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The map label for this gene is fadA [H]

Identifier: 83721513

GI number: 83721513

Start: 646332

End: 647531

Strand: Direct

Name: fadA [H]

Synonym: BTH_I0566

Alternate gene names: 83721513

Gene position: 646332-647531 (Clockwise)

Preceding gene: 83718546

Following gene: 83719344

Centisome position: 16.97

GC content: 68.17

Gene sequence:

>1200_bases
ATGAGCAAACAACTGCAAGACGCATACATCGTCGCCGCAAGCCGCACGCCGATCGGCAAGGCGCCCCGCGGTGCATTCAA
GAACACGCGCCCGGACGAACTGCTCGTCCACGCGATCAAGTCGGCGATCGCGCAGGTGCCGGGATTCGACACGAAGCTGA
TCGAGGATGCGATCGTCGGCTGCGCGATCCCCGAGGCCGAGCAGGGCCTGAACGTCGCGCGGATGGGCGCGCTGCTCGCC
GGCCTGCCGAACACGGTCGGCGGCGTGACGGTGAACCGCTTCTGCGCGTCGGGCGTCACCGCGCTTGCGATGGCGGCGGA
CCGCATCCGCGTCGGCGAATCGGACGCGATCCTCGCGGCCGGCGTCGAATCGATGAGCATGGTGCCGATGATGGGCAACA
AGCCGTCGATGTCGCCGCACATCTTCGATCGCAGTGAAGATTTCGGCATCGCGTATGGGATGGGCCTCACCGCCGAGCGC
GTCGCCGAGCAGTGGAAGGTGAGCCGCGAAGACCAGGACGCGTTCTCGGTCGAGTCGCACCGCAAGGCGATCGCCGCGCA
GCAGGCGGGCGAGTTCAACGACGAGATCGCGCCGTACACGCTCGTCGAGCGCTTCCCGAATCTCGCGACGGGCGAAATCG
AAACGAGGACGCGCGAGATCGCGCTCGACGAAGGCCCGCGCGCGGAGACGTCGCTCGAAGGGCTCGCGAAGCTGAAGACG
GTGTTCGCGAACAAGGGTTCGGTGACGGCGGGCAACAGCTCGCAGACGTCGGACGGCTCGGGCGCGCTGCTCGTCGTGTC
GGAGAAGGTGCTCAAGCAATTCAACCTGACCCCGCTCGCGCGCTTCGTCAGTTTCGCCGTGCGCGGCGTGCCGCCGGAGA
TCATGGGCATCGGCCCGAAGGAAGCGATTCCGGCTGCGCTGAAGGCGGCGGGCCTCAAGCAGGACGACATCGACTGGATC
GAGCTGAACGAGGCGTTCGCCGCGCAATCGCTCGCGGTGATCCGCGATCTCGGCCTCGATCCGTCGAAGATCAACCCGCT
CGGCGGCGCGATCGCGCTCGGCCACCCGCTCGGCGCGACGGGCGCGATCCGCGCGGCGACCGTCGTGCACGGCCTGCGCC
GCCGCAACCTGAAGTACGGGATGGTGACGATGTGCGTCGGCACCGGCATGGGCGCGGCGGGCATCATCGAGCGGCTCTGA

Upstream 100 bases:

>100_bases
GAGCAGAGTCAGCGCCACGGCGCTAACTGCGATCGACCGCCCAAGGGCATGGGACCAGAGTCAGCGCTGAGGCGCCAACT
CTGGTCGACAGGAGTCTCAA

Downstream 100 bases:

