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The map label for this gene is rph [C]

Identifier: 84490040

GI number: 84490040

Start: 1419509

End: 1420306

Strand: Direct

Name: rph [C]

Synonym: Msp_1252

Alternate gene names: 84490040

Gene position: 1419509-1420306 (Clockwise)

Preceding gene: 84490039

Following gene: 84490041

Centisome position: 80.32

GC content: 30.45

Gene sequence:

>798_bases
ATGGTAAATGTAATCTCTGAAGTTTCTAAAGAAAAAGTATTTGATTTATTAAATCAGGGAAAAAGAATTGATGATAGAAA
ATTTAGTGAATATAGAAATATTTCCATAAAAACCAATTATATTGGAAAGGCTGATGGTTCTGCAATGGTGTCTATTGGTT
GTACTACTGTGATTGTTGGAGTTAAAGCTCAAATGACAACACCATTTAATAATGCTCCAAATAGTGGTATTATCATAACA
AATACTGAGTTACTTGCCATTGCAAGTCGTAATTTTGAATATGGCCCTCCAAATAAATTTGCTGTTGAAATATCACGCGT
TGTAGATAGAGCTATTCGTGAATCTCCTGTTGTTGATTTAGATAAATTATGTGTTATTGAAGGAAGTAAATCATGGAAGT
TACATATTGATATGTATATTGTTGACTTTGATGGAAATATTATGGATGCGGCATGCCTTGGAGCTATTTGTGCACTTTTA
ACAACAAAAATTCCTACAGCAACCAGTGTAAATGGTGAGATTGTTATTGATGAAGAAAATTTAACTCCCCTTCCTATTAA
AAATAGAAGTATTTTATGTACAGTTGTGAAAATCAACAACCAGTTAATTGTTGATCCTTCAAAAATTGAGGAAATATTAA
TGGATTCAAGTGTATCATTTGGATTTAGAGAGGATGGTAGTTTATGTGCCCTTCAAAAATGTGGTCTTAATACATTAACA
CATAAGGAAGTTACAAAAGCTATGAAGATTGCAAGTATTCGTGCAAAAGAATTATTTTCTATAATTGATACTATATAA

Upstream 100 bases:

>100_bases
AAGAATTTGAAGAAGCATTAGATTTAGCTTATGATGGATGTTATTATATAAATCAACTACAAAAAGAAGCTTTACTTAGT
AAATATGGGGGTAGTTATTA

Downstream 100 bases:

>100_bases
TAACAAACTATATATTATATGATTACTAAAAATATTATATAGTTATATTATAAGGATAATAGATTTTAGGTGTCTATTAG
TTTAATTCCGAAATAATATT

Product: exosome complex RNA-binding protein Rrp42

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MVNVISEVSKEKVFDLLNQGKRIDDRKFSEYRNISIKTNYIGKADGSAMVSIGCTTVIVGVKAQMTTPFNNAPNSGIIIT
NTELLAIASRNFEYGPPNKFAVEISRVVDRAIRESPVVDLDKLCVIEGSKSWKLHIDMYIVDFDGNIMDAACLGAICALL
TTKIPTATSVNGEIVIDEENLTPLPIKNRSILCTVVKINNQLIVDPSKIEEILMDSSVSFGFREDGSLCALQKCGLNTLT
HKEVTKAMKIASIRAKELFSIIDTI

Sequences:

