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The map label for this gene is hemL

Identifier: 84489972

GI number: 84489972

Start: 1350287

End: 1351558

Strand: Direct

Name: hemL

Synonym: Msp_1180

Alternate gene names: 84489972

Gene position: 1350287-1351558 (Clockwise)

Preceding gene: 84489971

Following gene: 84489973

Centisome position: 76.4

GC content: 31.45

Gene sequence:

>1272_bases
ATGAAACTTGATAAATCAAAAGAATTATTTGATGAAGCTGTAAATTACCTTCCCGGAGGAGTTAATTCACCAGTACGAGC
ATACAAACCTTATCCTTTCTTTGCTAAAAGTGCTAAAGGTTCAAAAATATATGATGTTGATGGAAATGAATATATAGATT
ATTGTTTAGGATATGGACCCTTACTTTTTGGTCATGCAAATGAACATATTATTGAAAAATCCATTGAACAATTAAAATTA
GGTACAGATTATGGAGTACCTTCAGAAAAAGAAGTTCAACTAGCAAAAGAAGTAATCAAAAGAGTGCCATGTGCACAAAT
GGTTCGATTTACAAATTCTGGAACTGAAGCTACAATGAGTGCTATTAGATTAGCACGTGGAATTACAAAAAGAGACAAAA
TAATCAAATTCGAAGGAGCATACCATGGAGCTCATGACGCTGTACTAGTCAAATCAGGATCAGGAGCTGCAGGACTACCC
GATTCTCCAGGAATACCTACAGATACAACAAAAAATACTATGCTCGTAGAATTCAATGATGAAGAAGCCCTAAAAAAACT
TATTAATGAAAATAAAGATGAAATTGCATGTATTATTGTTGAACCTGTTATGGGAAATATTGGATGTGTTCCACCTAAAG
AAGGTTACCTTGATTTTTTACGTGAAATTACATTAGAAAATGGAATTTTATTAATTATTGATGAAGTTATCACAGGTTTC
AGAATAAGTAAAGGTGGTGCACAAGAATATTATAATGTTATCCCTGACTTAGCTACATTTGGTAAAATTGTAGGTGGAGG
ATTCCCTATTGGAGCTATTGCAGGAAAAAAAGAATATATGGAACAATTTACTCCTAGTGGAAAAATATATCAAGCTGGTA
CATTTAGTGGAAATCCAATGTCCATTAATGGAGGATTAGCTGCATTTGAAGTTTTAGATGATAATAGTTATAAACAGTTA
CATAAAAGTGGAGAATATTTCAGAAATGGAATTGTAGACATACTAGATAAATTAAATATTAACTTCCATGTAAATGGTGT
TGAATCTATGACACAAATATACTTCACTGAAAATGAGGTATATGATTATAAAACAGCACAAACATCTGATACAGAAAACT
TCTTAAAATACTTCCACCTACTTCTTGAAAATGGAGTGTTTATTGCTCCATCACAGTATGAATGTGGTTTTATATCAACA
TCACATAGTAGAGATGACTTAGATAAAACCTTAAATGCAATTGAAATTGCTCTAACAAAATTATATAAATAA

Upstream 100 bases:

>100_bases
ACCTTATGCAATTACAACAGGACCTAAAGGTGGAACACCAATTGCAGTTGCAATTATTAATTCATTATTAAATATTAAAA
AATAAAAGAGGAGACAATAA

Downstream 100 bases:

>100_bases
ACTCCCCTTCTTTTTTTACTTTTTTTATATTAGAACTTCTTTTAAAAAAAAATAATTACTTATCCTTAAATTTAATAATA
TATTCATATAAAATTATTAA

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MKLDKSKELFDEAVNYLPGGVNSPVRAYKPYPFFAKSAKGSKIYDVDGNEYIDYCLGYGPLLFGHANEHIIEKSIEQLKL
GTDYGVPSEKEVQLAKEVIKRVPCAQMVRFTNSGTEATMSAIRLARGITKRDKIIKFEGAYHGAHDAVLVKSGSGAAGLP
DSPGIPTDTTKNTMLVEFNDEEALKKLINENKDEIACIIVEPVMGNIGCVPPKEGYLDFLREITLENGILLIIDEVITGF
RISKGGAQEYYNVIPDLATFGKIVGGGFPIGAIAGKKEYMEQFTPSGKIYQAGTFSGNPMSINGGLAAFEVLDDNSYKQL
HKSGEYFRNGIVDILDKLNINFHVNGVESMTQIYFTENEVYDYKTAQTSDTENFLKYFHLLLENGVFIAPSQYECGFIST
SHSRDDLDKTLNAIEIALTKLYK

