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The map label for this gene is lon [C]

Identifier: 84490016

GI number: 84490016

Start: 1396682

End: 1398526

Strand: Direct

Name: lon [C]

Synonym: Msp_1227

Alternate gene names: 84490016

Gene position: 1396682-1398526 (Clockwise)

Preceding gene: 84490014

Following gene: 84490017

Centisome position: 79.02

GC content: 34.15

Gene sequence:

>1845_bases
ATGTTAATTGACCAAATAATTGGACAAGAAGAAGCAGTGGAAACTATAAAAAAAGCTGCAAAACAAAGACGTAATGTTCT
ACTTATAGGAGAACCTGGTATTGGTAAATCCATGATAGCTAAAGCAATGGCAGAATTATTACCACCTGAAGATTTACAAG
ACATACTAGTATATCCCAATGTTGAAGATACAAACAATCCATTAGTTGGAGTTATGCCGGCAGGTCAAGGTAAAAAAGTA
ATCGAAAATGCTAAAAAACAAAATAAAGGCCAAGAAGAACGTAGAAACATACTGATGATTACTATAATTGCATTTATTAT
GGCAATAGGATTTTTAACAAATCAATTCCTAAGTGCAATAATTGCTGTGGGAATAGTGTTCTTTGCACTCTACCAACTCA
GACCAAAAGGACAACAATCAACACCAAAACTTCTTATAAATAGTGATGGTAAAGAAGTAGCACCATTTGTTGATGCTACT
GGAGCACATGCAGGTGCATTACTTGGTGATGTAAGACACGACCCATACCAATCTGGAGGATTAGGAACTCCAGCTCATGA
AAGAGTAGAAAGTGGAATGATACACAGAGCAAACAAAGGAGTACTATACATAGATGAAATCGGTACAATGACCATGAAAA
CACAACAAGAACTCCTAACAGCAATGCAAGAACACAAGTACCAAATTACAGGACAAAGTGATAACAGTAGTGGAGCAATG
GTTAGAACAAATCCAGTTCCATGTGATTTTGTATTAGTTGCATCAGGAAACATGGAAGTATTAAAAGATATGCATATAGC
ACTTAGATCAAGAATACGTGGATATGGATATGAAGTATTCATGAAAGATTCCATGAAAGACACCCCTGAAAATCGTAAAA
AATTAGGTCAATTTGTAGCACAAGAAGTTAAAAACGATGGAAGAATACCACATTTTACAAAAGAAGCAGTAGCAGAAGTT
ATTAAAGAAGCACAACGTAGAGCTGGAAAAAAAGATGCTTTAACACTCAAACTAAGAGATCTTGGTGGACTTGTAAGGGC
TGCTGGAGATGTAGCTGTTGAAGAAAATGCTAAAGAAGTAACAGTAGAACATGTACATGAAGCAAGAAAACAATCAAGAA
CATTAGAACAACAAATAGCAGACAGATACATATCCCAAAGAAAAGAATACAGTGTATTCTCAAATGAAGGATCTAAAATT
GGTTGTATCAATGGTTTAGCAGTTATAGGAAATTCAAGTGGTATTGTTCTACCAATAGCAGCAGAAGCAGCACCATCCCA
GAGTAAAGAAGAAGGTAAAATAATTGCAGCAGGTAAACTTGGAGATATAGCAAAAGAAGCTGTGCAAAATGTTGGTGCTA
TTATTAAAAAAAGTATTGGTACTGACATATCAAATTATGATATACACATCCAATTTGTACAATCATATGATGGAGTAGAA
GGAGATAGTGCAAGTGTATCTATGGCTACAGCAATTATTTCAGCAATAGAAAACATACCAATCGATCAAACACTAGCATT
AACTGGTTCATTAAGTGTAAGGGGAACAGTACTTCCAATTGGTGGAGCAACATATAAAATAGAAGCTGCTGCTGAATCTG
GAATGAAAAAAGTACTTATACCTGCATCAAACATGGATGATGTACTTATTGATAAAAAATATGTAGATCAAATCGAGATT
ATTCCAGTTAAAACATTGACTGATGTATTAGAACATGCACTTGTAGGACCTCAAAAAGATGAATTTATCAAAAGTCTAAA
AGAAAATAAAATTGATAAAATAAAAAATTACATACCAAATCCCACAGACATAATCAATTCTAAACCTTCCAAAAGTAACA
ATTAA

Upstream 100 bases:

>100_bases
AGAAAATACTAACAAAGACAAAACCGACTTAACAAAACATGTTGTATCTGAAATTAATCCAGAAGAATATATTGATACAG
ATGAAATAGACATACCACCC

Downstream 100 bases:

>100_bases
ATAATAACCTCTTCTTTTTTTATTTTTTAAAAATCATTATTAACTATTTTCCAAGATATACATAAATAGTAATAAGTAGA
AAAATTAACACTAGAAATAA

Product: ATP-dependent protease Lon

Products: NA

Alternate protein names: ATP-dependent protease La homolog [H]