>100_bases
TCGGAGCGCGCGACGCATGACGACGGTGCGCGGGCGGCGAGCTCGCGCACCGTTTTTTTTGATCGAGTGAAAACAGCCAT
GGAGACGGCTCAAATGGATA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MSKQLQDAYIVAASRTPIGKAPRGAFKNTRPDELLVHAIKSAIAQVPGFDTKLIEDAIVGCAIPEAEQGLNVARMGALLA
GLPNTVGGVTVNRFCASGVTALAMAADRIRVGESDAILAAGVESMSMVPMMGNKPSMSPHIFDRSEDFGIAYGMGLTAER
VAEQWKVSREDQDAFSVESHRKAIAAQQAGEFNDEIAPYTLVERFPNLATGEIETRTREIALDEGPRAETSLEGLAKLKT
VFANKGSVTAGNSSQTSDGSGALLVVSEKVLKQFNLTPLARFVSFAVRGVPPEIMGIGPKEAIPAALKAAGLKQDDIDWI
ELNEAFAAQSLAVIRDLGLDPSKINPLGGAIALGHPLGATGAIRAATVVHGLRRRNLKYGMVTMCVGTGMGAAGIIERL

Sequences:

>Translated_399_residues
MSKQLQDAYIVAASRTPIGKAPRGAFKNTRPDELLVHAIKSAIAQVPGFDTKLIEDAIVGCAIPEAEQGLNVARMGALLA
GLPNTVGGVTVNRFCASGVTALAMAADRIRVGESDAILAAGVESMSMVPMMGNKPSMSPHIFDRSEDFGIAYGMGLTAER
VAEQWKVSREDQDAFSVESHRKAIAAQQAGEFNDEIAPYTLVERFPNLATGEIETRTREIALDEGPRAETSLEGLAKLKT
VFANKGSVTAGNSSQTSDGSGALLVVSEKVLKQFNLTPLARFVSFAVRGVPPEIMGIGPKEAIPAALKAAGLKQDDIDWI
ELNEAFAAQSLAVIRDLGLDPSKINPLGGAIALGHPLGATGAIRAATVVHGLRRRNLKYGMVTMCVGTGMGAAGIIERL
>Mature_398_residues
SKQLQDAYIVAASRTPIGKAPRGAFKNTRPDELLVHAIKSAIAQVPGFDTKLIEDAIVGCAIPEAEQGLNVARMGALLAG
LPNTVGGVTVNRFCASGVTALAMAADRIRVGESDAILAAGVESMSMVPMMGNKPSMSPHIFDRSEDFGIAYGMGLTAERV
AEQWKVSREDQDAFSVESHRKAIAAQQAGEFNDEIAPYTLVERFPNLATGEIETRTREIALDEGPRAETSLEGLAKLKTV
FANKGSVTAGNSSQTSDGSGALLVVSEKVLKQFNLTPLARFVSFAVRGVPPEIMGIGPKEAIPAALKAAGLKQDDIDWIE
LNEAFAAQSLAVIRDLGLDPSKINPLGGAIALGHPLGATGAIRAATVVHGLRRRNLKYGMVTMCVGTGMGAAGIIERL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=392, Percent_Identity=43.8775510204082, Blast_Score=295, Evalue=5e-80,
Organism=Homo sapiens, GI167614485, Length=407, Percent_Identity=39.3120393120393, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI148539872, Length=400, Percent_Identity=37.75, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI4557237, Length=406, Percent_Identity=35.4679802955665, Blast_Score=215, Evalue=5e-56,
Organism=Homo sapiens, GI4504327, Length=440, Percent_Identity=30.9090909090909, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI194353979, Length=392, Percent_Identity=32.1428571428571, Blast_Score=131, Evalue=1e-30,
Organism=Escherichia coli, GI1787663, Length=412, Percent_Identity=43.4466019417476, Blast_Score=301, Evalue=6e-83,
Organism=Escherichia coli, GI48994986, Length=402, Percent_Identity=43.2835820895522, Blast_Score=281, Evalue=7e-77,
Organism=Escherichia coli, GI1788554, Length=406, Percent_Identity=39.9014778325123, Blast_Score=261, Evalue=7e-71,
Organism=Escherichia coli, GI87082165, Length=404, Percent_Identity=39.1089108910891, Blast_Score=253, Evalue=1e-68,
Organism=Escherichia coli, GI1788683, Length=379, Percent_Identity=31.3984168865435, Blast_Score=153, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI133906874, Length=402, Percent_Identity=41.7910447761194, Blast_Score=270, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI17535921, Length=405, Percent_Identity=37.037037037037, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI25147385, Length=402, Percent_Identity=32.089552238806, Blast_Score=199, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17551802, Length=441, Percent_Identity=29.9319727891156, Blast_Score=154, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI17535917, Length=395, Percent_Identity=28.3544303797468, Blast_Score=144, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6322031, Length=407, Percent_Identity=41.7690417690418, Blast_Score=284, Evalue=1e-77,
Organism=Saccharomyces cerevisiae, GI6325229, Length=407, Percent_Identity=37.5921375921376, Blast_Score=231, Evalue=2e-61,
Organism=Drosophila melanogaster, GI17648125, Length=408, Percent_Identity=39.7058823529412, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24655093, Length=406, Percent_Identity=38.1773399014778, Blast_Score=254, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24640423, Length=409, Percent_Identity=33.7408312958435, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI17137578, Length=442, Percent_Identity=31.6742081447964, Blast_Score=160, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41972; Mature: 41841