Sequences:

>Translated_423_residues
MKLDKSKELFDEAVNYLPGGVNSPVRAYKPYPFFAKSAKGSKIYDVDGNEYIDYCLGYGPLLFGHANEHIIEKSIEQLKL
GTDYGVPSEKEVQLAKEVIKRVPCAQMVRFTNSGTEATMSAIRLARGITKRDKIIKFEGAYHGAHDAVLVKSGSGAAGLP
DSPGIPTDTTKNTMLVEFNDEEALKKLINENKDEIACIIVEPVMGNIGCVPPKEGYLDFLREITLENGILLIIDEVITGF
RISKGGAQEYYNVIPDLATFGKIVGGGFPIGAIAGKKEYMEQFTPSGKIYQAGTFSGNPMSINGGLAAFEVLDDNSYKQL
HKSGEYFRNGIVDILDKLNINFHVNGVESMTQIYFTENEVYDYKTAQTSDTENFLKYFHLLLENGVFIAPSQYECGFIST
SHSRDDLDKTLNAIEIALTKLYK
>Mature_423_residues
MKLDKSKELFDEAVNYLPGGVNSPVRAYKPYPFFAKSAKGSKIYDVDGNEYIDYCLGYGPLLFGHANEHIIEKSIEQLKL
GTDYGVPSEKEVQLAKEVIKRVPCAQMVRFTNSGTEATMSAIRLARGITKRDKIIKFEGAYHGAHDAVLVKSGSGAAGLP
DSPGIPTDTTKNTMLVEFNDEEALKKLINENKDEIACIIVEPVMGNIGCVPPKEGYLDFLREITLENGILLIIDEVITGF
RISKGGAQEYYNVIPDLATFGKIVGGGFPIGAIAGKKEYMEQFTPSGKIYQAGTFSGNPMSINGGLAAFEVLDDNSYKQL
HKSGEYFRNGIVDILDKLNINFHVNGVESMTQIYFTENEVYDYKTAQTSDTENFLKYFHLLLENGVFIAPSQYECGFIST
SHSRDDLDKTLNAIEIALTKLYK

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=352, Percent_Identity=27.5568181818182, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI37574042, Length=329, Percent_Identity=27.6595744680851, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI24119277, Length=390, Percent_Identity=26.1538461538462, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI13994255, Length=381, Percent_Identity=25.1968503937008, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI226442709, Length=298, Percent_Identity=28.1879194630872, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI284507298, Length=262, Percent_Identity=28.6259541984733, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI226442705, Length=329, Percent_Identity=27.0516717325228, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1786349, Length=426, Percent_Identity=46.2441314553991, Blast_Score=396, Evalue=1e-111,
Organism=Escherichia coli, GI1789016, Length=371, Percent_Identity=29.9191374663073, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1787560, Length=350, Percent_Identity=30, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1788044, Length=334, Percent_Identity=31.7365269461078, Blast_Score=134, Evalue=8e-33,
Organism=Escherichia coli, GI1789759, Length=349, Percent_Identity=29.2263610315186, Blast_Score=121, Evalue=8e-29,
Organism=Escherichia coli, GI145693181, Length=337, Percent_Identity=29.673590504451, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1786991, Length=315, Percent_Identity=23.4920634920635, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71992977, Length=351, Percent_Identity=27.3504273504274, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI25144271, Length=308, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI32564660, Length=339, Percent_Identity=27.1386430678466, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI25144274, Length=141, Percent_Identity=31.9148936170213, Blast_Score=71, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6323470, Length=309, Percent_Identity=28.4789644012945, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6324432, Length=329, Percent_Identity=28.8753799392097, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21357415, Length=315, Percent_Identity=27.6190476190476, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI161085790, Length=374, Percent_Identity=25.4010695187166, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI28574759, Length=374, Percent_Identity=25.4010695187166, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSA_METST (Q2NF42)

