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The map label for this gene is napA [H]

Identifier: 84623102

GI number: 84623102

Start: 1573491

End: 1574756

Strand: Direct

Name: napA [H]

Synonym: XOO_1445

Alternate gene names: 84623102

Gene position: 1573491-1574756 (Clockwise)

Preceding gene: 84623101

Following gene: 84623105

Centisome position: 31.85

GC content: 63.27

Gene sequence:

>1266_bases
ATGACCACTGCGCAGATGTCGGTGTATTTCTTTTTGCAGGCTGCCGCGATCTTGCTGGTGTGTCGGCTGGTCGGCATGCT
GGCCAAGCGCCTCGGACAGCCGCAGGTGGTGGGCGAAATGATTGCCGGCGTGATGCTGGGGCCCTCGCTGTTCGGCTTGC
TGGCACCTGGCGCGCAGGCGGCCTTGTTCCCCAAGCAGACCATGGACGTGCTGTACGTGTTCGCGCAGTTCGGCGTGGGC
ATGTACATGTTTCTGGTCGGTACCGATTTTCGCAGCGATCACTTTCGCGCGCGCTATCGCAGCGCGATGAGCGTGTCGCT
GGCGGGCATCGCGGTGCCGTTCCTGCTGGCGTTTGCCATGTGCCCATGGTTGATCAACGTGGAAGGCCTGTTCTCGGAAA
AGGCCAAGCTGATGGAAGCGTCGCTGTTCCTGGGCGCGGCGATCGCGATCACCGCCTTCCCGATGCTGGCACGCATCATC
CACGAGCGCGGTCTGGCCACTAGCCCTTTGGGGACCTTGGCGTTGACCGCTGGTGCGTTCGACGATGCGTCTGCGTGGTG
CATTTTGGCCGTGGTGCTGGCCAGCTTCGGCGGCAGTTGGGGCAGTGCCTACCTGGCCATCGGCGGCGGCATTGGGTATG
CGGTTTTCATGATTTTCGTCGGCCGGCATCTGCTCAAGCGGCTGGCCGATCATGTGGTGCCCGGCCAGCCGCTGAGCAAT
AGTGTGTTGGCAGTGGTGCTGATCCTGTTCTGCGTCAGCGCCTGGGCGATGGACGCGATCGGTATCCACGCGGTCTTCGG
TGGTTTCCTGCTCGGCGTCTGCCTGCCCAGAGGCGCATTGACCGAGAAGCTGCGCGAGATGCTGCAGCCGTTCGTCGTGG
TCTTGCTGCTGCCGATGTTCTTCACCTATTCGGGCTTGAAAACCCAGCTCAGCGTGTTGCTGCAGCCGCAGATCATGCTG
GCCGGCGTGGCGATCCTGGCCGCCTCGTTCATCGGCAAGGGCGTGGCCTGCTGGGCAGCGGCGCGTACGACCGGCGAGAA
CAACCGCGACGCGATGGCGATCGGCGCGCTGATGAATGCACGCGGGCTGATGGAGCTGATCATCATCAACATCGGCTTGC
AGGCGGGTGTGATCGAACAAGGCCTGTTCTCGGTGCTGGTGCTGATGGCGATCCTGTCCACGTTGATGGCCACGCCGTTG
TTCAACTGGATCATGCGTCGCCACGCCCACGTGAGCGACGCGGTGCCGAGCCTGCAATCGCGGTGA

Upstream 100 bases:

>100_bases
GCGCGCGCTTGGGCCCGGATAGCCACCGGCAACTGCATGCTATCGAAGCGCGGCATGTCCGGTTACGATCTGCGCACTTT
TCAGGGATGTTGCCGCACGC

Downstream 100 bases:

>100_bases
TAGCGCGCAGTTGTCTGCTGTGGCCGGCAACTGCAGCGGCGTGCGCGTTTGGGGGGCGTCAACGCCCCAGCGGTAACCGC
ACGCCGGCCAGCAGGCCACC

Product: cation:proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MTTAQMSVYFFLQAAAILLVCRLVGMLAKRLGQPQVVGEMIAGVMLGPSLFGLLAPGAQAALFPKQTMDVLYVFAQFGVG
MYMFLVGTDFRSDHFRARYRSAMSVSLAGIAVPFLLAFAMCPWLINVEGLFSEKAKLMEASLFLGAAIAITAFPMLARII
HERGLATSPLGTLALTAGAFDDASAWCILAVVLASFGGSWGSAYLAIGGGIGYAVFMIFVGRHLLKRLADHVVPGQPLSN
SVLAVVLILFCVSAWAMDAIGIHAVFGGFLLGVCLPRGALTEKLREMLQPFVVVLLLPMFFTYSGLKTQLSVLLQPQIML
AGVAILAASFIGKGVACWAAARTTGENNRDAMAIGALMNARGLMELIIINIGLQAGVIEQGLFSVLVLMAILSTLMATPL
FNWIMRRHAHVSDAVPSLQSR

Sequences:

>Translated_421_residues
MTTAQMSVYFFLQAAAILLVCRLVGMLAKRLGQPQVVGEMIAGVMLGPSLFGLLAPGAQAALFPKQTMDVLYVFAQFGVG
MYMFLVGTDFRSDHFRARYRSAMSVSLAGIAVPFLLAFAMCPWLINVEGLFSEKAKLMEASLFLGAAIAITAFPMLARII
HERGLATSPLGTLALTAGAFDDASAWCILAVVLASFGGSWGSAYLAIGGGIGYAVFMIFVGRHLLKRLADHVVPGQPLSN
SVLAVVLILFCVSAWAMDAIGIHAVFGGFLLGVCLPRGALTEKLREMLQPFVVVLLLPMFFTYSGLKTQLSVLLQPQIML
AGVAILAASFIGKGVACWAAARTTGENNRDAMAIGALMNARGLMELIIINIGLQAGVIEQGLFSVLVLMAILSTLMATPL
FNWIMRRHAHVSDAVPSLQSR
>Mature_420_residues
TTAQMSVYFFLQAAAILLVCRLVGMLAKRLGQPQVVGEMIAGVMLGPSLFGLLAPGAQAALFPKQTMDVLYVFAQFGVGM
YMFLVGTDFRSDHFRARYRSAMSVSLAGIAVPFLLAFAMCPWLINVEGLFSEKAKLMEASLFLGAAIAITAFPMLARIIH
ERGLATSPLGTLALTAGAFDDASAWCILAVVLASFGGSWGSAYLAIGGGIGYAVFMIFVGRHLLKRLADHVVPGQPLSNS
VLAVVLILFCVSAWAMDAIGIHAVFGGFLLGVCLPRGALTEKLREMLQPFVVVLLLPMFFTYSGLKTQLSVLLQPQIMLA
GVAILAASFIGKGVACWAAARTTGENNRDAMAIGALMNARGLMELIIINIGLQAGVIEQGLFSVLVLMAILSTLMATPLF
NWIMRRHAHVSDAVPSLQSR

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6322367, Length=404, Percent_Identity=31.6831683168317, Blast_Score=182, Evalue=9e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 44896; Mature: 44764

Theoretical pI: Translated: 9.25; Mature: 9.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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C
>Mature Secondary Structure 
TTAQMSVYFFLQAAAILLVCRLVGMLAKRLGQPQVVGEMIAGVMLGPSLFGLLAPGAQA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCH
ALFPKQTMDVLYVFAQFGVGMYMFLVGTDFRSDHFRARYRSAMSVSLAGIAVPFLLAFAM
HCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CPWLINVEGLFSEKAKLMEASLFLGAAIAITAFPMLARIIHERGLATSPLGTLALTAGAF
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEECCCC
DDASAWCILAVVLASFGGSWGSAYLAIGGGIGYAVFMIFVGRHLLKRLADHVVPGQPLSN
CCHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
SVLAVVLILFCVSAWAMDAIGIHAVFGGFLLGVCLPRGALTEKLREMLQPFVVVLLLPMF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
FTYSGLKTQLSVLLQPQIMLAGVAILAASFIGKGVACWAAARTTGENNRDAMAIGALMNA
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHH
RGLMELIIINIGLQAGVIEQGLFSVLVLMAILSTLMATPLFNWIMRRHAHVSDAVPSLQS
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]