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The map label for this gene is rio1 [H]

Identifier: 84490125

GI number: 84490125

Start: 1504280

End: 1505059

Strand: Direct

Name: rio1 [H]

Synonym: Msp_1337

Alternate gene names: 84490125

Gene position: 1504280-1505059 (Clockwise)

Preceding gene: 84490124

Following gene: 84490126

Centisome position: 85.11

GC content: 29.87

Gene sequence:

>780_bases
TTGAATAAACACTATATTGATGCAGATAAGCAAATGAGAAAATTAGAAGAAACTAAAAGATTAAAAAGTGTTGAAGATAA
ACAAGTTTCTAGTGAAGTTTTTGATGACAAAACATTAAAAGTTCTCTATAAACTTGCAAATAAGGGATATATTCGAAGTT
TAAATGGAGTTATAAGTACTGGTAAGGAAGCAAATGTATTTCTTGGTATTGATGATGATGACAATCCTGTTGCTGTGAAA
ATATATAGGGTTATGACACTTGATTTTAAAAAGATTAAGGAATATATTGCTGGTGATCCTAGATTCAAGAGTCATGGAAA
TAATACAAGACAGATTATTACTGCATGGACTCAGAAGGAATTTAAAAATCTTAGTAGGTTATATAAGTTAGGTCTTAGAG
TTCCTGAACCCTATATTGCCATGGAAAATGTGTTGGTAATGGAATACTTAGAATACTCTGATGATGATAATAGTGCAGCA
CCTCCACTGAGTAAGGCCAAATTAGATAATGCTAGTGAGGTTTTTGAGGAGATTATTGATTTTATGGATGTTGCATATAA
CAAGGCACATCTTGTTCATGGTGATCTTTCTAGATACAATATTCTCTTATCACATGGACACCCCTATATTATTGATGTTT
CACAATCTACACTAGATAGTCATCCTTCAAGTAGAAGTTTACTTGAACGCGATATTAAAAATATACTATATGATAGTAAG
AAATTCAAATTAAATTTAACATATGAATATGTTAGAAATAGAATTATTAAAAATGACTAA

Upstream 100 bases:

>100_bases
CTGTTTTATATATTGTATCAAGAGTGTTGTTATATATACAAAAAAAATATTAGGTAATAAAAATACAAAAGAATAATAAG
AAGTAGAAGAGGGTTGTTAC

Downstream 100 bases:

>100_bases
GTATATTCTTGGATAGTATGTAGAAGCAATATTTTACATATACTTTTTTATAATAGTTAAAACAAAGTAAGATACAGAGA
ATTTAGAAATAATAAATATA

Product: serine/threonine protein kinase

Products: NA

Alternate protein names: AfRio1 [H]

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MNKHYIDADKQMRKLEETKRLKSVEDKQVSSEVFDDKTLKVLYKLANKGYIRSLNGVISTGKEANVFLGIDDDDNPVAVK
IYRVMTLDFKKIKEYIAGDPRFKSHGNNTRQIITAWTQKEFKNLSRLYKLGLRVPEPYIAMENVLVMEYLEYSDDDNSAA
PPLSKAKLDNASEVFEEIIDFMDVAYNKAHLVHGDLSRYNILLSHGHPYIIDVSQSTLDSHPSSRSLLERDIKNILYDSK
KFKLNLTYEYVRNRIIKND

Sequences:

>Translated_259_residues
MNKHYIDADKQMRKLEETKRLKSVEDKQVSSEVFDDKTLKVLYKLANKGYIRSLNGVISTGKEANVFLGIDDDDNPVAVK
IYRVMTLDFKKIKEYIAGDPRFKSHGNNTRQIITAWTQKEFKNLSRLYKLGLRVPEPYIAMENVLVMEYLEYSDDDNSAA
PPLSKAKLDNASEVFEEIIDFMDVAYNKAHLVHGDLSRYNILLSHGHPYIIDVSQSTLDSHPSSRSLLERDIKNILYDSK
KFKLNLTYEYVRNRIIKND
>Mature_259_residues
MNKHYIDADKQMRKLEETKRLKSVEDKQVSSEVFDDKTLKVLYKLANKGYIRSLNGVISTGKEANVFLGIDDDDNPVAVK
IYRVMTLDFKKIKEYIAGDPRFKSHGNNTRQIITAWTQKEFKNLSRLYKLGLRVPEPYIAMENVLVMEYLEYSDDDNSAA
PPLSKAKLDNASEVFEEIIDFMDVAYNKAHLVHGDLSRYNILLSHGHPYIIDVSQSTLDSHPSSRSLLERDIKNILYDSK
KFKLNLTYEYVRNRIIKND

Specific function: Autophosphorylation of the rio1 protein is not necessary for maintenance of kinase activity. Prefers ATP over GTP. The yeast ortholog is involved in ribosome biogenesis [H]

COG id: COG1718

COG function: function code TD; Serine/threonine protein kinase involved in cell cycle control

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI23510356, Length=233, Percent_Identity=36.480686695279, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI22325377, Length=252, Percent_Identity=32.5396825396825, Blast_Score=130, Evalue=9e-31,
Organism=Homo sapiens, GI23510358, Length=126, Percent_Identity=37.3015873015873, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI229331971, Length=225, Percent_Identity=23.1111111111111, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI229331967, Length=225, Percent_Identity=23.1111111111111, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115532073, Length=222, Percent_Identity=37.3873873873874, Blast_Score=151, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17556977, Length=223, Percent_Identity=37.219730941704, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71989043, Length=153, Percent_Identity=38.562091503268, Blast_Score=111, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6324693, Length=246, Percent_Identity=35.3658536585366, Blast_Score=133, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6324122, Length=219, Percent_Identity=24.2009132420091, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24662811, Length=216, Percent_Identity=39.3518518518519, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI21356879, Length=216, Percent_Identity=39.3518518518519, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI19920700, Length=229, Percent_Identity=38.4279475982533, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24649986, Length=210, Percent_Identity=23.3333333333333, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR018934
- InterPro:   IPR000687
- InterPro:   IPR018935 [H]

Pfam domain/function: PF01163 RIO1 [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 30005; Mature: 30005

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: PS00109 PROTEIN_KINASE_TYR ; PS50011 PROTEIN_KINASE_DOM ; PS01121 CASPASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKHYIDADKQMRKLEETKRLKSVEDKQVSSEVFDDKTLKVLYKLANKGYIRSLNGVIST
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHCC
GKEANVFLGIDDDDNPVAVKIYRVMTLDFKKIKEYIAGDPRFKSHGNNTRQIITAWTQKE
CCCCEEEEEECCCCCCEEEEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
FKNLSRLYKLGLRVPEPYIAMENVLVMEYLEYSDDDNSAAPPLSKAKLDNASEVFEEIID
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCHHHHHHHHHH
FMDVAYNKAHLVHGDLSRYNILLSHGHPYIIDVSQSTLDSHPSSRSLLERDIKNILYDSK
HHHHHCCCCEEEECCHHHEEEEEECCCCEEEECCHHHHHCCCCHHHHHHHHHHHHHCCCC
KFKLNLTYEYVRNRIIKND
EEEEEEEHHHHHHHHCCCC
>Mature Secondary Structure
MNKHYIDADKQMRKLEETKRLKSVEDKQVSSEVFDDKTLKVLYKLANKGYIRSLNGVIST
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHCC
GKEANVFLGIDDDDNPVAVKIYRVMTLDFKKIKEYIAGDPRFKSHGNNTRQIITAWTQKE
CCCCEEEEEECCCCCCEEEEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHH
FKNLSRLYKLGLRVPEPYIAMENVLVMEYLEYSDDDNSAAPPLSKAKLDNASEVFEEIID
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCHHHHHHHHHH
FMDVAYNKAHLVHGDLSRYNILLSHGHPYIIDVSQSTLDSHPSSRSLLERDIKNILYDSK
HHHHHCCCCEEEECCHHHEEEEEECCCCEEEECCHHHHHCCCCHHHHHHHHHHHHHCCCC
KFKLNLTYEYVRNRIIKND
EEEEEEEHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]