>Translated_265_residues
MVNVISEVSKEKVFDLLNQGKRIDDRKFSEYRNISIKTNYIGKADGSAMVSIGCTTVIVGVKAQMTTPFNNAPNSGIIIT
NTELLAIASRNFEYGPPNKFAVEISRVVDRAIRESPVVDLDKLCVIEGSKSWKLHIDMYIVDFDGNIMDAACLGAICALL
TTKIPTATSVNGEIVIDEENLTPLPIKNRSILCTVVKINNQLIVDPSKIEEILMDSSVSFGFREDGSLCALQKCGLNTLT
HKEVTKAMKIASIRAKELFSIIDTI
>Mature_265_residues
MVNVISEVSKEKVFDLLNQGKRIDDRKFSEYRNISIKTNYIGKADGSAMVSIGCTTVIVGVKAQMTTPFNNAPNSGIIIT
NTELLAIASRNFEYGPPNKFAVEISRVVDRAIRESPVVDLDKLCVIEGSKSWKLHIDMYIVDFDGNIMDAACLGAICALL
TTKIPTATSVNGEIVIDEENLTPLPIKNRSILCTVVKINNQLIVDPSKIEEILMDSSVSFGFREDGSLCALQKCGLNTLT
HKEVTKAMKIASIRAKELFSIIDTI

Specific function: Probably involved in the 3'->5' degradation of a variety of RNA species (Potential) [H]

COG id: COG2123

COG function: function code J; RNase PH-related exoribonuclease

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase PH family [H]

Homologues:

Organism=Homo sapiens, GI31415882, Length=254, Percent_Identity=33.0708661417323, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI77812672, Length=264, Percent_Identity=29.9242424242424, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI77812670, Length=264, Percent_Identity=29.9242424242424, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI189083688, Length=268, Percent_Identity=26.1194029850746, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI25144570, Length=269, Percent_Identity=26.7657992565056, Blast_Score=123, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6320486, Length=250, Percent_Identity=28, Blast_Score=108, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24642649, Length=249, Percent_Identity=27.3092369477912, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI28573444, Length=216, Percent_Identity=30.5555555555556, Blast_Score=99, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001247
- InterPro:   IPR015847
- InterPro:   IPR020869
- InterPro:   IPR020568 [H]

Pfam domain/function: PF01138 RNase_PH; PF03725 RNase_PH_C [H]

EC number: 3.1.13.-

Molecular weight: Translated: 29075; Mature: 29075

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNVISEVSKEKVFDLLNQGKRIDDRKFSEYRNISIKTNYIGKADGSAMVSIGCTTVIVG
CCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCEEEEEEEECCCCCCEEEEECCEEEEEE
VKAQMTTPFNNAPNSGIIITNTELLAIASRNFEYGPPNKFAVEISRVVDRAIRESPVVDL
EEEEEECCCCCCCCCCEEEECCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
DKLCVIEGSKSWKLHIDMYIVDFDGNIMDAACLGAICALLTTKIPTATSVNGEIVIDEEN
CCEEEEECCCCEEEEEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCC
LTPLPIKNRSILCTVVKINNQLIVDPSKIEEILMDSSVSFGFREDGSLCALQKCGLNTLT
CCCCCCCCCEEEEEEEEECCEEEECHHHHHHHHHCCCCCCCCCCCCCEEEHHHCCCCCCH
HKEVTKAMKIASIRAKELFSIIDTI
HHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVNVISEVSKEKVFDLLNQGKRIDDRKFSEYRNISIKTNYIGKADGSAMVSIGCTTVIVG
CCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCEEEEEEEECCCCCCEEEEECCEEEEEE
VKAQMTTPFNNAPNSGIIITNTELLAIASRNFEYGPPNKFAVEISRVVDRAIRESPVVDL
EEEEEECCCCCCCCCCEEEECCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
DKLCVIEGSKSWKLHIDMYIVDFDGNIMDAACLGAICALLTTKIPTATSVNGEIVIDEEN
CCEEEEECCCCEEEEEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCC
LTPLPIKNRSILCTVVKINNQLIVDPSKIEEILMDSSVSFGFREDGSLCALQKCGLNTLT
CCCCCCCCCEEEEEEEEECCEEEECHHHHHHHHHCCCCCCCCCCCCCEEEHHHCCCCCCH
HKEVTKAMKIASIRAKELFSIIDTI
HHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]