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The map label for this gene is psmA

Identifier: 84490036

GI number: 84490036

Start: 1416315

End: 1417178

Strand: Direct

Name: psmA

Synonym: Msp_1248

Alternate gene names: 84490036

Gene position: 1416315-1417178 (Clockwise)

Preceding gene: 84490035

Following gene: 84490037

Centisome position: 80.14

GC content: 32.52

Gene sequence:

>864_bases
ATGCGACAATTTTCAGAAGCAGGTTATGACAGAGCATTAACAGTATTCAGTCCAGATGGACGTTTATTCCAAATTGAATA
TGCACGAGAAGCAGTGAAAAGAGGAACTACATCTGTTGGAATTATTTCAAAAGAAGGAGTAGTTTTTGCTGTTGATAAAA
AAATTAAAAGCAAACTAATTGTTCCATCATCAATTGAAAAAATATTCAAAATAGATGATCATATTGCTACTGCTTCAAGT
GGACTTGTAGCTGATGCTAGAAGATTAATTGATATTGCTAGAAATCAAGCACAAGTAAATAAATTACAGTACCATGAACC
AATCACTGTTACAGGATTAGCAAAATATCTTGGTGACTTAGAACAAATGTACACCCAAAGTGGAGGTGTAAGACCATTTG
GTATTTCCTTAATCATTGGTGGTGTATCTGATGGAGAATGTAGAATCTATGAAACTGATCCAAGTGGTGCATTAGTTGAA
TATAAAGCTACAGCAATAGGTCTTGGAAGAGATAAAACCTTAAATTTATTTGAAGATAAGTATGAAGACGATCTTACATT
AGATGAAGCTATTGACTTAGCAATTGAAGGTATTTATGTTGCAACAGATGGTAAAGTTGCTGATGATAGTATAGAAATAT
CAGTAATTGAGAAGGAAAATGCAAAATACCGTAAATTCAATGAGGATGAAATTGAAAAATACGTTCAAAAACTCCTTGAC
CGTAAAGAACAAGAACAAAAAGACGCTGAAGAAAAAAGAAAAGCTGAAGAAGAAGCTAAAAAAGCTGAAGAAGAAGCTAA
AAAAGCTGAAGAAGAAGCTAAAGAATCCTCTGATGATGAAAATGAAGATATTAATGAAGAATAA

Upstream 100 bases:

>100_bases
ATAAGTAATTGTATACATAAATAATATATTAATAGAAAAAAGAATTTTTAAAATAAATCATAATGCTAAAATAATTAAAA
TAAAAAAGAGGTAGATATAT

Downstream 100 bases:

>100_bases
TATCTTCACACTTTTTTTTATAAGAAAAAAAAATATTTTACCACCTGAAAATCACTTGTTTTAATAAAAAATTAAACAAT
ACTTTTTTTTTAACTAAAAA

Product: proteasome subunit alpha

Products: NA

Alternate protein names: 20S proteasome alpha subunit; Proteasome core protein PsmA [H]

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MRQFSEAGYDRALTVFSPDGRLFQIEYAREAVKRGTTSVGIISKEGVVFAVDKKIKSKLIVPSSIEKIFKIDDHIATASS
GLVADARRLIDIARNQAQVNKLQYHEPITVTGLAKYLGDLEQMYTQSGGVRPFGISLIIGGVSDGECRIYETDPSGALVE
YKATAIGLGRDKTLNLFEDKYEDDLTLDEAIDLAIEGIYVATDGKVADDSIEISVIEKENAKYRKFNEDEIEKYVQKLLD
RKEQEQKDAEEKRKAEEEAKKAEEEAKKAEEEAKESSDDENEDINEE

Sequences:

>Translated_287_residues
MRQFSEAGYDRALTVFSPDGRLFQIEYAREAVKRGTTSVGIISKEGVVFAVDKKIKSKLIVPSSIEKIFKIDDHIATASS
GLVADARRLIDIARNQAQVNKLQYHEPITVTGLAKYLGDLEQMYTQSGGVRPFGISLIIGGVSDGECRIYETDPSGALVE
YKATAIGLGRDKTLNLFEDKYEDDLTLDEAIDLAIEGIYVATDGKVADDSIEISVIEKENAKYRKFNEDEIEKYVQKLLD
RKEQEQKDAEEKRKAEEEAKKAEEEAKKAEEEAKESSDDENEDINEE
>Mature_287_residues
MRQFSEAGYDRALTVFSPDGRLFQIEYAREAVKRGTTSVGIISKEGVVFAVDKKIKSKLIVPSSIEKIFKIDDHIATASS
GLVADARRLIDIARNQAQVNKLQYHEPITVTGLAKYLGDLEQMYTQSGGVRPFGISLIIGGVSDGECRIYETDPSGALVE
YKATAIGLGRDKTLNLFEDKYEDDLTLDEAIDLAIEGIYVATDGKVADDSIEISVIEKENAKYRKFNEDEIEKYVQKLLD
RKEQEQKDAEEKRKAEEEAKKAEEEAKKAEEEAKESSDDENEDINEE

Specific function: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation [H]

COG id: COG0638

COG function: function code O; 20S proteasome, alpha and beta subunits

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase T1A family [H]

Homologues:

Organism=Homo sapiens, GI68303563, Length=232, Percent_Identity=46.1206896551724, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI4506189, Length=232, Percent_Identity=44.8275862068966, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI68303561, Length=238, Percent_Identity=44.9579831932773, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI4506181, Length=232, Percent_Identity=40.948275862069, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI23110942, Length=233, Percent_Identity=38.1974248927039, Blast_Score=169, Evalue=2e-42,
Organism=Homo sapiens, GI23110944, Length=245, Percent_Identity=33.8775510204082, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI156713442, Length=234, Percent_Identity=37.6068376068376, Blast_Score=147, Evalue=8e-36,
Organism=Homo sapiens, GI4506185, Length=234, Percent_Identity=37.6068376068376, Blast_Score=147, Evalue=8e-36,
Organism=Homo sapiens, GI68303565, Length=232, Percent_Identity=40.5172413793103, Blast_Score=145, Evalue=3e-35,
Organism=Homo sapiens, GI4506183, Length=249, Percent_Identity=36.5461847389558, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI23110939, Length=247, Percent_Identity=36.4372469635627, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI23110935, Length=261, Percent_Identity=29.5019157088123, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI4506179, Length=261, Percent_Identity=29.5019157088123, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI156713444, Length=166, Percent_Identity=35.5421686746988, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI221316716, Length=110, Percent_Identity=39.0909090909091, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4506191, Length=208, Percent_Identity=27.8846153846154, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17508491, Length=227, Percent_Identity=44.4933920704846, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17508493, Length=225, Percent_Identity=36.4444444444444, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI25143215, Length=216, Percent_Identity=37.962962962963, Blast_Score=148, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17562788, Length=245, Percent_Identity=30.2040816326531, Blast_Score=131, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17562790, Length=232, Percent_Identity=33.6206896551724, Blast_Score=128, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI71998965, Length=219, Percent_Identity=32.4200913242009, Blast_Score=103, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17562792, Length=203, Percent_Identity=30.0492610837438, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324535, Length=243, Percent_Identity=40.7407407407407, Blast_Score=172, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6324938, Length=243, Percent_Identity=40.7407407407407, Blast_Score=161, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6321574, Length=213, Percent_Identity=39.906103286385, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6321692, Length=255, Percent_Identity=35.6862745098039, Blast_Score=156, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6323547, Length=246, Percent_Identity=35.7723577235772, Blast_Score=141, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6323974, Length=233, Percent_Identity=32.1888412017167, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321427, Length=234, Percent_Identity=30.7692307692308, Blast_Score=103, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24654391, Length=237, Percent_Identity=39.2405063291139, Blast_Score=191, Evalue=3e-49,
Organism=Drosophila melanogaster, GI24654389, Length=237, Percent_Identity=39.2405063291139, Blast_Score=191, Evalue=3e-49,
Organism=Drosophila melanogaster, GI21356137, Length=249, Percent_Identity=37.7510040160643, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI17737927, Length=230, Percent_Identity=40.4347826086956, Blast_Score=171, Evalue=5e-43,
Organism=Drosophila melanogaster, GI17933602, Length=232, Percent_Identity=39.6551724137931, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI19922898, Length=184, Percent_Identity=41.304347826087, Blast_Score=155, Evalue=2e-38,
Organism=Drosophila melanogaster, GI281360341, Length=244, Percent_Identity=33.6065573770492, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24586406, Length=244, Percent_Identity=33.6065573770492, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24586400, Length=244, Percent_Identity=33.6065573770492, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24586402, Length=244, Percent_Identity=33.6065573770492, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI17136420, Length=240, Percent_Identity=34.1666666666667, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24651571, Length=242, Percent_Identity=30.5785123966942, Blast_Score=124, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24652204, Length=242, Percent_Identity=35.1239669421488, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI19921232, Length=235, Percent_Identity=31.4893617021277, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI17737405, Length=184, Percent_Identity=36.9565217391304, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24584895, Length=208, Percent_Identity=27.8846153846154, Blast_Score=78, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019982
- InterPro:   IPR000426
- InterPro:   IPR001353 [H]

