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The map label for this gene is icd [H]

Identifier: 83721398

GI number: 83721398

Start: 873208

End: 874467

Strand: Direct

Name: icd [H]

Synonym: BTH_I0759

Alternate gene names: 83721398

Gene position: 873208-874467 (Clockwise)

Preceding gene: 83719990

Following gene: 83720936

Centisome position: 22.92

GC content: 61.9

Gene sequence:

>1260_bases
ATGCCGTATCAGCACATCAAGGTTCCGGAAGGCGGTGACAAGATCACCGTCAACAAGGATTTCTCGCTCAACGTTTCCGA
TCAGCCGATCATTCCCTACATCGAGGGCGACGGCACGGGCTTCGATATCACGCCGGTGATGATCAAGGTCGTCGACGCGG
CGGTCGAGAAGGCGTACGGCGGCAAGAAGAAGATCCACTGGATGGAGATCTACGCCGGCGAGAAGGCGACGAAGGTCTAC
GGTCCGGACGTGTGGCTGCCGGAAGAGACGCTGCAGGTGCTGAAGGAGTACGTCGTGTCGATCAAGGGGCCGCTCACGAC
CCCGGTCGGCGGCGGCATCCGTTCGCTGAACGTCGCGCTGCGCCAGGAGCTCGACCTGTACGTCTGCCTGCGCCCGATTC
AGTACTTCAAGGGCGTTCCCTCGCCCGTGCGCGAGCCGGAGAAGACCAACATGGTGATCTTCCGCGAGAACTCGGAAGAC
ATCTACGCCGGCATCGAATGGGCGGCCGAATCCGAGCAGGCGAAGAAGGTCATCAAGTTCCTGCAGGAAGAGATGGGCGT
GAAGAAGATCCGCTTCCCGGAAACGTCGGGCATCGGCATCAAGCCCGTGTCGAAGGAAGGCACCGAGCGCCTCGTGCGCA
AGGCGATCCAGTACGCGATCGACAACGACCGCAAGTCGGTCACGCTCGTCCACAAGGGCAACATCATGAAGTTCACGGAA
GGCACGTTCCGTGACGCCGGCTATGCGCTCGCCCAGAAGGAGTTCGGCGCGGTGCTGATCGACGGCGGCCCGTGGATGAA
GTTCAAGAACCCGAAGACGGGCAACGAGATCGTGATCAAGGATTCGATCGCCGATGCGTTCCTGCAGCAGATCCTGCTGC
GCCCGGCCGAGTACGACGTGATCGCGACGCTGAACCTGAACGGCGACTACATCTCGGACGCGCTTGCCGCGCAAGTCGGC
GGCATCGGCATCGCGCCGGGCGCGAACCTGTCGGATTCGGTCGCGATGTTCGAAGCGACGCACGGCACGGCGCCGAAGTA
CGCAGGCAAGGACTACGTGAACCCGGGTTCGGAAATCCTGTCCGCCGAAATGATGCTGCGCCACCTCGGCTGGACCGAAG
CGGCCGACGTCATCATCGCCGCGATGGAAAAGTCGATCAAGCAGAAGCGCGTCACGTACGACTTCGCGCGCCTGATGGAA
GGCGCGACGCAAGTGTCGTGCTCGGGCTTCGGTCAGGTGCTGATCGAAAACATGCAGTAA

Upstream 100 bases:

>100_bases
GAATAGCGGCTCGCCGTCGCGGACGCAGGGCCGGCGCCGCGCTTGCCCGACCGCGCACAACCAGATACCCACCAGCCCAG
CCATATCACTGGAGTCGATC

Downstream 100 bases:

>100_bases
GCGCGTCGGCGTAGCCGATGTCGAGCGACACCCCGGCGGGCCGCGTGCCCGCCGGGGTGTTTCGTTTTGGTGCGGCGCGC
GCATCGTTTGCAAGTAGTGC

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MPYQHIKVPEGGDKITVNKDFSLNVSDQPIIPYIEGDGTGFDITPVMIKVVDAAVEKAYGGKKKIHWMEIYAGEKATKVY
GPDVWLPEETLQVLKEYVVSIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPIQYFKGVPSPVREPEKTNMVIFRENSED
IYAGIEWAAESEQAKKVIKFLQEEMGVKKIRFPETSGIGIKPVSKEGTERLVRKAIQYAIDNDRKSVTLVHKGNIMKFTE
GTFRDAGYALAQKEFGAVLIDGGPWMKFKNPKTGNEIVIKDSIADAFLQQILLRPAEYDVIATLNLNGDYISDALAAQVG
GIGIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHLGWTEAADVIIAAMEKSIKQKRVTYDFARLME
GATQVSCSGFGQVLIENMQ

Sequences:

>Translated_419_residues
MPYQHIKVPEGGDKITVNKDFSLNVSDQPIIPYIEGDGTGFDITPVMIKVVDAAVEKAYGGKKKIHWMEIYAGEKATKVY
GPDVWLPEETLQVLKEYVVSIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPIQYFKGVPSPVREPEKTNMVIFRENSED
IYAGIEWAAESEQAKKVIKFLQEEMGVKKIRFPETSGIGIKPVSKEGTERLVRKAIQYAIDNDRKSVTLVHKGNIMKFTE
GTFRDAGYALAQKEFGAVLIDGGPWMKFKNPKTGNEIVIKDSIADAFLQQILLRPAEYDVIATLNLNGDYISDALAAQVG
GIGIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHLGWTEAADVIIAAMEKSIKQKRVTYDFARLME
GATQVSCSGFGQVLIENMQ
>Mature_418_residues
PYQHIKVPEGGDKITVNKDFSLNVSDQPIIPYIEGDGTGFDITPVMIKVVDAAVEKAYGGKKKIHWMEIYAGEKATKVYG
PDVWLPEETLQVLKEYVVSIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPIQYFKGVPSPVREPEKTNMVIFRENSEDI
YAGIEWAAESEQAKKVIKFLQEEMGVKKIRFPETSGIGIKPVSKEGTERLVRKAIQYAIDNDRKSVTLVHKGNIMKFTEG
TFRDAGYALAQKEFGAVLIDGGPWMKFKNPKTGNEIVIKDSIADAFLQQILLRPAEYDVIATLNLNGDYISDALAAQVGG
IGIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHLGWTEAADVIIAAMEKSIKQKRVTYDFARLMEG
ATQVSCSGFGQVLIENMQ

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=407, Percent_Identity=30.958230958231, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI28178816, Length=298, Percent_Identity=29.8657718120805, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI28178821, Length=298, Percent_Identity=29.8657718120805, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI28178838, Length=281, Percent_Identity=29.1814946619217, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI4758582, Length=279, Percent_Identity=29.0322580645161, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI28178819, Length=184, Percent_Identity=32.0652173913043, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1787381, Length=411, Percent_Identity=75.669099756691, Blast_Score=648, Evalue=0.0,
Organism=Escherichia coli, GI1788101, Length=377, Percent_Identity=27.8514588859416, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI87081683, Length=404, Percent_Identity=23.7623762376238, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71986051, Length=377, Percent_Identity=31.2997347480106, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI25144293, Length=305, Percent_Identity=30.8196721311475, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17505779, Length=301, Percent_Identity=31.2292358803987, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17550882, Length=297, Percent_Identity=26.9360269360269, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324709, Length=364, Percent_Identity=28.8461538461538, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6322097, Length=383, Percent_Identity=27.4151436031332, Blast_Score=131, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6324291, Length=370, Percent_Identity=29.7297297297297, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6319830, Length=390, Percent_Identity=24.6153846153846, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24643268, Length=383, Percent_Identity=33.6814621409922, Blast_Score=184, Evalue=7e-47,
Organism=Drosophila melanogaster, GI24643270, Length=383, Percent_Identity=33.6814621409922, Blast_Score=184, Evalue=8e-47,
Organism=Drosophila melanogaster, GI24661184, Length=390, Percent_Identity=30.7692307692308, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI161078635, Length=273, Percent_Identity=30.7692307692308, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI161078637, Length=273, Percent_Identity=30.7692307692308, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI161078633, Length=273, Percent_Identity=30.4029304029304, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24650122, Length=273, Percent_Identity=30.4029304029304, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI161078639, Length=273, Percent_Identity=30.4029304029304, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI20130355, Length=388, Percent_Identity=25, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI281362242, Length=338, Percent_Identity=26.9230769230769, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24648872, Length=338, Percent_Identity=26.9230769230769, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 46145; Mature: 46013

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYQHIKVPEGGDKITVNKDFSLNVSDQPIIPYIEGDGTGFDITPVMIKVVDAAVEKAYG
CCCCEEECCCCCCEEEEECCEEECCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCC
GKKKIHWMEIYAGEKATKVYGPDVWLPEETLQVLKEYVVSIKGPLTTPVGGGIRSLNVAL
CCCEEEEEEEECCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
RQELDLYVCLRPIQYFKGVPSPVREPEKTNMVIFRENSEDIYAGIEWAAESEQAKKVIKF
HHCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCEEECEEHHCCHHHHHHHHHH
LQEEMGVKKIRFPETSGIGIKPVSKEGTERLVRKAIQYAIDNDRKSVTLVHKGNIMKFTE
HHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECC
GTFRDAGYALAQKEFGAVLIDGGPWMKFKNPKTGNEIVIKDSIADAFLQQILLRPAEYDV
CCCCCCCHHHHHHCCCEEEECCCCEEEECCCCCCCEEEEECHHHHHHHHHHHCCCCCCCE
IATLNLNGDYISDALAAQVGGIGIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEIL
EEEEECCCCHHHHHHHHHHCCEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHH
SAEMMLRHLGWTEAADVIIAAMEKSIKQKRVTYDFARLMEGATQVSCSGFGQVLIENMQ
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHCCCC
>Mature Secondary Structure 
PYQHIKVPEGGDKITVNKDFSLNVSDQPIIPYIEGDGTGFDITPVMIKVVDAAVEKAYG
CCCEEECCCCCCEEEEECCEEECCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCC
GKKKIHWMEIYAGEKATKVYGPDVWLPEETLQVLKEYVVSIKGPLTTPVGGGIRSLNVAL
CCCEEEEEEEECCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
RQELDLYVCLRPIQYFKGVPSPVREPEKTNMVIFRENSEDIYAGIEWAAESEQAKKVIKF
HHCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCEEECEEHHCCHHHHHHHHHH
LQEEMGVKKIRFPETSGIGIKPVSKEGTERLVRKAIQYAIDNDRKSVTLVHKGNIMKFTE
HHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECC
GTFRDAGYALAQKEFGAVLIDGGPWMKFKNPKTGNEIVIKDSIADAFLQQILLRPAEYDV
CCCCCCCHHHHHHCCCEEEECCCCEEEECCCCCCCEEEEECHHHHHHHHHHHCCCCCCCE
IATLNLNGDYISDALAAQVGGIGIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEIL
EEEEECCCCHHHHHHHHHHCCEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHH
SAEMMLRHLGWTEAADVIIAAMEKSIKQKRVTYDFARLMEGATQVSCSGFGQVLIENMQ
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10361714; 10556719; 12704232 [H]