Number of amino acids: Translated: 614; Mature: 614

Protein sequence:

>614_residues
MLIDQIIGQEEAVETIKKAAKQRRNVLLIGEPGIGKSMIAKAMAELLPPEDLQDILVYPNVEDTNNPLVGVMPAGQGKKV
IENAKKQNKGQEERRNILMITIIAFIMAIGFLTNQFLSAIIAVGIVFFALYQLRPKGQQSTPKLLINSDGKEVAPFVDAT
GAHAGALLGDVRHDPYQSGGLGTPAHERVESGMIHRANKGVLYIDEIGTMTMKTQQELLTAMQEHKYQITGQSDNSSGAM
VRTNPVPCDFVLVASGNMEVLKDMHIALRSRIRGYGYEVFMKDSMKDTPENRKKLGQFVAQEVKNDGRIPHFTKEAVAEV
IKEAQRRAGKKDALTLKLRDLGGLVRAAGDVAVEENAKEVTVEHVHEARKQSRTLEQQIADRYISQRKEYSVFSNEGSKI
GCINGLAVIGNSSGIVLPIAAEAAPSQSKEEGKIIAAGKLGDIAKEAVQNVGAIIKKSIGTDISNYDIHIQFVQSYDGVE
GDSASVSMATAIISAIENIPIDQTLALTGSLSVRGTVLPIGGATYKIEAAAESGMKKVLIPASNMDDVLIDKKYVDQIEI
IPVKTLTDVLEHALVGPQKDEFIKSLKENKIDKIKNYIPNPTDIINSKPSKSNN

Sequences:

>Translated_614_residues
MLIDQIIGQEEAVETIKKAAKQRRNVLLIGEPGIGKSMIAKAMAELLPPEDLQDILVYPNVEDTNNPLVGVMPAGQGKKV
IENAKKQNKGQEERRNILMITIIAFIMAIGFLTNQFLSAIIAVGIVFFALYQLRPKGQQSTPKLLINSDGKEVAPFVDAT
GAHAGALLGDVRHDPYQSGGLGTPAHERVESGMIHRANKGVLYIDEIGTMTMKTQQELLTAMQEHKYQITGQSDNSSGAM
VRTNPVPCDFVLVASGNMEVLKDMHIALRSRIRGYGYEVFMKDSMKDTPENRKKLGQFVAQEVKNDGRIPHFTKEAVAEV
IKEAQRRAGKKDALTLKLRDLGGLVRAAGDVAVEENAKEVTVEHVHEARKQSRTLEQQIADRYISQRKEYSVFSNEGSKI
GCINGLAVIGNSSGIVLPIAAEAAPSQSKEEGKIIAAGKLGDIAKEAVQNVGAIIKKSIGTDISNYDIHIQFVQSYDGVE
GDSASVSMATAIISAIENIPIDQTLALTGSLSVRGTVLPIGGATYKIEAAAESGMKKVLIPASNMDDVLIDKKYVDQIEI
IPVKTLTDVLEHALVGPQKDEFIKSLKENKIDKIKNYIPNPTDIINSKPSKSNN
>Mature_614_residues
MLIDQIIGQEEAVETIKKAAKQRRNVLLIGEPGIGKSMIAKAMAELLPPEDLQDILVYPNVEDTNNPLVGVMPAGQGKKV
IENAKKQNKGQEERRNILMITIIAFIMAIGFLTNQFLSAIIAVGIVFFALYQLRPKGQQSTPKLLINSDGKEVAPFVDAT
GAHAGALLGDVRHDPYQSGGLGTPAHERVESGMIHRANKGVLYIDEIGTMTMKTQQELLTAMQEHKYQITGQSDNSSGAM
VRTNPVPCDFVLVASGNMEVLKDMHIALRSRIRGYGYEVFMKDSMKDTPENRKKLGQFVAQEVKNDGRIPHFTKEAVAEV
IKEAQRRAGKKDALTLKLRDLGGLVRAAGDVAVEENAKEVTVEHVHEARKQSRTLEQQIADRYISQRKEYSVFSNEGSKI
GCINGLAVIGNSSGIVLPIAAEAAPSQSKEEGKIIAAGKLGDIAKEAVQNVGAIIKKSIGTDISNYDIHIQFVQSYDGVE
GDSASVSMATAIISAIENIPIDQTLALTGSLSVRGTVLPIGGATYKIEAAAESGMKKVLIPASNMDDVLIDKKYVDQIEI
IPVKTLTDVLEHALVGPQKDEFIKSLKENKIDKIKNYIPNPTDIINSKPSKSNN

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively [H]

COG id: COG1067

COG function: function code O; Predicted ATP-dependent protease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S16 family. Archaeal LonB subfamily [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=129, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1786643, Length=196, Percent_Identity=32.6530612244898, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1787188, Length=416, Percent_Identity=23.7980769230769, Blast_Score=82, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17556486, Length=178, Percent_Identity=33.7078651685393, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17505831, Length=155, Percent_Identity=30.9677419354839, Blast_Score=66, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6319449, Length=159, Percent_Identity=30.8176100628931, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000523
- InterPro:   IPR004663
- InterPro:   IPR008269
- InterPro:   IPR001984
- InterPro:   IPR020568
- InterPro:   IPR002078 [H]