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQLQDAYIVAASRTPIGKAPRGAFKNTRPDELLVHAIKSAIAQVPGFDTKLIEDAIVG
CCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
CAIPEAEQGLNVARMGALLAGLPNTVGGVTVNRFCASGVTALAMAADRIRVGESDAILAA
CCCCCHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEC
GVESMSMVPMMGNKPSMSPHIFDRSEDFGIAYGMGLTAERVAEQWKVSREDQDAFSVESH
CCHHHEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHCCCCCCHHHHHHHH
RKAIAAQQAGEFNDEIAPYTLVERFPNLATGEIETRTREIALDEGPRAETSLEGLAKLKT
HHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHEEECCCCCCCHHHHHHHHHHHH
VFANKGSVTAGNSSQTSDGSGALLVVSEKVLKQFNLTPLARFVSFAVRGVPPEIMGIGPK
HHHCCCCEECCCCCCCCCCCCEEEEEEHHHHHHCCCCHHHHHHHHHHHCCCHHHHCCCCH
EAIPAALKAAGLKQDDIDWIELNEAFAAQSLAVIRDLGLDPSKINPLGGAIALGHPLGAT
HHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEEECCCCCCC
GAIRAATVVHGLRRRNLKYGMVTMCVGTGMGAAGIIERL
HHHHHHHHHHHHHHCCCCCCHHEEEHHCCCCHHHHHHCC
>Mature Secondary Structure 
SKQLQDAYIVAASRTPIGKAPRGAFKNTRPDELLVHAIKSAIAQVPGFDTKLIEDAIVG
CCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
CAIPEAEQGLNVARMGALLAGLPNTVGGVTVNRFCASGVTALAMAADRIRVGESDAILAA
CCCCCHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEC
GVESMSMVPMMGNKPSMSPHIFDRSEDFGIAYGMGLTAERVAEQWKVSREDQDAFSVESH
CCHHHEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHCCCCCCHHHHHHHH
RKAIAAQQAGEFNDEIAPYTLVERFPNLATGEIETRTREIALDEGPRAETSLEGLAKLKT
HHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHEEECCCCCCCHHHHHHHHHHHH
VFANKGSVTAGNSSQTSDGSGALLVVSEKVLKQFNLTPLARFVSFAVRGVPPEIMGIGPK
HHHCCCCEECCCCCCCCCCCCEEEEEEHHHHHHCCCCHHHHHHHHHHHCCCHHHHCCCCH
EAIPAALKAAGLKQDDIDWIELNEAFAAQSLAVIRDLGLDPSKINPLGGAIALGHPLGAT
HHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEEECCCCCCC
GAIRAATVVHGLRRRNLKYGMVTMCVGTGMGAAGIIERL
HHHHHHHHHHHHHHCCCCCCHHEEEHHCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]