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The map label for this gene is gch3

Identifier: 84490186

GI number: 84490186

Start: 1579313

End: 1580080

Strand: Direct

Name: gch3

Synonym: Msp_1404

Alternate gene names: 84490186

Gene position: 1579313-1580080 (Clockwise)

Preceding gene: 84490185

Following gene: 84490187

Centisome position: 89.36

GC content: 32.29

Gene sequence:

>768_bases
ATGATACAAGTTACATTAATACAAATAGATAATTATGGGCCTTGGACAGTTACACCAGGACCAAGAGCAGAACCAGATTT
ACAAACATTACAATCAAGATTATATGGAGATTTAGAACGCGAATTTGGTGCACATGGAGCAATAGTATTTTTTAATAGAT
TTGATAATCTTATTGCAATAAGTAATGGTATGGATTATGATGATCATCTACTTATTCAACAATCTATAAGAAATAGATAT
CCTATCACTATAAGTATGGGGGTAGGTACAGCAGATACTGCATATGAAGCTCAAAAAATCGCTACTAAGATGATTCAAAA
TGGTGGTGGAGCTCAAAGTGCTAATAGATGTGAAGTTTTAAATATTGATTCATTAGCAGATGATGATAATAGTCTTGTCC
AAATTGCCCATATTGATATTAATGATATAACAAATACATTAACTGATATTGAAACTGCCTTTGATACATCTATAAAGGTA
TATGAAGTACTTCTTGCATTGATGGATGAACTTGCAAAAATTGGAGGTATGTGTTTTTTCATAGGTGGAGATAATTATAT
GGCTCCTACTAATGGAATATCTAAAGATCAATTACGAGAGGCTCTAAAAGTTGTTGATAAAAAAACTGGTGTTACCTTAA
AAGCAGGAATTGGTGTTGCAAAACAGGCAGGACGTGCTGCTGATTTAGCAGACATTGGATTAGAGGATATTAGAGCAGAA
CTTGTAGATGATTCTGTCTTGTTATTTAATGATTTAGATGAATATTAA

Upstream 100 bases:

>100_bases
CTAGCAAAAATGATACTTGAATAAATAATTATAATTTAAATTCATATATTGAAGTAAAAAATTGGAGAAAATTTTTTTAA
AGAATAATAAAAGTGATTGA

Downstream 100 bases:

>100_bases
TAACCATCCTTTTTTTTATTTTTATGAAAACTATTTTTTATTAAAATTATACTAAAATAAATGTTTATGTGAGAGGTTAT
TATTATGAATGTATTATCTG

Product: GTP cyclohydrolase III

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MIQVTLIQIDNYGPWTVTPGPRAEPDLQTLQSRLYGDLEREFGAHGAIVFFNRFDNLIAISNGMDYDDHLLIQQSIRNRY
PITISMGVGTADTAYEAQKIATKMIQNGGGAQSANRCEVLNIDSLADDDNSLVQIAHIDINDITNTLTDIETAFDTSIKV
YEVLLALMDELAKIGGMCFFIGGDNYMAPTNGISKDQLREALKVVDKKTGVTLKAGIGVAKQAGRAADLADIGLEDIRAE
LVDDSVLLFNDLDEY

Sequences:

>Translated_255_residues
MIQVTLIQIDNYGPWTVTPGPRAEPDLQTLQSRLYGDLEREFGAHGAIVFFNRFDNLIAISNGMDYDDHLLIQQSIRNRY
PITISMGVGTADTAYEAQKIATKMIQNGGGAQSANRCEVLNIDSLADDDNSLVQIAHIDINDITNTLTDIETAFDTSIKV
YEVLLALMDELAKIGGMCFFIGGDNYMAPTNGISKDQLREALKVVDKKTGVTLKAGIGVAKQAGRAADLADIGLEDIRAE
LVDDSVLLFNDLDEY
>Mature_255_residues
MIQVTLIQIDNYGPWTVTPGPRAEPDLQTLQSRLYGDLEREFGAHGAIVFFNRFDNLIAISNGMDYDDHLLIQQSIRNRY
PITISMGVGTADTAYEAQKIATKMIQNGGGAQSANRCEVLNIDSLADDDNSLVQIAHIDINDITNTLTDIETAFDTSIKV
YEVLLALMDELAKIGGMCFFIGGDNYMAPTNGISKDQLREALKVVDKKTGVTLKAGIGVAKQAGRAADLADIGLEDIRAE
LVDDSVLLFNDLDEY

Specific function: Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity

COG id: COG2429

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the archaeal-type GTP cyclohydrolase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCH3_METST (Q2NEH8)

Other databases:

- EMBL:   CP000102
- RefSeq:   YP_448418.1
- ProteinModelPortal:   Q2NEH8
- SMR:   Q2NEH8
- STRING:   Q2NEH8
- GeneID:   3854880
- GenomeReviews:   CP000102_GR
- KEGG:   mst:Msp_1404
- NMPDR:   fig|339860.6.peg.1342
- eggNOG:   arNOG04785
- HOGENOM:   HBG497452
- OMA:   FIGGDNF
- ProtClustDB:   PRK02240
- BioCyc:   MSTA339860:MSP_1404-MONOMER
- HAMAP:   MF_00608
- InterPro:   IPR007839
- PIRSF:   PIRSF009265
- ProDom:   PD313320

Pfam domain/function: PF05165 GGDN

EC number: =3.5.4.29

Molecular weight: Translated: 27880; Mature: 27880

Theoretical pI: Translated: 4.13; Mature: 4.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQVTLIQIDNYGPWTVTPGPRAEPDLQTLQSRLYGDLEREFGAHGAIVFFNRFDNLIAI
CEEEEEEEEECCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEE
SNGMDYDDHLLIQQSIRNRYPITISMGVGTADTAYEAQKIATKMIQNGGGAQSANRCEVL
ECCCCCCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
NIDSLADDDNSLVQIAHIDINDITNTLTDIETAFDTSIKVYEVLLALMDELAKIGGMCFF
ECCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCEEEE
IGGDNYMAPTNGISKDQLREALKVVDKKTGVTLKAGIGVAKQAGRAADLADIGLEDIRAE
EECCCEECCCCCCCHHHHHHHHHHHHHHCCEEEEECCCHHHHCCCCCCHHHCCHHHHHHH
LVDDSVLLFNDLDEY
HHCCCEEEECCCCCC
>Mature Secondary Structure
MIQVTLIQIDNYGPWTVTPGPRAEPDLQTLQSRLYGDLEREFGAHGAIVFFNRFDNLIAI
CEEEEEEEEECCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEE
SNGMDYDDHLLIQQSIRNRYPITISMGVGTADTAYEAQKIATKMIQNGGGAQSANRCEVL
ECCCCCCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
NIDSLADDDNSLVQIAHIDINDITNTLTDIETAFDTSIKVYEVLLALMDELAKIGGMCFF
ECCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCEEEE
IGGDNYMAPTNGISKDQLREALKVVDKKTGVTLKAGIGVAKQAGRAADLADIGLEDIRAE
EECCCEECCCCCCCHHHHHHHHHHHHHHCCEEEEECCCHHHHCCCCCCHHHCCHHHHHHH
LVDDSVLLFNDLDEY
HHCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA