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The map label for this gene is bioD

Identifier: 83721594

GI number: 83721594

Start: 374614

End: 375336

Strand: Reverse

Name: bioD

Synonym: BTH_I0338

Alternate gene names: 83721594

Gene position: 375336-374614 (Counterclockwise)

Preceding gene: 83718450

Following gene: 83718411

Centisome position: 9.85

GC content: 74.83

Gene sequence:

>723_bases
ATGAGCGCGCCGCTCTCGCTGTTCGTGACGGGCACCGACACCGAGATCGGCAAGACCTTCGTATCGACCGCGCTGCTGCA
CGGCTTCGCGCGCGCGGGGCTGCGCGCGGCCGCGATGAAGCCGATCGCCGCGGGCGCGTACCAGCGCGACGGCGTGTGGC
GCAACGAGGACGCGGACCAGCTCGACGCGGCCGCGAACGTCGCGCTGCCCGCCACGATCCGCACGCCGTTCCTGCTGAAG
GCGGCCGCCGCGCCGCACATCGCCGCCGCGCGCGAGGGCGTCGCGCTCGACATCGATACGATCGTCGGCGCGCATCGCCG
CGCGTGCGAGAGGGCGGACGTCGTCGTCGTCGAAGGCGTCGGCGGCTTTCGCGTGCCGCTCGCCGGCACGCGCGACACCG
CCGATCTGGCGGTCGCGCTCGGCCTGCCCGTCGTGCTCGTCGTCGGCGTGCGGCTCGGCTGCATCAGCCACGCGCTCCTC
ACCGCCGACGCGATCGCCGCGCGCGGCCTCGCGATCGCCGGCTGGGTCGCGAACCGCGTCGATGCCGCGATGCGCTTCGC
CGACGACAACGTCGACACGCTGCGCGCGTGGCTCGAACGCGAGCACGGCGCGCCGCTACTCGGCGACATCGCGCACATGA
GCCCGCCGTCGCCGGAAGCGGCGTCGCGCTCGCTCGACGTGAACCGCTTGCTGGGCGCGCTGCGCGAAACCGCGCCGCGC
TGA

Upstream 100 bases:

>100_bases
CCGGCACGTCGCGGCTGCGGATCTCGCTGTCGGCCGCGCACTCGTTCGCCGATCTCGCGCGCCTCGAAGCGGCGCTCGTC
ACGCCGATCGAGGCCGCCGC

Downstream 100 bases:

>100_bases
CGCGCGCCCCGTTTATCACTGATTTTTCGAATCGATCCCTGACCGAAGGATGACCGACATGACTGAAGCTCAAACCGCTT
GCCCGACGACCGAAACGCCG

Product: dithiobiotin synthetase

Products: NA

Alternate protein names: DTB synthetase; DTBS; Dethiobiotin synthase

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MSAPLSLFVTGTDTEIGKTFVSTALLHGFARAGLRAAAMKPIAAGAYQRDGVWRNEDADQLDAAANVALPATIRTPFLLK
AAAAPHIAAAREGVALDIDTIVGAHRRACERADVVVVEGVGGFRVPLAGTRDTADLAVALGLPVVLVVGVRLGCISHALL
TADAIAARGLAIAGWVANRVDAAMRFADDNVDTLRAWLEREHGAPLLGDIAHMSPPSPEAASRSLDVNRLLGALRETAPR

Sequences:

>Translated_240_residues
MSAPLSLFVTGTDTEIGKTFVSTALLHGFARAGLRAAAMKPIAAGAYQRDGVWRNEDADQLDAAANVALPATIRTPFLLK
AAAAPHIAAAREGVALDIDTIVGAHRRACERADVVVVEGVGGFRVPLAGTRDTADLAVALGLPVVLVVGVRLGCISHALL
TADAIAARGLAIAGWVANRVDAAMRFADDNVDTLRAWLEREHGAPLLGDIAHMSPPSPEAASRSLDVNRLLGALRETAPR
>Mature_239_residues
SAPLSLFVTGTDTEIGKTFVSTALLHGFARAGLRAAAMKPIAAGAYQRDGVWRNEDADQLDAAANVALPATIRTPFLLKA
AAAPHIAAAREGVALDIDTIVGAHRRACERADVVVVEGVGGFRVPLAGTRDTADLAVALGLPVVLVVGVRLGCISHALLT
ADAIAARGLAIAGWVANRVDAAMRFADDNVDTLRAWLEREHGAPLLGDIAHMSPPSPEAASRSLDVNRLLGALRETAPR

Specific function: Bioconversion of pimelate into dethiobiotin. [C]

COG id: COG0132

COG function: function code H; Dethiobiotin synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dethiobiotin synthetase family

Homologues:

Organism=Escherichia coli, GI1786995, Length=221, Percent_Identity=40.7239819004525, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI87081944, Length=229, Percent_Identity=36.2445414847162, Blast_Score=132, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6324385, Length=172, Percent_Identity=34.3023255813954, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIOD_BURTA (Q2T1Q3)

Other databases:

- EMBL:   CP000086
- RefSeq:   YP_440896.1
- ProteinModelPortal:   Q2T1Q3
- STRING:   Q2T1Q3
- GeneID:   3848467
- GenomeReviews:   CP000086_GR
- KEGG:   bte:BTH_I0338
- TIGR:   BTH_I0338
- eggNOG:   COG0132
- HOGENOM:   HBG650065
- OMA:   IDTIVAC
- ProtClustDB:   PRK00090
- BioCyc:   BTHA271848:BTH_I0338-MONOMER
- HAMAP:   MF_00336
- InterPro:   IPR004472
- InterPro:   IPR002586
- PIRSF:   PIRSF006755
- TIGRFAMs:   TIGR00347

Pfam domain/function: PF01656 CbiA

EC number: =6.3.3.3

Molecular weight: Translated: 24955; Mature: 24824

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPLSLFVTGTDTEIGKTFVSTALLHGFARAGLRAAAMKPIAAGAYQRDGVWRNEDADQ
CCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCHHCCCCCCCCCHHH
LDAAANVALPATIRTPFLLKAAAAPHIAAAREGVALDIDTIVGAHRRACERADVVVVEGV
HHHHHCCCCCHHHCCCHHHHHHCCCHHHHHCCCCEEEHHHHHHHHHHHHHHCCEEEEECC
GGFRVPLAGTRDTADLAVALGLPVVLVVGVRLGCISHALLTADAIAARGLAIAGWVANRV
CCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
DAAMRFADDNVDTLRAWLEREHGAPLLGDIAHMSPPSPEAASRSLDVNRLLGALRETAPR
HHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
SAPLSLFVTGTDTEIGKTFVSTALLHGFARAGLRAAAMKPIAAGAYQRDGVWRNEDADQ
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCHHCCCCCCCCCHHH
LDAAANVALPATIRTPFLLKAAAAPHIAAAREGVALDIDTIVGAHRRACERADVVVVEGV
HHHHHCCCCCHHHCCCHHHHHHCCCHHHHHCCCCEEEHHHHHHHHHHHHHHCCEEEEECC
GGFRVPLAGTRDTADLAVALGLPVVLVVGVRLGCISHALLTADAIAARGLAIAGWVANRV
CCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
DAAMRFADDNVDTLRAWLEREHGAPLLGDIAHMSPPSPEAASRSLDVNRLLGALRETAPR
HHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA