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The map label for this gene is tetA [H]

Identifier: 84621919

GI number: 84621919

Start: 287731

End: 289035

Strand: Direct

Name: tetA [H]

Synonym: XOO_0262

Alternate gene names: 84621919

Gene position: 287731-289035 (Clockwise)

Preceding gene: 84621918

Following gene: 84621920

Centisome position: 5.82

GC content: 67.2

Gene sequence:

>1305_bases
ATGACTCTCCCACCCGATTCCGCTCCCGCCCCGGGCCGGCGCCGCGCCGCACTGATCTTCATCTTCATCACCGTCCTGAT
CGACGTGCTGTCGTTCGGCGTGATCATTCCGGTGCTGCCGGGCCTGGTGCGGCACTTTACCGGTGGCGATTACGTGCAGG
CCGCGGCCTGGATCGGCTGGTTCGGCTTTCTGTTCGCCGCCATCCAGTTCGTCTGCTCGCCGTTGCAGGGCGCGCTCTCC
GACCGCTTCGGTCGCCGCCCGGTGATCCTGCTCTCGTGCCTGGGTCTGGGTCTGGACTTCATCCTGATGGCCGTCGCCCA
CAGCCTGCCCATGCTGCTGCTGGCACGGGTGATCTCCGGCGTGTGCTCGGCCAGCTTCTCCACCGCCAACGCCTACATCG
CCGACGTCACCGCCTCCGACCAACGCGCCGGCGCGTTCGGCATGCTCGGTCCCGTATTCGGCATTGGCCTCGTCGCTGGC
CCGTTGATCGGTGGTTGGCTGGGCAGCATGGGGTTACGCTGGCCGTTCTGGTTTGCCGCCGGCTTGGCCTTGTTGAATGT
GCTGTACGGCTGGTTCGTGCTGCCCGAATCGCTGCCCGTCGAACGCCGCACCGCACGGCTGGATTGGTCGCATGCCAATC
CACTTGGCGCGCTCAAGCTGCTGCGCCGCTATCCGCAGGTGTTCGGCCTGGCCTCGGTGGTGTTCCTGGCCAACCTGGCG
CACTACGTGTATCCCAGCATCTTCGTGCTGTTCGCCGGCTACCAATATCACTGGGGCCCGCGCGAAGTGAGTTGGGTACT
GGCCGGCGTCGGCGTGTGCAGCATCATCGTCAACGTGTTGCTGGTCGGCCGCCTGGTGCGCTGGCTCGGCGAACCCCGCG
CCTTGCTGCTGGGGCTGGGCTGCGGGGTGATCGGCTTTGTCATCTATGGGCTGGCCGATAGCGGCGCCGCGTTCCTGATC
GGGGTGCCGATCAGCGCGTTGTGGGCGCTCGCCGCCCCTTCCGCGCAAGCCCTGATCACCCGCGAGGTCGGCGCCGATGC
GCAAGGTCGCGTGCAGGGCGCGCACCGGTCTGGTCAGCCTGGCCGGCATCGCCGGCCCGCTGTTGTTCGCCAATGTGTTC
GCCTTGTTTATCGGCAGCGGTGCGCCACTGCATCTGCCCGGCGCACCATGGTTGCTGGCCGGTGTGCTGCTCGCCGCAGG
CTGGGGCATGGCCTGGAAACGGGCAGGGCGGGGCACCGGCACCGCGGCTGCAACGCAGGGATAAAGACAACCTATTCAGC
TTGCGCTCGCGTCCGCTTTTTCTGA

Upstream 100 bases:

>100_bases
CAGCATCCAAGCTCCAACTCCGTCACGTTGAGCCTGCCTCGGCCAACAGACCCAGCGCTTCCCTGGCTACACTCGCCGCT
TCGCCCAACTGCGCCGCGCG

Downstream 100 bases:

>100_bases
TTTGCGCAAGCGCTGCTAGGCTGGTGTCCTTCGTGCCGCGGCACTGCCTTGAGCTCTTAATGTCTTCCGATGCACTGGCA
GTTCCCCCATCGGCCGCGCT

Product: tetracycline-efflux transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: TetA(A) [H]

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MTLPPDSAPAPGRRRAALIFIFITVLIDVLSFGVIIPVLPGLVRHFTGGDYVQAAAWIGWFGFLFAAIQFVCSPLQGALS
DRFGRRPVILLSCLGLGLDFILMAVAHSLPMLLLARVISGVCSASFSTANAYIADVTASDQRAGAFGMLGPVFGIGLVAG
PLIGGWLGSMGLRWPFWFAAGLALLNVLYGWFVLPESLPVERRTARLDWSHANPLGALKLLRRYPQVFGLASVVFLANLA
HYVYPSIFVLFAGYQYHWGPREVSWVLAGVGVCSIIVNVLLVGRLVRWLGEPRALLLGLGCGVIGFVIYGLADSGAAFLI
GVPISALWALAAPSAQALITREVGADAQGRVQGAHRSGQPGRHRRPAVVRQCVRLVYRQRCATASARRTMVAGRCAARRR
LGHGLETGRAGHRHRGCNAGIKTTYSACARVRFF

Sequences:

>Translated_434_residues
MTLPPDSAPAPGRRRAALIFIFITVLIDVLSFGVIIPVLPGLVRHFTGGDYVQAAAWIGWFGFLFAAIQFVCSPLQGALS
DRFGRRPVILLSCLGLGLDFILMAVAHSLPMLLLARVISGVCSASFSTANAYIADVTASDQRAGAFGMLGPVFGIGLVAG
PLIGGWLGSMGLRWPFWFAAGLALLNVLYGWFVLPESLPVERRTARLDWSHANPLGALKLLRRYPQVFGLASVVFLANLA
HYVYPSIFVLFAGYQYHWGPREVSWVLAGVGVCSIIVNVLLVGRLVRWLGEPRALLLGLGCGVIGFVIYGLADSGAAFLI
GVPISALWALAAPSAQALITREVGADAQGRVQGAHRSGQPGRHRRPAVVRQCVRLVYRQRCATASARRTMVAGRCAARRR
LGHGLETGRAGHRHRGCNAGIKTTYSACARVRFF
>Mature_433_residues
TLPPDSAPAPGRRRAALIFIFITVLIDVLSFGVIIPVLPGLVRHFTGGDYVQAAAWIGWFGFLFAAIQFVCSPLQGALSD
RFGRRPVILLSCLGLGLDFILMAVAHSLPMLLLARVISGVCSASFSTANAYIADVTASDQRAGAFGMLGPVFGIGLVAGP
LIGGWLGSMGLRWPFWFAAGLALLNVLYGWFVLPESLPVERRTARLDWSHANPLGALKLLRRYPQVFGLASVVFLANLAH
YVYPSIFVLFAGYQYHWGPREVSWVLAGVGVCSIIVNVLLVGRLVRWLGEPRALLLGLGCGVIGFVIYGLADSGAAFLIG
VPISALWALAAPSAQALITREVGADAQGRVQGAHRSGQPGRHRRPAVVRQCVRLVYRQRCATASARRTMVAGRCAARRRL
GHGLETGRAGHRHRGCNAGIKTTYSACARVRFF

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI39753965, Length=292, Percent_Identity=31.1643835616438, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI94721311, Length=338, Percent_Identity=29.585798816568, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI225703104, Length=167, Percent_Identity=34.1317365269461, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI225703102, Length=167, Percent_Identity=34.1317365269461, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71996331, Length=350, Percent_Identity=25.1428571428571, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17551570, Length=232, Percent_Identity=24.5689655172414, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24656463, Length=342, Percent_Identity=28.0701754385965, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24656468, Length=342, Percent_Identity=28.0701754385965, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI161080926, Length=342, Percent_Identity=28.0701754385965, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI161080924, Length=342, Percent_Identity=28.0701754385965, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI21357569, Length=341, Percent_Identity=28.1524926686217, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI17738085, Length=396, Percent_Identity=25.2525252525253, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI221513297, Length=339, Percent_Identity=26.5486725663717, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24667557, Length=165, Percent_Identity=29.0909090909091, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24667561, Length=168, Percent_Identity=27.9761904761905, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 46667; Mature: 46535

Theoretical pI: Translated: 11.40; Mature: 11.40

Prosite motif: PS00141 ASP_PROTEASE ; PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHCCC
>Mature Secondary Structure 
TLPPDSAPAPGRRRAALIFIFITVLIDVLSFGVIIPVLPGLVRHFTGGDYVQAAAWIGW
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
FGFLFAAIQFVCSPLQGALSDRFGRRPVILLSCLGLGLDFILMAVAHSLPMLLLARVISG
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VCSASFSTANAYIADVTASDQRAGAFGMLGPVFGIGLVAGPLIGGWLGSMGLRWPFWFAA
HHHCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
GLALLNVLYGWFVLPESLPVERRTARLDWSHANPLGALKLLRRYPQVFGLASVVFLANLA
HHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
HYVYPSIFVLFAGYQYHWGPREVSWVLAGVGVCSIIVNVLLVGRLVRWLGEPRALLLGLG
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
CGVIGFVIYGLADSGAAFLIGVPISALWALAAPSAQALITREVGADAQGRVQGAHRSGQP
HHHHHHHHHHHCCCCCEEEEECCHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCC
GRHRRPAVVRQCVRLVYRQRCATASARRTMVAGRCAARRRLGHGLETGRAGHRHRGCNAG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
IKTTYSACARVRFF
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312499; 6310527 [H]