Other databases:

- EMBL:   CP000102
- RefSeq:   YP_448204.1
- ProteinModelPortal:   Q2NF42
- SMR:   Q2NF42
- STRING:   Q2NF42
- GeneID:   3855237
- GenomeReviews:   CP000102_GR
- KEGG:   mst:Msp_1180
- NMPDR:   fig|339860.6.peg.1132
- eggNOG:   arNOG04972
- HOGENOM:   HBG725944
- OMA:   DKVIKFE
- PhylomeDB:   Q2NF42
- ProtClustDB:   PRK00062
- BioCyc:   MSTA339860:MSP_1180-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00375
- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR00713

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =5.4.3.8

Molecular weight: Translated: 46758; Mature: 46758

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLDKSKELFDEAVNYLPGGVNSPVRAYKPYPFFAKSAKGSKIYDVDGNEYIDYCLGYGP
CCCCCHHHHHHHHHHHCCCCCCCCHHHCCCCCCEECCCCCCEEEECCCCHHHHHHHCCCC
LLFGHANEHIIEKSIEQLKLGTDYGVPSEKEVQLAKEVIKRVPCAQMVRFTNSGTEATMS
EEECCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHH
AIRLARGITKRDKIIKFEGAYHGAHDAVLVKSGSGAAGLPDSPGIPTDTTKNTMLVEFND
HHHHHHCCCCCCCEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECC
EEALKKLINENKDEIACIIVEPVMGNIGCVPPKEGYLDFLREITLENGILLIIDEVITGF
HHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEHHHCCE
RISKGGAQEYYNVIPDLATFGKIVGGGFPIGAIAGKKEYMEQFTPSGKIYQAGTFSGNPM
EECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHCCCCCEEEECCCCCCCE
SINGGLAAFEVLDDNSYKQLHKSGEYFRNGIVDILDKLNINFHVNGVESMTQIYFTENEV
EECCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHEEEEEEECCCE
YDYKTAQTSDTENFLKYFHLLLENGVFIAPSQYECGFISTSHSRDDLDKTLNAIEIALTK
EEEECCCCCCHHHHHHHHHHHHHCCEEEECCCCCCCEEECCCCHHHHHHHHHHHHHHHHH
LYK
HCC
>Mature Secondary Structure
MKLDKSKELFDEAVNYLPGGVNSPVRAYKPYPFFAKSAKGSKIYDVDGNEYIDYCLGYGP
CCCCCHHHHHHHHHHHCCCCCCCCHHHCCCCCCEECCCCCCEEEECCCCHHHHHHHCCCC
LLFGHANEHIIEKSIEQLKLGTDYGVPSEKEVQLAKEVIKRVPCAQMVRFTNSGTEATMS
EEECCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHH
AIRLARGITKRDKIIKFEGAYHGAHDAVLVKSGSGAAGLPDSPGIPTDTTKNTMLVEFND
HHHHHHCCCCCCCEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECC
EEALKKLINENKDEIACIIVEPVMGNIGCVPPKEGYLDFLREITLENGILLIIDEVITGF
HHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEHHHCCE
RISKGGAQEYYNVIPDLATFGKIVGGGFPIGAIAGKKEYMEQFTPSGKIYQAGTFSGNPM
EECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHCCCCCEEEECCCCCCCE
SINGGLAAFEVLDDNSYKQLHKSGEYFRNGIVDILDKLNINFHVNGVESMTQIYFTENEV
EECCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHEEEEEEECCCE
YDYKTAQTSDTENFLKYFHLLLENGVFIAPSQYECGFISTSHSRDDLDKTLNAIEIALTK
EEEECCCCCCHHHHHHHHHHHHHCCEEEECCCCCCCEEECCCCHHHHHHHHHHHHHHHHH
LYK
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA