGVTADYVGVEVADR
YVFGFGMDVNEQLRGIPAIYAMKQ
>Mature_183_residues
STLTISQALAQADLLVDRPAIDAAVATIADAIARDYAGEVPVYLTIMHGALPFSGQLALELGARGQDLQFDYLHATRYRG
ETTGGELVWKHRPATALFGRRVILVDDILDEGYTLQGVCQWCLEQGATDVRVAVLTVKRHDRCVPGVTADYVGVEVADRY
VFGFGMDVNEQLRGIPAIYAMKQ

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=163, Percent_Identity=27.6073619631902, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20098; Mature: 19967

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLTISQALAQADLLVDRPAIDAAVATIADAIARDYAGEVPVYLTIMHGALPFSGQLAL
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEE
ELGARGQDLQFDYLHATRYRGETTGGELVWKHRPATALFGRRVILVDDILDEGYTLQGVC
EECCCCCCCEEEEEEHHHCCCCCCCCEEEEEECCCHHHHCCEEEEEEHHHCCCCCHHHHH
QWCLEQGATDVRVAVLTVKRHDRCVPGVTADYVGVEVADRYVFGFGMDVNEQLRGIPAIY
HHHHHCCCCEEEEEEEEEECCCCCCCCCCCHHHHHEEECEEEEEECCCCCHHHCCCCCEE
AMKQ
EECC
>Mature Secondary Structure 
STLTISQALAQADLLVDRPAIDAAVATIADAIARDYAGEVPVYLTIMHGALPFSGQLAL
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEE
ELGARGQDLQFDYLHATRYRGETTGGELVWKHRPATALFGRRVILVDDILDEGYTLQGVC
EECCCCCCCEEEEEEHHHCCCCCCCCEEEEEECCCHHHHCCEEEEEEHHHCCCCCHHHHH
QWCLEQGATDVRVAVLTVKRHDRCVPGVTADYVGVEVADRYVFGFGMDVNEQLRGIPAIY
HHHHHCCCCEEEEEEEEEECCCCCCCCCCCHHHHHEEECEEEEEECCCCCHHHCCCCCEE
AMKQ
EECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]