Pfam domain/function: PF00227 Proteasome; PF10584 Proteasome_A_N [H]

EC number: =3.4.25.1 [H]

Molecular weight: Translated: 32116; Mature: 32116

Theoretical pI: Translated: 4.39; Mature: 4.39

Prosite motif: PS00388 PROTEASOME_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQFSEAGYDRALTVFSPDGRLFQIEYAREAVKRGTTSVGIISKEGVVFAVDKKIKSKLI
CCCCCCCCCCCEEEEECCCCCEEEEHHHHHHHHCCCCEEEEEECCCEEEEECHHHHHCCC
VPSSIEKIFKIDDHIATASSGLVADARRLIDIARNQAQVNKLQYHEPITVTGLAKYLGDL
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHH
EQMYTQSGGVRPFGISLIIGGVSDGECRIYETDPSGALVEYKATAIGLGRDKTLNLFEDK
HHHHHHCCCCCEEEEEEEEECCCCCCEEEEEECCCCCEEEEEEEEEECCCCCCCHHHHHC
YEDDLTLDEAIDLAIEGIYVATDGKVADDSIEISVIEKENAKYRKFNEDEIEKYVQKLLD
CCCCCCHHHHHHHHEEEEEEEECCEECCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHH
RKEQEQKDAEEKRKAEEEAKKAEEEAKKAEEEAKESSDDENEDINEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MRQFSEAGYDRALTVFSPDGRLFQIEYAREAVKRGTTSVGIISKEGVVFAVDKKIKSKLI
CCCCCCCCCCCEEEEECCCCCEEEEHHHHHHHHCCCCEEEEEECCCEEEEECHHHHHCCC
VPSSIEKIFKIDDHIATASSGLVADARRLIDIARNQAQVNKLQYHEPITVTGLAKYLGDL
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHH
EQMYTQSGGVRPFGISLIIGGVSDGECRIYETDPSGALVEYKATAIGLGRDKTLNLFEDK
HHHHHHCCCCCEEEEEEEEECCCCCCEEEEEECCCCCEEEEEEEEEECCCCCCCHHHHHC
YEDDLTLDEAIDLAIEGIYVATDGKVADDSIEISVIEKENAKYRKFNEDEIEKYVQKLLD
CCCCCCHHHHHHHHEEEEEEEECCEECCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHH
RKEQEQKDAEEKRKAEEEAKKAEEEAKKAEEEAKESSDDENEDINEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]