Pfam domain/function: PF05362 Lon_C; PF01078 Mg_chelatase; PF00158 Sigma54_activat [H]

EC number: 3.4.21.-

Molecular weight: Translated: 66692; Mature: 66692

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIDQIIGQEEAVETIKKAAKQRRNVLLIGEPGIGKSMIAKAMAELLPPEDLQDILVYPN
CCHHHHCCHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCEEECCC
VEDTNNPLVGVMPAGQGKKVIENAKKQNKGQEERRNILMITIIAFIMAIGFLTNQFLSAI
CCCCCCCEEEEEECCCCHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
IAVGIVFFALYQLRPKGQQSTPKLLINSDGKEVAPFVDATGAHAGALLGDVRHDPYQSGG
HHHHHHHHHHHHCCCCCCCCCCEEEEECCCCEECCHHCCCCCHHHHHHHHHCCCCCCCCC
LGTPAHERVESGMIHRANKGVLYIDEIGTMTMKTQQELLTAMQEHKYQITGQSDNSSGAM
CCCCHHHHHHCCCCEECCCCEEEEECCCCHHHHHHHHHHHHHHHCCEEEECCCCCCCCCE
VRTNPVPCDFVLVASGNMEVLKDMHIALRSRIRGYGYEVFMKDSMKDTPENRKKLGQFVA
EECCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHH
QEVKNDGRIPHFTKEAVAEVIKEAQRRAGKKDALTLKLRDLGGLVRAAGDVAVEENAKEV
HHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHCCHHCCCCCHHH
TVEHVHEARKQSRTLEQQIADRYISQRKEYSVFSNEGSKIGCINGLAVIGNSSGIVLPIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCEEEEECCCCEEEEEE
AEAAPSQSKEEGKIIAAGKLGDIAKEAVQNVGAIIKKSIGTDISNYDIHIQFVQSYDGVE
CCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCC
GDSASVSMATAIISAIENIPIDQTLALTGSLSVRGTVLPIGGATYKIEAAAESGMKKVLI
CCCCHHHHHHHHHHHHHCCCCCCEEEEEECCEECEEEEECCCCEEEEEHHHHCCCEEEEE
PASNMDDVLIDKKYVDQIEIIPVKTLTDVLEHALVGPQKDEFIKSLKENKIDKIKNYIPN
CCCCCCHHHHCHHHHCCEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
PTDIINSKPSKSNN
CHHHHCCCCCCCCC
>Mature Secondary Structure
MLIDQIIGQEEAVETIKKAAKQRRNVLLIGEPGIGKSMIAKAMAELLPPEDLQDILVYPN
CCHHHHCCHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCEEECCC
VEDTNNPLVGVMPAGQGKKVIENAKKQNKGQEERRNILMITIIAFIMAIGFLTNQFLSAI
CCCCCCCEEEEEECCCCHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
IAVGIVFFALYQLRPKGQQSTPKLLINSDGKEVAPFVDATGAHAGALLGDVRHDPYQSGG
HHHHHHHHHHHHCCCCCCCCCCEEEEECCCCEECCHHCCCCCHHHHHHHHHCCCCCCCCC
LGTPAHERVESGMIHRANKGVLYIDEIGTMTMKTQQELLTAMQEHKYQITGQSDNSSGAM
CCCCHHHHHHCCCCEECCCCEEEEECCCCHHHHHHHHHHHHHHHCCEEEECCCCCCCCCE
VRTNPVPCDFVLVASGNMEVLKDMHIALRSRIRGYGYEVFMKDSMKDTPENRKKLGQFVA
EECCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHH
QEVKNDGRIPHFTKEAVAEVIKEAQRRAGKKDALTLKLRDLGGLVRAAGDVAVEENAKEV
HHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHCCHHCCCCCHHH
TVEHVHEARKQSRTLEQQIADRYISQRKEYSVFSNEGSKIGCINGLAVIGNSSGIVLPIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCEEEEECCCCEEEEEE
AEAAPSQSKEEGKIIAAGKLGDIAKEAVQNVGAIIKKSIGTDISNYDIHIQFVQSYDGVE
CCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCC
GDSASVSMATAIISAIENIPIDQTLALTGSLSVRGTVLPIGGATYKIEAAAESGMKKVLI
CCCCHHHHHHHHHHHHHCCCCCCEEEEEECCEECEEEEECCCCEEEEEHHHHCCCEEEEE
PASNMDDVLIDKKYVDQIEIIPVKTLTDVLEHALVGPQKDEFIKSLKENKIDKIKNYIPN
CCCCCCHHHHCHHHHCCEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
PTDIINSKPSKSNN
CHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]